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서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
국가 석유정책의 패러다임적 변화 고찰 : 정통론과 신정치경제론적 시각의 대비 Based on Orthodox and New Political Economy Approach
이준범,장지호 대한정치학회 2004 大韓政治學會報 Vol.12 No.2
본 논문은 변화하는 국제시장에서의 석유정책을 진단하고 이런 면화가 우리가 속한 동북아시아의 국제석유 질서에 주는 의미를 찾아보는데 그 목적이 있다. 우선 국제석유 시장에 대한 실질적인 이해를 위해 석유가 어떻게 세계경제의 주력 에너지원이 된 과정을 살펴보았다. 그리고 1970년대 OPEC이 주도하면서 형성된 미국중심의 패러다임인 정통론(orthodox)이 석유자원의 국제적 분배를 정치적 가치분배 방식을 기본으로 한다는 점을 이해한 후, 90년대의 들어 새롭게 형성된 신정치경제 패러다임은 경제에 의한 석유자원의 국제적 배분을 기본으로 한다는 것을 고찰한다. 마지막으로 이런 패러다임의 변화가 동북아시아 석유관계에 주는 의미를 살펴보기 위해 동북아시아의 석유현실을 살펴본 뒤 이런 변화가 주는 의미에 대해 논의하였다. 상이한 두 개의 패러다임 하에서 살펴본 아·태지역은 두 패러다임이 혼재하는 것으로 이해되었다. 이 지역은 석유수급 불균형이 심각하여 중동에 대한 의존도가 지나치게 높은 상태에서 공급원을 다원화할 만한 유력한 공급원도 확보하기 어려운 상황이다. 또한, 아태지역은 국제 석유시장 제도의 발달이 아직 만족할 만한 수준이 아닌 관계로, 이 지역의 입장이 국제유가에 제대로 반영된다고 보기는 어렵다고 하겠다. 이런 상황에 대처하기 위해 아·태지역은 집단적 협력방안을 모색하고 있으나, 여러가지 내적인 조건으로 IEA의 설립과정보다 진척이 느린 편이다. This study explores paradigm change of petroleum policy in world market. In the 1970s, the mainstream approach is orthodox which emphasizes allocation of political value depending on United States. However, new paradigm is emerged in the 1990s. According to this new political economic approach, economic value is the major criteria of international oil allocation. Oil economy of Northeast Asia area expose itself to the mixed two paradigms. Due to increasing oil demand, the limited number of oil supply sources and as a result, deepening overdependence on Middle East; consequently, increasing vulnerability of oil supply security, the Northeast Asian economy shows fragile conditions. Facing these conditions of supply and demand, the Northeast Asian economy is making a cooperative effort in a limited number of areas. Nevertheless, the effort to cooperation is still needed much to improve in such areas as oil products trade, oil development business, and research and development.
당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구
한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4
Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.
류재나,기범준,박규홍,이차돈 대한상하수도학회 2004 상하수도학회지 Vol.18 No.2
A long-term sewer rehabilitation project consuming an enormous budget needs to be conducted systematically using an optimization skill. The optimal budgeting and ordering of priority for sewer rehabilitation projects are very important with respect to the effectiveness of investment. In this study, the sewer rehabilitation optimization model using fast-messy genetic algorithm is developed to suggest a schedule for optimal sewer rehabilitation in a subcatchment area by modifying the existing GOOSER model having been developed using simple genetic algorithm. The sewer rehabilitation optimization model using fast-messy genetic algorithm can improve the speed converging to the optimal solution relative to GOOSE , suggesting that it is more advantageous to the sewer rehabilitation in a larger-scale subcatchment area than GOOSER .
돼지에서 정맥, 근육 그리고 경구 투여시의 enrofloxacin의 약물동태학
윤효인,김무열,박승춘,조준형,박병권,이내경,노상석,장범수,신광순,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-
In order to characterize pharmacokinetic profiles according to route of a new enrofloxacin salt form (Enrotil®), it was given to 4 healthy pigs via oral (p.o.), intramuscular (i.m.) or intravenous (i.v.) administrations at a dose rate of 5 ㎎/㎏ body weight. Enrofloxacin (ENFX) in serum was detected by bioassay using E. coli BE1186 as a test organism. The biological elimination half-lives (t_1/2(β)) of ENFX were 6.76±0.99 h (i.v.), 7.16±2.30 h (i.m.) and 11.45±3.90 h (p.o.), Volume of distribution (Vd) of enrofloxacin was 2.20±0.31 L/㎏ (i.v.), 2.52±0.60 L/㎏ (i.m.) and 1.88±0.33 L/㎏ (i.m.). Mean residence time (MRT) was 8.77±1.26 h after i.v. injection and the maximal concentration time (Tmax) following p.o. and i.m. administration was 0.76±0.09 h and 0.60±0.12 h, indicating a rapid absorption from these routes. Bioavailibility (F) was calculated as 64.1% for p.o. administration and 59.71% for i.m. injections. In summary, the newly formulated enrofloxacin salt form has shown a high water solubility, rapid absorption and large tissue distribution, suggesting a potential antibacterials for oral application on a large scale in veterinary sectors.
토끼에서 근육주사시 입자 크기에 따른 amoxicillin의 비교 약물동태학
박승춘,윤효인,오태광,장범수,배순이,조준형,정상희,이내경,김민규 충남대학교 수의과대학 동물의과학연구소 1998 動物醫科學硏究誌 Vol.6 No.-
To investigate the pharmacokinetic difference between the two amoxicillin (AMX) particles in rabbits after intramuscular injection (i.m.), both of AMX-S (particle size: 10 ㎍) and AMX-L (particle size: 100 ㎍) were injected into New Zealand White rabbits (1.2±0.3 ㎏) at a dose rate of 10 ㎎/㎏ of body weight. In this study, serum AMX concentrations were detected by microbiological assay with E. coli BE 1186 which shows high antibiotic sensitivity. After i.m. administration, AMX-S and AMX-L were best fitted as 1-compartment model with the absorption and elimination phase. The biological half-life (T_1/2, _k10) of AMX-S is 4.06±1.09 h and that of AMX-L 4.76±0.69 h. The serum maximal concentration time (T_max) of AMX-S and AMX-L were 0.88±0.17 h and 0.77±0.11 h, respectively. Maximal AMX concentration (C_max) (AMX-S: 5.71±0.62 ㎍/㎖, AMX-L: 5.04±0.25 ㎍/㎖) in serum showed a significant difference (p<0.05). In terms of bioequivalance, however, there was no difference between the two AMX's after i.m. injection in the basis of C_max and AUC.