GO에 의해 유도된 培養 脊髓感覺神經細胞 독성에 대한 鎭肝熄風湯의 방어효과

박광수,이호승,김인수,강길성,김인규,김인섭,류도곤 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1

To evaluate the effect of Jingansikpungtang water extract on cultured mouse spinal sensory neuron which was inhibited by glucose oxidase(GO)-induced cytotoxicity, NR assay and TBARS assay for lipid peroxidation were carried out after the cultured mouse spinal sensory neuron were pre-incubated with various concentrations of Jingansikpungtang water extract for 3 hours prior to exposure of GO. GO, a oxygen radical, decreased the survival rate of the cultured mouse spinal sensory neuron cells on NR assay. Jingansikpungtang water extract have efficacy of decreasing lipid peroxidation increasing by GO in cultured mouse spinal sensory neuron. From above the results, it is concluded that Jingansikpungtang has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process.

Case Report : Autosomal Translocation Patient Who Experienced Premature Menopause: A Case Report

( Tae-hee Kim ),( Yesol Kim ),( Do-won Jeong ),( Eun-gyeong Lee ),( Dong-su Jeon ),( Jun-mo Kim3 ) 대한폐경학회 2015 대한폐경학회지 Vol.21 No.2

Premature ovarian failure (POF) is a condition in which the ovarian functions of hormone production and oocyte development become impaired before the typical age for menopause. POF and early menopause are present in a broad spectrum of gonad dysgenesis, from a complete cessation of ovarian function to an intermittent follicle maturation failure. Actually POF has been identified as a genetic entity (especially chromosome X), but data on genetic factors of premature menopause are limited. Until now, several cases revealed that inactivation of X chromosomes has an effect on ages of premature menopause and females with balanced or unbalanced X-autosome translocations can have several reproductive problems. On the other hand, there have been a few data that was caused by autosome-autosome translocation can lead. Therefore we report a relevant case of POF with translocation between chromosomes 1 and 4. She had her first menstrual period at the age of 12, and after 7 years she stopped menstruation. Chromosomal analysis showed 46, XX, t (1;4) (p22.3;q31.3). While evaluating this rare case, we could review various causes (especially genetic factors) of POF. To remind clinicians about this disease, we report a case of POF caused by autosomeautosome translocation with a literature review. (J Menopausal Med 2015;21:112-114)

경기 북부지역에서 발생한 한국형 출혈열의 임상적 특성

전성주(Seoung Ju Chun),전정수(Jung Su Chun),김재하(Jae Ha Kim),최두혁(Do Hyok Choi) 대한내과학회 1987 대한내과학회지 Vol.33 No.5

N/A Korean hemorrhagic fever which was recognized for the first time in Korea near the Demilitarized Zone between North and South Korea in 1951 during Korea War have spread to the southern part of the Korean peninsula and several hundreds of cases are clinically and serologically diagnosed each year. However the Northern Part of Kyoung Ki Do is still remained as epidemic area. In recent years, we experienced 55 cases of Korean Hemorrhagic Fever in the northern part of Kyoung Ki Do during the period, 1984-1986, and we found different clinical patterns of Korean hemorrhagic fever from those reported earlier. Here we report the epidemiological and clinical observations with laboratory findings. 1) The disease was prevalent in adult male farmers and the epidemic seasons were fall and early winter. The epidemic areas of the disease are mainly Yang Ju, Yeoncheon and Pocheon. 2) Clinical pictures of Korean Hemorrhagic Fever were characterized by headache (76%), abdominal pain (69%), nausea & vomiting (67%), fever (56%) and myalgia & general aching (49%). 3) On physical examination, fever (56%), abdominal tenderness (36%), tachycardia (35%), hypotension (27%), petechia (24%), conjunctival injection (22%) and facial flushing and edema (16%) were found. 4) On laboratory examination, leukocytosis, thrombocytopenia, left shift of leukocyte, toxic granule, proteinuria, microscopic hematuria and increased specific gravity were found. Blood chemistry findings were characterized by increased BUN & creatinine, increased SGOT & SGPT, hyponatremia, increased LDH & FDP and hyperkalemia. 5) Clinical forms of typical hemorrhagic fever were as follows: Typical oliguric type 49%, typical nonoliguric type 21% and atypical type 29%. 6) Double infection to Leptospirosia was found in 8 cases.

Multiple Markers of Contrast Induced Nephropathy after the Percutaneous Coronary Intervention

Byoung-won Park,Seong Soon Kwon,Min Ho Lee,Do Hoi Kim,Min Su Hyon,Duk Won Bang 순천향대학교 순천향의학연구소 2018 Journal of Soonchunhyang Medical Science Vol.24 No.1

Objective: Contrast-induced nephropathy (CIN) frequently occurs after percutaneous intervention. Objective of this study was to investigate the usefulness of serum cystatin C, neutrophil gelatinase-associated lipocalcin (NGAL), urinary kidney injury molecule-1 (KIM-1), and interleukin-18 (IL-18) as early predictors for CIN after percutaneous coronary intervention (PCI). Methods: In 53 patients who underwent PCI were enrolled. Serum creatinine and cystatin C level were measured immediately before, and 24 hours and 48 hours after catheterization. Serum NGAL, urinary KIM-1, and IL-18 were measured immediately before, and 4 hours, 24 hours, and 48 hours after catheterization. CIN was defined as a rise in creatinine 0.5 mg/dL or 25% above baseline. Results: CIN occurred in four patients (7.5%). Serum cystatin C levels were higher at 24 hours and 48 hours in CIN patients than in those without CIN (P<0.05). Serum NGAL levels were higher at 48 hours in CIN patients than in those without CIN. Urinary KIM-1 levels were higher at 48 hours in CIN patients than in those without CIN. There were no significant markers of CIN on multi-variate analysis. Conclusion: In this study, the occurrence of CIN after PCI was 7.5%. Although there were some time-course changes in serum cystatin C and urinary KIM-1 after PCI, there was no significant predictor for CIN after PCI.

대동맥 협착증과 동반된 출혈성 위장관 동정맥 기형에서 Estrogen-Progesterone 치료 1예

김도연,김화정,김효정,남준식,박수영,박영미,신정은,주미순,황민규,정혜경,손혜영,이선영,이한주 大韓消化器內視鏡學會 1999 Clinical Endoscopy Vol.19 No.부록2

버들치(Rhynchocypris oxycephalus)의 vitellogenin 생성량 측정을 이용한 수중 estrogen휴 화합물의 정량분석법에 관한 연구

김을환,이도부,한상훈,윤병수 경기대학교 부설 기초과학연구소 2005 경기대학교 기초과학논문집 Vol.18 No.1

Vitellogenin(Vtg), a phospholipoglycoprotein precursor of egg yolk, is synthesized and secreted from the liver in response to estrogens in female fish. Vtg is normally undetectable in the blood of male fish, but can be induced by exposure to chemicals possessing estrogenic activity. Thus, the presence of Vtg in blood of male fish can serve as a useful biomarker for assessing previous exposure to estrogenic compounds. In the present study, Vtg was abnormally expressed in Rhynchocypris oxycephalus treatment of Estradiol Benzoate (E_(2)). As the result, it was found that the level of Vtg in blood from R. oxycephalus was increased by treated quantity of E_(2) with dose-effect manner.

거대첨규 콘딜로마로부터 속발된 음경암 1치험예 : A Case Report

김수현,정충식,노준,박도영,장대수 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

The giant condyloma or carcinoma-like condylima is relatively rare. Although the disease is considered clinically mailgant. the possiblity of maligant changes from them are controversial even among the investigators but cannot be entirely overlooked. Most authorists consider that they get the possibility of malignant change. A case of malignancy of the penis which have apparently been transformed from giant condyloma acuminatum of the penis is herein presented with review of literature.

기계시각을 이용한 강구 자동 검사장치

김윤수,박수우,임병훈,김태균,최병재,박철영,이문락,도용태 대구대학교 정보통신연구소 2008 情報通信硏究 Vol.5 No.1

Metal balls are commonly used in mechanical elements and systems including bearings. If there is a defect in a metal ball, it can cause a serious machine failure. By this reason every balls produced are required to be inspected, and the inspection is usually done by human eyes. However, the inspection by human eyes is always with the risk of mistakes, and a need to automate the inspection process is arisen. This paper describes a design of an automatic inspection system for detecting defects on ball surface. A machine vision system is used, and design process and techniques are described in detail. 강구는 베어링을 비롯한 기계 요소 및 장치에서 널리 사용되는 부품이다. 만약 강구에 결함이 있을 시, 이를 사용하는 기계에서 치명적인 결함이 초래될 수 있다. 따라서 제조된 강구에 대해서는 전량검사가 요구되고 있고, 검사과정은 사람의 육안에 의한 검사가 주를 이루고 있다. 그런데 사람에 의한 검사에는 항상 실수의 가능성이 있으므로, 이를 자동화하는 것이 필요하다. 본 논문에서는 강구의 표면 결함을 자동적으로 검사할 수 있는 장치를 설계한다. 기계시각 장치가 사용되었고, 설계에 따른 구체적 절차와 기술들이 서술된다.

인공 석회화 기질의 개발 및 파골세포에 의한 기질흡수에 관한 연구

김현만,박주철,임도선,박수진,김윤지,고재승 대한구강해부학회 1997 대한구강해부학회지 Vol.21 No.1

To develop artificial matrix resorbable by osteoclasts can be used as a model system that biological function of osteoclasts would be assayed in vitro in a standardized condition instead of using heterogenous bone or dentin slices. The present study developed artificial substrates consisted of apatite crystals. collagen gen. agar, apatite crystals under collagen film, mixture of apatite crystals and collagen, and mixture of agar and apatite crystals. And osteoclastic attachement and resorption activity on the each substrate was assayed in vitro. Osteoclasts attached to apatite crystals, collagen, mixture of apatite crystals and collagen, and mixture of apatite crystals and agar, however, not to agar. This suggested that apatite crystals and collagen should be exposed on the surface of artificial substrate where osteoclasts can attach. Osteoclasts attached to the substrate resorbed the substrate consisted of apatite crystals, mixture of apatite crysals and collagen, and apatite crystals under thin film of collagen, however, not of collagen, mixture of apatite crystals and agar. This suggested that the first phase of osteoclasts in resorbing matrix is to secrete acid and the end result of this phase, whatever it may be, may activate secretion of hydrolytic enzymes specific to organic components.

GPS 측위법을 이용한 차량추종자료 측위방법간 정확성 비교

김도균,이종달,김성훈,정광수,박관 嶺南大學校 工業技術硏究所 2003 工業技術硏究所論文集 Vol.31 No.2

The purpose of this study is to examine GPS data accuracy on traffic behavior analysis and to investigate GPS measurement in the real road condition. This measurement uses GPS hardware and software for collecting speed and position of two model cars at the same time. Data of Disto meter and GPS data which are bases of GPS data value are compared for judging through t-testing and correlation analysis. GPS data is used for calculating car moving distance and speed change. It is useful to traffic control in a city by analyzing basic traffic behavior appeared on leading car and following car.