Alcohol extract of Geum Chung Cho alleviates alcohol-induced short-term memory impairment in gerbils

Han-Sam Cho,Tae-Woon Kim,Sang-Seo Park,Mal-Soon Shin,Jae-Min Lee,Eun-Sang Ji,Chang-Ju Kim 한국운동재활학회 2015 한국운동재활학회 학술대회 Vol.2015 No.10

Chronic ethanol consumption leads to memory impairment and also induces brain damage. The hippocampus has been particularly regarded as a possible target organ of alcoholic intoxication, since this structure plays a prominent function in memory processes. Cordyceps has been used as a traditional medicine in Asian countries for a long time. Different types of Cordyceps extract were reported to have various pharmacological activities including anti-tumor, anti-inflammatory, anti-viral, and immune modulatory effects. Guem Chung Cho is an artificial cultivated Cordyceps, and was supplied from GCordy (Seoul, Korea). Ethanol extract of Cordycep (50 g) was made by rotary evaporate, and resulting powder 8.29 g was obtained (yield 17%). In the present study, we investigated the effects of ethanol extract of Geum Chung Cho on short-term memory, cell proliferation and apoptosis in the hippocampus of ethanol-treated gerbils. The gerbils were divided into 5 groups (n = 10 in each group): Control group, alcohol-treated group, alcohol-treated and 0.001 mg/kg Geum Chung Cho-applied group, alcohol-treated and 0.01 mg/kg Geum Chung Cho-applied group, and alcohol-treated and 0.1 mg/kg Geum Chung Cho-applied group. Gerbils in the alcohol-treated groups were orally administered ethanol (1 g/kg) once a day for 2 weeks. Gerbils in the Guem Chung Cho-applied groups were orally administered Guem Chung Cho extract at each dosage 1 hour before ethanol consumption. Our results revealed that consumption of alcohol for 2 weeks deteriorated short-term memory, induced apoptosis, and inhibited cell proliferation, and reduced expressions of brain-derived neurotrophic (BDNF) and tyrosine kinase B (TrkB). However, Guem Chung Cho treatment alleviated alcohol-induced short-term memory impairment through enhancing cell proliferation and BDNF expression with inhibiting apoptosis in the hippocampus. Guem Chung Cho showed maximum effects at 0.1 mg/kg. Based on these results, alcohol extract of Guem Chung Cho may provide therapeutic value for the treatment of chronic alcohol-inducted brain injury. This study was supported by GCordy company.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

지하 무선 CDMA 망의 전파 측정 및 Micro BTS의 성능 분석

안호중,노재성,조성언,조성준 한국항공대학교 1998 論文集 Vol.36 No.-

지하 무선망에서 CDMA(Code Division Multiple Access)시스템의 용량과 품질은 다중 사용자 간섭과 임펄스성 간섭의 영향을 받는다. 그러므로 CDMA 시스템에서는 간섭을 최소화하려는 연구가 필요하다. 최근에는 서비스 영역을 확대하기 위한 방법으로 지하 공간 또는 음영 지역에서 LCX(Leakage Coaxial Cable)가 이용되고 있다. 본 논문에서는 지하 무선 CDMA 망의 전파의 세기를 측정하였다. 그리고 측정된 결과를 이용하여 이론적인 Micro BTS의 성능을 분석하였다. 이론적인 BER 해석을 위하여 지하 무선 CDMA 망의 임펄스성 간섭 모델을 제안하고, 측정된 파라미터 값을 이용하여 Micro BTS의 BER 성능을 구하였다. 측정 결과, 지하철이 없을 경우보다 지하철이 운행함에 따라서 임펄스성 간섭이 중대됨을 알 수 있었으며, 단방향 운행보다 양방향 운행에서 임펄스성 간섭이 더욱 증가하였다. 수치 계산을 통하여 임펄스성 간섭의 발생 시간율과 다중 사용자 수에 따라 Micro BTS의 BER 성능이 주로 열화됨을 알 수 있었다. The capacity and quality of CDMA(Code Division Multiple Access) system are affected by multi user interference and impulsive interference in the underground wireless network. Therefore, it is essential to minimize the interference in CDMA system. Recently, LCX (Leaxial Cable) is used to expand service area in the underground area or shadow region. In this paper, the propagation of underground wireless CDMA network is measured. And then, using the measured data the theoretical performance of Micro BTS(Base Transmitter Station) is analyzed. For theoretical BER analysis, the impulsive interference model in the underground wireless CDMA network is proposed and the BER performance of Micro BTS is obtained by using the measured data. From the measurement results, it is found that the impulsive interference increases in the presence of passing train than the absence of passing train. Also, it is known that more interference appears in the presence of crossing two way train than in the presence of passing one way directional train. From the numerical results, the BER performance of Micro BTS is to be mainly degraded by the occurrence rate of impulsive interference and the number of multiple users.

바터 팽대부에 생긴 유암종 1예

강명주,지삼룡,박석주,이재익,조영완,김준영,박성재,박은택,이연재,이상혁,설상영,배상균 인제대학교 2006 仁濟醫學 Vol.27 No.-

Carcinoid tumors have been reported in a wide range of organs but most commonly involve the lungs, bronchi and gastrointestinal tract. Within the gastrointestinal tract, appendix is the most common location for carcinoid, followed by the distal small intestine, the rectum, and the stomach. Among these, primary involvement of the ampulla of Vater is extremely rare. We report a case of carcinoid tumor of ampulla of Vater. A 62-year-old man presented with epigastric soreness. Gastroduodenal endoscopy showed hyperemic bulging mass on ampulla of Vater and diagnosed as carcinoid tumor by histologic finding, with immunohistochemical study. In ^(111)In-octreoscan, tumor had regional lymph node metastasis, but no evidence of distant metastasis. Pancreatoduodenectomy with lymph node dissection was performed.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

3T Multi Voxel Spectroscopy에서 SENSE와 NEX 변화에 따른 정상인 뇌 대사물질 변화 분석

성열훈,임재동,이재현,조성봉,우동철,최보영,Seong, Yeol-Hun,Rhim, Jae-Dong,Lee, Jae-Hyun,Cho, Sung-Bong,Woo, Dong-Chul,Choe, Bo-Young 한국의학물리학회 2008 의학물리 Vol.19 No.4

자기공명분광법(magnetic resonance spectroscopy: MRS)은 인체내 대사물질을 정량분석하여 병변의 조기진단 및 정밀진단에 도움을 주고 있으며, 최근 임상에 이용되고 있는 자기공명분광법은 single voxel spectroscopy (SVS) 기법과 multi voxel spectroscopy (MVS) 기법이 있다. 본 연구에서는 SENSE와 NEX를 변화시킨 multi voxel spectroscopy (MVS)의 데이터와 기존 single voxel spectroscopy (SVS)의 데이터를 비교 분석하여, 각각의 데이터의 유의성 차이를 평가하고자 하였다. 정상 성인 지원자 13명(남자: 5명, 여자: 8명, 평균 41세, 표준편차 11.65세)을 대상으로 chemical shift image (CSI)를 이용한 MVS검사를 시행하였다. 장비는 3.0T Achieva Release Version 2.1 (Philips Medical System, Netherland)을 이용하였고, 8 channel head coil을 사용하여 brain thalamus 부위에서 CSI spectrum을 1 slice 획득하였다. Scan parameter로는 FOV (field of view): $230{\times}184mm^2$, TR (time to repetition): 2000 msec, TE (time to echo): 288 msec, matrix: $15{\times}12$, VOI(view of interest): $110{\times}110mm^2$, voxel size: $15{\times}15{\times}15mm^3$로 하였다. SENSE factor (S)와 NEX (N)는 S1*N1, S2*N1, S2*N2, S3*N2로 변화하여 스펙트럼을 획득하였고, 각 scan time은 5분 54초, 3분 32초, 6분 20초, 4분 20초였다. 얻은 모든 MRS 데이터는 jMRUI 3.0 Version 프로그램에서 분석하였고, SENSE factor와 NEX를 변화시켜 얻은 MVS data 그룹들이 정상 성인 뇌 대사물질의 변화에 영향을 주는지 검증하기 위해 그룹 간에 ANOVA분석을 실행하여 P 값이 0.05보다 크게 나오면 그룹들 사이에 유의한 차이가 없다고 분석하였다. NAA/Cr과 Cho/Cr의 상대적 비율은 MV와 SVS사이에서는 유의한 차이가 없었다. 즉, SENSE factor와 NEX를 변화시켜 얻은 MVS data에서 정상 성인 뇌조직의 대사물질의 변화를 관찰한 결과, S1*N1의 NAA/Cr은 $1.45{\pm}0.03$, Cho/Cr은 $0.88{\pm}0.03$이고, S2*N1의 NAA/Cr은 $1.44{\pm}0.03$, Cho/Cr은 $0.87{\pm}0.05$, S2*N2의 NAA/Cr은 $1.43{\pm}0.02$, Cho/Cr은 $0.87{\pm}0.04$이며, S3*N2의 NAA/Cr은 $1.45{\pm}0.03$, Cho/Cr은 $0.87{\pm}0.03$으로 나타났다(F-value : 1.37, D.F : 3, P-value : 0.262). 그러나 데이터의 질을 측정하기 위한 MVS 데이터의 NAA Peak line-width는 SVS 데이터의 NAA Peak line-width 보다 약 3배 정도 넓었다. 본 연구에서는 MVS에서 SENSE factor와 NEX 값을 다양하게 변화시킨 MVS의 데이터와 SVS의 데이터가 큰 차이가 없음을 확인하였다. 즉, 어는 특정 부위의 뇌 조직의 대사물질은 MVS와 SVS 기법 모두 큰 차이가 없음을 확인할 수 있었다. 그러므로 MVS는 SVS보다 광범한 부위를 짧은 시간 안에 검사할 수 있으므로 매우 유용한 방법이라고 사료된다. To evaluate the metabolic changes in normal adult brains due to alterations SENSE and NEX (number of excitation) by multi voxel MR Spectroscopy at 3.0 Tesla. The study group was composed of normal volunteers (5 men and 8 women) with a mean ($\pm$ standard deviation) age of 41 (${\pm}11.65$). Their ages ranged from 28 to 61 years. MR Spectroscopy was performed with a 3.0T Achieva Release Version 2.0 (Philips Medical System-Netherlands). The 8 channel head coil was employed for MRS acquisition. The 13 volunteers underwent multi voxel spectroscopy (MVS) and single voxel spectroscopy (SVS) on the thalamus area with normally gray matter. Spectral parameters were as follows: 15 mm of thickness; 230 mm of FOV (field of view); 2000 msecs of repetition time (TR); 288 msecs of echo time (TE); $110{\times}110$ mm of VOI (view of interest); $15{\times}15{\times}15$ mm of voxel size. Multi voxel spectral parameters were made using specially in alteration of SENSE factor (1~3) and 1~2 of NEX. All MRS data were processed by the jMRUI 3.0 Version. There was no significant difference in NAA/Cr and Cho/Cr ratio between MVS and SVS likewise the previous results by Ross and coworkers in 1994. In addition, despite the alterations of SENSE factor and NEX in MVS, the metabolite ratios were not changed (F-value : 1.37, D.F : 3, P-value : 0.262). However, line-width of NAA peak in MVS was 3 times bigger than that in SVS. In the present study, we demonstrated that the alterations of SENSE factor and NEX were not critically affective to the result of metabolic ratios in the normal brain tissue.

스포츠시설 이용자의 구매만족 요인 연구

조동진,김재현,김상대 조선대학교 스포츠과학연구소 1999 스포츠科學硏究 Vol.10 No.-

This study uses three factors of sport facilities: a location, facilities, and staffs’ service attitude, to grasp how they have influence on purchase satisfaction experienced by Purchase activities through rising sport facilities and concludes as follows. Staffs’ service attitude is the most influential in the purchase satisfaction, while the location is not very significant. In addition, dissatisfied location and facilities tends to be offset by the staff’s service attitude. Populations who intend to complain with behavior, despite of satisfaction are ; First, in a population statistic variable, women are higher than men by sex ; the younger by age, office workers who earn in the range of 1,500,000 won to 3,000,000 won by income and those who finished a university by education. As a result of verifying a significant level of a correlation coefficient of each population, an occupation, income, and education are likely to function as a regulative variable for complaint behavior purpose. In other words, a part of the population statistic variable can be used for promoting efficiency by regulation of satisfied customers’ purpose of complaint behavior. Second, in case of use types, population with swimming by joining events and in a method of using a sport center, those who apply for more than one year are more likely to complain with behavior. But they do not play a role as a regulating variable of complaint behavior purpose, despite of satisfaction.

위상배열 초음파를 이용한 터빈 블레이드 루트부내 결함평가 기법 연구

조용상,정계조,박상기,김재훈 한국비파괴검사학회 2004 한국비파괴검사학회지 Vol.24 No.2

초음파검사는 재료의 표면 또는 내부에 존재하는 불 연속부를 검출하기 위해, 초음파를 재료에 전달시켜 검사하는 비파괴검사법의 일종이다. 이러한 일반 초음파검사 방법 및 일반 결함평가 방법은 복잡한 현상에서 반사되는 신호로부터 결함을 구분하기가 어려워 결함의 평가 및 검사결과에 신뢰성이 떨어지고 있는 실정이다. 따라서 이러한 crack성 결함의 발생 가능성이 높으나 기존의 초음파검사 방법으로는 결함 판별에 어려움이 있는 설비에서의 검사방법 및 결함평가 방법의 제고가 필수 불가결한 실정이다. 본 연구에서는 위상배열 초음파를 사용하여 크랙 검출능력이 높고 길이 평가가 가장 정확한 방사각도를 규명하고, 주요발전설비중 하나인 터빈에 적용하였다. 기존의 초음파 검사 방식이 아닌 위상배열 초음파를 이용하여 결함의 크기를 평가할 수 있는 신 기법 및 이를 이용하여 터빈 블레이드 루트부 내에 존재하는 미세 결함에 대하여 크기평가 방법 및 결함탐지 방법에 대하여 고찰하였다. Ultrasonic testing is a kind of nondestructive test to detect a crack or discontinuity in materials or on material surfaces by sending ultrasound to it. This conventional ultrasonic technique has some limitations in reliably detecting crack or accurately assessing materials in the case of complex-shaped power plant components such as a turbine blade root. An alternative method for such a difficult inspection is highly needed. In this study, application of a phased array ultrasonic testing (UT) system to a turbine blade, one of the critical power plant components, has been considered, and the particular incident angle has been determined so that the greatest crack detectability and the most accurate crack length evaluation may be achieved. The response of ultrasonic phased array was also analyzed to establish a special method to determine the crack length without moving the transducer. The result showed that the developed method for crack length assessment is a more accurate and effective method, compared with the conventional method.

분산DBMS 환경에서의 개선된 동시성제어 알고리즘에 대한 연구

조성제 경주대학교 1997 論文集 Vol.9 No.-

Conventional DB systems suffers from poor execution speed due to disk I/O bottleneck. Recently, with a drop in memory chip price and rapid development of mass storage memory chip technology, research on main memory database system has gained wide attention. This paper discusses transaction management technique in distributed main-memory DB environment. Althought most researchers have been studied distributed systems, the technique has been investigated only in(5). Conventional existing concurrency control techniques employee the second phase looking protocol(2PL) and the waiting time can be increased because the same page can not be accessed more than once at the sametime. The characteristic of proposed method different from conventional methods is that it allows accessing data in th page which is already accessed by the another transaction. In addition to this, the proposed concurrency control algorithms are described. Finally, in order to evaluate the performance of the proposed concurrency control methods based on the proposed client-server recovery method and optimistic concurrency control method. The simulation model was developed using the SLAM Ⅱ language, and the model was compared with other related researches by analyzing transaction service times, transaction processing times, transaction processing time using concurrency control techniques.