산후 자가면역성 갑상선염 환자의 병후경과에 관한 연구

김현만,허갑범,이현철,임승길,김경래 대한내분비학회 1986 Endocrinology and metabolism Vol.1 No.1

Autoimmune postpartum thyroiditis is thought of as the same or the variant of Hashimoto's thyroiditis, but is characterized by several clinical aspects, such as the occurrence afterdelivery or abortion, and the reversiblity of thyroid function.The present study was performed on the patients followed up more than 12 months after delivery.1) The age of patients with autoimmune postpartum thyroiditis at diagnosis was the range of 22 to 38 years(mean 28.4 years).2) Of 55 cases who were followed-up during 12 to 73 months(mean 31.8 months), 48 cases(87.3%) recovered, 5 cases(9.1%) remained in hypothyroidism and 2 cases(3.6%) transformed to hyperthyroidism.3) Of 16 cases who were known to deliver subsequent baby, 10 cases(62,5%) recurred transient postpartum thyroiditis, among the cases with transient sypothyroidism, 2 cases were induced by unknown precipitating factors. 4) The male and female bagies of patients were 72.7%(16 cases), 27.3%(6 cases), respectively. 5) Although there were a little differrences in clinical feature among recovery, hypothyriodism and hyperthyroidism groups, the cases of the latter two groups were too small to characterize each group. These data indicate that the majority of patients with autoimmune postpartum thyroiditis recover, but some transform to hypo- or hyperthyroidism, and following subsequent delivery, more han half patients recur the same disease.

갑상선 안증 치료의 최신지견

김현만 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.3

당뇨병성 신경병증

김현만 대한당뇨병학회 2001 Diabetes and Metabolism Journal Vol.25 No.1

한국인 산후 갑상선염 환자의 Antibody - Dependent Cell - Mediated Cytotoxicity

김현만,이현철,임승길,이은직,이관우,김경래,안광진,정재희,정윤석,김미림,허갑범 대한내분비학회 1993 Endocrinology and metabolism Vol.8 No.3

산후 갑상선염의 병인을 규명하기 위하여, 16명의 산후 갑상선염 환자와 8명의 정상 산후 여성에서 Antibody-Dependent Cell-Mediated Cytotoxicity(ADCC)를 측정하였다. ADCC는 산후 갑상선염 환자(32.4±24.5%)에서 정상 산후 여성(7.9±7.2%)에 비하여 의미있게 높았으며, 또한 percent specific lysis와 antimicrosomal antibody 사이에는 의미있는 상관관계(r=0.5046, p=0.02)를 보였다. 결론적으로, 산후 갑상선염 환자에서 FRTL-5 세포에 대한 ADCC 활성도가 증가된 소견으로 보아 ADCC 활성도가 산후 갑상선염의 발생에 관여할 것으로 사료된다. (대한내분비학회지 8:296~302, 1993)

자가면역성 갑상선 질환 환자의 혈청으로 자극된 백서 갑상선세포(FRTL-5)의 미세구조

김현만 연세대학교 원주의과대학 1993 원주의대논문집 Vol.6 No.1

공복혈당 110 ~ 139mg/dL 를 대상으로 당뇨병 진단에 관한 새로운 권고기준과 NDDG/WHO 진단기준의 비교

김현만,허갑범,이현철,김용성,이관우,조용욱,김경래,정춘희,김미림,남문석,남수연,차봉수,김여주,권삼 대한당뇨병학회 1998 Diabetes and Metabolism Journal Vol.22 No.2

당뇨병성 케톤산증 환자의 당뇨병형

김현만,이관우,송민경,박의련,정윤석 대한당뇨병학회 1996 Diabetes and Metabolism Journal Vol.20 No.4

신경섬유종증과 병발된 말단비대증 1예

김현만,홍욱균,한지영 대한내분비학회 1991 Endocrinology and metabolism Vol.6 No.4

Although it has been well recognized that the neurofibromatosis frequently associates with endocrine anomalies such as pheochromocytoma, thyroid tumor and hyperparathyroidism, there are very few instances of neurofibromatosis associated with acromegaly. The etiological basis of this association is not clear. We report one case of neurofibromatosis concurrently occurenored with acromegaly in a 17-year-old man. A diagnosis of neurofibromatosis had been made by typical skin manifestation on physical examination followed by pathological findings of biopsied tissue from the lesion. A diagnosis of acromegaly had been made by elevated serum growth hormone level followed by detection of mass lesion on brain CT scan. His growth hormone level became lower after bromocriptine therapy. The tumor will be regularly checked up by brain CT scan for growing or changing in nature. (J Kor Soc Endocrinol 6:371~376, 1991)

흰쥐 탈회 경조직의 이식시 탈회정도에 따른 조직반응에 관한 연구

김현만 대한치과이식임플란트학회 1989 The Korean Academy of Implant Dentistry Vol.9 No.1

The histochemical and ultrastructural feature of tissue reaction was studied after implantation of decalcified hard tissues which were demineralized completely or partially in 0.6 N HC1. Decalcified tooth, parietal bone, and femur of rat were implanted on rat epimyslum. The completely* or partially- decalcified tissue implants caused different tissue reaction around/in the implant. Partially decalcified hard tissues were surrounded with vascular connective tissue in which no cartilage or bone was developed. The most characteristic feature of cells adjacent to partially decalcified implants was the numerous mast cells were found near the implants and a number of macrophages contacting it. The cartilage and bone were developed in the case of the implantation of the completely decalcified hard tissue. The most cartilage was resorbed at the time of bone development, but a part of cartilage matrix was found in the matrix of new bone. Recalcified implants not related with cartilage or bone development were found among completely decalcified implants. These recalcified implants were surrounded with osteoclast-like giant cells, which suggested that the exposed calcified matrix is important in the differentiation of osteoclast-like cells.

갑상선 여포선암 진단시 HBME - 1 면역염색법의 유용성

김현만,정윤석,신영구,이기범 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4

Background: Currently, in follicular lesion of aspirates of thyroid, pathologic evaluation of surgical specimen is the only diagnostic method whether the patient had follicular thyroid malignancy or not. The aim of this study is the evaluation of the clinical utility of HBME-I immunostaining in the diagnosis of follicular thyroid malignancy in surgical specimen, and to establish the diagnostic guideline of HBME-I immunostaining. Methods: From 1994 to Sep. 1999, the 72 paraffin embedded tissue, which was already diagnosed as thyroid follicular carcinoma or adenoma through the pathologic evaluation of surgical specimen, were studied. Among 72 specimens, the 29 follicular carcinoma were included, and the others were follicular adenoma. The specimens were stained with HBME-1 monoclonal antibody by standard avidin-biotin peroxidase complex methods. One limited pathologist had read the findings of the immunostaining with a basis such as percent of tumor area. These percentage were divided to 4 grades as follows: 1) Grade 0: negative stained, 2) Grade 1: stained area $lt; 30%, 3) Grade 2: 30 � stained area $lt; 60%, and 4) Grade 3: stained area � 60%. After we had set a basis of follicular carcinoma as more than Grade 2, defined the clinical utility of HBME-1 immunostaining. The clinical utility was based that the concordance rate between pathologic diagnosis and the findings of immunostaining was more than 80% in both groups. Results: 1) There was significant difference between two groups in intensity of cellular staining(p=0.04, �2). But, there might not be helpful to rule out follicular carcinoma of thyroid from adenoma in fine-needle aspirates. 2) In both groups, the percent of stainde area of tumor was very diverse from 0% to 100%, and was statistically significant different(p=0.007). 3) Because the only 5 cases of normal tissue in both groups were stained weakly, the HBME-1 immunostaining was like to specific reaction with tumor tissue in both groups. 4) When we had set a basis of follicular thyroid carcinoma as more than Grade 2(�30%), the concordance rate between pathologic diagnosis and the findings of immuno-staining was 69.7% in follicular adenoma, 65.5% in follicular carcinoma, respectively. Conclusion: The HBME-1 immunostaining may not be help to differentiate follicular carcinoma from adenoma(J Kor Soc Endocrinol 15:513-521, 2000).