정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

이온주입이 금속의 일함수에 미치는 영향(Ⅰ)

김현경,강석태,황정남,이철주,최대선,정병두 연세대학교 자연과학연구소 1984 學術論文集 Vol.13 No.-

이온 주입이 일함수 차이에 미치는 영향을 연구하기 위하여 낮은 에너지 이온 가속기, 전자총과 기타 일함수 차이를 측정하기 위한 장치를 설계, 제작하였다. 제작된 이온 가속기의 집속 특성은 이론적인 값과 일치하였다. 즉, 집속 렌즈의 확대율이 이론값은 2.0인데 비하여 1.2로 상당히 작은 값이었다. 또한 집속 렌즈의 전압 V_L과 추출 전압 V_e에 의한 집속 특성 역시 이론값과 매우 잘 일치하였다 . 제작된 장치를 사용하여 다결정 Cu와 Ni의 일함수 차이를 측정한 결과 0.45eV임을 알았다. 그리고 전자선을 이용하여 억제 전위차로 일함수를 측정할때 입사 전자의 반사율을 고려해야 함을 알았다. Low energy ion accelerator, electron gun, and apparatus for measuring work function difference are designed and constructed in order to study the effect of ion implantation on the work function. The focusing properties of accelerator is coincided with theoretical results; the magnification of Einzel lens is found to be 1.2, while theoretical value is 2.0, and the focal properties as a function of V_L/V_e are in good agreement with theory. Using these systems, the work function difference between polycrystalline Cu and Ni is found to be 0.45eV, and the experimental retarding potential plots indicate close agreement with the theoretical values modified by electron reflection.

액정의 물리화학적 특성 및 합성에 관한 연구-네마틱-스메틱 A 상전이 근처의 네마틱상에서 임계현상에 대한 광산란 실험연구

김두철,임동건,변영태 濟州大學校 基礎科學硏究所 1989 基礎科學硏究 Vol.2 No.1

Rayleigh 광산란 실험방법을 이용하여 액정 Octyloxycynobiphenyl(8OCB)의 네마틱-스메틱 A 상전이 근처의 네마틱상에서 산란된 빛의 세기를 온도의 함수로 측정하였다. 실험 데이타 분석으로부터 bend 탄성상수(K₃)에 비례하는 세로 방향 상관거리 ??가 임계지수 ??=0.64±0.02를 갖고 발산함을 알 수 있었다. 이 결과는 de Gennes의 모델에서 계산된 값인 ??=0.67과 유사함을 알 수 있었다. By utilizing the Rayleigh light scattering technique, we have measured the temperature dependence of scattered light in the nematic-smectic-A phase transition point of Octyloxycynobiphenyl(8OCB). The temperature dependence of bend elastic constant K₃is deduced from analysis of this data, and it is found that the longitudinal correlation length ?? diverges with critical exponent ??=0.64±0.02. This result is similar to de Gennes's prediction ??=0.67.

제주지역 고등학생들의 과학과목 선호성향에 관한 조사연구

김두철 濟州大學校 師範大學 科學敎育硏究所 1988 科學敎育 Vol.5 No.-

In this paper, high school students' preference on science course in Cheju do were examined to compare with in other provincial students. The result was that they would decide their department choice in consideration of their futures and aptitudes. In investigating the preference on science course, it proved that they prefered Biology to Physics and Chemisty in comparision with the other provincial student. In the case of the examination of the satisfaction on science learning, only 17.4% of the students agreed on the class, while the rest of them did not. And it turned out that the reason of disagreement was lack of practical experiments relating with a learing contents.

광 산란 실험방법을 이용하여 액정 네마틱-스멕틱 A 상전이 근처의 임계현상 연구

金斗哲,高正大 제주대학교 1989 논문집 Vol.28 No.-

A electrical oven that was able to controle a millidegree was made and it's tempearature stability was investigated. The temperature gradient of electrical oven was ±2.5m℃. In a light scattering experiment, The temperature dependence of sattering light intensity near nematic to smectic-A phase transition of 80CB was measured. The intensity of scattered light from 80CB was continuous at T?? and it proved that nematic to smectic-A phase transition is second order. The longitudinal correlation length ?? diverges with critical exponent ?=0.66 ±0.02. This result is consistent with de Gennes' prediction.

不動産物權變動에 있어서의 登記請求權

金斗熙,許承喆 제주대학교 1974 논문집 Vol.6 No.-

In the New Civil Law of korea there are many different doctrines on the claims of Registration in the transfer of the right of real estate. Therefor, it is the purpose of this study to introduce and study the legislative example of the foreign countries about the cause and Nature of the claims of registration by means of legal acts in the Civil Law and also to study and criticize the doctrines and the court decisions. So, this study asserts that the New Civil Law of korea cloes not admit the individuality of the act of real right in the transfer of the right of real estate, and the claims of registration in the pure claims of credit raised in the claim acts that are the cause acts.

回分式 反應器에서 活性炭에 依한 液相吸着의 內部粒子擴散係數에 관한 硏究

金昺圭,梁斗錫,李鏞喆 成均館大學校 科學技術硏究所 1987 論文集 Vol.38 No.2

Liquid-phase adsorption of organics (aniline, phenol, p-chlorophenol, and m-cresol) on activated carbon was carried out in a batch system. Diagrams showing concentration change in an agitated tank adsorber are presented to estimate intraparticle diffusivities under nonlinear isotherm, where either pore or surface diffusion is assumed to be controlling. The experimental data were analyzed by two proposed model, the pore diffusion model and the surface diffusion model with an effective diffusion coefficient as a model parameter. For mass transport in the- liquid-phase adsorption process, it could be concluded chat the intraparticle diffusion was the rate-controlling step, and it was shown that surface diffusion contributed more to intraparticle diffusion than the pore diffusion in the adsorption system studied. The time-concentration curves predicted by the surface diffusion model and the pore diffusion model coincide well With experimental data.

단백질 응고체의 프랙탈 구조에 관한 광 산란 실험 연구

김두철 濟州大學校 基礎科學硏究所 2000 基礎科學硏究 Vol.13 No.1

Using light scattering techniques, the radii of cluster and the fractal dimensions for clustered proteins were measured under different conditions of pH and precipitation ammonium sulfate. Our results show that at pH=3 the growth of aggregates forms with a power law R_(H) - t^(1/D_(f)), which is agreed with the DLCA model. The fractal dimensions of clustered protein decrease as concentrations of protein increase. And the fractal dimensions ncrease with concentrations of precipitation.

GdFe 박막의 Kerr 이력곡선 연구

金斗哲,鄭原基 제주대학교 1990 논문집 Vol.30 No.-

GdFe amorphous thin film used were prepared by the rf sputtering technique on the slide glass substrates held at room temperature, Composition ratios of GdFe films were measured by AES and kerr hysteresis loops of these films were studied by using the polar kerr loop tracer. It has been found that some of these films show the anomalous hystersis loops. this anomaly has been explained by the double layers model with a surface oxidation layer.