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렙토스피라증에서 출혈성 폐병변의 병인론에 관한 실험적 연구
우준희 대한내과학회 1990 대한내과학회지 Vol.38 No.5
The outbreak among Koprean farmers of acute infectious diseases accompanied by fever, hemoptysis, dyspnea and respiratory failure during the harvest season has been a great concern of the Korean medical community since 1975. In 1985, the causative agent was found to be Leptospira interrogans, but the clinical syndrome of leptospirosis was quite different from that of the typical Weil's disease. In experimentally induced leptospirosis in animals infected with a virulent strain of Leptospira interrogans, widespread hemorrhage of the lung was observed, as well as hemorrhages in the skeletal muscles, diaphragm, retroperitoneal and perirenal adipose tissues and vasculitis, accompanied by inflammatory reactions and coagulation necrosis of the liver, myocardium, and skeletal muscles. Further is needed regarding the pathogenetic mechanism of the pulmonary hemorrhagic lesions in leptospirosis. In guinea pigs inoculated with Leptospira interrogans(HH-4), which was isolated from a patient in Seoul, Korea(October 1987), the platelet counts, fibrinogen concentration, FDP concentration and pathologic changes utilizing light microscope and an electron microscope were studied according to the time elapsed after inoculation. Consequently the platelet counts were showed to have decreased over a period of time. The fibrinogen concentration was the lowest at four hours after infection and recovered and decreased on fifth and seventh days after infection, but no changes of FDP concentrations were found. Alveolar hemorrhages and monouclear cell infiltration with bleb formation in the alveolar capillary endothelium, formations of the villous cytoplasmic process; the moving of erythrocytes into subendothelial space and fibrin in the alveolar space were the main pathologic findings. Howevere, no trace of Leptospira was found. The above results suggest that the toxic substance of Leptospira which injured the alveolar capillary endothelium might play a role in the pathogenetic mechanism for consequent hemorrhages.
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우준희,정두련,류지소 대한의진균학회 1997 대한의진균학회지 Vol.2 No.2
There is an increasing tendency of systemic fungal infection because of increse in the number of immunocompromised patients such as the patients receiving anticancer chemotherapy or organ transplant. The frequency of systemic fungal infection is problematic, since it is often difficult for clinicians to manage the patients with fungal infection. Amphotericin B was one of the representative antifungal agent for the systemic antifungal infection even though it has many kinds of adverse reactions for instance nephrotoxicity, electrolyte imbalance, etc. Therefore ketoconazole, fluconazole, and itraconazole were developed and prescribed with effect. Because of increase in the number of resistant strains of Candida, Fusrium or Trichosporon nowadays, as for azole antifungal agents there were something to be desired. Other new antifungal agents with fungicidal effect under development include ployoxins, echinocandins and pradimicin.
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쯔쯔가무시병에서 Doxycycline 일회요법과 장기 요법의 효과와 독성
우준희,김현태,염윤기 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1
Tsutsugamushi disease(scrup typhus) is an acute febrile infectious disease caused by R.tsutsugamushi transmitted by chiggers, that is larvae of trombiculid mite(Leptotrombidium akamushi and L.delinese). It is characterized by a lesion at the site of the bite of an infected mite, a fever of 2 weeks' duration, and cutaneous rash. Tetracycline, doxycycline and chloramphenicol are all effective in scrub typhus. The drug should be continued for at least 2 days after the patient has become afebrile. We investigated the efficacy of single dose of doxycycline for 21 case of scrub typhus versus long term multiple doses of doxycycline for 28 patients of scrub typhus. There wer no statisitical differences between the two treatment groups in clinical success rate(85.7% in single dose vs 89.3% in longterm group)(p>0.05). There were 2 cases of relapse in both groups. A single dose of 200? of doxycycline is as effective as longterm multiple doses of doxycycline in patients with scrub typhus.
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고이즈미 정권기 일본의 노동연계복지(workfare): 사회적 포섭에서 사회적 배제로의 전환
우준희,이대진 세종연구소 2011 국가전략 Vol.17 No.4
This article critically reviews workfare policy under the Koizumi administration, and evaluates its implications for social policy. Before Koizumi administration, Japan's government had provided work-based social protection in terms of the intervention on the market and protection of job. However, Koizumi administration showed different policy. In Japan, workfare came from Koizumi’s neo-liberal reforms. It intended to provide social protection to losers from labor market, but led to re-commodification of labor forces and shifted the responsibility to firms and local governments. This article argues that labor-market policy with social inclusion was transformed to one with social exclusion under the Koizumi administration, and criticizes existing literature which considered the paths to workfare as a model of welfare state. 본 논문은 고이즈미(小泉) 정권기 일본의 노동연계복지를 비판적으로 검토하고, 이것이 사회정책으로서 가지는 의미를 평가하고 있다. 고이즈미 정권 이전 시기까지 일본정부는 시장에 대한 규제와 개입, 일자리를 보호하고 유지케 하는 정책들을 통해 사회적 보호를 제공해왔다. 그러나 고이즈미 정권 하에서 과거와 구별되는 정책노선 상의 변화가 나타났다. 일본에서 노동연계복지는 고이즈미 정권의 신자유주의적 개혁 노선 하에서 등장하였다. 노동연계복지는 노동시장에서 소외된 계층에게 사회적 보호를 제공하고 자립과 취로를 지원한다는 내용을 담고 있었지만, 노동력의 재상품화와 기업 및 지자체에의 책임이양의 특징이 강하였다. 본 논문은 오랜 기간 사회적 포섭을 가능하게 하였던 일본의 노동시장정책이 고이즈미의 정권 이후에는 사회적 배제를 양산하게 되었음을 주장하고 있다. 본 논문은 다음과 같은 몇 가지 함의를 가진다. 첫째, 이론적인 측면에서 노동연계복지의 경로를 복지국가유형론을 통해 설명해 온 기존 연구들에 비판점을 제공한다. 둘째, 학술적인 측면에서 일본 복지 연구가 가지고 있는 연구 영역의 편협성을 극복하고 연구범위의 확장에 기여할 수 있다. 그간 일본의 복지는 사회지출의 크기나 사회보험제도의 특성 등을 중심으로 연구되어 왔으며, 상대적으로 낮은 실업률과 종신고용 등 고용보호기제의 존재로 인해 노동연계복지에 관한 연구는 거의 수행되지 않았다. 노동연계복지가 복지국가의 위기와 대응과정 속에서 등장하였다는 점에서 노동연계복지를 통해 일본을 분석하는 것은 탈산업화, 세계화 이후 일본복지국가의 역동성을 설명하는데 보다 풍성한 논의를 제공할 수 있을 것이다. 셋째, 민주당 정권으로의 정계개편 이후 활발하게 진행 중인 신자유주의냐 신복지국가냐의 논의에 시사점을 제공한다.
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Thiamphenicol(Urfamycin^(�) 療法의 臨床的 觀察
禹竣熙,沈永秀 대한화학요법학회 1983 대한화학요법학회지 Vol.1 No.1
A clinical trial for therapeutic effect of thiamphenicol was made of 41 cases of medical Eatients which consist of typhoid fever, shigellosis and acute respiratory infection. The results were e d a a t e d by the improvement of clinical symptoms and eradication of causative organism. The result was good in 37 cases (90%). In typhoid fever group, the result was good in 27 cases among 30 cases (90%) wirith mean defeverscence days of 5.27, which was better than other antibiotics, Observed side effect was 1 reversible leukocytopenia. It was tfie conclusion of this observation that the drug is effective in control of acute gastrointestinal infection. and respiratory infection.
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