타리비드 정(오플록사신 100㎎)에 대한 파비드 정의 생물학적동등성

박완수,조성희,이헌우,임호택,홍성제,서성훈,류재환,이경태 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1

The purpose of the present study was designed to evaluate the bioequivalence of two ofloxacin tablets, Tarivid (Jell Pharm. Co., Ltd.) and Favid (ILHWA Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, 23.67±3.12 year in age and 68.50±7.23 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After four tablets containing 100 mg of ofloxacin were orally administered, blood was taken at predetermined time intervals and concentrations of ofloxacin in plasma were deter mined using HPLC. Pharmacokinetic parameters such as AUC_(t) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), and C_(max) and untransformed T_(max). There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log 0.8 to log 1.25 (e.g., log 0.94-log 1.04 and log 0.90-log 1.07 for AUC_(t) and C_(max) respectively). The major parameters. AUC_(t) and C_(max) met the criteria of KDFA for bioequivalence indicating that Favid tablet is bioequivalent to Tarivid tablet.

中·長距離 選手의 身體造成 및 最適體重에 關한 硏究

盧成圭,吳壽一,金斗卿 江原大學校附設 體育科學硏究所 1986 江原大學校附設體育科學硏究所論文集 Vol.- No.11

To find the best prediction on the body composition and optimum body weight those are need to perform the excellent performance in middle-long distance running, 15 numbers of junior high school boys and college man players who national superior middle-long distance runners were repeatedly measured 4 times by anthropometric measuring system. Conclusions from these measured data which are analyzed by statistical methods are follows. 1) Physical characteristics Physical characteristics of Middle-long Distance runners which were measured are presented as ; Body weight ratio on standing Height is 32.64±3.22%, Chest circumference ratio on Standing Height is 50.44±2.51%, Fat weight is 4.28±1.38㎏, % Fat weight is 8.69±1.84%, 2) Optimum Body weight for the best performance Equation of multiple regression for calcalation of optimum body weight in view of anthropometric method shows : Standing Height×(0.85)+Chest Depth×(0.32)+Bi-iliac Diameter×(0.09)+Bitrochanteric Diameter×(1.41)+Wrist Diameter×(-0.30)+Ankle Diameter×(1.28)=Y(Optimum wt.) In addition to regressional equation on optimum body weight in runners is showed as Y=Height×0.57-42.69 3) Optimum Net body weight : If runners Fat Weight Volume is over the level of Body fat weight volume it's calculus equations which should be decreased body weight for the best performance, are follows % Fat weight of runner - 7 Y-(Y× ------------------------------------)...............middle-long 100 Distance runner % Fat weight of runner -5 Y-( Y× --------------------------------------).............Marathoner 100

교사 학습공동체(Teacher Learning Community)를 통한 유아 평가의 실행에 관한 연구

심성경,함은숙,박수경 부산대학교 과학교육연구소 2013 교사교육연구 Vol.52 No.1

This study aims at examining what teachers experience while implementing children assessment through teacher learning community, and furthermore, at investigating the functions and meanings of a learning community from a teacher’s viewpoint. For this study, action research was conducted on 12 incumbent teachers belonging to A kindergarten for 7 months. Results showed that the teachers came to have self-confidence over children assessment while experiencing the new challenge of thinking again about assessment of children through the teacher learning community, and also they realized the importance of consideration and cooperation among teachers in the moving dynamic body of learning. The results of this study have the implications of the meanings and roles of a teacher learning community as an alternative for the teachers’ field training for the improvement of expertise in the knowledge-based society. 본 연구의 목적은 학습공동체를 통한 유아 평가의 실행과정에서 교사가 어떠한 경험을 하는지 살펴보고 나아가 교사가 바라보는 학습공동체의 기능과 의미에 대해 탐색하는 것이다. 이 연구를 위해 A유치원에 소속된 현직교사 12명을 대상으로 7개월 동안 실행연구가 이루어졌다. 그 결과, 교사 학습공동체를 통하여 유아 평가에 대해 다시 생각해 보는 새로운 도전을 경험하면서 유아 평가에 대한 자신감을 갖게 되었고 움직이는 배움의 역동체에서 교사 간의 배려와 협력의 중요성을 느끼게 되었다. 본 연구의 결과는 지식기반사회에서 전문성 신장을 위한 현장교사교육의 새로운 대안이 될 수 있는 교사 학습공동체의 의미와 그 역할에 대해 시사하였다.

빈발재발성 미세변화 신증후군환아에서 발생한 다발성 뇌경색증

조성옥,한헌석,차상훈,이경희,박범수,하태선,채수안 충북대학교 의과대학 충북대학교 의학연구소 1995 忠北醫大學術誌 Vol.5 No.2

신증후군에서는 동맥 및 정맥의 혈전에 의한 혈전색전증의 위험이 높다. 이는 혈 중 응고인자 Ⅰ, Ⅱ, Ⅶ, Ⅷ, Ⅹ등의 증가와 뇨소실로 인한 antithrombin Ⅲ의 감소, 섬유소 용해계의 변화, 혈소판 응집력의 증가에 기인하며 그 외 스테로이드 투여, 이뇨제 투여, 저체액 상태도 관여한다고 생각하나 이런 과응고현상에 대한 정확한 병태생리는 규명되고 있지 않다. 저자들은 내원 21개원 전 처음 신증후군 증상을 보였고 신장 조직 검사상 미세변화 신증후군으로 진단을 받고 스테로이드와 면역 억제제를 사용하였으나 6개월에 3-4회의 재발을 보이던 중 내원 1달 전 보호자 자의로 모든 약물 복용을 중단한 채로 지내다가 고열과 반혼수 상태를 보여 내원한 7세 남아에서 다발성 뇌경객증을 발견하였기에 문헌 고찰과 함께 보고하는 바이다. The risk of thromboembolism by arterial or venous thrombosis is high in the nephrotic syndrome. This may be due to the increased serum concentrations of the factor Ⅰ, Ⅱ, Ⅶ, Ⅷ, Ⅹ etc, decrease of antithrombin Ⅲ due to urinary loss, the change of thrombolytic system, increase in the platelet aggregation capacity, the use of steroid, diuretics, and hypovolemic state. But, the pathophysiology of this hypercoagulable state has not been clear. A 7-year- old boy had been diagnosed as having frequently relapsing minimal change nephrotic syndrome, 21 months ago. In spite of the administration of prednisolone and cytoxan, he had presented recurrent proteinuria in the frequency of 3-4 times per 6 months. From 1 month prior to visiting emergency room, his parents discontinued his medications, therefore, he showed fever and semicomatous mental status. In brain MRI study, multiple cerebral infarcts were noted. So, the authors report a case of multiple cerebral infarcts in a patient with frequently relapsing minimal change nephrotic syndrome with a brief review of related literature.

한국판 대칭 및 정리정돈 성향 척도(K-SOAQ)의 표준화 연구

차경렬,임준석,박준영,이수영,김광욱,노대영,김세주,구민성,김찬형 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.3

Objectives : The Symmetry, Ordering and Arranging Questionnaire (SOAQ) has been reported as a valid tool for the assessment of symmetry, ordering and arranging compulsive behaviors of patients with obsessive compulsive disorder. It was introduced by Radomsky and Rachman in 2004. The aim of this study was to assess the reliability, validity and psychometric properties of the Korean-version of the SOAQ (K-SOAQ). Methods : Two hundreds twenty eight under-graduate college students were enrolled in this study. They were assessed with K-SOAQ, Obsessive-Compulsive Inventory-Revised (OCI-R), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Statistical analysis was done using calculation of Cronbach’s alpha, Spearman Correlation Coefficient and Principal Components Analysis. Results : There were no significant differences in sex, education, and total scores of BDI and BAI. The Cronbach’s alpha coefficient of K-SOAQ was high, Cronbach’s α=0.96. There was strong evidence for a one-factor solution, accounting for 60.3% of the variance. Convergent validity was examined through correlations between the SOAQ and the OCI-R (r=0.61). Divergent validity was examined through correlations between the SOAQ and two self report measures; BDI (r=0.12) and BAI (r=0.19). Conclusion : The K-SOAQ showed good reliability and validity for the assessment of severity of compulsive characteristics regarding symmetry, ordering and arranging. The K-SOAQ is a useful instrument for assessing compulsive symptoms related with symmetry, ordering and arranging in Korea.

무균돼지 사육시설 계획을 위한 사례연구 : 공간구성 및 동선계획을 중심으로

권순정,성제경,염수청 한국의료복지시설학회 2006 의료·복지 건축 Vol.12 No.1

According to the increase of demand for human organs such as kidney, heart, pancreas, joint, and cornea for therapeutic transplantation, the production of alternative organs based on Gnotobiotic Pigs gains a lot of concerns all over the world. However, it is not common to design and build Gnotobiotic Pigs' facility, and there are only a few those facilities and planning principles for them. Considering the situation above, this paper tries to develop planning guidelines for space organization and circulation system of standardized Germ Free Pig's facility on the bases of case analysis. The results of this study are as follows. At first, four swine farms including a Gntobiotic Pig's facility has been analysed from the point of space organization and circulation system. Secondly, the space zoning of Gnotobiotic Pigs' facility has been proposed into 5 groups : pigs' area, adminstration area, operating room and laboratory, service area, and mechanical area. Space components of each group have been presented also. Finally, circulation system of Gnotobiotic Pigs' facility has been explored from a operational point of view. This, also, includes human circulation, pig's circulation, and goods' circulation. This study has some limitations because it does not consider the SOPs(standard operational policies) of that facility to the fullest measure and does not suggest space area of each part, either. Despite of some weaknesses, it is expected that this study can give some useful guidelines for the design and planning of Germ Free Pigs' facilities.

의약품 키랄분석의 임상적 응용

최현수,진건파,오은기,이은주,이은실,박경래,강종성 충남대학교 약학대학 의약품개발연구소 2009 藥學論文集 Vol.24 No.-

Chirality plays an important role in biology, and many of the processes essential for life are stereospecific. Hence, the chiral chromatographic separation of drugs becomes more important for the pharmacologists and toxicologists to offer the appropriate tools to find the solution for many problems related with stereoisomers of drugs. This review discusses the clinical applications of chiral separation for meploquine salbutamol, omeprazole, ketamine and some fluorinated volatile inhalation anaesthetics. The chirality in clinical situations was illustrated by these drugs in the field of enantiospecific pharmacokinetics and therapeutic activities. The results indicated that the racemic switch to a single enantiomer for these drugs will promote the development of more effective and safe drugs.

농작물 해충 및 진균류 방제를 위한 방선균의 분리 및 동정

이은정,강경돈,황교열,김두호,김신덕,성수일 한국잠사학회 1998 한국잠사곤충학회지 Vol.40 No.1

Twenty seven out of ca. 5,000 actinomycete strains, which were isolated from soil collected throughout the country, showed antimicrobial effects against fungi, Rhizopus stronifer (ATCC6227a), Rhizoctonia solani (KCCM 11271) and yeast, Candida albicans(ATCC10231). From these antifungal microorganisms, we further selected seven strains which seemed to produce insecticidal substances with in vivo test, using silkworm, Bombyx mori and beet armyworm, Spodoptera exigua. Morphological and biochemical experiments revealed that three strains out of seven were streptomyces. Further investigations on the physical and chemical properties of these antifungal and insecticidal substances are now in progress.

고콜레스테롤 혈증 환자에서 Cerivastatin(LIPOBAY, 의과학연구소)의 임상효과 및 안전성에 관한 연구

박성훈,김미연,정수진,이영숙,박창한,변은경,전성희 梨花女子大學校 醫科大學 醫科學硏究所 2001 EMJ (Ewha medical journal) Vol.24 No.3

목적 : Cerivastatin(LIPOBAY)은 최근에 개발되어 사용되기 시작한 HMG-CoA 환원효소 억제제로서 저용량으로 탁월한 콜레스테롤 강하효과를 보이는 약물이다. 저자들은 Cerivatatin(LIPOBAY)의 혈중 콜레스테롤 강하효과를 평가하고 약물의 안전성을 평가하기 위하여 본 연구를 시행하였다. 방법 : 고콜레스테롤혈증 환자 37명(남자 13명, 여자 24명)을 대상으로 하였다. 대상환자는 2주간의 저콜레스테롤 식이 후에도 혈청 콜레스테롤이 240㎎/㎗이상이거나, 관상동맥질환이 있는 환자는 혈청콜레스테롤이 220㎎/㎗이상인 경우 cerivastatin 0.4㎎을 8주간 복용하도록 하였다. 임상적 관찰과 검사실 검사(간기능검사, 일반혈액검사, 혈청지질검사)는 투약개시 후 4주 및 8주 후에 시행하였다. 결과 : Cerivastatin 0.4㎎을 4주간 투여한 후 측정한 LDL 콜레스테롤, 총콜레스테롤, triglyceride, 및 HDL 콜레스테롤은 각각 38%, 28.8%, 11.6% 및 7.8% 감소하였다. 총콜레스테롤/HDL 콜레스테롤 비 및 LDL/HDL비는 각각 20.8% 및 31.1% 감소하였다. 투약 8주후에 측정한 검사소견은 4주후에 비해 유의한 변화를 보이지 않았다. 한명의 환자(2.7%)에서 간기능 검사상 AST, 및 ALT의 지속적인 상승으로 투약을 중지하였다. 결론 : Cerivastatin 0.4㎎/day는 혈청콜레스테롤을 효과적으로 감소시켰으며 심각한 부작용은 볼 수 없었다. 따라서 적극적으로 LDL콜레스테롤을 낮출 필요가 있는 고콜레스테롤혈증 환자에서 cerivastatin은 효과적이고 안전한 약물이라고 생각된다. Objectives : Cerivastain(LIPOBAY) is recently developed HMG-CoA reductase inhibitor which is effective in lowering serum cholesterol levels at microgram does. We evaluated the clinical efficacy and safety of cerivastatin(LIPOBAY) in patients with hypercholesterolemia. Method : Thirty-seven patients(male : 13, female : 24) with hypercholesteolemia defined as baseline serum total cholesterol ≥240㎎/㎗, or ≥220㎎/㎗ in patients with known coronary artery disease were included for this study. After 2 weeks of low cholesterol diet, if the serum total choesterol level meet the criteria, cerivastain 0.4㎎/day was prescribed for 8 weeks. Clinical follow-up and laboratory tests were performed 4 weeks and 8 weeks after medication. Results : After 4 weeks of cerivastain 0.4㎎/day treatment, low density lipoprotein(LDL) cholesterol decreased 38% and total cholesterol decreased 28.8% from baseline. Triglyceride decreased 11.6%, and high density lipoprotein(HDL) cholesterol decreased 7.8% from baseline. Total cholesterol/HDL ratio decreased 20.8% and LDL/HDL ratio decreased 31.1% from baseline. After 8 weeks of treatment, no further significant changes were noted compared with the values at 4 weeks. Cervastatin was discontinued in one patient(2.7%) due to continuous liver enzyme elevation. Conclusion : Cerivastatin 0.4㎎/day is effective in lowering serum cholesterol levels without significant adverse reactions. Cerivastatin is effective and safe for patients with hypercholesterolemia who needs aggressive LDL cholesterol lowering.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.