서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

휴대폰 카메라용 자동초점 구동기의 충격해석

이성민,김봉석,송준호,이수훈,이혜진,이문구,송준엽,이창우 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

Recently, the robustness against daily impact is important according to portablization and downsizing of mobile electronics. Especially, almost parts of cellular phone should undergo drop test when they fall 1.5 m above ground. This test simulates the case when cellular phone slips through user's fingers while he is talking on the phone. This paper studies a drop test of auto focusing (AF) actuator for camera module in cellular phone. This component is composed of voice coil motor (VCM) as an actuator and leaf spring as a guide and suspension. The leaf spring's deformation is essential for the test because its permanent distortion disables the focusing, and then, a high quality photograph cannot be obtained. Up to now the drop test has been carried out after fabricating real AF actuator. We propose a dropt test model which simulates the drop test based on finite element analysis. This model makes us enable investigate the stress acting on the clamping and curved parts of leaf spring. Stress over Von Mises criterion lets the spring deformed permanently, and then AF actuator malfunctioned, It helps us to design and modify AF actuator without manufacturing the real product. And also, it saves the time and cost for the development of new products.

한국인 제2형 당뇨병 환자의 골격근에서 인슐린 신호전달체계의 결함

최준혁,이관우,김효정,이동훈,이종우,김정은,엄현채,김경미,최성이,정윤석,김현만 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.5

연구배경: 제2형 당뇨병에서 나타나는 인슐린 저항성은 간, 지방, 근육 같은 말초조직에서 인슐린의 작용이 떨어지는 것을 말한다. 제2형 당뇨병의 발생기전에 인슐린 저항성과 인슐린 분비능 저하가 같이 관여함은 잘 알려진 사실이다. 인슐린의 세포내에서의 저항성을 규명하기 위한 인슐린의 세포내 신호전달체계에 대한 연구가 활발히 진행되고 있으며 몇몇 연구에서 인슐린 저항성을 가진 골격근육에서 IRS와 관련된 PI3-kinase의 활성감소와 Akt kinase의 활성감소를 보고하고 있으나 아직까지 명확하게 그 기작이 설명되어지지 않고 있다. 본 연구에서는 정상성인, 제2형 당뇨병 환자를 대상으로 경구당부하검사 및 인슐린 클램프검사를 시행하고 인슐린 클램프 검사시 대상인의 근육을 채취하여 인슐린 신호전달 체계(IR-β, IRS, Akt(PKB, Rac) kinase, GSK-3)를 연구하였다. 방법: 연구대상자는 한국인으로서 경구당부하검사상 정상인 및 당뇨병 환자 각각 11명, 9명을 대상으로 하였으며, 정상인은 건강인으로 과거력상 당대사에 영향을 줄 질환이 없고, 현재 당대사에 영향을 줄 약물 복용 및 다른 소견이 없는 경구당부하검사상 정성 내당능을 보이는 대상자로 하였다. 당뇨병환자는 모두 제2형 당뇨병 환자로 이환기간이 만 5년 이내인 경우로 하고, 인슐린으로 치료하는 대상자는 제외하도록 하였다. 대상자의 연령, 체질량지수, 체지방량, 공복시 총콜레스테롤, 중성지방, 고밀도지단백 콜레스테롤 및 HbA1c, 인슐린, C-peptide를 측정하였고, "HOMA model"을 이용하여 베타세포의 기능와 인슐린저항성 정도를 평가하였다. 정상혈당클램프 검사(euhlycemic hyperinsulinemic clamp test)를 시행하고 인슐린 투입 전과 인슐린 투입 30분후, 두차례에 걸쳐 대퇴부 근육생검을 실시한후 western 법으로 IR-β, IRS, Akt kinase, GSK-3의 인산화량을 측정하였다. 결과: 정상인 11명과 당뇨병 환자 9명을 대상으로 하였으며 대상자의 평균 연령, 평균 체질량지수, 체지방량, 허리/엉덩이 둘레의 비(waist hip ratio; WHR)는 두 군간에 차이가 없었다. 평균 공복혈당은 정상군 98.0±0.3㎎/dL, 당뇨병군 208.1±16.5㎎/dL(p<0.05), HbA1c는 정상군 5.4±0.5%, 당뇨병군 9.2±0.6%(p<0.05)였다. "HOMA model"을 이용한 베타세포의 기능과 인슐린저항성은 정상군 56.4±8.5%, 1.4±0.2, 당뇨병군 72.2±52.3%(p<0.01), 10.2±6.3(p<0.01)였으며 정상혈당클램프 검사상 포도당 이용률은 정상군 8.2±0.6㎎/㎏/min, 당뇨병군 3.7±1.1㎎/㎏/min(p<0.01)로 정상군과 당뇨병군간에 유의한 차이를 나타내었다. Western blot법으로 IR-β, IRS, Akt kinase, GSK-3의 인산화량을 인슐린 투입전과 인슐린 투입 30분후 측정하였을 때 IR-β에서는 정상군이 103.9±2.3에서 241.3±18.6, 당뇨군이 108.9±2.2에서 198.7±6.3으로 증가하였다(p=NS). 이는 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 통계적인 차이가 없었다. IRS에서는 정상군이 111.6±7.3에서 295.6±17.2, 당뇨군이 114.5±6.1에서 222.0±23.2로 증가하였으며(p<0.05), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 24% 감소하였다. Akt kinase에서는 103.4±6.0에서 416.8±29.5로 증가하였으며(p<0.01), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 43% 감소하였다. GSK-3에서는 정상군이 107.7±6.7에서 595.7±28.1, 당뇨군이 104.3±4.8에서 443.3±12.9로 증가하였으며(p<0.01), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 25% 감소하였다. 결론: 제2형 당뇨병 환자에서 정상인과 비교하여 인슐린 자극후 IR-β는 인산화량의 증가정도가 큰 차이가 없었으나, IRS, Akt kinase, GSK-3에서는 인산화량의 증가 정도가 감소되는 것으로 보아 상위 인슐린 신호전단체계부터 결함이 있는 것으로 생각된다. Background: The glucose uptake rate is the limiting step in glucose utilization and storage. The failure of insulin to stimulate glucose uptake in muscle appears to be a primary defect of insulin resistance. This study was undertaken to examine the effect of physiological hyperinsulinemia on the phosphorylation of the insulin receptor (IR-β), insulin receptor substrate (IRS), Akt kinase and GSK-3 in isolated skeletal muscle, in people with type 2 diabetes(n=9) and control subjects(n=11). Methods: 75g OGTT and euglycemic hyperinsulinemic clamp test were done. And vastus lateralis muscle was obtained before and 30 min into the euglycemic clamp. Western blots were performed for tyrosine phosphroylation of insulin receptor substrate (IRS) and phosphorylation of the insulin receptor(IR-β), Akt and GSK-3. Result: There were no statistical differences in the mean age, BMI and body fat between the control subjects and diabetic patients. The fasting blood sugar and HbA_1c in controls and diabetic patients were 98.0±0.3 and 208.1±16.5ng/dl, and 5.4±0.5 and 9.2±0.6%, and 1.4±0.2 in the control subjects, and 72.2±52.3%(p<0.01) and 10.2±6.3(p<0.01) in the diabetic patients, respectively. The insulin resistance from the euglycemic hyperinsulinemic clamp test were 8.2±0.6㎎/㎏/min and 3.7±1.1ng/㎏/min in the control subjects and in the diabetic patients, respectively(p<0.01). Compared with the normal controls, insulin-stimulated IR phosphorylation was no different to that in the diabetic patients. However, insulin-stimulated IRS phosphorylation, insulin-stimulated Akt phosphorylation and insulin-stimulated GSK-3 phosphorylation were reduced in the diabetic patients compared with the normal controls by 24, 43 and 25%, respectively(p<0.05). Conclusion: In Korean type 2 diabetic patients, the insulin resistance may be due to the impairment of the upstream insulin signal molecular network. Further studies will focus on determining whether these signaling defects are the cause of the development of insulin resistance, or secondary to the altered metabolic state, associated with type 2 diabetes mellitus (J Kor Soc Endocrinol 17:685∼697, 2002).

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

Wavelet을 이용한 정상 시계열 데이터 해석에 관한 연구

이오걸,이준탁,김태우 동의공업대학 1999 論文集 Vol.25 No.1

Wavelet analysis is applying to many fields such as the time-frequency localization of a time series and a time varying data. In this paper, a statistical testing based Wavelet power spectrum analysis for the stationary Nino3 Sea Surface Temperature(S.S.T) data was executed. Specially, the 95% confidence level for S.S.T was effective in searching the periods of El-Nino using various wavelet basis functions.

유류오염 토양에 대한 복원기술의 적용과 선정 방법

이우범,이원준,권경오,박종천 國立 麗水大學校 환경문제硏究所 2001 環境硏究論文集 Vol.4 No.-

This paper has attempted to provide the latest design approaches, their application site characterization and selecting alternatives for the remediation action of oil contaminated soil. The classification of hazardous materials, the fate of hazardous contaminants in soil and the conventional prediction model and assesment tools were introduced. From the investigation of the trends of soil remediation technology in USA, the classification of organic compounds for the treatability evaluation. the assesment techniques of teratability of contaminants and the estimatcd cost of remediation technology, the fundamentals that support to select the alternatives for the oil contaminated soil in petrochemical complex were suggest.

동태적 패널 모형을 이용한 한국 상장기업의 자본구조 결정요인 : Evidence from Panel Data

이소영,남준우 서강대학교 경제학연구원 2005 시장경제연구 Vol.34 No.1

This paper analyzes the determinants of capital structure for a panel of 314 Korean companies listed in the Korea stock exchange from 1994 to 2003. This study also develops a target adjustment process, which is a trade-off between the adjustment costs towards a target ratio and the cost of being in disequilibrium. In this framework, the GMM estimation procedure is used to estimate this dynamic panel model consistently. It is found that the non-debt tax shield is positively related to debt ratio, while profitability and liquidity are negatively associated with debt ratio. The sign of these relations suggest that the pecking order theory is at work in explaining the capital structure of Korea companies. This paper also shows that Korean firms adjust toward a target debt ratio, but the adjustment process is much slower than in other countries. This study also empirically analyze whether financial crisis in 1997 affect the determinants of capital structure. The result confirms that the adjustment process toward a target has become slower since financial crisis. The negative signs of profitability and liquidity and the positive sign of growth opportunity after financial crisis provide strong evidence on the pecking order theory.

다층 양막이식술로 치유된 각막천공 1 례

이우진,조문식,김준순 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Purpose : We report a case of corneal perforation and descemetocele which was treared with multilayer amniotic membrane transplantation. Patient and Methods : A male patient was referred to the Department of Ophthalmology, Soonchunhyang University Cheonan Hospital for the management of corneal perforation from long-standing persistent epithelial defect and stromal lysis. Three to four layers of cryopreserved amniotic membrane were applied to the perforation site and anchored with interrupted 10-0 nylon sutures for the purpose of restoring the integrity of the eye and regaining corneal thickness. Postoperatively, the patient was treated with topical antibiotics, corticosteroids and autologous serum eyedrops. Result : Multilayer amniotic membrane transplantation was successful in sealing the corneal perforation. The cornea remained stable with no further leakage of the aqueous postoperatively and no signs of infection and rejection were noted. Also, restoration of the corneal thickness was observed to a considerable amount. Conclusion : Multiplayer amniotic membrane transplantation allowed a successful repair of corneal perforation and seems to be an excellent alternative to tissue adhesive, patch graft, conjunctival flap, or even panetrating keratoplasty for treating corneal perforations.

레이저 초음파와 Wavelet변환을 이용한 재료표면균열 평가

이민래,최상우,이준현 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.2

비파괴 평가 기술들 중의 하나인 레이저 초음파 응용 기술은 각종 구조물에 존재하는 표면결함에 의한 신호를 통해 건전성을 평가하는 기법이다. 따라서 결함의 신뢰성 높은 정량적 평가를 위해서는 결함으로부터의 레이저 초음파 신호특성에 대한 기본적 이해가 필수적이며 따라서 이를 위한 신호해석 연구가 요구된다. 본 연구에서는 레이저 유도 초음파에 의한 one-sided 기법을 이용하여 표면균열을 평가하고자 하였다. 하지만 레이저를 이용한 평가방법들은 수신된 신호의 해석이 까다로우며 또한 상당한 전문적인 지식이 요구된다. 웨이블렛 변환(wavelet transform, WT) 기법은 신호처리 분야에서 하나의 새로운 방법으로서 다양한 분야에 적용되고 있으며 특히 한 시점에 대한 주파수 분해가 가능한 신호처리 방법으로서 시간-주파수 분석에 아주 유용하게 이용되고 있다. 본 연구에서는 이러한 레이저 유도 초음파를 이용하여 재료의 표면 결함신호들에 대한 웨이블렛 변환기법을 적용하여 보다 정량적인 결함 크기를 예측하고 그 타당성을 평가하고자 하였다. Laser-generated ultrasonic technique which is one of the reliable nondestructive evaluation techniques has been applied to evaluate the integrity of structures by analyzing the characteristics of signal obtained from surface crack. Therefore, the signal analysis of the laser-generated ultrasonics is absolutely necessary for the accurate and quantitative estimation of the surface defects. In this study, one-sided measurement by laser-generated ultrasonic has been applied to evaluate the depth of the surface-breaking crack in the materials. However, since the ultrasonic waveform excited by pulse laser is very difficult to distinguish the defect signals, it is necessary to consider the signal analyses of the transient waveform. Wavelet Transform(WT) is a powerful tool for processing transient signals with temporally varying spectra that helps to resolve high and low frequency transient components effectively. In this paper, the analyses of the surface-breaking crack of the ultrasonic signal excited by pulse laser are presented by employing the WT analyses.