판막 질환에서의 심근 섬유화 : 심근 조직을 이용한 형태학적 연구 및 혈청 생화학적 지표의 분석

강수진,박덕우,송재관,박경민,송종민,강덕현,한기훈,송현,이재원,주석중,송명근,김정선 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

안지오텐신 변환효소 억제제와 안지오텐신 II 수용체 차단제 투여 후 발생한 급성 신부전과 폐부종으로 전원된 선천성 단일신 환자의 치료 1예

백두현,김경진,홍성철,강석형,송하응,김혜인,김수현,오현정,강혜원,김서우,유민아,류동열,최규복,강덕희 이화여자대학교 의과대학 2010 EMJ (Ewha medical journal) Vol.33 No.1

Blockers of renin-angiotensin system(RAS) including ACE inhibitor or ARB are one of the most frequently prescribed medications for the treatment of hypertension, heart failure and proteinuria. One of the major side effects of these RAS blockers is the deterioration of renal function, mainly due to a reduction of intraglomerular pressure. Therefore, close monitoring of renal function is recommended when RAS blockers are initially prescribed, especially for the patients with impaired renal function. We report a patient who was transferred to our hospital due to the sudden development of oliguria and dyspnea after treatment for hypertension with ACEi and ARB. She was finally diagnosed as RAS blocker-induced acute renal failure with pulmonary edema complicated on congenital solitary kidney. After hemodialysis and conservative treatment, her renal function was recovered with maintenance of normal urine output. Conclusion:This case highlights the necessity of the functional and structural evaluation of kidney to prevent the serious complication such as acute renal failure before the administration of ACEi and/or ARB.

鹿脛骨이 卵巢摘出로 誘發된 흰쥐의 骨多孔症에 미치는 影響

姜智天,金頀哲,林康鉉,安德均 대한본초학회 1999 大韓本草學會誌 Vol.14 No.2

The purpose of this study is to examine what are the effects of the Deer Tibia on the postmenopausal osteoporosis. In order to observe the effects of the Deer Tibia on the osteoporosis induced from ovariectomy, administered the Deer Tibia in p.o to the ovariectomized Rats, and measured the variance of weight related to osteoporosis, the variance of osteocalcin, calcium, ALP, phosphorus, GOT and GPT in serum, the variance of creatinine, calcium to creatinine rate in urine and urinary volume, the variance of the organs in weight and the variance of the bones. The results of the experiment are as follows: 1. The level of serum ALP, S-GOT and S-GPT in Deer Tibia group was showed a significant decrease in comparison with control group. The level of serum osteocalcine, calcium, phosphorus in Deer Tibia group was showed no efficiency in comparison with control group. 2. The level of urinary volume in Deer Tibia group was showed a significant increase in comparison with control group, and calcium to creatnine ratio in Deer Tibia group showed a significant increase. 3. The weight of tibia ash and the length of femur in Deer Tibia group showed no significant change. The bone density in Deer Tibia group showed a significant increased in comparison with control group. 4. Body weight in Deer Tibia group was increased in comparison with control group, but showed no efficiency. The weight of heart, liver, spleen, kidney and uterus in Deer Tibia group showed no significant change in comparison with control group. According to the above results, effects of the Deer Tibia on the aged ovariectomized rat model showed a efficiency in elevation of bone density by increasing bone mass and in prevention of renal function failure by ovariectomy. So Deer Tibia can be used for prevention and curing of the postmenopausal osteoporosis, as for it's effects, continuous clinical study is needed.

급성 심근허혈에 의해 윤발된 승모판 폐쇄부전의 기전에 관한 실험적 연구

강덕현,송현,송재관,김현숙,이재환,임희영,이재원,박성욱,박승정,송명근 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.8

알코올리즘 환자에서 뇌교외수초용해증과 연관된 주기교대눈떨림과 주기교대주시편위

강성원,이명제,정주리,김영진,양현덕 원광대학교 의과학연구소 2009 圓光醫科學 Vol.24 No.1

주기교대눈떨림와 주기교대주시편위는 이상안구 운동에서도 흔히 관찰되지 않는다. 이런 안구운동은 뇌교와 소뇌에 병변이 있을 때 나타난다고 보고되고 있다. 50세 남자 환자가 과음을 하고 난 이후 심하게 구토를 하여 입원하였다. 다음날 아침에 의식이 없었으며 주기교대눈떨림과 주기교대주시편위가 관찰되었다. 뇌자기공명영상에서는 뇌교나 소뇌에 병변없는 교뇌외수초용해증에 합당한 소견을 보였다. 저자는 아마도 교뇌외수초용해증이 소뇌와 전정신경핵의 경로중에 GABA 시스템에 이상이 발생하여 주기교대눈떨림과 주기교대 주시편위가 나타났을 것으로 추정한다. Background; Periodic alternating gaze deviation(PAGD) and periodic alternating nystagmus(PAN) are rare forms of abnormal eye movement. Multiple lesions in the cerebellum and brainstem have been reported with PAN and PAGD. Case Report; A 50-year-old man presented with severe vomiting after binge drinking. The next morning he. became vegetative state and showed PAGD and PAN. Brain MRI showed findings compatible with extrapontine myelinolysis(EPM) without any brainstem or cerebellar lesions. Conclusions; We postulate that the disturbed GABAnernic system in the pathway from the cerebellum to vestibular nuclei caused probably by EPM developed PAGD and PAN.

높은 입체선택성을 나타내는 고리카보네이트의 친핵성 치환반응과 광학활성인 β-Hydroxy Ester의 합성

강석구,박동철,노호식,윤승현,홍덕표 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.1

The nucleophilic ring opening of the cyclic carbonates of optically active threo-2,3-dihydroxy esters afforded α-substituted β-hydroxy esters with highly regio- and stereoselectivity under mild conditions. The α-substituted β-hydroxy esters were transformed to β-hydroxy esters

급성 신우신염과 동반된 자발적 신장 파열 1예

송현주,최문영,김미연,이영숙,김승정,최규복,윤견일,서정수,강덕희 대한신장학회 2003 대한신장학회잡지 Vol.22 No.6

일 대학병원에서 양극성장에 환자의 흡연 특성 : 정신분열병 환자와의 비교 연구

이강수,천덕희,김지혜,김현진,조현상 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.4

Objectives : This study aimed to investigate smoking characteristics and nicotine dependence severity in bipolar disorder Comparing those of schizophrenia. Methods : 70 bipolar and 123 schizophrenic patients, diagnosed using DSM-IV-TR criteria and treated at the Severance Mental Health Hospital, were interviewed regarding socio-demographic variables, smoking characteristics and Fagerstrom Test for Nicotine Dependence (FTND), designed to evaluate the intensity of smoking. Results : The rate of current smoking was 60.0% in the bipolar group, and 50.4% in the schizophrenia group. No significant difference was seen in terms of the rate of current smoking between the groups. Rates of having ever smoked also did not differ between bipolar (73%) and schizophrenic patients (65%). Daily cigarette consumption of bipolar patients (15.9 cigarettes/day) was significantly lower than that of schizophrenic patients (21.2 cigarettes/day), but FTND score didn't appear to differ between bipolar and schizophrenic patients. Bipolar females showed higher rate of current smoking (44%) than schizophrenic females (17%). Among bipolar patients, antipsychotics dose was not correlated with daily cigarette consumption and FTND total score. Age of disease onset didn't appear to differ between smokers and non-smokers in bipolar group. Conclusion : Although daily consumption was significantly lower in the bipolar group, the rate of smoking and smoking severity in bipolar disorder were as high as in schizophrenia. This fact suggests that the bipolar disorder might be related to the nicotinic acetylcholine system dysfunction as like schizophrenia.

뇨(尿)중 3-Methylhistidine 함량의 측정과 이용

정수현,서형주,김윤숙,이효구,강덕호 한국식품영양학회 1996 韓國食品營養學會誌 Vol.9 No.2

기존의 방법을 일부 수정하여 뇨중 3-methylhistidine을 분석하였다. 뇨중 3-methylhistidine을 fluorescamine 유도체화하여 HPLC에 주입하고 C_18 column과 10 mM acetonitrile/sodium phosphate buffer(pH 7.5)로 분리·용출시켜 형광검출기로 측정하였다. 3-methylhistidine의 체류시간은 7분 이내이었으며, histidine과의 분리상태도 서로 간섭함이 없이 양호하였다. 뇨에 3-methylhistidine을 첨가하고 이를 분석하였을 때의 회수율은 93∼106%로 높은 수준이었다. 체육학과 남학생중 웨이트 트레이닝 단련자와 비단련자를 대상으로 조사한 단기간의 웨이트 트레이닝에 따른 뇨중 3-methylhistidine 함량의 변화는 두 집단 모두 웨이트 트레이닝후의 3-methylhistidine 분비량이 유의하게 증가하였다. A modified method is given for the precolumn derivatization and subsequent high-pressure liquid chromatographic seperation of 3-methylhistidine from urine. The elution contained isocratic solution with acetonirile and 10 mM sodium phosphate(pH 7.5) requires less than 7 min. The recoveries of 3-methylhistidine from urine control were 93% to 106%. 3-Methylhistidine determinations were performed on urine samples from volunteers who were both male trained and non-trained physical undergraduates. As the result, urinary 3-methylhistidine content of volunteers increased significantly after weight training.

한약에 의해 유발된 급성 간질성 신염 2례

김덕윤,박동건,김응석,강영모,양창헌,이정호,이동철,이영현,김정란 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

간질성 신염은 신장의 간질을 선택적으로 침범하는 염증성 질환으로 여러가지 원인에 의해 유발되며, 이 중 약물에 의한 경우는 각종 항생제, 비스테로이드성 진통제, 항경련제, 이뇨제, 면역억제제등에 의한 증례들이 보고되고 있다. 현재 각종 질환-특히 만성질환-의 치료에서 한약이 차지하는 비중이 적지 않으나, 그 각각의 성분들이 유발할 수 있는 부작용들에 대한 연구는 거의 없는 실정이다. 저자들은 관절염 치료를 위해 중국산 한약을 복용한 후 복통, 피로감 및 육안적 혈뇨를 주소로 내원한 두 환자에서, 단백뇨와 신기능 장애를 보여 시행한 신조직 생검상 급성 간질성 신염에 합당한 병리학적 소견을 보이고, 한약 복용 중지 후 급속한 회복을 보여, 한약에 의해 유발된 것으로 사료되는 급성 간질성 신염 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Acute interstitial nephritis is a disease characterized by renal interstitial inflammatory cell infiltration and acute renal functional deterioration. This is caused mainly by antibiotics, NSAID and diuretics such as thiazide, but cases induced by herb medication are rare. We experienced two cases of acute interstitial nephritis after treatment with herb medication. One 71-year-old female patient and the other 60-year-old female were admitted to the hospital because of general weakness and gross hematuria. Microscopic hematuria, pyuria, and proteinuria were presented. After definitive diagnosis with a renal biopsy, we noted rapid recovery of renal function by drug withdrawal and steroid therapy. We report these cases with a review of the referenced literatures. Key Words : Herb medication, Acute Interstitial nephritis.