‘고양 가와지볍씨’의 고고학적 접근 - 파른 손보기교수 탄신 100주년을 기리며 -

손보기(Powkee SOHN),이융조(Yung-jo LEE),박태식(Tae-shik PARK),우종윤(Jong-yoon WOO) 한국박물관학회 2022 博物館學報 Vol.- No.43

우리나라 최초의 신도시개발계획의 일환으로 시작된 일산신도시문화유적 조사를 이끈 손보기 교수(단장, 한국선사문화연구소 소장, 전 연세대교수)는 일산일대에 발달된 토탄층에서 볍씨를 찾고자 1지역(한국선사문화연구소팀), 2지역(가와지, 충북대학교 고고미술사학과팀), 3지역(단국대학교 박물관팀) 으로 조직하였다. 그 가운데 충북대학교 팀은 가와지 현장 (1지구)에서 볍씨를 찾고, 그 연대가 5,020년(미국 Beta연구소)으로 밝혀내어, 학계의 중요한 논제로 등장하였다. 이어서 2지구(3,000년)에서도 볍씨를 찾아 박태식박사의 노력으로 재배벼의 진화에 관한 연구업적을 학계에 보고하였다. 또한 김정희선생의 연구로 단국대팀(3지역)의 빗살무늬 토기에서 벼의 규소체를 확인하여, 보다 확실한 기준을 제시하였다. 이들 자료는 충주 조동리유적(충북대 발굴)에서도 증명되어, 우리나라 벼 재배와 농경문제에 대한 분명한 자료와 근거로 제시하게 되었다. 계속하여 충북대는 청주 소로리볍씨 (15,000 ~ 17,000BP) 발견과 연구로 가와지볍씨가 소로리에서 부터 진화한 것으로 밝혀내었다. 신용하교수(서울대)는 이러한 자료와 연구위에서 좀 더 발전하여 “한강문화권”의 설정․위상을 세우는 큰 업적을 학계에 발표하였다. 그러한 점에서 30년 전 발굴된 고양 가와지볍씨 연구와 성과를 위하여 큰 격려와 배려를 아끼지 아니하신 손보기교수의 탄신 100주년을 기리고자 이 글을 봉정하고자 한다. 마침 고양시에서는 볍씨 기념탑의 준공과 “고양 가와지쌀”을 서울 롯데백화점에 출시하여, 손교수님의 탄신을 축하하는 의미로 해석되어 더욱 경하하는 바이다. ‘Goyang Gawaji Rice’ refers to rice crops found from the Gawaji site, Daehwa- dong, Ilsanseo-gu, Goyang City, Gyeonggi Province. Korea. The site was investigated by the department team of Archaeology and Art History, Chungbuk National University for 102 days through 2 times of excavation. The site includes 3 localities, Gawaji Loc.1, Loc.2 and Loc.3. In this paper, the writers talk about the Gawaji Locs.1 and 2, except the Loc.3 belonging to the Paleolithic age. From the cultural layer named Daehwa-ri at the Loc.1, there were excavated rice grains dated 5,020BP. It immediately suggested possibility of the Neolithic agriculture. In addition to the remains from Loc.1, the Gawaji Loc. 2 also yielded other rice grains dated 3,000~2,500BP. Consequently, the rice remains have been thought a valuable information on evolution process of rice species. In general, wild rice has bigger shattering habits. By G. B. Thompson’s theory (Thompson, 1992), it is thought that the rice contains evidence of human gathering activity with cut pedicel observed by SEM (Lee et al, 1994). Charcoal from the layer was dated 4,330±80bp (Beta-45536), that was recalibrated 5,020BP by MASCA (Lee, 1977). Heu pointed out that the Type I looks a little smaller but narrower and longer, that is longer than japonica but shorter than indica.

Kodamaea ohmeri Fungemia in a Patient with Carcinoma of the Ampulla of Vater

손보라,신경섭 충북대학교 동물의학연구소 2016 Journal of Biomedical and Translational Research Vol.17 No.2

Kodamaea ohmeri, previously known as Pichia ohmeri or Yamadazyma ohmeri, is an ascosporogenous yeast that belong to the Saccharomycetaceae family, and it is a rare yeast-form fungus recently identified as an etiological agent of fungemia, endocarditis, urinary tract infection and peritonitis in immunocompromised patients. This paper presents a case of K. ohmeri fungemia in a 70-year-old man with carcinoma of the ampulla of Vater. After receiving endoscopic retrograde cholangiopancreatography (ERCP) for releasing obstruction of ampulla of Vater by insertion of the biliary stent, he was pyrexial with a temperature of 38.5°C. Two set of blood samples were obtained from a peripheral vein for culture. The pathogen was identified as K. ohmeri using the Vitek YST card (bioMérieux, France) and was confirmed by the sequencing of the D1/D2 domains of the 26S rRNA gene and the internally transcribed spacer region. The minimal inhibitory concentrations of the antifungal agents were as follows: amphotericin B 0.5 μg/mL; fluconazole 2 μg/mL; voriconazole ≤ 0.12 μg/mL; fluocytosine ≤ 1 μg/mL. According to the Clinical and Laboratory Standard Institute recommended breakpoint for Candida spp, the isolate was susceptible to fluconazole, amphotericin B, voriconazole, and flucytosine. This is the first report of the isolation of K. ohmeri in the patient with a gastrointestinal neoplasm following ERCP.

B군 사슬알균에 의한 독소충격증후군: 증례보고 및 문헌고찰

손보라,신경섭 대한임상미생물학회 2014 Annals of clinical microbiology Vol.17 No.3

Toxic shock syndrome is an acute and febrile illness that rapidly progress to shock and multi-organ failure, and it is caused by toxin-producing strains of Staphylococcus aureus or Streptococcus species. Streptococcal toxic shock syndrome (STSS) is usually caused by group A streptococci, but non-group A STSS is rare. In this study, we describe a case of STSS caused by Streptococcus agalactiae (group B streptococci) in a patient with alcoholic liver cirrhosis. At arrival in our hospital, the patient had a decreased mental status with hemorrhagic bullae on four extremities, and he progressed to a fatal outcome within 4 days in spite of antibiotic treatment. (Ann Clin Microbiol 2014;17:91-94)

Allopurinol에 의한 호산구 증가증 1예

손보라,이창규,조윤정,김인선,김민자 大韓血液學會 1991 大韓血液學會誌 Vol.26 No.1

인슐린비의존성 당뇨병환자에서 홍삼이 혈소판 응집능에 미치는 영향

손보라,김영기,최동섭 대한임상검사정도관리학회 1994 臨床檢査와 精度管理 Vol.16 No.1

Association of CD4+CD25+FoxP3+ regulatory T cells with natural course of childhood chronic immune thrombocytopenic purpura

손보라,김지윤 대한소아청소년과학회 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.5

Purpose: The purpose of this study was to determine the frequency of CD4+CD25+FoxP3+ regulatory T cells (Treg) in the peripheral blood of patients with childhood chronic immune thrombocytopenic purpura (ITP) exhibiting thrombocytopenia and spontaneous remission. The findings of this study indicate the possibility of predicting spontaneous recovery and pathogenesis of childhood chronic ITP. Methods: Eleven children with chronic ITP (seven thrombocytopenic and four spontaneous remission cases; mean age, 8.8 years; range, 1.7–14.9 years) were enrolled in this study. Five healthy children and eight healthy adults were included as controls. The frequency of Treg was evaluated by flow cytometry in the peripheral blood. Results: In this study, four patients (36%) achieved spontaneous remission within 2.8 years (mean year; range, 1.0–4.4 years). The frequency of Treg was significantly lower in patients with persisting thrombocytopenia (0.13%±0.09%, P<0.05), than that in the patients with spontaneous remission (0.30%±0.02%), healthy adults controls (0.55%±0.44%), and healthy children controls (0.46%±0.26%). A significantly positive correlation was found between the frequency of Treg and the platelet count in children. Conclusion: These data suggest that a lower frequency of Treg contributes to the breakdown of self-tolerance, and may form the basis for future development of specific immunomodulatory therapies. Furthermore, Treg frequency has prognostic implication toward the natural course and long-term outcomes of childhood chronic ITP.

자가면역성 혈소판감소증 환자의 골수조직에서 Basic Fibroblast Growth Factor의 발현양상

손보라,신경섭,배숙영,윤수영 대한진단검사의학회 2003 Annals of Laboratory Medicine Vol.23 No.4

배경 : Basic Fibroblast Growth Factor (bFGF)는 골수섬유Number of stromal cells stained by bFGF was scored as follows: 0=none; 1+= few, scattered; 2+= moderate; 3+= abundant. Total 17 (8) 7 (0)

혈액응고 자동분석기 CA-540을 이용한 PT, aPTT, 내인성 혈액응고인자 측정

손보라 충북대학교 의과대학 충북대학교 의학연구소 2003 忠北醫大學術誌 Vol.13 No.1

연구목적:혈액응고자동화분석기 CA-540(Sysmex Co., Japan)의 정밀도를 평가하고 프로 트롬빈 검사(prothrombin time, PT), 활성화 부분 트롬보플라스틴 시간 (activated partial thromboplastin time, aPTT) 및 내인성 혈액 응고인자(8, 9, 11과 12번) 검사에 대한 참고치를 산정하였으며 기존 장비인 Electra 800 (Medical Laboratory Automation, Inc. USA)과의 상관관계를 비교하고자 하였다. 대상 및 방법:CA-540의 정밀도를 평가하기 위하여 Ci-Trol Level 1을 이용하여 20일간 측정하였다. PT, aPTT, 내인성 혈액응고인자(8, 9, 11과 12번)의 정상 참고범위를 구하고, Electra 800으로 측정한 PT와 INR 값의 결과를 비교하였다. 결과:검사실내 정밀도는 변이계수가 PT는 1.60%, aPTT는 2.32% 범위로 비교적 양호한 결과를 보였다. 총 정밀도는 PT 3.12%, aPTT 3.77%의 양호한 결과를 나타내었다. 정상인 68명을 대상으로 측정한 참고치는 PT 9.8-12.5 초, aPTT 24.9-35.3 초 이었다. 정상인 22명을 대상으로 측정한 내인성 응고인자들의 활성도는 8번 응고인자 132-774% 7번 64.6- 139.1%, 11번 72.6-240.7%, 12번 30.8-107.7%의 활성도치가 관찰되었다. INR은 기울기 1.53, R2 0.98로 모두 Electra 800과 좋은 상관관계를 보였다. 결론:CA-540의 정밀도는 양호하였고, INR 결과는 Electra 800과 존은 상관관계를 보였다. CA-540의 검사종목, 검체처리능력을 고려할 때 중소규모 검사실에 유용한 기기로 사료되었다. Purpose:CA-540 (Sysmex Co., Japan) automatic coagulation analyzer was evaluated in the measurement of prothrombin time (PT), activated partial thromboplastin time (aPTT) and intrinsic coagulation factors (Ⅷ, Ⅸ, XI, XII) assay. And also it was compared with another coagulation analyzer, the Electra 800 (Medical Laboratory Automation, Inc. USA). Materials and Methods:The precision of the CA-540 was evaluated with Ci-Trol 1 (Dade Behring Marburg GmbH, Germany) for 20 days. The normal reference ranges of PT, aPTT and Intrinsic coagulation factors were obtained. The results of CA-540 were compared with those of Electra 800. Results:Within-run precision of PT and aPTT ranged from 1.60% to 2.32% by coefficients of variation (CV). Total precision (CV) was in the range of 3.1% to 3.77% for PT and aPTT. The normal reference ranges for PT and aPTT were 9.8-12.5 seconds and 24.9-35.3 seconds respectively. The normal ranges of Factor VIII, IX, XI and XII were 132-774%, 64.6-139.1%, 72.6-240.7% and 30.8-107.7% respectively. INR results showed good correlation (slope 1.53, R2 0.98) between the results form CA-540 and Electra 800. Conclusion:The precision of CA-540 and correlation results of INR between CA-540 and Electra 800 were acceptable. We concluded that CA-540 would be a useful analyzer for routine coagulation test in medium sized laboratory.

주제발표 : 청소년활동프로그램의 재조명

손보라 한국청소년활동학회 2013 추계 학술대회 Vol.2013 No.-

Antimicrobial Susceptibility and Distribution of Salmonella spp., Shigella spp., and Vibro parahaemolyticus Isolated from Stool Specimen in a Tertiary Hospital in 2003-2010

손보라,Kyeong Seob Shin 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

Recently, antibiotic resistant salmonellosis is increasing, making it difficult to treat patients with Salmonella infections. This study analyzed the changes in the species, serogroups, and antimicrobial susceptibility of enteric pathogens isolated from stool specimens during the 8 years from 2003 to 2010 in a tertiary hospital. In total, 237 (1.9%) were isolated from 12,289 stool specimens, comprising 50.6% NTS and 49% Vibrio parahaemolyticus. Serogroups D, B, and C Salmonella were isolated most frequently in that order. Of the Salmonella, 49% of the isolates were ampicillin resistant and this rate for serogroups B, C, and D Salmonella was 56.8, 64.7, and 43.5%, respectively. Overall, the rates of trimethoprim-sulfamethoxazole (SXT), chloramphenicol (CM), and ciprofloxacin resistance were 11.0, 22.0, and 0%, respectively. Two cefotaxime-resistant Salmonella were isolated in 2010. All of the V. parahaemolyticus were susceptible to SXT, CM, and tetracycline. In conclusion, NTS and V. parahaemolyticus were the major enteric pathogens isolated from stool during the 8 years examined, and the rate of Salmonella resistance to antimicrobial agents increased significantly. Antimicrobial susceptibility testing is mandatory for the proper treatment of patients with Salmonella spp. infection.