Clear cell sarcoma of the kidney : Immunohistochemical study and flow cytometric DNA analysis of 7 cases

Choi, Yoon-Jung,Jung, Woo-Hee,Jung, Soon-Hee,Park, Chanil Yonsei University, College of Medicine 1994 Yonsei medical journal Vol.35 No.3

급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.

교정적 치아초기배열단계시 발생하는 치근 변화에 관한 주사전자현미경적 연구 : A SCANNING ELECTIRON MICROSCOPIC STUDY

최정윤,정규림 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.4

본 연구는 교정치료를 목적으로 발치가 예정된 치아를 대상으로 임상적으로 매우 중요한 치료과정 중의 한 부분인 초기치아배열단계에서 다양한 기간과 크기의 교정력을 가하여 치아배열기간, 교정력의 크기, 치아이동방향에 따라 치근표면에 일어나는 흡수와 회복 양상에 대한 정보를 얻기 위하여 시행되었다. 치료받지 않은 13개의 치아를 대조군으로 하고 교정치료계획상 제1소구치를 발거하기로 예정된 37개의 치아를 실험군으로 하여 20-450gm의 초기교정력을 가한 후 주사전자현미경적 관찰을 통하여 다음과 같은 결과를 얻었다. 1. 실험군 37개 중 22개의 치아(59.5%)에서 치근흡수가 발견되었다. 치근흡수는 최소실험기간인 3주군부터 나타났으며 흡수부위의 회복은 3개월군부터 나타났다. 2. 교정력의 기간 증가에 따라 치근흡수의 발생빈도가 증가하는 경향을 보였다. 3. 교정력이 클수록 상아질을 포함하는 흡수가 증가하는 경향을 보였다. 4. 치근 흡수의 부위는 하중 받는 부위와 일치하는 경향을 보였다. 5. 치근 흡수 부위는 면적과 가장 상관성이 높은 변수는 교정력의 크기였다. The purpose of this study was to investigate the root resorption and repair pattern of human teeth according to the force magnitude, direction and duration during the initial leveling and alignment phase. 40gms to 500gms of force applied to the 37 experimental teeth with duration of 3 weeks to 7 months. Then, the experimental teeth were extracted. 13 control teeth were extracted without treatment. The results are as follows: 1. 59.5% of 37 teeth exhibited root resorption. The initial resorption site was visible at the apex within 3 weeks with 100 gms samples, and the initial repair site was visible at the apex within 3 months with 400 gms samples. 2. Number of resorbed teeth increased with the duration of the force. 3. The depth of the resorption increased with the magnitude of the force. 4. The areas of resorbed root corresponded with the loading pattern. 5. The areas of resorbed root were highly correlated with the magnitude of the force. The result of this study suggest that root resorption could occur during the initial leveling and alignment phase. These initial injuries are all small and insignificant. It is the extensive type of apical root resorption that must be regarded as deleterious to the function and stability of the tooth moved. During the initial leveling and alignment phase lighter force of the interrupted type and short treatment period would be favorable with regard to avoidance of root resorption and repair of resorbed root surface.

유치원 교실의 빛환경 향상을 위한 조도측정 사례연구

최윤정 충북대학교 교육 ·생활연구소 생활과학연구센터 2002 생활과학연구논총 Vol.6 No.2

This study is an attempt to establish the improvement process of indoor visual environment. The purpose of this study are to evaluate the illumination condition of a kindergarten and to propose the plan for improvement of indoor visual environment. The field measurement on the illumination and the interview with teachers were carried out at a kindergarten in Seoul. This survey was taken on 1st of May, 1999. The illumination level of the eastern classroom in the first floor (242~288 lux) was lower than standard (500 lux) but the illumination uniformity (1/2~1/3) was better condition than standard (1/7~1/5). The illumination level of the western classroom in the first floor (435~992 lux) was higher than standard, but the illumination uniformity (1/15~1/8) was worse condition than standard. The illumination level of the western classroom in second floor (850~1575 lux) was higher than standard, but the illumination uniformity (1/17~1/10) was worse condition than standard. It was found that the eastern classroom in the first floor and the underground gymnasium were low condition in illumination level, but the western spaces were bad condition in illumination uniformity.

대학교 대형강의실의 조명조건별 조명환경평가

최윤정,이상운,조현주 충북대학교 교육 ·생활연구소 생활과학연구센터 2003 생활과학연구논총 Vol.7 No.1

The purposes of this study are to evaluate the lighting environment of a university assembly hall and to make clear the problems of conditions of lighting operation. The field measurement on the illumination level and the questionnaire survey on subject response of the lighting environment with students were carried out at an assembly hall in C university, Cheongju. These survey were taken on 4th and 9th of December, 2002. The illumination levels of the assembly hall in the condition A (157∼403 lux) were lower than standard (400lux). The illumination levels of the condition B (16∼372 lux) and condition C (0∼1 lux) were poor. The illumination levels of the condition D (231∼510 lux) were somewhat lower than standard. It was found that the present condition of the lighting environment of the university assembly hall is inappropriate illumination level and uniformity for lecture.

SJO¨GREN'S SYNDROME 환자에게 즉시 임프란트 술식을 행한 치험례

최정환,손동석,이지연,이윤서,안선희,이재목 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

The old edentulous patients experience xerostomia commonly. They have considerable difficulty in wearing tissue-supported prosthesis and high risk rate of caries. One of them is Sj□gren's syndrome patient. Sj□gren's syndrome is a chronic inflammatory autoimmune disorder that results in a lymphocyte-mediated destruction of exocrine glands. We planned to place implants immediately after extraction in this case of autoimmune disease. The advantages of immediate implant placement include considerable decrease in time from tooth extraction to placement of the final prosthesis, fewer surgical procedures, and better acceptance of the overall treatment plan. We present a case of Sj□gren's syndrome patient treated with immediate implant placement & immediate loading in anterior region and immediate implant placement in posterior region.

상수도 배관의 부식감지시스템 개발 (Ⅰ)

최윤석,김정구 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.10

In order to develop a new corrosion sensor for detecting and monitoring the corrosion of buried pipeline, sensor element design and the correlation of its output to corrosion rate of steel pipe itself were evaluated by laboratory test methods in synthetic groundwater. It uses well-known principles of galvanic corrosion and consists of two dissimilar metals (anode and cathode) installed on the buried pipeline. In this paper, two types of electrochemical probes were used: galvanic cells containing pipeline steel (CS)-copper (Cu) and pipeline steel (CS)-type 304 stainless steel (SS) couples. The corrosion behavior in synthetic groundwater for the different electrodes was investigated by potentiodynamic test. The galvanic corrosion test was accomplished by a zero resistance ammeter technique. Weight loss measurements were conducted to obtain the corrosion rates of pipeline steel in synthetic groundwater. The correlation between galvanic current and corrosion rate was obtained by galvanic current measurement and corrosion rate measurements. The results of the potentiodynamic test indicated that copper exhibited an active corrosion behavior, while stainless steel demonstrated spontaneous passivation. In galvanic corrosion tests, the galvanic current of copper-steel couple was higher than that of other couple. The comparison of the sensor output and corrosion rate revealed that a linear relationship was found between the probe current and the corrosion rate. Especially, a better linear quantitative relationship was found between the Cu-CS probe current and the weight loss data of the pipeline steel coupons. In addition, the Cu-CS probe is more suitable for high resistance soil than SS-CS probe, due to the high current output.

아파트 전면발코니의 실내환경 조절효과 및 공간기능

최윤정 대한가정학회 2004 Family and Environment Research Vol.42 No.5

The purpose of this study is to make clear the indoor envirwunental efficiency and spatial function of the front balcony in apartments using responses from residents'. An interview survey carried out during the l4th ~24th of January 2003, and a questionnaire survey was given during the 17th-29th of January. Intervhwes consisted of 31 residents living in renovated apartments, which had the front &ny added onto the living mom. The respondents of the questionnaire survey consisted of 37 residents living in ordinary apartments with an existing front balcony. The residents living in o r d i i apartments show relatively positive responses on the indoor thermal environment during winter, glare by daylight, and outdoor noise. The average heating cham of the renovated apartments came out to be more expensive than the ordinary apartments. In most renovated apartments, rhe living area converted from front balcony was used as the same functions ('space for dying the laundry', 'storage space', or 'space for cultivating of flower pots') of ordinary front balcony. From the results of this study, it is undesimbie to renovate the front balmy as an addition to the Ikringroom.

한국인 제2형 당뇨병 환자의 골격근에서 인슐린 신호전달체계의 결함

최준혁,이관우,김효정,이동훈,이종우,김정은,엄현채,김경미,최성이,정윤석,김현만 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.5

연구배경: 제2형 당뇨병에서 나타나는 인슐린 저항성은 간, 지방, 근육 같은 말초조직에서 인슐린의 작용이 떨어지는 것을 말한다. 제2형 당뇨병의 발생기전에 인슐린 저항성과 인슐린 분비능 저하가 같이 관여함은 잘 알려진 사실이다. 인슐린의 세포내에서의 저항성을 규명하기 위한 인슐린의 세포내 신호전달체계에 대한 연구가 활발히 진행되고 있으며 몇몇 연구에서 인슐린 저항성을 가진 골격근육에서 IRS와 관련된 PI3-kinase의 활성감소와 Akt kinase의 활성감소를 보고하고 있으나 아직까지 명확하게 그 기작이 설명되어지지 않고 있다. 본 연구에서는 정상성인, 제2형 당뇨병 환자를 대상으로 경구당부하검사 및 인슐린 클램프검사를 시행하고 인슐린 클램프 검사시 대상인의 근육을 채취하여 인슐린 신호전달 체계(IR-β, IRS, Akt(PKB, Rac) kinase, GSK-3)를 연구하였다. 방법: 연구대상자는 한국인으로서 경구당부하검사상 정상인 및 당뇨병 환자 각각 11명, 9명을 대상으로 하였으며, 정상인은 건강인으로 과거력상 당대사에 영향을 줄 질환이 없고, 현재 당대사에 영향을 줄 약물 복용 및 다른 소견이 없는 경구당부하검사상 정성 내당능을 보이는 대상자로 하였다. 당뇨병환자는 모두 제2형 당뇨병 환자로 이환기간이 만 5년 이내인 경우로 하고, 인슐린으로 치료하는 대상자는 제외하도록 하였다. 대상자의 연령, 체질량지수, 체지방량, 공복시 총콜레스테롤, 중성지방, 고밀도지단백 콜레스테롤 및 HbA1c, 인슐린, C-peptide를 측정하였고, "HOMA model"을 이용하여 베타세포의 기능와 인슐린저항성 정도를 평가하였다. 정상혈당클램프 검사(euhlycemic hyperinsulinemic clamp test)를 시행하고 인슐린 투입 전과 인슐린 투입 30분후, 두차례에 걸쳐 대퇴부 근육생검을 실시한후 western 법으로 IR-β, IRS, Akt kinase, GSK-3의 인산화량을 측정하였다. 결과: 정상인 11명과 당뇨병 환자 9명을 대상으로 하였으며 대상자의 평균 연령, 평균 체질량지수, 체지방량, 허리/엉덩이 둘레의 비(waist hip ratio; WHR)는 두 군간에 차이가 없었다. 평균 공복혈당은 정상군 98.0±0.3㎎/dL, 당뇨병군 208.1±16.5㎎/dL(p<0.05), HbA1c는 정상군 5.4±0.5%, 당뇨병군 9.2±0.6%(p<0.05)였다. "HOMA model"을 이용한 베타세포의 기능과 인슐린저항성은 정상군 56.4±8.5%, 1.4±0.2, 당뇨병군 72.2±52.3%(p<0.01), 10.2±6.3(p<0.01)였으며 정상혈당클램프 검사상 포도당 이용률은 정상군 8.2±0.6㎎/㎏/min, 당뇨병군 3.7±1.1㎎/㎏/min(p<0.01)로 정상군과 당뇨병군간에 유의한 차이를 나타내었다. Western blot법으로 IR-β, IRS, Akt kinase, GSK-3의 인산화량을 인슐린 투입전과 인슐린 투입 30분후 측정하였을 때 IR-β에서는 정상군이 103.9±2.3에서 241.3±18.6, 당뇨군이 108.9±2.2에서 198.7±6.3으로 증가하였다(p=NS). 이는 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 통계적인 차이가 없었다. IRS에서는 정상군이 111.6±7.3에서 295.6±17.2, 당뇨군이 114.5±6.1에서 222.0±23.2로 증가하였으며(p<0.05), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 24% 감소하였다. Akt kinase에서는 103.4±6.0에서 416.8±29.5로 증가하였으며(p<0.01), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 43% 감소하였다. GSK-3에서는 정상군이 107.7±6.7에서 595.7±28.1, 당뇨군이 104.3±4.8에서 443.3±12.9로 증가하였으며(p<0.01), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 25% 감소하였다. 결론: 제2형 당뇨병 환자에서 정상인과 비교하여 인슐린 자극후 IR-β는 인산화량의 증가정도가 큰 차이가 없었으나, IRS, Akt kinase, GSK-3에서는 인산화량의 증가 정도가 감소되는 것으로 보아 상위 인슐린 신호전단체계부터 결함이 있는 것으로 생각된다. Background: The glucose uptake rate is the limiting step in glucose utilization and storage. The failure of insulin to stimulate glucose uptake in muscle appears to be a primary defect of insulin resistance. This study was undertaken to examine the effect of physiological hyperinsulinemia on the phosphorylation of the insulin receptor (IR-β), insulin receptor substrate (IRS), Akt kinase and GSK-3 in isolated skeletal muscle, in people with type 2 diabetes(n=9) and control subjects(n=11). Methods: 75g OGTT and euglycemic hyperinsulinemic clamp test were done. And vastus lateralis muscle was obtained before and 30 min into the euglycemic clamp. Western blots were performed for tyrosine phosphroylation of insulin receptor substrate (IRS) and phosphorylation of the insulin receptor(IR-β), Akt and GSK-3. Result: There were no statistical differences in the mean age, BMI and body fat between the control subjects and diabetic patients. The fasting blood sugar and HbA_1c in controls and diabetic patients were 98.0±0.3 and 208.1±16.5ng/dl, and 5.4±0.5 and 9.2±0.6%, and 1.4±0.2 in the control subjects, and 72.2±52.3%(p<0.01) and 10.2±6.3(p<0.01) in the diabetic patients, respectively. The insulin resistance from the euglycemic hyperinsulinemic clamp test were 8.2±0.6㎎/㎏/min and 3.7±1.1ng/㎏/min in the control subjects and in the diabetic patients, respectively(p<0.01). Compared with the normal controls, insulin-stimulated IR phosphorylation was no different to that in the diabetic patients. However, insulin-stimulated IRS phosphorylation, insulin-stimulated Akt phosphorylation and insulin-stimulated GSK-3 phosphorylation were reduced in the diabetic patients compared with the normal controls by 24, 43 and 25%, respectively(p<0.05). Conclusion: In Korean type 2 diabetic patients, the insulin resistance may be due to the impairment of the upstream insulin signal molecular network. Further studies will focus on determining whether these signaling defects are the cause of the development of insulin resistance, or secondary to the altered metabolic state, associated with type 2 diabetes mellitus (J Kor Soc Endocrinol 17:685∼697, 2002).

아버지의 支配性(dominance)이 子女의 性役割 選好에 미치는 影響

최보가,張允玉,金貞姬 慶北大學校 師範大學 1987 敎育硏究誌 Vol.29 No.-

Sex-role development is one of the essential tasks of child development and a part of one's personality. Many studies have been undertaken to examine the children's sex-role preference and verified the difference between boys and girls. There are many factors that effect on the children's sex-role preference. For example, there is home environment that is included parents, -family structure, home's social level, brothers and sisters' formation and birth-rank,... etc. Also, there is social environment that is included peer, teacher and mass media. But we can expect that preschool children are most effected by parents. Thus the present study was undertaken to examine the influences of father dominance on preschool children's sex-role preference. This study is aimed to find out the follows facts. 1. Degree of father dominance that is perceived by child. 2. To find out father dominance has any influence on the boy's sex-role preference. To find out father dominance has any influence on the boy's sex-role preference under each of four lowranking domains, that is, decision-making, competence, nurture and limit setting. 3. To find out father dominance has any influence on the girl's sex-role preference. To find out father dominance has any influence on the girl's sex-role preference under each of four lowranking domains, that is, decision-making, competence, nurture and limit setting. The dependent measures are 1. Toy Preference Test. 2. Father dominance examination used Father Dominance Test (Henry, B. H.) Subjects were obtained from 100 boys and 100 girls, that they were all preschool children in Daegu. For statistical analysis, Mean, the Standard Deviation, t-test, one way ANOVA and Scheffe's test were used. The levels of significant were established at 0.05 and 0.01. The results were as follows 1. Generally, both boys and girls have perceived father dominant more than mother. In case of boys, they perceived father dominant more than mother in domains of decision-making and competence. In case of girls, they perceived father dominant more than mother in domains of decision-making, competence and nurture. 2. Father dominance perceived by young children had effects on boy's sex-role preference. In general, the higher father dominance was, the higher boy's masculinity was. In domains of decision-making, competence and nurture, father dominance have significant influences to boy's sex-role preference, but in domain of limit-setting, father dominance have no significant influence. 3. Father dominance perceived by young children had effects on girl's sex-role preference. In general, the higher father dominance was, the higher girl's feminity was. In domains of decision-making and limit-setting, father dominance have significant influences to girl's sex-role preference, but in domains of nurture and competence, father dominance have no significant influence on the girl's sex-role preference.