普遍者의 問題 小考 : Aristoteles의 Metaphysics를 中心으로

朴範洙 서울 敎育大學校 1982 論文集 Vol.15 No.-

Tagetes erecta Linn flower extract inhibits particulate matter 2.5-promoted epithelial-mesenchymal transition by attenuating reactive oxygen species generation in human retinal pigment epithelial ARPE-19 cells

박범수,방은진,이혜숙,김기영,최영현 한국영양학회 2025 Nutrition Research and Practice Vol.19 No.2

BACKGROUND/OBJECTIVES: Particulate matter 2.5 (PM2.5) exposure can promote epithelial- mesenchymal transition (EMT) in human retinal pigment epithelial (RPE) cells. The flowers of Tagetes erecta Linn, commonly known as marigold, are rich in diverse flavonoids and carotenoids and play a significant role in preventing cellular damage induced by oxidative stress, but the role of their extracts in RPE cells has not been reported. This study aimed to evaluate the influence of an ethanol extract of T. erecta Linn flower (TE) on PM2.5-induced EMT processes in RPE ARPE-19 cells. MATERIALS/METHODS: To investigate the protective effect of TE against ARPE-19 cell damage following PM2.5 treatment, cells were exposed to TE for 1 h before exposure to PM2.5 for 24 h. We investigated whether the efficacy of TE on suppressing PM2.5-induced EMT was related to antioxidant activity and the effect on the expression changes of factors involved in EMT regulation. Additionally, we further explored the role of intracellular signaling pathways associated with EMT inhibition. RESULTS: TE significantly blocked PM2.5-induced cytotoxicity while effectively preventing mitochondrial dysfunction, increased reactive oxygen species (ROS) generation, and mitochondrial membrane potential disruption. TE inhibited PM2.5-induced EMT and inflammatory response by suppressing the ROS-mediated transforming growth factor-β/ suppressor of mothers against decapentaplegic/mitogen-activated protein kinases signaling pathway. CONCLUSION: Our results suggest that marigold extract is a highly effective in protection against PM2.5-induced eye damage.

『악기(樂記)』에 나타난 유가적(儒家的) 음악예술론(音樂藝術論)

박범수 덕성여자대학교 인문과학연구소 1995 인문과학연구 Vol.1 No.2

일측성 신낭성 질환

박범수,김태환,임성직,이형래,전승현 대한비뇨의학회 2007 Investigative and Clinical Urology Vol.48 No.6

Population dynamics of the microalgae Gymnodinium catenatum and Gymnodinium impudicum (Dinophyceaes) using EvaGreen-based quantitative Real-Time PCR assay

박범수,한명수 대한조선학회 2011 대한조선학회 학술대회자료집 Vol.2011 No.6

고대 예서[禮書]에 나타난 예[禮]의 개념 : 가정의례의 배경과 근거를 밝히기 위한 시도로서

박범수 서울교육대학교 초등교육연구소 1997 한국초등교육 Vol.9 No.2

In ancient China the term of Li had broad meanings. It was the foundation of all orders in cosmos. Therefore, the gods in heavens, the governors of nations and patresfamilias had to obey the L So the term of L meaned sometimes rules of property, sometimes rules of ceremonial usage Without L , there were no laws of nature, no Justices of politic societies and no morals of human lives. There were six fields in L The first was public benefit in conflict between self and others, L introduced us to public benefit The second was the method of policy to realize justices in nations Six parts of government in ancient China and Korea originated in six sides of nature, which were heaven, earth, east, west, south and north The third was the orders of nature, of society and human relations The forth was the principles of all social systems and human actions The fifth was the family code of etiquette. The sixth was self-control.

善惡論小考 : 理想主義的 立場

朴範洙 서울 敎育大學校 1979 論文集 Vol.12 No.-

Interval from Prostate Biopsy to Radical Prostatectomy Does Not Affect Immediate Operative Outcomes for Open or Minimally Invasive Approach

박범수,추설호,전황균,정병창,서성일,전성수,이현무,최한용 대한의학회 2014 Journal of Korean medical science Vol.12 No.12

Traditionally, urologists recommend an interval of at least 4 weeks after prostate biopsybefore radical prostatectomy. The aim of our study was to evaluate whether the intervalfrom prostate biopsy to radical prostatectomy affects immediate operative outcomes, witha focus on differences in surgical approach. The study population of 1,848 radicalprostatectomy patients was divided into two groups according to the surgical approach:open or minimally invasive. Open group included perineal and retropubic approach, andminimally invasive group included laparoscopic and robotic approach. The cut-off of thebiopsy-to-surgery interval was 4 weeks. Positive surgical margin status, operative time andestimated blood loss were evaluated as endpoint parameters. In the open group, therewere significant differences in operative time and estimated blood loss between the< 4-week and ≥ 4-week interval subgroups, but there was no difference in positivemargin rate. In the minimally invasive group, there were no differences in the threeoutcome parameters between the two subgroups. Multivariate analysis revealed that thebiopsy-to-surgery interval was not a significant factor affecting immediate operativeoutcomes in both open and minimally invasive groups, with the exception of the interval< 4 weeks as a significant factor decreasing operative time in the minimally invasive group. In conclusion, performing open or minimally invasive radical prostatectomy within 4 weeksof prostate biopsy is feasible for both approaches, and is even beneficial for minimallyinvasive radical prostatectomy to reduce operative time.

Endovascular Mechanical Thrombectomy in Basilar Artery Occlusion: Initial Experience

박범수,강창우,권현조,최승원,김선환,고현송,염진영,송시헌 대한뇌혈관외과학회 2013 Journal of Cerebrovascular and Endovascular Neuros Vol.15 No.3

Objective:This study was conducted to assess the efficacy and safety of endovascular mechanical thrombectomy (EMT) for patients diagnosed with basilar artery (BA) occlusion. Materials and Methods : We retrospectively analyzed clinical and imaging data of 16 patients diagnosed with BA occlusion who were treated with endovascular intervention from July 2012 to February 2013. Direct suction using the Penumbra system and thrombus retrieval by the Solitaire stent were the main endovascular techniques used to restore BA flow. The outcomes were evaluated based on rate of angiographic recanalization, rate of improvement of National Institutes of Health Stroke Scale (NIHSS) score, rate of modified Rankin Scale (mRS) at discharge and after 3 months, and rate of cerebral hemorrhagic complications. Successful recanalization was defined as achieving Thrombolysis In Cerebral Infarction (TICI) of II or III. Results : Sixteen patients received thrombectomy. The mean age was 67.8 ± 11 years and the mean NIHSS score was 12.3 ± 8.2. Eight patients treated within 6 hours of symptom onset were grouped as A and the other 8 patients treated beyond 6 hours (range, 6-120) were grouped as B. Successful recanalization was met in six patients (75%) for group A and 7 (87.5%) for group B. Favorable outcome occurred in 4 patients (50%) for group A and 5 (62.5%) for group B. Conclusion : Our study supports the effectiveness and safety of endovascular mechanical thrombectomy in treating BA occlusion even 6 hours after symptom onset.

Cushing Syndrome: A Potential Risk of Bilateral Postoperative Ischemic Optic Neuropathy after Lumbar Fusion

박범수,최승원,한상현,염진영,임정욱,권현조 대한신경손상학회 2019 Korean Journal of Neurotrauma Vol.15 No.2

This is a report of a 58-year-old female with Cushing syndrome who underwent posterior lumbar fusion and lost both her vision completely. She was diagnosed with posterior ischemic optic neuropathy. Cushingoid features such as buffalo hump and central obesity might have attributed in triggering posterior ischemic optic neuropathy. When laid prone for surgery, perioperative high abdominal pressure causes venous hypertension leading to increase amount of blood loss. To compensate, infusion of large quantities of intravenous fluids is necessary which leads to hemodilution which decreases ocular perfusion pressure. Hypercoagulability of Cushing syndrome is also potentially a risk factor of this condition which increases the incidence of venous thromboembolism. For there is no known effective treatment for posterior ischemic optic neuropathy, means to prevent this complication must be strategically reviewed. When performing long spine surgery on patient who has Cushing syndrome or cushingoid features, caution must be taken to avoid this devastating complication.