홧병 경험군과 홧병 비경험군간의 홧병의 질병개념에 대한 비교연구

홍진표,김창윤,이창화,김성윤,박인호,이철,한오수 울산대학교 의과대학 1995 울산의대학술지 Vol.4 No.2

Objective The concept of Hwa-byung in terms of illness entity remains vague. In order to clarify such illness entity, this study was conducted to find out differences and similarities in subjects who experienced Hwa-byung and those who did not experienced Hwa-byung from a wide distribution within the general population. Method (1) Test Material The questionnaires were made up with reference to previously published articles on Hwa-byung, to SCL-90-R and to diagnostic criteria of DSM-Ⅲ-R. The questionnaires included the subject's demographic variables, their awareness of Hwa-byung, their experience of Hwa-byung, and also their opinions about its possible causes, precipitating factors, symptomatology, effective treatment modalities, course and prognosis of Hwa-byung. Such questionnaires were given to 50 subjects, all of whom are psychiatric out-patients at Asan Medical Center, for determining its validity and reliability before selecting 27 questionnaires. (2) Subject Subjects were recruited from among patients and their family members who visited the out-patient clinics of seven different departments at Asan Medical Center in Seoul a large metropolis (N=334), the out-patient clinics of seven different departments of Hae Sung General Hospital in the industrial city of Ulsan, Korea (N=299) and the seven branches of the public health center of Yeonchun county, Korea (N=262), a rural area. From these 895 subjects, 67 subjects who don't know about Hwa-byung and 34 subjects who didn't answered to the question on experience were eliminated from study subjects. The final number of study subjects was 794. (3) Methods of analysis The subjects were divided into the Hwa-byung experienced group and the Hwa-byung inexperienced group. The demographic data and the concepts of Hwa-byung were statistically analyzed by the student t-test or the chi-sq test. Results and Discussion The mean age of the Hwa-byung experienced group is significantly higher than that of the Hwa-byung inexperienced group. MOre women experienced Hwa-byung than men and lesser educated subjects experienced significantly more Hwa-byung. The place of residence, the place of upbringing and socioeconomic status have no significant difference statistically between the two groups. Both groups considered the primary cause of Hwa-byung as being psychological origin. However in the Hwa-byung experienced group, more subjects considered that the supernatural factor was the primary cause of Hwa-byung. One of the primary precipitating events causing Hwa-byung in both groups is conflict in interpersonal relationships ; however, the Hwa-byung inexperienced group exhibited more experiences in the realm of economical losses such as "failure of business" or "loss of capital" as precipitating factors causing Hwa-byung. Both groups consider that the symptoms of Hwa-byung are a combination of multiple physical and mental symptoms. With particular respect to in mental symptoms, such as depressive symptoms, anxiety symptoms and hostility are thought to be prominent features. As effective treatment modalities, subjects in both groups consider that both himself and his family members should make effort to resolve intrafamilial conflicts. But in contrast with the Hwa-byung inexperienced group, the Hwa-byung experienced group requires more concrete and more attention-giving modalities as important treatment strategies. The Hwa-byung experienced group considers its prognosis more grave than the Hwa-byung inexperienced group.

입원환자 낙상예방 프로그램에서 근력운동의 효과: 낙상 고위험군 노인환자를 중심으로

이현옥 ( Hyun-ok Lee ),이병화 ( Byung-hwa Lee ),이창희 ( Chang-hee Lee ) 한국보건정보통계학회(구 한국보건통계학회) 2017 보건정보통계학회지 Vol.42 No.4

Objectives: The purpose of this study is to analyze the changes in the indices of body muscle strength, the indices of muscle strength associated with physical balance, and index of the pain relief between the intervention group who performed the muscle strength exercise and control group who not performed the muscle strength exercise. The study period was from September 7, 2016 to May 12, 2017, and it was conducted after receiving Institutional Review Board approval. Methods: Among 40 participants who were recruited in this study, the final analysis subjects were a total of 39 people, excluding the one people who dropped out during the 2-week. For analysis, the changes were compared with baseline and after two weeks by comparing three types of body muscle strength indices, four types of physical balance indices, and one type of pain relief index. Finally, we analyzed whether there is a difference between the groups in the each changes. Results: In the body muscle strength index change analysis, the change of muscle mass relative to weight was not statistically significant, but the difference between the groups regard to change was statistically significant (p<0.05). The lower body strength and the bone mineral were statistically significant in both the intervention and control group, but the difference between the groups regard to change was not statistically significant. In the index of muscle strength associated with physical balance change analysis, the intervention group showed improvement much higher in the right arm, left arm, right leg, and left leg of muscle mass than the control group. Also, the muscle mass of the right arm and the left arm was statistically significant in the analysis of the difference between the groups regard to change (p<0.05). Analysis of changes in pain relief index showed that the intervention group showed significantly improvement higher than the control group, and the difference between the groups regard to change was statistically significant (p<0.05). Conclusions: In the elderly patients in the hospital where the fall prevention program was provided, it was concluded that the intervention group higher improved the muscle strength associated with physical balance and the pain relief compared with the control group.

MaxEnt 모델링을 이용한 기후변화 시나리오에 따른 서어나무 (Carpinus laxiflora)와 개서어나무 (C. tschonoskii)의 분포변화 예측

이민기 ( Min-ki Lee ),천정화 ( Jung-hwa Chun ),이창배 ( Chang-bae Lee ) 한국농림기상학회 2021 한국농림기상학회지 Vol.23 No.1

Hornbeams (Carpinus spp.), which are widely distributed in South Korea, are recognized as one of the most abundant species at climax stage in the temperate forests. Although the distribution and vegetation structure of the C. laxiflora community have been reported, little ecological information of C. tschonoskii is available. Little effort was made to examine the distribution shift of these species under the future climate conditions. This study was conducted to predict potential shifts in the distribution of C. laxiflora and C. tschonoskii in 2050s and 2090s under the two sets of climate change scenarios, RCP4.5 and RCP8.5. The MaxEnt model was used to predict the spatial distribution of two species using the occurrence data derived from the 6^th National Forest Inventory data as well as climate and topography data. It was found that the main factors for the distribution of C. laxiflora were elevation, temperature seasonality, and mean annual precipitation. The distribution of C. tschonoskii, was influenced by temperature seasonality, mean annual precipitation, and mean diurnal rang. It was projected that the total habitat area of the C. laxiflora could increase by 1.05% and 1.11% under RCP 4.5 and RCP 8.5 scenarios, respectively. It was also predicted that the distributional area of C. tschonoskii could expand under the future climate conditions. These results highlighted that the climate change would have considerable impact on the spatial distribution of C. laxiflora and C. tschonoskii. These also suggested that ecological information derived from climate change impact assessment study can be used to develop proper forest management practices in response to climate change.

Ischemia-Related Changes in Galanin Expression in the Dentate Hilar Region after Transient Forebrain Ischemia in Gerbils

LEE, Hyeon Yong,HWANG, In Koo,KIM, Dae Ho,KIM, Jung Hwa,KIM, Chang Ho,LIM, Beong Ou,KANG, Tae-Cheon,BANG, Kyung Hwan,SEONG, Nak Sul,LEE, Hak Ju,KIM, Jong Dai,WON, Moo Ho Japanese Association for Laboratory Animal Science 2005 EXPERIMENTAL ANIMALS Vol.54 No.1

<P>Although galanin (GAL) protects hippocampal neurons from ischemic damage, no study has examined ischemia-related changes in endogenous GAL in the hippocampal dentate gyrus. We investigated the chronological changes of GAL, well-known as the potassium channel opener, expression in the dentate gyrus at various times after 5 min of transient forebrain ischemia in gerbils. A few GAL-immunoreactive (IR) neurons were found in the polymorphic layer of the sham-operated group. Three hours after ischemia-reperfusion, the pattern of GAL immunoreactivity was similar to that of the sham-operated group and the number of GAL-IR neurons and immunoreactivity were highest 12 h after ischemic insult. At this time, GAL-IR neurons in the polymorphic layer showed strong GAL immunoreactivity. Thereafter, GAL-IR neurons and immunoreactivity significantly decreased in the dentate hilar region. Four days after ischemic insult, GAL-IR neurons were not detectable. In addition, the results of a Western blot study showed a pattern of GAL expression similar to the immunohistochemical changes. GAL protein content also was highest 12 h after ischemia. In conclusion, the increased expression of endogenous GAL in the dentate gyrus after ischemia is related to response to the ischemic damage.</P>

Nutrikinetics of Isoflavone Metabolites After Fermented Soybean Product (Cheonggukjang) Ingestion in Ovariectomized Mice

Lee, Da‐,Hye,Kim, Min Jung,Ahn, Jiyun,Lee, Sang Hee,Lee, Hyunjung,Kim, Jin Hee,Park, So‐,Hyun,Jang, Young‐,Jin,Ha, Tae‐,Youl,Jung, Chang Hwa John Wiley and Sons Inc. 2017 Molecular Nutrition & Food Research (Print) Vol.61 No.12

<P><B>Scope</B></P><P>Cheonggukjang (CGJ) is a soybean‐based quick‐fermented food popular in Korea that contains a variety of biologically active compounds including isoflavones and saponins. Isoflavone bioavailability may be important for the bone health of postmenopausal women; therefore, the aim of this study is to evaluate the influence of fermentation on the isoflavone metabolite nutrikinetic profile after single dose CGJ or unfermented soybean administration in ovariectomized (OVX) and sham mice.</P><P><B>Methods and results</B></P><P>We identify 34 isoflavone metabolites using UPLC–QTOF‐MS and analyze their nutrikinetics at different time points (0.25, 0.5, 1, 2, 4, 8, 16, and 24 h) to understand their fermentation‐ and OVX‐mediated time‐dependent concentration changes. Nutrikinetics analysis shows that genistein, daidzein, genistein 4′‐sulfate, dihydrodaidzein sulfate, equol 4′‐sulfate, and equol‐7‐glucuronide are present at high concentrations in all groups based on area‐under‐the‐curve analysis. OVX mice appear to show lower isoflavone bioavailability than mice in the sham group. CGJ enhances various isoflavone metabolite bioavailability including genistein, 3‐hydroxygenistein, and equol 7‐glucuronide, compared to the unfermented soybean‐treated group. Among these metabolites, intact isoflavones, 3‐hydroxygenistein, genistein 4′‐sulfate, and equol 7‐glucuronide promote osteoblastogenesis and inhibit osteoclast formation.</P><P><B>Conclusions</B></P><P>CGJ has good isoflavone bioavailability and may be beneficial for the bone health of postmenopausal women.</P>

Epigenetic regulation in bladder cancer: development of new prognostic targets and therapeutic implications

Lee, Kyoung-Hwa,Song, Chang Geun AME Publishing Company 2017 Translational cancer research Vol.6 No.-

<P>Epigenetic and genetic alterations contribute to cancer initiation and progression. Epigenetics refers to heritable alterations in gene expression without DNA sequence changes. Epigenetic changes include reversible alterations in DNA methylation, chromatin modification, nucleosome positioning, and non-coding RNA profiles. In bladder cancer, many epigenetic changes have been reported to exhibit correlation with cancer progression and malignances. In particular, both DNA hypermethylation and hypomethylation have been reported to be associated with higher bladder cancer rates or advanced tumor stages. The association of changes in histone modifying enzyme expression with bladder cancer stages has been extensively studied. MicroRNA (miRNA) expression also has been studied in bladder cancer diagnosis and disease progression. The use of epigenetics for the diagnosis of and therapeutic target screening in bladder cancer is an emerging and rapidly evolving field. The reversible nature of epigenetic changes may facilitate additional therapeutic options in the future.</P>

Near-Normalized Gene Expression Profiles in Bladder With Detrusor Overactivity in Rats With Bladder Outlet Obstruction After Deobstruction

Lee, Tack,Lim, U-Sung,Kang, Dong Hyuk,Jung, Hae-Do,Kim, Hyunzu,Choi, Bo-Hwa,Kang, Ju-Hee,Yoon, Sang-Min,Park, Chang-Shin Korean Continence Society 2017 International Neurourology Journal Vol.21 No.4

<P><B>Purpose</B></P><P>The pathophysiological role of detrusor overactivity (DO) in the bladder, which is commonly observed in various bladder diseases, is not well understood. DO appears in bladder outlet obstruction (BOO), and may continue even after subsequent deobstruction. DO therefore provides an excellent opportunity to observe molecular biological changes.</P><P><B>Methods</B></P><P>In this study, to understand the molecular effects of persistent DO after BOO induction and deobstruction, we performed awake cystometry on female Sprague-Dawley rats divided into 4 groups: a sham group, a BOO group, a deobstructed group with DO after BOO (DDO), and a deobstructed group without DO after BOO (non-DDO). Total RNA was extracted from the bladder samples, and gene expression profiles were compared between the sham and model groups.</P><P><B>Results</B></P><P>DO was observed in 5 of the 6 rats (83%) in the BOO group, and in 6 of the 13 rats (46%) in the deobstructed group. The non-DDO group showed a significantly greater residual volume than the DDO group. Through a clustering analysis of gene expression profiles, we identified 7,532 common upregulated and downregulated genes, the expression of which changed by more than 2 fold. In the BOO group, 898 upregulated and 2,911 downregulated genes were identified. The non-DDO group showed 3,472 upregulated and 4,025 downregulated genes, whereas in the DDO group, only 145 and 72 genes were upregulated and downregulated, respectively.</P><P><B>Conclusions</B></P><P>Abnormal function and gene expression profiles in bladders after BOO were normalized in the BOO rats with DO after deobstruction, whereas in those without DO, abnormal function persisted and the gene expression profile became more abnormal. DO may play a protective role against the stress to the bladder induced by BOO and deobstruction as a form of adaptive neuroplasticity.</P>

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

계절에 따른 토양 방선균의 속 다양성 분포

박동진,이상화,박상호,김창진,Park, Dong-Jin,Lee, Sang-Hwa,Park, Sang Ho,Kim, Chang-Jin 한국미생물학회 1998 미생물학회지 Vol.34 No.3

산림, 밭, 초지, 논 토양의 두 깊이(0~2cm, $50{\pm}1cm$)에서 계절별로 채취한 토양 시료로부터 서로 다른 방선균주를 분리, 동정하여 계절별 토양 방선균의 속 다양성을 조사하였다. 토양 표층에 분포하는 Streptomyces속 방선균주의 계절별 변동율은 논(18%)과 산림(18%) 토양에 비해 초지(41%)와 밭(39%) 토양에서 더 높게 나타났으며 $50{\pm}1cm$깊이에서는 논(36%), 밭(28%), 초지(26%), 산림(16%) 토양 순으로 높게 나타났다. 한편 희소 방선균의 계절별 분포 변동율을 토양 표층의 경우 논 토양(26%)을 제외하고는 모두 45%이상이었으나 $50{\pm}1cm$깊이에서는 산림(79%), 논(36%), 밭(24%), 초지(10%) 토양 순으로 높게 나타났다. 따라서, 토양 중에 분포하는 방선균의 속 다양성은 계절 변화에 의지하며 또한 이는 방선균군의 종류, 토양의 유형, 그리고 토양 깊이에 의해서 영향을 받을 것으로 고려된다. From soils seasonally collected at two depths (0~2 cm, $50{\pm}1cm$) of forest, field, grass land, or paddy field, distinct strains of actinomycetes were isolated and identified to the genus level. The genus-diversity of soil actinomycetes was revealed to be considerably different by seasonal change. It was also affected by soil depths, soil types, or actinomycete groups. At the soil depth of 0~2 cm, the seasonal distribution fluctuation (%) of streptomycete strains was higher in grass land (41%), field (39%) soil than paddy field (18%), or forest (18%), whereas that of streptomycete strains at the soil depth of $50{\pm}1cm$ was high in order of paddy field (36%), field (28%), grass land (26%), and forest (16%). On the other hand, the seasonal distribution fluctuation ratio of rare actinomycete strains at the soil depth of 0~2 cm was above 45% except for paddy field (26%). At the soil depth of $50{\pm}1cm$, the seasonal distribution of rare actinomycete strains exhibited high fluctuation (%) in order of forest (79%), paddy field (36%), field (24%), and grass land (10%).

회 전문 레스토랑에 나타난 공간구성적 특성 연구

이선화(Lee, Sun-Hwa),이창노(Lee, Chang-No) 한국실내디자인학회 2014 한국실내디자인학회 학술대회논문집 Vol.2014 No.11

In line with the change of lifestyle in the contemporary society, the eating space is not a simple eating place for food, but a place of complicated roles such as social meeting, entertainment and conference. The reason of such diversified and complicated space is caused by the increase of income level of consumers, increase of urban population and consumption pattern change. However, despite diverse spaces of food culture, studies on ‘sashimi’ restaurants are very scanty. Accordingly, this study selected the target of case study as representative ‘sashimi’ restaurant and examined through drawing analysis, site analysis, photo taking and actual measurement of main parts. As a result, as for the floor structure of food and drink space, it was found that securing excellent view is important for seat display. Secondly, 1F, 2F and 5F were mainly occupied by cooking and management divisions. Thirdly, the area ratio of sales, cooking and management divisions affected the customer movement and employee movement. Fourthly, standing seats were displayed for customers and room seats were displayed for the premium image of restaurant and for customers who want independent eating space. It is believed that this study would be useful in spatial structure of ‘sashimi’ restaurant. However, as it is the result of an analysis of 1 restaurant at Suyoung-gu, Busan, it would be hard to generalize the result as the common for ‘sashimi’ restaurant. Therefore, continual further studies are recommended to generalize it.