김정은 감독 단편선

김정은,최성규 한국독립영화협회 2019 한국독립영화협회 기타간행물 Vol.- No.-

광나무 열매 발효 추출물의 항염 및 항산화 활성

김정은,김소희,김미애,고미선,신찬성,이남호 사단법인 대한화장품학회 2023 대한화장품학회지 Vol.49 No.2

In this study, the anti-inflammatory and anti-oxidative activities were compared for the extracts of non-fermented Ligustrum japonicum fruits (LJF) and fermented counterparts. U se of Latilactobacillus curvatus (L. curvatus) and Weissella minor (W. minor), isolated from the Jeju Chromis notata, as fermented strains led to the extracts of LJF-LC and LJF-WM in this experiment. The yield of each fermented extract (LJF-LC and LJF-WM) was 40.5 ~ 46.0%, higher than 29.5% of non-fermented extract (LJF). As a result of an activity experiment using RAW 264.7 macrophages stimulated by lipopolysaccaride (LPS), it was confirmed that LJF-WM, a fermented extract, has an excellent effect of inhibiting NO production in a concentration-dependent manner without cytotoxicity. Upon the screening of DPPH and ABTS+ radical scavenging activities, the fermented LJF-LC and LJF-WM showed comparable to the non-fermented LJF. In the study of cell protection effect using HaCaT keratinocytes damaged by hydrogen peroxide (H2O2), the fermented LJF-WM indicated protective effect against oxidative stress. In addition, quantitative analysis of a major constituent salidroside by HPLC indicated about 15.6 mg/g for the LJF-LC and 13.9 mg/g for the LJF-WM, which were higher than that of non-fermented LJF (12.0 mg/g). Based on these results, it was suggested that the fermented extract from L. japonicum fruits could be used as a natural cosmetics material with anti-inflammatory and anti-oxidative effects. 본 연구에서는 광나무(Ligustrum japonicum) 열매 발효 추출물의 항염 및 항산화 효능을 비발효 추출물과비교 분석하였다. 광나무 열매의 발효는 제주 자리돔(Chromis notata) 내장에서 분리한 Latilactobacillus curvatus (L. curvatus) 및 Weisella minor (W. minor) 균주를 이용하였으며, 각각의 발효 추출물(LJF-LC 및 LJF-WM)의 수율은 40.5 ~ 46.0%로 비발효 추출물(LJF)의 29.5% 보다 높게 나타났다. Lipopolysaccaride (LPS)로 자극된 RAW 264.7 대식세포를 이용한 nitric oxide (NO) 생성 억제 활성 실험 결과, 발효 추출물인LJF-WM이 세포 독성 없이 농도 의존적으로 NO의 생성을 저해시키는 효과가 우수함을 확인하였다. 또한 DPPH 및 ABTS+ 라디칼 소거 활성 실험 결과, 발효 추출물의 라디칼 소거 활성이 비발효 추출물과 유사하게 나타났으며, 발효 추출물 LJF-WM은 과산화수소(H2O2)로 유도된 세포 손상에 대한 세포보호 효과를 보였다. 광나무 열매의주성분인 salidroside의 함량을 HPLC를 이용하여 분석한 결과, 발효 추출물 LJF-LC에서 15.6 mg/g, LJF-WM 에서 13.9 mg/g으로 확인되어 비발효 추출물(12.0 mg/g) 보다 함유량이 높게 분석되었다. 이상의 연구 결과를바탕으로 광나무 열매 발효 추출물은 항염 및 항산화 효과를 갖는 천연 화장품 소재로써 활용 가능할 것이라사료된다.

IgE Sensitization to Cephalosporins in Health Care Workers

김정은,김승현,Hyun-Jung Jin,Eui-Kyung Hwang,김주희,예영민,박해심 대한천식알레르기학회 2012 Allergy, Asthma & Immunology Research Vol.4 No.2

Purpose: Cephalosporins can induce occupational allergies, such as asthma, urticaria, and anaphylaxis. We investigated the prevalence and risk factors of sensitization to cephalosporin. Methods: A total of 161 health care workers (HCW), including 138 nurses and 23 pharmacists, and 86unexposed non-atopic healthy controls were recruited from a single tertiary hospital and the general population. A questionnaire regarding work-related symptoms was administered along with skin prick tests (SPT) to the three most commonly used cephalosporins (cefotiam, ceftriaxone, and ceftizoxime). Serum specific IgE antibodies to conjugates of the three cephalosporins and human serum albumin (HSA) were measured by enzymelinked immunosorbent assay (ELISA). Binding specificities were confirmed by ELISA inhibition tests. Results: The prevalence of work-related symptoms in association with cephalosporins was 17.4%. The sensitization rate to any cephalosporin was 3.1% by SPT. Sensitization rates determined by measurement of serum specific IgE antibodies were 17.4% for any cephalosporin, 10.4% for cefotiam, 6.8% for ceftriaxone, and 3.7% for ceftizoxime. A personal history of any antibiotic allergy was a risk factor for work-related symptoms (OR, 24.93; 95% CI, 2.61-238), but not for the presence of serum specific IgE antibodies to cephalosporins (OR, 0.9; 95% CI, 0.18-4.53). A personal history of atopic dermatitis was a risk factor for the presence of serum specific IgE antibodies to cefotiam-HSA conjugate (OR, 6.30; 95% CI, 1.23-32.3). Conclusions: A high cephalosporin sensitization rate (17.4%) was detected by ELISA in HCW exposed to cephalosporins. Monitoring of serum specific IgEs to cephalosporin-HSA conjugates will be useful for detecting sensitized subjects.

온라인 무용 수업에 있어 학습자들의 비언어적, 언어적 커뮤니케이션 방식에 따른 유형별 특성에 관한 연구

김정은 한국무용학회 2020 한국무용학회지 Vol.20 No.3

본 연구의 목적은 온라인 무용교육에 있어 커뮤니케이션 특성을 비언어적, 언어적 차원에서 탐색해 보고자 시도 되었으며 탐색적 분석인 구조주의적 기호분석이 적용되었다. 연구결과는 다음과 같다. 첫째, 비언어적 소통유형 은 외모, 모바일 이모티콘, 음성, 공간 커뮤니케이션으로 제시되었으며 직접적인 신체접촉 없이도 생체화된 환경 을 구축하고 있었다. 둘째, 언어적 소통방법에서 온라인 커뮤니티를 통한 커뮤니케이션의 경우 독립적인 소통과 상호의존적인 언어소통으로 구분해 볼 수 있었다. 셋째, 온라인과 오프라인에서 논할 수 있는 커뮤니케이션의 구조적 차이는 헌신적 소통과 효율성으로 구분해 그 차이가 논의되었다. 향후 온라인 소통에 관한 더 많이 연구 들이 지속되길 바라며 본 연구가 온라인 커뮤니케이션에 관한 이론적 자료로 축적되길 기대해 본다. The purpose of this study was to explore communication characteristics on a nonverbal and verbal level in online dance education, and structuralism symbol analysis, an exploratory analysis, was applied. The results of the study are as follows. First, nonverbal communication types were presented as appearance, mobile emoticons, voice and spatial communication, and they were building a biomaterialized environment even without direct physical contact. Second, in terms of verbal communication methods, communication through online communities could be divided into independent and interdependent verbal communication. Third, the structural differences in communication that can be discussed online and offline were divided into dedicated communication and efficiency, and the differences were discussed. We hope more studies on online communication will continue in the future and hope that this study will accumulate as theoretical data on online communication.

서평 : 환자안전 : 새로운 의료표준

김정은,김석화,안경애,강민아 한국의료QA학회 2005 한국의료질향상학회지 Vol.12 No.2

환자 안전 향상을 위한 병원정보시스템

김정은 서울대학교 간호과학연구소 2005 금요학술세미나 Vol.2004 No.-

Reliability and Validity of the Short Form of the Literacy-Independent Cognitive Assessment in the Elderly

김정은,정지향,한설희,류위진,이준영,유승호,이동우,심용수,최성혜 대한신경과학회 2013 Journal of Clinical Neurology Vol.9 No.2

Background and Purpose The Literacy-Independent Cognitive Assessment (LICA) has been developed for a diagnosis of dementia and is a useful neuropsychological test battery for illiterate populations as well as literate populations. The objective of this study was to develop the short form of the LICA (S-LICA) and to evaluate the reliability and validity of the S-LICA. Methods The subtests of the S-LICA were selected based on the factor analysis and validation study results of the LICA. Patients with dementia (n=101) and normal elderly controls (n=185)participated in this study. Results Cronbach’s coefficient alpha of the S-LICA was 0.92 for illiterate subjects and 0.94for literate subjects, and the item-total correlation ranged from 0.63 to 0.81 (p<0.01).The test-retest reliability of the S-LICA total score was high (r=0.94, p<0.001), and the subtests had high test-retest reliabilities (r=0.68-0.87, p<0.01). The correlation between the K-MMSE and S-LICA total scores were substantial in both the illiterate subjects (r=0.837, p<0.001) and the literate subjects(r=0.802, p<0.001). The correlation between the S-LICA and LICA was very high (r=0.989, p<0.001). The area under the curve of the receiver operating characteristic was 0.999for the literate subjects and 0.985 for the illiterate subjects. The sensitivity and specificity of the S-LICA for a diagnosis of dementia were 97% and 96% at the cutoff point of 72 for the literate subjects, and 96% and 93% at the cutoff point of 68 for the illiterate subjects, respectively. Conclusions Our results indicate that the S-LICA is a reliable and valid instrument for quick evaluation of patients with dementia in both illiterate and literate elderly populations.

Consensus Guidelines for the Treatment of Atopic Dermatitis in Korea (Part I): General Management and Topical Treatment

김정은,김현정,유박린,이경호,홍승필,장용현,박귀영,서성준,배정민,최응호,서기범,이승철,고현창,박영립,손상욱,서영준,이양원,조상현,박천욱,노주영 대한피부과학회 2015 Annals of Dermatology Vol.27 No.5

Background: Since the treatment guidelines for atopic dermatitis (AD) were released by the Korean Atopic Dermatitis Association (KADA) work group in 2006, there have been several advances in AD management. Objective: We aimed to establish updated evidence- and experience-based treatment guidelines for Korean AD. Methods: We collected a database of references from relevant systematic AD reviews and guidelines regarding general AD management such as bathing and skin care, avoidance of exacerbating factors, education and psychosocial support, and the use of moisturizers and topical anti-inflammatory and antipruritic drugs. Evidence for each statement was graded and the strength of the recommendation for each statement classified. Thirty-nine KADA council members participated in three rounds of voting to establish an expert consensus of recommendations. Results: Basic AD treatment includes proper bathing and skin care, avoidance of exacerbating factors, proper education and psychosocial support, and use of moisturizers. The regular use of moisturizer has a steroid-sparing effect and reduces relapse episodes. The short- and long-term use of topical corticosteroids and calcineurin inhibitors improves AD symptoms and should be encouraged to use in an active and proactive treatment. Wet-wrap therapy can be used for rapid recovery of acute exacerbation. Topical antipruritic drugs cannot be recommended for the treatment of AD. Conclusion: This report provides up-to-date evidence- and experience- based treatment guidelines for AD regarding general management and topical treatment. In addition, the average agreement scores obtained by a panel of experts based on the Korean healthcare system and patient adherence are presented.

장애대학생의 학업적응도에 영향을 미치는 사회적 지지와 임파워먼트 요인 분석

김정은 한국학습장애학회 2013 학습장애연구 Vol.10 No.3

This purpose of study was to investigate the difference in those of university academic adjustment, social support, empowerment caused by such factors as gender, age, grade, type of disorder, grade of disorder, admission type, type of graduated high school of disabled university students. The subjects of this study were 101 disabled university students. The results of this study were as followed. First, disabled university student’ university academic adjustment differed in type of disorder, grade, type of graduated high school. Second, disabled university student’ social support differed in grade, type of disorder Third, disabled university student’ empowerment cognition differed in grade, type of graduated high school. Fourth, the emotional support and information support factor accounted for 42% of the university academic adjustment on disabled university student. And personal ability, self-determination factor accounted for 48% of university academic adjustment variables on disabled university student. 본 연구는 장애대학생 101명을 대상으로 학업적 적응도와 사회적 지지, 임파워먼트 수준에 대한 인식을 배경변인별 로 그 차이를 살펴보고, 학업적 적응도에 영향을 미치는 사회적 지지와 임파워먼트의 하위 요인을 분석하는데 목적이 있다. 본 연구의 결과를 살펴보면 먼저, 장애대학생의 학업적 적응도에 대한 인식 수준은 지체장애 대학생이 청각이나 시각장애 대학생보다, 3, 4학년 장애대학생이 1학년 장애대학생보다, 일반학교를 졸업한 장애대학생이 특수학교를 졸업한 장애대학생보다 더 높은 것으로 나타났다. 둘째, 장애대학생의 사회적 지지에 대한 인식 수준을 배경변인별로 살펴본 결과, 지체장애학생이 다른 시각이나 청각장애유형의 학생보다, 4학년 장애대학생이 1학년 장애대학생보다 사회적 지지를 더 많이 받고 있다고 인식하는 것으로 나타났다. 셋째, 장애대학생의 임파워먼트 수준을 살펴본 결과, 3, 4학년 장애대학생이 1학년 학생보다, 일반 고등학교를 졸업한 학생이 특수학교를 졸업한 학생보다 더 높은 것으로 나타났다. 넷째, 본 연구에서는 장애대학생의 학업적 적응도에 영향을 미치는 사회적 지지와 임파워먼트 요인은 정서적 지지와 정보적 지지요인, 개인적 능력과 자기결정 요인으로 나타났다.

Teaching Second Language Grammar: Deductive versus Inductive Instruction

김정은 팬코리아영어교육학회 2014 영어교육연구 Vol.26 No.1

This study investigates differential effects of deductive versus inductive form-focusedinstruction (FFI) onthe acquisition of a generalization ability of L2 target rule when the FFI isprovided within a context of primarily meaning-focused instruction (MFI). Sixty-threeKorean-speaking adult learners of English participated in the study and were randomly assignedto one of the fourgroups, such as (1) a group who received deductive FFI and MFI; (2) a groupwho received inductive FFI and MFI; (3) a group who received MFI only; or (4) a control group,who received no instruction.Learning was measured by an auditory grammaticality judgmenttask and a metalinguistic knowledge task. The results indicate that both deductive and inductivetypes of FFI are equally effective in immediately developing the rule generalization ability;however, the deductive FFI promotes retention of the generalization ability in the long term.