정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

후막 전계발광소자(Electroluminescence)의 제조와 발광특성

정영호,김병권,박조용,명광식,Khatkar, S.P.,Liang, Yujun,한상도 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

자립생활센터의 중증장애인 고용과 고용지원 서비스 실태

조한진,전정식 한국장애인고용촉진공단 고용개발원 2007 장애와 고용 Vol.17 No.1

본 연구는 중증장애인의 고용 확대를 위해 자립생활센터가 하고 있는 일을 조사하고, 이것이 중증장애인 고용과 관련하여 시사하는 바를 분석해 보고자 하였다. 이를 위하여, 본 연구는 자립생활센터의 중증장애인 고용 실태와 장애인 고용지원 서비스의 실태에 초점을 두었다. 조사는 20개의 자립생활센터에 대한 전자우편 설문과 직접 면접을 통하여 2006년 7월부터 8월까지 2개월 동안 진행되었다. 연구 결과에 따르면, 자립생활센터는 장애인, 특히 중증장애인의 고용에 있어 적극성을 보였다. 자립생활센터에 고용된 중증장애인들의 근속기간도 길게 유지되는 것으로 나타났다. 자립생활센터의 중증장애인들은 근로자로서의 신분을 지니면서 다양한 내용의 직무를 수행하고 있었다. 또한 자립생활센터는 장애인에게 취업 전 지도 및 교육 서비스를 비롯한 고용지원 서비스를 제공하고 있었다. 이에 자립생활센터의 중증장애인 고용과 고용지원을 촉진하기 위한 방안을 제시하였다. This study intended to examine what independent living centers (ILCs) were doing to increase the employment of people with severe disabilities and intended to analyze what the roles of ILCs suggested with reference to their employment. For that purpose, the study focused on the state of employment of people with severe disabilities in ILCs and on the state of employment-support services for people with disabilities. Data collection was conducted for two months from July to August 2006 through e-mail questionnaires to and in-person interviews with 20 ILCs. The findings indicated that ILCs were very active in employing people with disabilities, more particularly people with severe disabilities. Employees with severe disabilities have served in ILCs for a long time. People with severe disabilities in ILCs were carrying out their various duties as employees. Also, ILCs were providing employment-support services, including pre-employment coaching and training services, to people with disabilities. Hereupon, the study came up with several suggestions to promote the employment of people with severe disabilities in ILCs and to expand employment-support services for people with disabilities.

불소가 함유된 세마제가 법랑질의 내산성에 끼치는 영향에 관한 생체외 연구

조중한,김대업,이광희 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.1

The purpose of study was to know the effect of addition of fluoride to prophylaxis paste on caries prevention. 2% sodium fluoride solution and 8% stannous fluoride solution were applied topically to enamel blocks made from human teeth. Also, 2% sodium fluoride-containing pumice and 8% stannous fluoride-containing pumice was applied to enamel blocks using rubber cup for ten seconds. Enamel surface hardness was measured before and after demineralization by 0.01 N lactic acid. The results were as follows ; 1. Enamel solubility was increased in NaF group and nearly unchanged in SnF₂group by prophyaxis with plain pumice after fluoride application. 2. Enamel solubility was increased in NaF group and decreased in SnF₂group by prophylaxis with fluoride-containing pumice after fluoride application. 3. Enamel solubility was lower in case of prophylaxis with fluoride-containing pumice after fluofied application and after no fluoride application than in case of prophyalxis with plain pumice after fluoride application. 4. Enamel solubility was lower incase of no prophylaxis after fluoride application than in case of prophylaxis with fluoride-containing pumice in NaF group, and vice versa in SnF₂group.

초등학교 아동의 치과치료장면 그림의 주조색과 불안도의 연관성에 관한 연구

조중한,이광희,김대업,배상만 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.1

The purpose of the study was to observe the association between the main colors of school chidlren's drawings of dental treatment situation and their dental anxiety. The subjects of study were 688 school children from 2nd to 4th grade. Caries experience was investigated by oral examination. Questionnaire survey was done regarding children's attitude toward the dentist and dental treatment and their experience of pain and fear during the dental treatment. Colors with high frequency of use were green, blue, yellow, orange, pink, purple, gray, brown, yellow ochre, red, white and black in order. Boys used green and blue, and girls used yellow and orange, more than each other. As the grade increased, white, yellow, and blue increased and brown decreased. Colors with high dental anxiety level were black, brown, red, white, blus, orange, yellow and green, yellow ochre, gray, pink, and purple in order, and the upper four represented 10.5% of the subjects. Children with high decayed teeth rate had a tendency to use colors of high dental anxiety level. Black color had the most obvious association with the pain and fear of dental treatment.

등간격 병진스프링으로 지지되는 단순곡선보의 고유진동수해석

조정래,이용운,윤한익 동의대학교 산업기술개발연구소 2000 産業技術硏究誌 Vol.14 No.-

The transfer matrix method is used to study the influence of the translational spring support on the transverse vibration of the simple curved beam. The translational spring supports are constituted by the middle point and the nine points at regular interval on the curved beam. The influence of the translational spring constants on the natural frequency of the simple curved beam is very much at 1st and 3rd mode and the natural frequency is augmented as increasing of the translational spring constants. Since the amplitude of the curved beam is small at high mode, the translational spring constant has a little influence on the transverse vibration of the simple curved beam. The simple curved beam supported elastically at middle point has high frequency than that supported elastically at nine points at regular interval. If the translational spring constant supporting the simple curved beam become very large, and then since the elastic support is similar to the rigid support, the transverse natural frequencies increase very much at the each mode of the simple curved beam.

당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

韓日涉外事件의 私法的硏究

鄭照根,金容漢 新羅大學校 1980 論文集 Vol.8 No.-

In accordance with the rapid growth of Korean economy, Korea is getting more important position in the international society. Keeping pace with such improvement and modernity of Korean economic society, our legal culture has fully arranged with required conditions for constitutionalism and in some particular parts it has remarkably developed. Besides, rationality and validity in legislation and its application are being varified. But we could not overlook the fact that the Japanese cognition about Korean Law is so unexpectedly feeble that precedents the international cases between Korea and Japan which are treated by the every Japanese courts including Japanese supreme court based on their misunderstanding about Korean Law or ignorance are not seldom. At this point, this paper, through positive study of precedents about international cases between Korea and Japan, focuses to improve international cognition about Korean legal culture and to verify proper position in private law of Korean residents in Japan. And this hind of study can not only improve Korean legal culture internationally but also induce national pride to 660 thousands of Korean residents in Japan and further more influence them greatly to ensure their private rights in Japan society. Therefore, I collected precedents of status relations in this study, for example, competence of courts cases, nationality and adoption cases, marriage cases, rights and duties of the parents and guardianship cases among Korea-Japan relations, which has been treated by the every Japanse courts including supreme court, and analyzed and criticized them. This writing is composed of following; 1. Introduction 2. The right of Jurisdiction in the international cases 3. Nationality and adoption cases between Korea and Japan 4. International marriage cases between Korea and Japan 5. International rights and duties of the parents and guardianship cases between Korea and Japan 6. Conclusion

光質이 채소作物의 種子發芽와 初期生育 및 除草劑의 活性에 미치는 效果

李政明,金侊來,權臣漢,曺哉銑,朴啓仁,金尙根,李承雨 慶熙大學校 1987 論文集 Vol.16 No.-

Studies were conducted to investigate the response of some horticultural plants to various light qualities provided by different kind of materials such as cellophane sheets, EVA, PVC(polyvinyl chloride, and polyethylene (PE) films of different color. Major findings are summarized as follows. White fluorescence light and red light promoted seed germination of lettuce and inhibited that of radish seeds. Blue light inhibited the seed germination of both types of light-sensitive seeds. The light sensitivity varied considerably depending upon the kind of crops, cultivars, and the seed batches of the same cultivar. The blue light was equally or more strongly effective in inhibiting the seed germination as compared to the farred light. The growth of young seedlings developed from seeds was considerably promoted when grown under orange colored plastic film coverings. The growth of larger seedlings was, however, not influenced by the color of plastic films. Mulching pepper field with colored PVC film did not show further advantages over the commonly-used black PE film. Herbicidal activity of oxyfluorfen was very strong under natural light or red light conditions' and weak under blue or green light conditions. The degree of oxyfluorfen-induced phytotoxicity varied considerably depending upon the light quality and the kind of vegetable crops.

光質이 채소作物의 種子發芽와 初期生育 및 除草劑의 活性에 미치는 效果

李政明,金侊來,權臣漢,曺哉銑,朴啓仁,全尙根,李承雨 경희대학교 부설 식량자원개발연구소 1987 硏究論文集 Vol.8 No.-

Studies were conducted to investigate the response of some horticultural plants to various light qualities provided by different kind of materials such as cellophane sheets, EVA, PVC(polyvinyl chloride,. and polyethylene (FE) films of different color. Major findings are summarized as follows. White fluorescence light and red light promoted seed germination of lettuce and inhibited that of radish seeds. Blue light inhibited the seed germination of both types of light-sensitive seeds. The light sensitivity varied considerably depending upon the kind of crops, cultivars, and the seed batches of the same cultivar. The blue light was equally or more strongly effective in inhibiting the seed germination as compared to the farred light. The growth of young seedlings developed from seeds was considerably promoted when grown under orange colored plastic film coverings The growth of larger seedlings was, however. not influenced by the color of plastic films Mulching pepper field with colored PVC film did not show further advantages over the commonly -used black PE film. Herbicidal activity of oxyfluorfen was very strong under natural light or red light conditions, and weak under blue or green light conditions The degree of oxyfluorfen-induced phytotoxicity varied considerably depending upon the light quality and the kind of vegetable crops.