췌장염에 의한 가성낭종내에 생긴 가성동맥류 : 1례 보고

오연희,이채경,김승현,이성우,양창현,이정호,이영현 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

만성 췌장염의 합병증으로 생긴 가성동맥류는 드문질환으로, 반복적으로 다량의 출혈을 일으킬 수 있으며, 치료를 하지 않을 경우 사망율이 높기 때문에, 조기 진단과 치료가 필수적이다. 저자들은 38세 남자 환자에서 췌장염의 합병증으로 생긴 가성낭종내에서 발생한 가성동맥류 1예를 경험하였기에 보고하는 바이다. 가성 동맥류의 색혈류도플러상 낭종내에 양방향 흐름의 와류를 볼 수 있었다. Pancreatic Pseudoaneurysm within Pseudocyst from Pancreatitis: 1 Case Department of Diagnostic Radiology and Internal Medicine, College of Medicine,DongGuk University Yeon Hee OH M.D., Chae Kyeong Lee M.D., Seoung Hyeon Kim M.D., Sung Woo Lee M.D., Chang Heon Yang M.D., Jung Ho Lee M.D., Young Hyun Lee M.D. Pseudoaneurysm from pancreatitis is uncommon, but it can cause recurrent and massive hemorrhage. Because of high morbidity and mortality, early detection and treatment of the pseudoaneurysm is needed. We report a case of pseudoaneurysm within pseudocyst from pancreatitis. Color-flow Doppler sonography shows bidirectional flow and turbulent arterial flow, within anechoic mass.

골수이식 후 골밀도 및 골대사의 변화 : 2년 추적관찰 2-Year Prospective Study

이원영,강무일,오은숙,오기원,한제호,손현식,윤건호,차봉연,이광우,손호영,강성구,신완식,민우성,김춘추 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

加工用 菜蔬에 關한 硏究 (Ⅰ) : 加工用 오이의 品種에 關하여 On varieties for processing cucumber

李愚昇,朴小守 慶北大學校 1972 論文集 Vol.16 No.-

In order to select the better varieties for pickling use, the authors studied on the characteristics and yields of cultivated cucumber varieties in Korea. The results obtained were as follows; 1. Yields per plant was the highest in Sa-Yeup, Sung Ho Won-Chung Jang, Sung Ho Won-New No. 1, KeRyang-Seoul Madi and Chung Yong-Sam chuck in order. 2. The nember of fruit set per plant was the most in Sung HO Won-Chung Jang, Sung Ho Won-New No. 1, KeRyang-Seoul Madi, Sa-Yeup and Chung Yong-Sam chuck in order. 3. Yields percentage of salt pickling was 62% to 72%. 4. The varieties of Sung Ho Won-Chung Jang, Sung HO Won-New No. 1 and KeRyang-Seoul Madi were similar in the plant growth type and the characteristics of fruit. On the other hand, Sa-Yeup and Chung Yong-Sam Chuck were similar. 5. It was postulated that Sa-Yeup variety was the best in processig because sarcocarp was delicacy, placenta was small, and yield was the most among the varieties used for this study.

高麗中期의 民族敍事詩 : 東明王篇과 帝王韻紀의 硏究 A Study of old Korean Gests Dong-Myung-Pyun and Je-Wang-Woon-Ki

李佑成 成均館大學校 1962 論文集 Vol.7 No.-

Korean literature reaped a precious harvest of two splendid and long epic poems during the one century period from the late 12th to the late 13th century. These are Dong-Myung-Wang-Pyun (東明王篇), the Geste of King Dong-Myung by Yi, Kyu-Bo (1168-1241), and Je-Wang-Woon-Ki (帝王韻紀), the Geste of the Kings by Yi, Sung Hyoo (1224-1300). The Geste of King Dong-Myung clarifies in the opening chapters the remote genealogy of King Dong-Myung, hero and the founder of Koguryo; and in the main chapters, it depicts the King's history from the birth to his great work of foundation; and finally in the closing chapters, his history up to the coronation of King Luri who succeeded to his heroic works and also the impressing comments expressed by the poet. The Geste is written in Chinese poetry, composed of the main part of a little over two hundred and eighty lines and of the descriptive part of four hundred and thirty some lines. Each being a five-word line, the total Chinese word-characters used in the Geste amount to a length of three thousand six hundred (3,600). Je-Wang-Woon-Ki, the Geste of the Kings,(hereafter referred to as simply the Kings), consists of two volumes. The first volume carols the history of the ancient Chinese dynasties, from Bango (盤古) to Kum (金) and in the second volume, the history of Korea. The second volume is of two parts. The first part deals with the rise and fall of the Korean dynasties, starting from Dan-Goon (檀君), the remotes founder of Korea, to the dynasties of Wiman (衛滿), Sagoon (四群), Samhan (三韓) (Three-Kingdoms), Silla (新羅), Koguryo (高句麗), Bekje (百濟), later Koguryo, later Bekje and Balhe (渤海). The first part consists of two hundred and ten (210) seven-word lines, total character-words amounting to one thousand four hundred and sixty. The second part deals with the history of the period from the foundation of Koryo (高麗) down to the reign of King Choongyul (忠烈王) under which the poet lived. The second part is of seven hundred character-words in total, in one hundred and twenty (120) lines, each containing five words. The Geste and The Kings have attracted the attention of the scholar historians, both domestic and foreign, as the historical documents since much earlier days, but it is quite recently that they have come to be considered valuable from the viewpoint of literature. In fatc, they began to be revaluated as "folk epic" when the present author of this thesis published "A Study of the Generation of Yi, Kyu-Bo and Yi, Sung-Hyoo", at Pusan in 1956, and in the following year, Professor Chang, Duk-Soon made his thesis public under the title of "King Dong-Myung, an Epic", which found its place later in his "General Survey of Korean Literature". Quite recently, Professor Yi, Byung-gi presented a new viewpoint, in his "Complete History of Korean Literautre", that the Geste and the Kings are the truthful origin of "Kasa" (歌辭), the ancient folk poetry. About this new theory, however, the author would refrain from mentioning because it has no direct relation with the following thesis of the present author. The present author's interest lies rather in that these two poems in Chinese style should find a position with importance in the system of Korean literature, which has been so far neglected by the Korean literary scholars. A word about the thesis of Professor Chang, Duk-Soon. The thesis is sufficient enough to give the readers a profound understanding of the "Geste of King Dong-Myung" through his structural analysis of the narrative of King Dong-Myung and its detailed comparison with the western getse, which are done in his fluent, rich style. To the regret of the present writer, however, Professor Chang's studies on the Geste ended only in the field of said "analysis" and said "comparison", largely destitute of the due historical background of it. As the result, he ventured to ascribe the motive of the creation to a "nostalgic fidelity" of a Koryo-man to the prceeding Dynasty, Koguryo, and also to determine that the epic poem of the Koryo era was entirely an "accidental eruption of the 13th century". All the literary heritage is the products of the history. We cannot easily be contented by hastily treating our literary heritage. Therefore, the present writer particularly intends to examine the historical background of the Geste to comprehend the position of the poet's subjecthood and furhtermore grasp the true significance of the work from the viewpoint of resuscitated moving history of that age. A rough survey of the dynastic history of Koryo shows us that the Dynasty, since its foundation in 919 A.D., aimed high at expanding its territory towards the North as its state principle. This enterprising spirit of early Koryo had constantly been checked by the powerful suppression on the part of "Kuran"(契丹), and "Yojin"(女眞), two northern races. And without any chance, the Dynasty had to meet the Mongolian Aggression (1231-1256). In this warfare, the regime of "Choi"(崔氏) family ruled Koryo standing siege in KangWha Island. Choi's regime had resisted against the Aggressors thirty, long years before the Dynasty met its total defeat. And the former, the failure of the expansion policy was caused by the corruption and inability of the then ruling aristocracy; and the latter, the defeat at the hands of Mongolians, was brought about by the decrepitude of Royal House, and also by the reactionary bureaucrats who overthrew the Choi regime through treason. In the history of Koryo, however, we should not fail to observe the strong flow of the people's movements. During the period, 1128-1135, people urged the government to transfer the capital to Pyungyang, a border city, to face and suppress the enemy nation, "Kum" (金) (Yojin), and also they advocated that Koryo's King should be retitled as "emperor" like in China, setting up Koryo's own new era, which, till then, had been forbidden by Great China, the powerful dominator. Another incident of the people's movement is seen in heroic resistance against the enemy throughout the Mongolian Aggression. People fought at every part of the country in conjunction with the army, refusing to surrender to the Mongolians till the last. The high spirit and energy of the people had led to the formation of "Sam-Byul-Cho" Army which continued, in isolation from the government, its resistance war for four years until 1273. The 12th and 13th centuries mark the period of great trials suffered by the Korean race. The great spirit of resistance oppressed by the realities inevitably found it way to inwardness, and again was fermented to find its spout in the essence of literature. Yi, Kyu-Bo and Yi, Sung-Hyoo were the writers representing this troubled age, both of whom reached the greatness under favorable care of the Choiregime. They were "Rising Intellectuals" who heralded" New Officials", that is, the class of "Literary Intellectuals" during the second half period of Koryo. They were entirely different in character, from those old aristocrats who had held power during the first half period of the Dynasty. Therefore, these two literary men belonged to the transitional, progressive group of people who later prepared the seed-bed for the new culture. The new culture meant the culture for the people, while the old culture meant the culture forthe aristocrats. No wonder that folk epic such as the Geste and the Kings should be written by these "Rising Intellectuals", and not "accidental" at all. There is no objection in concluding that the Geste and the Kings both are the folk epic. However, we should discern the considerable difference which exists between these two poetical works, either in their subjects or either in their structure. The Geste carols one and single prototype, King Dong-Myung who was the hero of dynastic foundation; while the Kings deals with various, important historical happenings during the entire period from the earliest mythical foundation of the country by "Dangoon" down to the author's age. Here, just for the convenience's sake, the present writer take the liberty of calling the Geste a heroic poem; and the Kings, a history poem, regardless of the fact that a heroic poem and a history poem are essentially the same. Firstly, the writer desires to deal with the Geste laying stress on the following two points: (1) the method of the plot development, and (2) the characteristic of the prototype. In the heroic poem, the development of the plot differs according to the singularity or plurality of the hero prototype. When single, the plot develops towards the direction of the will of the hero; meanwhile, when plural, the plot becomes a succession of human contrasts, and collisions. In the Geste which is a biographic description of a King, the only prototype is King Dong-Myung himself. And the principal actions of the King are narrated in chronological order. However, Yi, Kyu-Bo, the author of the Geste tactfully dealt with the single hero additionally presenting his counterparts to produce a variety in the plot-flow. As the result, contrasts, collision occurs in succession constantly taking a new turn towards a third phase. The plot, therefore, constantly flows breaking the stalmate deadlock. Thus the Geste, which otherwise would have ended by an individuals biography, is heightened up to a realm of heroic poem. In the Geste, the poet succeeded in portraying the character of the hero. The willpower and ambition of the King as a hero are successfully expressed in his escape from Buyo,(扶餘) the capital, and in his founding of a new counrty and a new capital in the South and also in his fight against a neighboring state, "Biru-Kuk"(沸流國). The portrayal of the King's character as hero is vivid and acute in his strategy, violence, cruelty and egotism. The violent hero who exhausts every mean to accomplish his purpose falls easily, like a child, in the arms of his tender mother. Readers of the Geste are struck to find themselves disposed to agree with the hero's strategy, egotism and violence. In this, we are obliged to acknowledge the author's success in sculpturing the fresh, healthy, original humanity of the ancient type. The Geste is a success as a hero poem, but is still insufficient as a folk epic, that is, an epic of the Korean Race. The present writer is of opinion that King Dong-Myung certainly is a hero of a tribe, but not the common patriarch of the entire Korean Race. He is a heroic chief of the tribe of Koguryo which is the predecessor of Koryo "people" since it is evident, in history, that Koryo is the successor of Koguryo. And the author of the Geste so treated the King. In this strict sence, the Geste is, the present writer concludes, more of "heroic poem" than of "history poem". The great task of discovering the common patriarch of the entire race of this land was possible at the hand of Yi, Sung-Hyoo, a little later than Yi, Kyu-Bo's time. Yi, Sung-Hyoo described, with his wider range of view, the total historical activities of the entire Korean Race. In this sence, Je-Wang-Woon-Ki, the Kings is the comprehensive compilation of "folk epic", or perhaps, more properly, of "racial epic", and is characteristic of history poem. The Kings sets in its uttermost beginning Dangoon, as the sole patriarch of the entire Korean race, and clarifies that all the tribal states, which had ever existed in this land covering from northern end to south, are the equal descendants of Dangoon, the Great Patriarch. These tribal states mentioned in the Kings are Shira" (尸羅), "Koye" (高禮), "Ye" (濊), "Mek" (貊), "Buyo" (扶餘) and "Okju" (沃沮). Here, the position of Dangoon far surpasses, in height, that of King Dong-.Myunp. In Sam-Kuk-Sa-Ki (三國史記) (The History of Three-Kingdoms), not a word is mentioned about the racial patriarch. In Sam-Kuk-Yu.-Sa (三國遺事), another old history book, Dangoon is breifly mentioned but his dominion and successors are not intelligibly stated. It is very interesting to find that in the Kings, which was written only ten years later than Sam-Kuk-Yu-Sa, the myth of Dangoon is so surprisingly concrete. The formation of racial consciousness having its base on common Patriarch influenced greatly on the view of history to awaken the various tribes in constant conflict to the sense of homologue. History was no longer regarded by the dynastic unit. A new insight, after the Kings, was given to the view of history that a consistent flow of racial life, regardless of the rises and the falls of dynasties, formed the unending history of the Race. This new consciousness motivated the author of the Kings to begin at the remotest origin of the Race and trace all the way down through to his age, and have a long view towards the future of the race. Thus, the author viewed the complexity of the racial history, the extensiveness of its crosswise comprehension, the remoteness of its lengthwise survey, but he integrated them all in his Kings and reduced them all to Dangoon, the Racial Patriarch. . The Kings, this history poem, is indeed the greatest and the most valuable among all the works including Sam-Kuk-Sa-Ki and Sam-Kuk-Yu-Sa, that have ever been written by the hands of Korean prose writers. The 12th and 13th centuries represented by Yi, Kyu-Bo and Yi, Sung-Hyoo were the golden age of epic poetry in Korea. We regret, however, that this literary trend was not succeeded by their posterity. Epic poem died out with the death of those two poets, which results from the historical reality of Koryo Dynasty. Epic poetry is above all characteristic of collective consciousness rather than individual, for essentially it is a product of collective consciousness. The cosufferings and the co-resistance of the Korean race in the 12th and 13th centuries led the Race to the racial consciousness of common destiny-to the formation of a collective consciousness. Both heroic and history poems were based on this collective consciousness. Unless comes any split in this homologue, collective consciousness can be maintained. However, the historical reality of Koryo was different. The Mongolian invaders were the common enemy of the people of Koryo. Therefore the entire people rose and fought. But the ruling class of Koryo government forsook the people's volition to resist and shamelessly surrendered to the foreign aggressors. The government, even allied with the Mongolian army to destroy its own resisting army and people. By these means, the ruling class once more enjoyed the wealth and power under the grace of the Mongolian Empire; on the other hand, the detressed people suffered under the duplicated tax privations by both Koryo government and Mongolian colonial government. Here, the interests of the government and people were seriously conflicting. A total collapse came in the collective consciousness of the people as a race with common destiny. This tragic collapse, it meant the loss of the base on which was to grow the epic poetry. Thereafter, no epics were ever produced in the literature of Koryo, but its literature took two different flows: the one was Kyong-Ki-Che-Ka (景幾體歌), the literature of the ruling class; and the other, Chang-Ka (長歌) (meaning long ballad), which was the literature of the people. - The End -

임상 검체에서 분리된 nontyphoid Salmonella에서의 integron의 빈도와 특징

이정은,박수진,김성한,김미나,이남용,이복권,이상오,김양수,우준희,최상호 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

Background : Nontyphoid Salmonella (NTS) is a leading cause of human food-borne enteritis, It has been known that integron, a naturally occurring gene capture and expression element, Plays an important role in the development and dissemination of multidrug-resistance. In this study, we investigated the prevalences and molecular characteristics of integrons in NTS clinical strains. Materials and Methods : Between 1995-96 and 2000-03, a total 261 NTS clinical strains comprising 39 serotypes were collected from clinical specimens. All strains were serotyped, and the MICs of ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, tetracycline, and trimethoprim were determined by agar dilution method. Integrons were detected by PCR amplification of integrase genes, and gene cassettes were determined by PCR and sequencing, Conjugation experiments were performed using E. coli J53 as a recipient. The clonal relationship was analyzed by pulsed-field gel electrophoresls (PFGE). Results : Of the 261 strains tested, class 1 integrons were present in 21 strains (8.0%). Class 2 and class 3 integrons were not found. The integron-positive rate was higher in S. Typhimurium (24.2% [8/33]) than in S. Enteritidis (2.0% [3/153]). Overall rates of antimicrobial resistance were higher in integron-positive strains. dhfr12-orfF-aadA2gene cassette was detected in 5 strains, aadA2in 4 strains, dhfr17-orfF-aadA5 in 2 strains, and addA1 in 1 strain. Ten integron-positive transconjugants were successfully selected. Among 8 integron-positive strains of S. Typhimurium, 7 had similar PFGE patterns. Conclusion: This study suggests that integrons are already playing a significant role in antimicrobial resistance in NTS. Continuous monitoring is needed to detect the emergence and spread of integron-mediated antimicrobial resistance.

韓國産 자작나무科의 系統分類學的 硏究(序論)

李相泰,蘇雄永,田寬培,李愚喆 全北大學校 生物學硏究所 1981 生物學硏究年報 Vol.2 No.-

The present paper is an introduction to the whole project of "The systematic studies on Korean Betulaceae". Three studies under the project were performed this year and presented in this report : a review of taxonomic literatures and the construction of distribution maps by Woo-Tchul Lee, pollen morphology by Sang-Tae Lee and Moo-Yeol Kim, and wood anatomy by Woong-Young Soh and Kwan-Bae Jeon.

동종골수이식 후 혈당 및 혈중 지질농도의 변화양상 및 관련인자

이원영,강무일,오은숙,오기원,손현식,윤건호,차봉연,이광우,손호영,강성구,신완식,민우성,김춘주 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.6

연구배경:골수이식은 비교적 젊은 연령의 환자들을 대상으로 하며 면역억제제의 사용기간이 비교적 짧으므로, 주로 고령의 만성 질환 환자에서 시행되는 고형장기이식에서와는 달리 당대사 및 지단백 대사에 있어서 많은 차이점이 있을 것으로 추측된다. 저자들은 전향적 연구를 통하여 골수이식 후 시기별로 혈당 및 혈중지단백 변화 양상을 알아보고 이와 관련된 임상인자들을 규명하고자 하였다. 방법:1998년 10월부터 1999년 8월까지 가톨릭대학교 성모병원에서 동종골수이식을 시행한 환자들 중 43명을 대상으로 이식 전 및 이식 후 1, 2, 3, 4주와 3개월, 6개월에 공복 혈당, 혈중 총 콜레스테롤, 중성지방, 고밀도지단백을 측정하여 골수이식 후 시기별 변화를 관찰하고 여러 임상인자들에 따른 차이를 알아보았다. 결과:1. 공복혈당은 골수이식 수 첫4주 동안 상승하였고 이후 감소하였으나 이식 6개월 시점의 평균 공복혈당은 이식 전보다 유의하게 높게 관찰되었다. 혈중 총 콜레스테롤은 이식 후 1주에 최고치를 형성하였고 이후 기저수준으로 회복되었다가 이식 수 3,6개월에 다시 증가하여 기저치에 비해 유의하게 높았다. 혈중 중성지방은 이식 후 1개월까지 유의하게 증가하였고 이후 감소하여, 3,6개월에는 기저치와 유의한 차이가 관찰되지 않았다. 혈중 고밀도지단백은 이식 후 2,3주에 이식 전보다 유의하게 감소하였고 이후 이식 전 수준으로 회복되었다. 혈중 저밀도지단백은 총 콜레스테롤의 변화와 매우 유사하였다. 2. 골수이식 후 6개월 시점에서 공복 혈당이 126㎎/dL이상인 환자는 7명(16%)이었다. 이들 환자들과 공복혈당 126㎎/dL 미만의 환자 36명을 비교한 결과, 공복혈당이 126㎎/dL 이상인 환자군에서 스테로이드 평균 투여량이 많았고 고밀도지단백이 유의하게 낮았다. 3. 이식편대숙주질환이 발생한 환자는 그렇지 않은 환자보다 이식 후 1, 2, 3주 및 6개월의 총 콜레스테롤이 더 낮았고, 3개월의 공복혈당이 더 높았다. 혈연골수이식 환자군은 비혈연골수이식 환자에 비해 투여된 스테로이드 용량이 더 적음에도 불구하고 이식 후 1, 2, 3주 및 6개월의 총 콜레스테롤 수치가 더 높았다. 스테로이드 고용량 투여군(하루 평균 7.5㎎기준)은 저용량군보다 이식 후 3개월 시점의 공복혈당이 더 높았으나 나머지 시점의 혈당, 혈중 지질농도에 있어서는 유의한 차이가 관찰되지 않았다. 결론:골수이식 후 초기시기에 주로 당 대사 및 지질대사이상이 관찰되며 이는 면역억제제 투여와 관련이 있음을 알 수 있었다. 면역억제제가 고용량 투여되는 합병증 발생 시 이들 대사이상에 관심을 기울여 대처해야 할 것이다. Background: In bone marrow transplantation(BMT), recipients are usually younger and immunosuppressants are open used in shorter period than in solid organ transplantation. Therefore, there might be a difference in glucose and lipid metabolism between BMT and solid organ transplantation. However, the serial changes of metabolic parameters following BMT have not been studied. Therefore, the aim of this study is to investigate the serial changes of blood glucose, lipids and the putative factors that are related with these changes after BMT. Methods: We have prospectively investigated 43 patients who underwent allogeneic BMT. Fasting plasma glucose(FPG), total cholesterol, triglyceride and high-density lipoprotein(HDL) were measured before BMT, and at 1, 2, 3, 4, 12 weeks and 6 months after BMT. The serial changes of these metabolic parameters according to clinical factors including type of BMT, mean daily steroid dosage, and occurrence of graft versus host disease (GVHD) were examined. Results: 1. Mean FPG level increased during 4 weeks after BMT and remained above basal value at post-transplant 6 months. Total Cholesterol level was increased during initial 4 weeks after BMT and was above basal value at post-BMT of 3 and 6 months. Triglyceride level was progressively increased during initial 4 weeks after BMT, but returned to basal value there after. HDL-cholesterol level was significantly decreased during initial 4 weeks after BMT, but returned to basal value there after. 2. Patients with FPG above 126 mg/dL and the other patients, the former received larger amounts of daily steroid and had lower HDL-cholesterol level. 3. The changes of metabolic parameters were different according to type of BMT, steroid dose, and occurrence of GVHD. Conclusion: Although there was increase of FPG, TC, TG and decrease of HDL-C during initial 4 weeks after BMT, these metabolic changes recovered slowly thereafter. Immunosuppressants are thought to be associated with these changes. Further observation will be needed for the long-term effect of BMT on metabolic changes(J Kor Diabetes Asso 24:689~698, 2000).

한국인의 갑상선 질환에서 RET 유전자 발현

이시훈,홍순원,문우철,오명열,이진경,안철우,차봉수,김경래,임승길,이현철 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

연구배경: RET 유전자는 제10번 염색체의 장완에 위치하는 전암유전자로서 갑상선 종양의 발생과 관련해서 두가지의 활성화 기전이 알려져 있는데, 하나는 RET/PTC 유전자 재배열로 갑상선 유두암의 발생과 연관이 있으며, 다른 하나는 점돌연변이로 갑상선 수질암과 연관이 있다. 한편 갑상선 유두암에서 RET의발현증가가 중요하다는 의견도 있으며, 한국인의 경우이에 대한 자료는 드물다. 이에 한국인의 갑상선 유두암을 비롯한 갑상선 질환에서 RET/PTC 유전자 재배열과 RET 유전자의 발현에 대해서 조사하였다. 방법: 병리 소견상 갑상선 유두암으로 진단된 27예, 갑상선 여포암 3예, 미분화암 1예, 선종 5예, 과증식 19예, 정상 소견 2예의 갑상선 조직을 대상으로 하여 RT-PCR 및 염기서열분석법을 이용하여 RET/PTC-1,-2, -3 유전자 재배열과 RET 유전자의 발현도를 조사하였고, 한편 면역조직화학 방법을 이용하여 ret 단백질의 발현을 검색하였다. 결과: RT-PCR분석 결과 갑상선 유두암중60.0%에서 RET 유전자가 검출되었고, 갑상선 여포암에서 100%, 과증식에서는 25.0%에서 RET 유전자가 검출되었으나, 미분화암, 선종, 정상 조직에서는 검출되지 않았다. 갑상선 유두암 2예에서 RET/PTC-1 재배열과RET/PTC-2 재배열이 한차례 관찰되었으나, RET/PTC-3 유전자의 재배열은 전혀 발견되지 않았다. 면역조직화학염색에서는 갑상선 유두암중 73.1%, 선종중 50%, 과증식 중 14.3%에서 RET가 강하게 발현되었으나, 정상 갑상선조직과 갑상선 여포암, 미분화암에서는 발현되지 않았다. RET의 발현 검색에 있어 RT-PCR 방법과 면역조직화학간에는 비교적 높은 일치도를 보였고, 하시모토 갑상선염에 해당하는 조직 14예 중 9예에서 ret 단백질이 강하게 발현되었다. 결론: 한국인의 갑상선 유두암에서는 RET/PTC 재배열은 드문 반면, RET 유전자의 과잉발현이 높은 빈도로 나타난다. RET의 과잉발현은 빈도가 낮긴 하나갑상선 유두암 뿐 아니라 선종과 과증식에서도 나타날 수 있다 이러한 결과는 RET의 과잉발현이 한국인의 갑상선유두암의 발병에 있어 중요한 원인이며, 지표가 될 수도 있음을 시사한다. Background: Activation of the RET proto-oncogene, located on the long arms of chromosome 10, contributes to the development of thyroid cancers in two different ways. Somatic rearrangements of RET with variable genes of activation are frequently found in papillary thyroid carcinomas. And Ggerm-line point mutations are responsible for the development of medullary thyroid carcinoma and the multiple endocrine neoplasia type 2 (MEN2). There are several conflicting reports on the influences of RET expression and RET/TTC rearrangements on the clinical outcome of thyroid cancer. Therefore, we performed an examination of RET expression and RET/TTC-1, -2, -3 rearrangements in papillary thyroid carcinomas and other thyroid diseases. Methods: Twenty-six papillary thyroid carcinomas (PTCs), three follicular thyroid carcinomas (FTCs), one anaplastic thyroid carcinoma (ATC), five follicular adenomas (FAs), nineteen hyper- plasias, and two normal thyroid tissues were included in this study. RT-PCR and immunohistochemistry analysis were done to identify RET gene, RET/TTC rearrangements, and ret RET protein expression. Results: By RT-PCR, 89.4% of PTCs, 100% of F K s , and 62.1% of hyperplasias expressed the RET gene, but no RET was observed in ATCs, FAs, and normal thyroid tissues. RETmC-1, -2, -3 rearrangements were not detected in any specimens. Immunohistochemical results revealed that 76.9% of PTCs, 50% of FAs, 52.3% of hyperplasias, and 20.6% of normal thyroid tissues expressed the RET ret protein, but lTCs and ATCs did not. Most PTCs showed strong cytoplasmic positivity in RET ret immunostaining, but the positive non- PTCs expressed weak and membranous staining. Overall, the two methods for detecting RET gene, RT-PCR and immunohistochemistry showed similar results. Conclusion: The RET gene was highly expressed in PTCs. In contrast to the previous reports of that theRET gene expression of RET gene is being limited to PTCs, RET was also expressed in hyperplasias, Fas, and normal thyroid tissues. However, the pattern and the degree of expression of the RET ret protein in non- PTCs were are different from those in PTCs (J Kor SOC Endocrinol 18: 140-152, 2003).

인터페론 치료에 반응이 없었던 예들을 포함한 만성 B형 간염 환자에서 lamivudine의 단기 치료 효과

이상우,이엄석,김선문,서승원,양현웅,성재규,이승민,이병석,김남재,이헌영 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

The efficacy and safety of lamivudine administration according to the presence or abscence of past history of interferon treatment were studied in 22 patients with chronic active hepatitis B who were diagnosed at ChungNam National Univerity Hospital. Nine of these patiens were no responders to interferon treatment. The change of HBV DNA, serum ALT and HBeAg values was analyzed during 12 weeks of lamivudine treatment. The results were as follow : 1. The mean values of HBV DNA and serum ALT were significantly reduced from 1793 9 to 2.0 pg/ml and from 202.5 to 36.3 IU/L after lamivudine treatment (p<0.001). The mean reduction rates of serum HBV DNA and serum ALT were 99.7% and 70.4%. 2. HBV DNA was undetectable in 18 patierits(81.8%) and serum ALT was normalized in 16 patients(68.2%%) after 12 weeks of lamivudine treatment. But there were temporary elevations of serum ALT value comparing to pretreatment value in 5 patients. 3. HBeAg was undetectable in 4 patients(18.1%) and in these 4 patients, anti-HBe was detected after 12 weeks treatment. 4. There was no significant difference of HBV DNA clearance rate and normalization rate of serum ALT between above and below 200 pg/mI group according to pretreatment HBV DNA values(p=0.74, p=0.08). 5. Each clearance rates of HBV DNA in patients without previous interferon treatment and patients with previous interferon treatment were 84.6% and 77.8%(p=0.68). Each clearance rates of HBeAg in patients without previous interferon treatment and with previous interferon treatment were 15.5% and 22.2%(p=0.683). 6. During the treatment periods, adverse effects of lamivudine were negligible in most patients except temporary leukopenia in one patient. Conclusively, lamivudine treatment over the short term period for patients with chronic active hepatitis B was effective in suppression of viral replication and improvement of abnormal serum ALT. Also the efficacy of lamivudine treatment was out of all relation to previous interferon treatment and adverse effects of this drug were negliable. But further study for the efficacy of long term period-lamivudine treatment and appearance of mutant shoud be necessary.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.