서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

한국인에서 다변성 D12S391 유전좌의 집단유전학적 연구

이용욱,김성민,구태완,이혜린,강일호,한길로,이혜승,황적준 大韓法醫學會 1999 대한법의학회지 Vol.23 No.1

The hypervariable short tandem repeat(STR) locus D12S391 was investigated in a Korean population. A total of 14 alleles were detected by size under denaturing conditions in 517 unrelated individuals. To confirm all of the alleles detected in a Korean population, a total of 34 fragments were sequenced. Prior to allele designation, we constructed the allelic ladders containing 11 alleles sequenced in this study. Allele 18 is the most common with a frequency of 0.281 in Koreans, and one variant allele 19.3 which have been confirmed by sequencing, was detected. The observed heterozygosity, the power of discrimination (PD), and the mean exclusion chance (MEC) for the locus D12S392 is 0.781, 0.946 and 0.652 , respectively. No deviation from Hardy-Weinberg equilibrium was observed in a Korean population (p=0.557). In the 424 meioses in 105 Korean families confirmed using other 17 STR loci, no mutation was detected in locus D12S391. The STR locus D12S391system is useful both for the analysis identification and parternity.

한 대학 신입생의 우울수준과 관련변인에 관한 연구

이명학,남해성,손석준,이정애,김병우 대한보건협회 1994 대한보건연구 Vol.20 No.2

1994년도 한 대학 1년생을 대상으로 8개항목의 생활만족지수(LSI-W) 그리고 20개항목의 우울지수(CES-D) 및 관련변인들을 조사하여 각각의 점수와 우울증의 유병률을 계산하고 서로간의 관련성을 조사하여 다음과 같은 결과를 얻었다. 1. 생활만족지수의 평균점수는 9.98이었고 비흡연군, 비음주군, 운동을 하는 군에서 평균점수가 유의하게 높았다(p<0.01). 2. 우울지수의 평균점수는 17.2였고 여학생에서 남학생보다 유의하게 높았고, 우울증의 유병률은 19.8%이었고 여학생에서 남학생보다 유의하게 높았다(p<0.01). 3. 우울증세 고위험군과 저위험군에 있어서 건강에 대한 본인의 생각과 본인이 인지하는 체중에서 차이가 있었으며, 생활만족지수, 가족수, 체중, 신장에서 유의한 차이를 보였다(p<0.05). 4. 우울지수와 생활만족지수, 연령, 종교활동기간, 신장, 체중등과는 음의 상관을 나타내고(p<0.01), 가족수, 수면시간, 경제수준과는 양의 상관을 보였다(p<0.01). 5. CES-D에 영향을 미치는 변수를 알아보기 위한 단계적 로지스틱 회귀분석에서 생활만족도, 성별, 건강에 대한 본인의 생각, 본인이 인지하는 체중, 흡연, 음주가 CES-D에 의한 우울증 발현에 있어서의 유의한 요인으로 나타났다(p<0.05). The questionnaire survey using the Center for Epidemiological Studies-Depression Scale(CES-D) and 8-items Life Satisfaction Index Well-being(LSI-W) and other variables was conducted to determine the prevalence of depression and to identify the correlation among CES-D and related factors. Study population was the whole freshman group newly enrolled in a university. The results were as follows; 1. Mean score of LSI-W was 9.98 and that score was higher in non-smokers, non-drinkers and exercise group (p<0.01). 2. Mean score of CES-D was 17.2 and the prevalence of depression was 19.8%. And those were significantly higher in female than in male(p<0.01). 3. Perceived health status, perceived weight, LSI-W, family size, weight and height were significant variables between high and low risk group of depression(p<0.05). 4. CES-D score was negatively correlated with LSI-W, age, duration of religious life, height, weight and po-sitively correlated with family size, sleeping time and economic status(p<0.01). 5. In the regression analysis significant predictors of the depression were sex, preceived health status, weight, smoking and drinking(p<0.05).

한국 남해ㆍ동해 및 동중국해 유종섬모충류의 분류학적 기재

이준백,김요혜 제주대학교 해양연구소 2000 해양과환경연구소 연구논문집 Vol.24 No.-

A total of 40 tintinnids were identified and described taxonomically based on samples collected in the southern Korean waters, the East Sea (the Japan Sea) and the East China Sea from July 1998 to June 2000. We also discussed the characteristics of ecological distribution of tintinnids.

IMT-2000 망에서의 Layered Cell 전송 성능해석 모델

이영교,정해원,최충열,조성준 한국항공대학교 1997 論文集 Vol.35 No.-

본 논문은 ATM 기반의 layered 셀 구조를 적용한 Mobile Trunking에 사용되는 AAL type 2 프로토콜에 대해 설명했다. AAL type 2는 지연에 민감한 어플리케이션에 있어서 길이가 짧고, 패킷 길이가 변동하며, 저속도인 데이터 전송에 대한 대역폭 효율을 제공한다. 본 논문에서는 짧은 길이의 패킷에 대한 프레임 구조와 이를 하나 또는 그 이상의 ATM셀에 다중화 시키는 방식과 전송에러를 복구하는 기능 등에 대해서도 설명했고, 통계적 다중화의 효율, 지연, 채널전송효율 등을 해석하기 위한 큐잉 모델도 제안했다. 그리고, 미니셀 패킷화 지연 및 layered셀로 다중화되는 미니셀의 다중화 효율 등을 산출했고, layered셀 구조를 사용할 경우 예측되는 전송효율을 알아보았다. 여기서 전송속도는 ATM기반의 45Mbps에서 155Mbps사이의 경우를 고려하였다. 전송효율의 관점에서는 layered셀 방식이 고정 길이 셀 방식보다 효율적임을 알 수 있었다. 끝으로, 이를 국내 IMT-2000환경에 적용하기 위한 성능해석 모델과 파라미터를 제시하고 트렁크 용량을 해석했다. In this paper, we explaned the protocol of AAL type 2 used in the Mobile Trunking which has the layered cell structure based on ATM. These AAL type 2 provides the bandwidth-efficient transmission of low-rate, short, and variable length packets in delay sensitive applications. This paper covers the frame structure of the short legnth packets, the packing of those into one(or more) ATM cells, and the mechanisms to recover from transmission errors. Also, we proposed queueing model to analyse the efficiency of statistical multiplexing, delay time, channel transmission efficiency. And we calculated short cell packetization delay and short cell multiplexing into layered cells, and measured transmission efficiency to predict the layered cell structure schemes. Here we set the transmission line speed(trunking) at the between 45Mbps to 155Mbps, which are the future services bsed on ATM. From the viewpoint of transmision efficiency, layered cell shcemes is revealed to be more useful than fixed length cell schemes. Finally, we applied the proposed queueing model to the domestic IMT-2000 systems and we analysed the performance of trunk capacity.

韓國洞窟의 動物生態에 關한 硏究 : 1. 寧越高氏窟과 龍潭窟의 동물상에 관하여 1) In the Gosi-cave and Yongdam-cave

李海浜,南宮俊 동국대학교 농림과학연구소 1971 農林科學 論文集 Vol.4 No.-

The authers surveyed the environmental factors with the faunae of Gosi-cave and yongdam-cave in Kangwon-do, Korea in July 30, 1966; Jan. 1, 1968; Jan. 24-27, 1968; Dec. 29-30, 1968; Oct. 22-25, 1970. As the enviornmental factors, air temperature, water temperature, moisture and Ph, were studied. The results are shown in the table 1 2. 1. In the Gosi-cave, the authers collected 38 species and these consisted of Troglobite 12 species (33.3%), Troglophile 9 species (25.0%), and Trogl-oxine 15 species (41.5%) 2. In the yongdam-Cave, 26 species animals collected and Troglobite 10 species(38.4%), Troglophile 5 species (19.2%) and Trogloxine 11 species (42.3%) constituted the faunae of the cave.

혈액의 전처리 방법에 따른 적혈구 pyrimidine 5'-nucleotidase 활성도의 비교

이은일,최재욱,염용태,김병헌,김해준 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.4

Sakai's method (1986) has been known as the simplest one for determination of erythrocyte pyrimidine 5' nucleotidase(P5N) activity using high performance liquid chromatography(HPLC). However the drawback of the method is that it is difficult to wash the erythrocyte for isolation. To search for the simpler method, we compared Sakai's method with other methods using whole blood treated with heparin and concanavalin A or whole blood treated with EDTA-2K instead of washing the erythrocyte. The mean concentrations of lead in blood samples collected from 44 male and 16 female workers who are healthy without any exposure to lead in their workplace were 4.30±1.31 ㎍/㎗(mean ±standard deviation), which were measured by frameless atomic absorption spectrophotometer. Erythrocyte P5N activities were measured by 3 methods; Sakai's method(Method Ⅰ), using whole blood treated with heparin and concanavalin A(Method Ⅱ), and using whole blood treated with EDTA-2K(Method Ⅲ). The results were obtained as follows; 1. The mean of erythrocyte P5N activity by Sakai's method(MethodⅠ) were 12.7±2.47 μmole uridine/hr/gm of Hb. 2. The mean of erythrocyte P5N activity by the method using heparinized whole blood treated with concanavalin A(Method Ⅱ) were 13.1,±2.41 μmole uridine/hr/gm of Hb. 3. The difference of mean erythrocyte P5N activity between Method Ⅰ and Method Ⅱwas mot significant. 4. The erythrocyte P5N activity by the method using whole blood treated with EDTA2K(Method Ⅲ) was significantly different from Method Ⅰ. We thought that omission of incubation period which was required on Method Ⅲ using EDTA-2K caused the difference between Method Ⅰ and Method Ⅲ. 5. Simple linear regression equation for erythrocyte P5N activity between Method Ⅰ(Y) and Method Ⅱ(X) was significant: Y= -0.012 +0.9724 X. These results suggest that the method using whole blood treated with heparin and concanavalin A is simpler to examine the erythrocyte P5N activity as a biological indicator of lead intoxication than Sakai's method.

알레르기 환자에서 특이알레르겐 항체 양성율과 관련요인

이선화,남해선,이성수,안현철,황규윤,박준수,,박춘식 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.2

Recently, allergic diseases are very prevalent in Korea, resulting in physical and economic losses during the life. It is well-known that the principle therapy is identification, eradication, and desensitization of allergens. There are many allergic diagnostic tools for identification of specific-allergens. However, none of them is satisfied with its efficiency due to lack of validity. Recently MAST-CLA has been widely used in the allergic clinical fields because of its simplicity and simultaneous identification of allergens. This study was designed to determine the positivity of allergen-specific antibodies using MAST-CLA in patients with allergic diseases, and evaluate the efficacy for allergen detection, compared to results of skin prick test. During June 2000 - September 2001, 325 study subjects visited Soonchunhyang University Chunan Hospital for the evaluation of allergic problems. Among them, 289 subjects were diagnosed with allergic disease and included for the study. Thirty four subjects visited children's allergic unit were evaluated specific allergens using a skin prick test at the same time. Our result as follows; 1. The positive rates of allergen-specific antibodies and total IgE were 51.2% and 73.4%, retrospectively. 2. There was significant difference in positive rate in age group, showing highest in teen ages(73.6%), but insignificant difference in sex in allergen-specific antibodies. 3. The positive rate was 60.4% in allergic rhinitis, 51.3% in allergic dermatitis, 46.9% in bronchial asthma, and 39.1% in urticaria in order(P=0.073). 4. Significant difference in month or season was observed, with highest rate in April(78.1%) and May(72.1%). The highest season was in spring(62.7%), and then summer(52.8%), fall(50.3%), and winter(41.4%) in order (P=0.04). 5. The three highest allergen-specific antibodies were D. pteronyssinus(39.3%), D. farinae(38.3%), and house dust(24.3%) in Korean inhalant pannel, However, in food pannel types of allergen-specific antibody were different as D. farinae(18.5%), Alternaria(18.5%), house dust(17.3%). 6. There were significant agreements between MAST-CLA and Skin prick test (D. farianae Kappa=0.636;D. pteronyssinus Kappa=0.78, both P<0.001) In conclusion, MAST-CLA could detect allergen-specific antibodies in patients with allergic diseases as a simple and valid tool of screening of allergy. Especially, it could be a useful measure of multiple allergens simultaneously in children However, more detailed allergens and valid assay for unmeasured allergens should be identified for Korean-specific allergens.

서울 소재 7개 종합병원 암환자들의 보완대체요법 이용양상

이은일,신유철,이주현,김순덕,김해준,조무성 대한보건협회 2002 대한보건연구 Vol.28 No.3

Objective of this study was to determine the prevalence and kinds of complementary and alternative medicine (CAM) used in cancer patients. Questionnaire survey was done by trained interviewers for use of CAM, demographic information, type of cancer and cancer stage for 512 cancer patients in 7 general hospitals in Seoul. Among the cancer patients, the total number of inpatients was 315 and outpatients 197. The results were as follows. Among cancer patients, 55.5% of them used CAM. The patients who were 30's and 40's showed high rate of CAM use(59.2%, 64,7%). Stomach cancer patients showed highest rate of CAM use(75.6%) among cancer patients. Liver cancer and breast cancer patients also showed high rate of CAM use(71.1%, 60.3%). The patients received chemotherapy showed higher rate of CAM use(60.6%) than the patients not received chemotherapy(43.7%). By multiple logistic regression, stomach cancer, liver cancer, and chemotheray were statistically significant variables for use of CAM. Among cancer patients, the use of herbs was highest(86.0%), followed by diet(46.5%) and chinese medicine(14.1%). Elm tree was the most frequently used(49.6%), however, total usage of mushrooms such as Sang-Whang, Young-Gee, Agaricus, Wooon-Gee were 57%. The number of CAM items used by cancer patients were limited and it is necessary for scientific data to prove the their effect.

용접공에서 혈중 중금속 농도와 혈장중 Malondialdehyde, α-tocopherol 및 적혈구내 Superoxide Dismutase 활성도에 관한 연구

이원진,장성훈,황천현,천병철,김해준 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2

We investigated the association between the oxidative stress and the concentration of heavy metals in blood among welders. The study subjects were male manual CO₂welders(N=127) exposed to several heavy metals. The age distribution was from 20 to 63(GM=33.7) and the geometric mean(GM) of work duration was 4.2 years. We analyze the level of blood lead, cadmium, manganese and chromium which was related with the oxidative stress in the animal studies. Blood selenuim, plasma malondialdehyde(MDA), plasma α-tocopherol and erythrocyte superoxide dismutase(SOD) were analyzed as biological markers of the oxidative stress. The results of univariate analysis showed that the plasma MDA was significantly correlated with α-tocopherol(r=0.327) and blood selenium(r=0.313) concentration. But we could not find out any relationship between the erythrocyte SOD activities and those metal concentrations. Neither smoking nor alcohol consumption was related to the level of heavy metals and the oxidative stress biomarkers. As the results of multiple regression analysis with stepwise selection method, 1) the change of MDA level were dependent with the level of α-tocopherol and blood selenium concentration(R²=19.7), 2) the plasma α-tocopherol level was dependant with MDA and blood chromium concentration(R²=15.6), 3) in case of erythrocyte SOD activity, only the duration of work was significantly selected.