정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

임신부의 인플루엔자 백신 접종률 및 관련요인

김미정,이승연,이광수,김아름,손동욱,정문현,박신구,박지현,이병익,이진수 대한감염학회 2009 감염과 화학요법 Vol.41 No.6

Background : During seasonal influenza epidemics and previous pandemics, pregnant women have been at increased risk for complications related to influenza infection. Although influenza vaccination has been widely recommended to pregnant women and immunocompromised hosts, the vaccination rate is presumed to be low in pregnant women. This study was aimed to evaluate the vaccination rate and factors associated with Influenza vaccination among pregnant women, who are at high risk for developing complications from the influenza. Materials and Methods : This study was carried out by telephone survey from April, 2007 to August, 2007. Women who were in their second trimester of pregnancy or above,- during October, 2006 and February, 2007, the recommended vaccination period, and had given birth at Inha University Hospital were selected as the study population. Immunization status, general understanding, and factors associated with vaccination were evaluated. Results : Among a total of 506 eligible pregnant women, 227 (44.8%) responded to the questionnaires. The influenza vaccination rate among the pregnant women was only 4% (9/227). Major reasons for not receiving vaccination were first, not awaring the necessity of immunization during pregnancy (48.5%, 110/227) and second, misunderstanding that it is prohibited during pregnancy (36.1%, 82/227). The major factors that influenced the compliance of vaccination were correct understanding and doctor's recommendation on the influenza immunization during pregnancy. Conclusions : The influenza vaccine coverage on pregnant women was very low and the awareness of influenza vaccination during pregnancy in general was inaccurate. Shift in perception is required and this can be achieved by educating the pregnant women on the safety and efficacy of vaccination. In addition, doctors' active encouragement to vaccination is highly recommended.

척수로 전이된 후두엽 다형성 교아세포종 : 증례보고 A Case Report

윤상민,송재욱,이창훈,조경자,김종현,이승훈 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.3

The tendency of glioblastoma to metastasize to the cerebrospinal fluid(CSF) is well documented, reaching approximately 20% in autopsy series. Nevertheless, clinical symptoms from spinal seeding seem to be infrequent or are at least rarely diagnosed. The authors report a case of 41-year old female patient with a cerebral glioblastoma multiform who developed paraplegia due to a pathologically confirmed spinal matastasis.

법랑질 형성 부전증에 대한 증례보고

이승영,백병주,이지연 大韓小兒齒科學會 1994 大韓小兒齒科學會誌 Vol.21 No.1

Amelogenesis imperfecta(AI) is defined as a genetically determined effect affecting enaml formation and may be associated with other ectodermal or systemic disorders. It is entriely an ectodermal disturbance, since the mesodermal components of the teeth are basically normal. The presentation of diverse clinical manifestations in thought to result from the heterogeneous structural and chemical defects. The anomaly occurs in the general population in the range of 1 n 14,000 to 16,000, to 1.4 in 1000, depending on the specific population studied. Classification of the AI types considers mode of inheritance and clinical manifestations. The most widely accepted classifi-cation system recognizes three major groups ; i.e., hypoplastic(thin enamel), hypocalcified (primary mineralization defect), hypomaturation(defect in enamel maturation). Delineationg speific AL types can be confusing given the phenotypical similarity of many forms and that the most recent classification lists 14 different AI types. A 8-years-old female patient with complaint of abnoraml crown shape and discoloration of maxillary anterior tooth and excessice wear of posterior dentition of both arch.came to Dept.of pedodontics, College of Dentistry, Chonbut National University for rahabilitation. The treatment depends on its severity and the demands of esthetic improvement. In this case, resin veneer crown of maxillary anteiror tooth and composite resin restoration of mandibular anterior tooth showed good esthetic result. Restoration of Mx. and Mn. 1st first molar with stainless steel crown rehabilitated the masticatory function and estabilished the vertical dimension of occlusion. But futher care is needed for estabilishment of final vertical dimension of occlusion after completion of permanent dentition.

모빅 캡슐(멜록시캄 7.5㎎)에 대한 멜락스 캡슐의 생물학적동등성

이예리,염승복,고연정,고정길,김호현,이희주,이경률 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5

A bioequivalence of Melax capsules (Chong Kun Dang Pharm., Korea) and Mobic™ capsules (Boehringer Ingelheim Korea) was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). Single 15 mg dose of meloxicam of each medicine was administered orally to 24 healthy male volunteers. This study was performed in a 2 x 2 crossover design. Concentrations of meloxicam in human plasma were monitored by a high-performance liquid chromatography. AUC, (the area under the plasma concentration-time curve from time zero to 72 hr) was calculated by the linear trapezoidal rule method. C_(max) (maximum plasma drug concentration) and T_(max) (time to reach Cma,.) were compiled from the plasma concentration-time data. Analysis of variance was performed using logarithmically transformed AUC, and C_(max). No significant sequence effect was found for all of the bioavailability parameters. The 90% confidence intervals of the AUCt ratio and the C_(max) ratio for Melax™/Mobic™ were 0.95 - 1.04 and 0.98 - 1.14, respectively. This study demonstrated a bioequivalence of Melax™ and Mobic™ with respect to the rate and extent of absorption.

정신분열병 환자와 직계 가족의 마음이론 능력 결함

이정임,이승환,김승연,배성만 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.2

Objectives Theory of mind (ToM) is the ability to conceptualize other people's mental states in order to explain their behavior. This study compared the ToM ability of schizophrenia patients, their first-degree biological relatives, and healthy controls. Methods ToM animation test was administered to schizophrenia patients (N=28), their healthy first-degree relatives (N=26), and healthy controls (N=28). The Korean version of schizotypal personality questionnaire (SPQ) was used to assess the schizotypal personality trait of all three groups. Results Schizophrenia patients and their first-degree relatives showed decreased accuracy on ToM animation test compared to healthy controls [F(2,78)=29.75, p<.001]. Additionally, first-degree relatives performed worse than the control group and better than schizophrenia patients. First-de-gree relatives had similar SPQ scores compared to healthy controls but showed decreased ToM accuracy compared to healthy controls. Conclusion ToM deficits in schizophrenia patients are apparent. The ToM deficit in first-degree relatives of schizophrenia patients raises the possibility that ToM deficit may be a endophenotype for schizophrenia pathology.

단 1차형 영구자석 선형 동기전동기의 디텐트력 저감 연구

연승환,이종진,함승진,고창섭 충북대학교 컴퓨터정보통신 연구소 2006 컴퓨터정보통신연구 Vol.14 No.1

최근 영구자석 선형 동기 전동기 (PMSLM)는 이송 장치로써 많은 분야에 사용되고 있다. 영구자석 선형 동기 전동기는 구조적으로 간단하며 고속화 고추력화 등의 많은 장점을 가지고 있다. 그러나 단 1차형 영구자석 선형 동기 전동기는 매우 큰 디텐트력을 지니고 있어 추력 맥동의 원인이 되며, 이는 소음과 진동을 발생시킨다. 단 1차형 영구자석 선형 동기 전동기의 디텐트력은 전기자 내부의 치와 영구자석 사이에 작용하는 힘과 전기자 양 단부와 영구자석 사이에서 작용하는 힘의 합으로 표현된다. 본 논문에서는 코깅력을 줄이기 위한 방법으로 영구자석의 극 수와 전기자의 슬롯 수의 비를 변경한 새로운 구조의 단 1차형 영구자석 선형 동기 전동기(PMLSM)을 제안하였고, 단부력을 줄이기 위하여 전기자 양 단부에 전기자 길이 조정법과 챔퍼링 법을 사용하였다. Recently Permanent Magnet Linear Synchronous Motors(PMLSMs) are widely being used for many linear transportation applications. The PMLSMs have many advantages such as simple structure, high speed and thrust force. However, especially in short primary type PMLSM, the PMLSMs have very large detent force, which makes the thrust force ripple and undesired vibration and noise. The detent force in PMLSMs is composed of two forces. The first is the cogging force which comes from the interaction between the permanent magnets and interior teeth of the stator, and the second is the end effect force which acts on the exterior teeth of the stator by the permanent magnets. This paper presents a new configuration of a short primary type PMLSM for cogging force reduction by changing the ratio of the numbers of winding slots and permanent magnet poles. The end effect force is also minimized by optimizing the stator length and chamfering the shape of the exterior teeth of the stator.

구내 표준 방사선사진을 이용한 구내방사선촬영기의 선질 평가

이상섭,권혁락,심우현,오승현,이지연,전국진,김기덕,박창서 대한구강악안면방사선학회 2000 Imaging Science in Dentistry Vol.30 No.3

Purpose : This study was to evaluate the beam quality of intraoral X-ray equipments used at Yonsei University Dental Hospital (YUDH) using the half value layer (HVL) and the characteristic curve of intraoral standard X-ray film. Materials and Methods : The study was done using the intraoral X-ray equipments used at each clinical department at YUDH. Aluminum filter was used to determine the HVL. Intraoral standard film was used to get the characteristic curve of each intraoral X-ray equipment. Results : Most of the HVLs of intraoral X-ray equipments were higher than the least recommended thickness, but the REX 601 model used at the operative dentistry department and the X-707 model used at the pediatric dentistry department had HVLs lower than the recommended thickness. The slopes of the characteristic curves of films taken using the PANPAS 601 model and REX 601 model at operative dentistry department, the X-705 model of prosthodontic dentistry department, and the REX601 model at the student clinic were relatively low. Conclusion : HVL and the characteristic curve of X-ray film can be used to evaluate the beam quality of intraoral X-ray equipment. In order to get the best X-ray films with the least radiation exposure to patients and best diagnostic information in clinical dentistry, X-ray equipment should be managed in the planned and organized fashion. (Korean J Oral Maxillofac Radiol 2000; 30: 183-188)

골수강과 관절면을 침범한 족무지 건막 거대 세포종 : 증례보고

이호승,성노현,이신노,허윤무 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.2

16세 남자 환자가 우측 족무지 동통과 종창을 주소로 내원하였다. 방사선 사진상 제1 족지 근위지골 골간에 낭포성 병변이 관찰되어 낭포성 골종양 의심하에 소파술 및 골이식술 시행하였다. 수술 소견상 단 족무지 굴근에서 기원한 연한 쵸콜렛 색깔의 소엽성 연부종양이 제1 족지 근위지골 피질골을 침식하여 골수강을 통해 관절면을 천공해 있었고, 조직 소견상 건막 거대 세포종에 일치하는 소견이 관찰되었다. 저자들은 제1 족지 근위지골을 침식하여 원위 관절면을 천공한 공격적 양태를 보이는, 족무지 굴근에서 기원한 건막 거대 세포종을 치험하였기에 문헌 고찰과 함께 보고하고자 한다. A 16-year-old man admitted with painful swelling of right big toe. plain radiographic examination demonstrated a cystic bony lesion at the metaphysis of proximal phalangeal bone toe. On operative findings, The medullary cavity was filled with multilobulated soft tissue mass and distal articular surface of the proximal phalangeal bone perforated by mass invasion. The mass was orginated from the sheath of the flexor hallucis brevis tendon. After curettage the mass, cancellous bone graft was done. Histologically, it was compatible with giant cell tumor of tendon sheath. We report a case of giant cell tumor of tendon sheath that invaded medullary cavity and articular surface of phalangeal bone

중등학교 체육수업 운영실태와 문제점 및 미래의 과제

이광재,김윤래,김승재,황향희,김수남 江原大學校附設 體育科學硏究所 1996 江原大學校附設體育科學硏究所論文集 Vol.- No.20

The purpose of this study was to offer the basic materials on the secondary physiscl education. The subjects were 129 physiscl education teachers at K provience. The results were as follows: In teaching learning methods, the more educated experience teacher had the more improvement feeled. In the degree of difficulty of current physiscl curriculum, the more educated experience teacher had, the higher it was to be thought. In the goal achievement, the more educated experience had, the more it affected the goal achievement. The efficiency and ability of methods was not shown a significant difference among educated experience group, but shouled be consider it. The equipment and implement of goal achievement was not show a significant difference among educated experience group, but should be consider it. The evaluation of propriety and objectivity and on psychomotor, affective, and cognitive domain was not shown a significant difference.