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본 연구에서는 물류 서비스 수요자들의 상이한 서비스 요구 특성들에 적합한 수배송 및 물류센터 맞춤서비스 결정 방법을 제안하였다. 제안된 방법은 전략, 시장, 물류 환경 측면에서의 서비스 요구 특성 정의, 서비스 요구 특성들과 수배송 및 물류센터 운영 전략들 사이의 적합성 매핑, 수배송 및 물류센터운영 시뮬레이션 평가를 포함한다. 가상의 시나리오를 통해 본 연구에서 제안한 수배송 및 물류센터 맞춤 서비스 결정 방법의 활용에 대해 설명하였다.
Objectives: Vanadate is known to mimic several effect of insulin including the stimulation of glucose uptake and oxidation, glycogen synthesis as well as the anti-lipolytic effect. But mechanisms for these effects of vanadate are still not completely understood. The aim of this study was to elucidate the effects of vanadate on intrinsic activity of the glucose transporter and the regulation of the glucose transporter mRNA. Methods: Using age and weight-matched male Sprague-Dawley rats (average weight 250 g), the experimental groups were divided into nondiabetic rats (n= 6), streptozotocin (STZ)-induced diabetic rats (n=6), metavanadate and pervanadate treated diabetic rats (n =12). We measured weight, blood glucose, glucose transporter activity, and glucose transporter 4 (GLUT4) mRNA change. Results: 1) STZ-induced diabetic rats became catabolic and they lost their weight, but after 3 to 4 weeks of treatment with metavanadate or pervanadate, body weights were increased. Blood glucose levels in metavanadate or pervanadate treated rats were significantly lower than STZ-induced diabetic rats after 1 week treatment. 2) There was no significant toxicity in vanadates treated rats, compared with STZ-induced diabetic rats and there was no abnormal change in kidney and liver of rats under light microscope 8 weeks after vanadates treatment. 3) The glucose transporter activity of diabetic rats was significantly decreased, compared with that of normal control rats, and increased after vanadates treatment. 4) The glucose transporter mRNA of diabetic rats was markedly decreased, compared with that of normal control rats, and increased after vanadates treatment. Conclusion: In STZ-induced diabetic rats, vanadates treatment may improve insulin sensitivity through in- creased expression of GLUT4 gene.
Central diabetes insipidus(DI) is a polyuric disorder characterized by a deficiency of circulating antidiuretic hormone. It may be resulted by any conditions that cause damage to neurohypophyseal system. Idiopathic cases constitute the major group of primary diabetes insipidus but one can postulate that perhaps the lack of reliable methods to investigate hypothalamus is responsible for this fact. Fourty patients with central diabetes insipidus were evaluated clinically, radiological ly and endocrinologically at Yonsei University Severance Hospital during the past 8 years and following results were obtained. 1) The male to female ratio was 1.2:1 and the highest incidence of central diabetes insipidus was in the third and fourth decades. 2) Daily mean urine output was 2~81, urine specific gravity 1.004±0.002, urine osmolarity 190±122mOsm/kg and serum osmolarity 297±41mOsm/kg, 3) The water deprivation test was performed in 22cases, among which 20cases(90.1%) had complete diabetes insipidus and 2cases(9.9%) haartial diabetes insipidus. 4) Of the 8cases who underwent sella coronal CT scan, 5cases(62.5%) had abnormal mass densities on the suprasella area. 5) Among 7 cases with suspicious idiopathic diabetes insipidus, basal serum prolactin levels were elevated in 4cases(57.1%), 6) Causes of central diabetes insipidus were idiopathic in 20cases(50%), surgery of the hypothalamopituitary area in 9 cases(22.5%), neoplastic or infiltrative lesions in 5cases(12.5%), and head injuries in 4cases. In conclusion, in cases with suspected idiopathic diabetes insipidus by conventional diagnostic methods, sella coronal CT scan might be useful to detect underlying minute lesions.