정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

완두 F_1세대의 조합능력 검정

정원복,오주성,황필성,황영현,신두철,한원영,김수경 동아대학교 교육대학원 2002 동아교육논총 Vol.28 No.-

완두의 이면교잡에 의한 F_1세대에 대한 조합능력을 검정한 결과는 다음과 같다. 9개 형질에 대한 GCA, SCA, RCA효과를 검정한 바 조합능력은 전 형질에서 GCA, SCA, RCA가 모두 유의하였고, 분지수·경직경·엽장·주당협수·협당립수·주당립수·100립중·주당립중은 GCA가 SCA보다 크고, 품종간 GCA효과는 고성종1호가 경직경과 100립중에서, 고성종2호가 경장·분지수·엽장에서, 김해종이 주당협수·주당립수·100립중·주당입중에서, 진해종이 협다립수에서 각각 정(+)으로 높았다. SCA효과에서 경장은 1×2(고성종1호×고성종2호)조합과 1×3(고성종1호×김해종)조합이, 분지수는 4×5(고성종3호×진해종)조합이, 경직경과 엽장은 1×3(고성종1호×김해종)조합이, 주당협수는 1×2(고성종1호×고성종2호)조합과 4×5(고성종3호×진해종)조합이, 협당립수는 1×2(고성종1호×고성종2호)조합·1×4(고성종1호×고성종3호)조합·2×3(고성종2호×김해종)조합이, 주당립수는 1×2(고성종1호×고성종2호)조합과 4×5(고성종3호×진해종)조합이, 100립중은 3×4(김해종×고성종3호)조합이, 주당립중은 1×2(고성종1호×고성종2호)조합·3×4(김해종×고성종3호)조합·4×5(고성종3호×진해종)조합이 각각 정으로 높았다. RCA효과에서 경장·엽장·주당협수·주당립중은 1×2(고성종1호×고성종2호)조합이, 주당협수·주당립수·100립중·주당립중은 2×4(고성종2호×고성종3호)조합이 각각 정으로 높았다. Five pea varieties in F₁ generation of the possible crosses among them were used to estimate the combining ability for nine characters, i. e., stem length, number of branches per plant, stem diameter, leaf length, number of pods per plant, number of seeds per pod, number of seeds per plant, 100-seed weight and seed weight per plant. Data for F₁ hybrid and parents were subjected to the analysis method proposed by Griffing. The results obtained were summarized as follows. Mean squares of general combining ability(GCA), specific combining ability(SCA) and reciprocal combining ability(RCA) were significant for all characters observed. Mean squares of GCA were higher than those of SCA and RCA in number of branches per plant, stem diameter, leaf length, number of pods per plant, number of seeds per pod, number of seeds per plant, 100-seed weight and seed weight and seed weight per plant. Variety Gimbae showed the highest GCA effect for number of pods per plant, number of seeds per plant and seed weight per plant and positively high effects of GCA were observed from variety Gosung#1 in stem diameter, 100-seed weight, and from variety Gosung#2 stem length, number of branches per plant, leaf length, from Jinhae in number of seeds per pod In SCA effects, hybrids in Gosung#1×Gosung#2 were wxhibited positively high for stem length, number of pods per plant, number of seeds per pod, number of seeds per plant and seed weight per plant, and high SCA effects for number of branches per plant, number of pods per plant, number of seeds per plant and seed weight per plant were found positively in Gosung#3×jinhae. In RCA effects, hybrids in Gosung#2×Gosung#3 were exhibited positively high for number of pods per plant, number of seeds per plant, 100-seed weight and seed weight per plant and high RCA effects for stem length, leaf length, number of pods per plant, and seed weight per plant were found positively in Gosung#1×Gosung#2.

족제비(Mustela sibirica coreana) 및 두더지(Talpa micurua coreana)의 생체부위별 중금속 축적 경향

손성원,한성용,양두하 경남대학교 환경문제연구소 1997 환경연구 Vol.19 No.-

This study was analyzed the heavy metal concentrations and companed with each of the organs of the weasels and moles. In case of the weasels, the elements were detected higher than the case of the moles en the A1, Fe, Cu, Zn, while the Pb, Cr were defected lower than the case of moles In case of Fe, was detected highly in kidney and liver than the other organs, and especially most highly detected in the case of moles. On the organs of samples, Cd was detected highly in kindev and liver than the other organs, and especially most highly detected in the ease of moles. And in case of the weasel's fur, Fe was very highly detected. The weasels seems to be shown that toxic elements were easily excreted by fur exchange system more than the case of the moles, or to be related with environmental factor of the collecting place that the weasel samples had been collected in the Sasang industrial areas of Pusan.

한반도 지진원의 특성을 고려한 응답스펙트럼

신재철,이두한,정인수,이창원 충남대학교 산업기술연구소 2003 산업기술연구논문집 Vol.18 No.1

The response spectrum is the best representation of earthquake for engineering purposes because it takes account of the natural frequencies of structures. In general PGA(Peak Ground Acceleration) is used to scale the standard response spectrum. But it is likely to lead to serious error, because the shapes of response spectra depend on magnitude, source distance and site conditions. Therefore, theoretical prediction called stochastic source models have been used for predicting ground motion and response spectrum by magnitude and distance in regions where strong ground motion data are sparse. The deterministic method that PGA scales the design spectrum is prescribed in Korea, so unexpected error can be occured. Therefore the stochastic simulation method is employed to predict ground motion and to estimate the response spectrum for comparison with the design spectrum in this study. Stochastic source model that the shape is controlled by two corner frequency is computed and verified by comparing with Gyeongju earthquake using site-amplification(Boor & Joyner, 1997) to consider site condition. And it is proved how much this difference has an effect on response of structure such as steel box girder bridge.

안면골 골절에 관한 임상적 연구

김현수,이상한,장현중,백상흠,차두원 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.1

To investigate epidermiologic trend in maxillofacial fractures, We retrospectively studied 934 patients with maxillofacial fractures between 1981∼1987 and 1995∼1999. The results were compared in the previous group (Group A, patients treated between 1981∼1987) with those in the recent group (Group B, 1995∼1999). Also, we studied 516 patient between 1995∼1999 for occupation, associated injuries, treatment and complications. The sex ratio of men to women decreased (5.6 : 1 in Group A vs. 3.5 : 1 in Group B), and the largest age group was 20 to 29 years. There was the highest incidence in September and Fall. The most frequent cause of maxillofacial fracture in both Group A and B was traffic accidents. The distribution of fracture site did not change appreciably, but the frequency of midfacial fracture increased. In the recent group, the largest occupational group was salaried men, and the largest associated injuries of maxillofacial fracture was head and neck injury. Open reduction was used in 91% of the cases, and post-operation complications were infection, neurologic problem, malocclusion, and mouth opening limitation etc. Our results suggest that the clinical features of patients with maxillofacial fractures have changed during the past decade.

농업부문 웹캐스팅의 이용 실태와 활성화 방안

최돈우,김두한,박원흠 한국식품유통학회 2004 食品流通硏究 Vol.21 No.2

Webcasting is a new trend of fusion media, which multimedia, musics and images are captured and stored in real time and broadcasted through internet. This study was attempted to observe the current status of webcasting in agriculture which are used by the farmer of fruit products, and identified the problems and issues which are currently confronted with the webcasting in agriculture and sought some feasible strategies for improving and activating the webcasting. In the near future. it is very important that decision-making of the farmers on production and marketing through webcasting information are to increase its market competitiveness under the current situation which is ever-changing domestic and international production and marketing environments. In order to activate the webcasting in agriculture, it is necessary to supply personal computers across farm level, to strengthen educational training programs of computer on farmers, and to found public webcasting center which is collected, developed and provided diversified and specialized contents of webcasting.

우리 나라 中等學校 科學敎育의 現況 및 改善方案

權五亨,高在杰,鄭遠佑,韓斗熙 경북대학교 과학교육연구소 1987 科學敎育硏究誌 Vol.11 No.-

In order to develop the intellective man power effectively, the educational processes are renewd by efforts of emphasizing the science education. We previewed the features, objects and doctrine of present science education. And dicussed the ideas of educational fields, poverty of experimental ability, the problems of educational environments in laboratory and relations between each science texts, and the college entrance examination system. With these discussions, we asserted the importance and improvemental devices of science education in terms of motivations of students, inquiry learning, laboratories, reeducation of science teacher, development of entrance examination system and national supports.

항정신병약물 사용 중인 정신분열병 환자에서 올란자판으로의 교체 방법에 관한 연구(II) : Comparison of Safety 안전성 비교

안용민,권용실,권준수,민성호,박두병,양문정,소형석,송종호,신윤식,우행원,유범희,이홍석,정한용,한창환,김용식 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.5

연구목적: 이 다기관 공동임상연구는 사용 중인 항정신병약물을 ’직접 교체 방법’또는 ’시작-감량 교체 방법’중 한 가지 방법으로 올란자핀으로 교체한 후, 안정성 측면에서 두 교체 방법 간의 비교와 교체후의 변화를 관찰하기 위한 것이다. 방법: 국내 13개 병원의 입원 및 외래에 내원한 환자들 중 ICD-10 지단기준으로 정신분열병에 해당되며, 임상적으로 항정신병약물 교체가 필요한 환자를 대상으로 하였다. 두 가지 교체 방법 중 한 가지를 무작위로 피험자에 적용하였으며, ’직접 교체 방법’에 배정된 경우에는 사용중인 항정신병약물을 일시에 중단하고 10㎎의 올란자핀을 바로 투여하였고, ’시작-감량 교체 방법’에 배정된 경우는 10㎎의 올란자핀 투여하고 2주에 걸쳐서 기존 약물을 감량하여 중단하였다. 올란자핀 사용기간은 총 6주이며, 용량은 5∼20㎎ 범위로 제한하였다. 한정성 평가를 위해서 체중, 생명징후, 자발적인 이상반응 복, 실험실 검사 그리고 Simpson-Angus Scale(SAS), Barnes akathisia rating scale(BARS), Abnormal involuntary movement scale(AIMS). Liverpool University neuroleptic side effect rating scale(LUNSERS)등을 이용하였다. 결과: 총 103명의 정신분열병 환자를 대상으로 하였다. 사용한 올란자핀의 용량, 벤조디아제핀의 병용률, 탈락률과 탈락 사유, 자발적인 이상반응 보고, 생명징후, 실험실 검사 그리고 대부분의 부작용 척도 상에서 임상적으로 의미 있는 차이를 두 교체 방법간에 발견하지 못하였다. 다만 AIMS의 감소는 ’직접 교체 방법’군에서 보다 적었고, 항콜린제의 병용률은 ’시작-감량 교체 방법’군에서 보다 많았다. 기저 상태에서 전체 피험자의 SAS와 BARS 점수는 각각 3.5점과 1.8점이었으며 70% 이상의 피험자가 고프로락틴 혈증을 보였다. 올란자핀으로 교체한 후, SAS, BARS, AIMS 점수의 유의한 감소가 있었으며 고프로락틴 혈증을 보인 피험자 분율도 약 30%이하로 감소하였다. 그러나 교체 방법과 상관없이 올란자핀 교체 후 유의한 체중 증가가 있었다. 결론: 이 연구를 통해 교체 방법에 관계없이 비교적 안전하고 용이하게 올란자핀으로 교체 할 수 있음을 알 수 있었다. 그리고 기존 항정신병약물을 올란자핀으로 교체함으로써 일부 부작용들을 줄일 수 있음을 간접적으로 관찰할 수 있었다. 하지만 이 연구는 여러 제한점과 문제점을 지니고 있기 때문에 보다 체계적인 연구를 통해 검정이 필요하리라 생각된다. Objectives: This multicenter clinical trial involving 13 hospital sites compared the safely of switching to olanzapine between ’direct switching method’ and ’start-tapering switching method’. Method: This study included both inpatients and outpatients who fulfilled the criteria for schizophrenia as defined in the ICD-10, and were in need to be appropriate for switching antipsychotics. Subjects were randomly assigned to one of the two switching methods. For ’direct switching method’group, previous antipsychotics were abruptly discontinued and 10㎎ of olanzapine was administered, and previous antipsychotics was gradually tapered for 2 weeks. Olanzapine was used for 6 weeks and the dose was adjusted within the range of 5-20㎎. The safety of switching to olanzapine was measured with vital sings including body weight, adverse events reported spontaneously, laboratory tests, and various scales such as Simpson-Angus Scale(SAS), Barnes Akathisia Rating Scale(BARS). Abnormal Involuntary Movement Scale(AIMS), and Liverpool University Neuroleptic Side Effect Rating Scale(LUNSERS). Results: 103 patients were switched to olanzapine in this study. The comparison between two switching methods did not show any significant difference in the dosage of olanzapine used, the concomitant use of benzodiazepine, the rate and reasons of drop-out, the adverse events, vital signs, laboratory tests, and most scales for measuring side-effects. However, the decrease in AIMS scores was significantly lower in ’direct switching method’ group, and the concomitant use of anticholinergics was comparatively greater in ’start-tapering switching method’ group. At baseline, SAS and BARS scores were 3.5 and 1.8 points respectively, and more than 70% of the subjects showed hyperprolactinemia. After switching to olanzapine, SAS, BARS, and AIMS scores were significantly decreased and the proportion of the patients with hyperprolactinemia was also decreased to less than 30%. However significant weight gain after the treatment of olanzapine was observed regardless of switching method. Conclusion: This study may suggest that switching to olanzapine can be done with relatively high safety regardless of switching methods and olanzapine can significantly decrease some side-effects induced by other antipsychotics.

S-267 Impact of Ezetimibe/Simvastatin on neointimal response to Biolimus-eluting stent Implantation

( Han Chul Lim ),( Young Joon Hong ),( Sang Wook Kim ),( Young Mi Cho ),( Ji Won Kim ),( Jung A Choi ),( Han Byul Kim ),( Min Chul Kim ),( Doo Sun Sim ),( Ju Han Kim ),( Youngkeun Ahn ),( Myung Ho Jeo 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Impact of Ezetimibe/Simvastatin on neointimal response to Biolimus-eluting stent Implantation

A New Black Seed Cost Soybean Cultivar, "Heugmi" with Lodging Tolerance and Green Cotyledon

Won Young Han,In Youl Baek,Hyun Tae Kim,Jong Min Ko,Nam Suk Kang,Doo Chull Shin,Sung Taek Kang,Myung Gun Chung,Ki Won Oh,Sang Ouk Shin,Keum Yong Park,Duck Yong Suh,Jin Hwan Lee 한국육종학회 2007 한국육종학회지 Vol.39 No.3

A new black seed coat soybean cultivar, “Heugmi” was developed at the Yeongnam Agricultural Research Institute (YARI) in 2006. The goal to breed the black seed coat soybean is to develop the cultivar with high yield, lodging tolerance, resistant to disease such as soybean mosaic virus (SMV), and bacterial pustule and seed size. Heugmi was selected from the cross between Milyang 78, which was late maturing, susceptible to lodging and SMV and with large seed size and green cotyledon, and Milyang 68, which was middle maturing, resistant to lodging and SMV and with middle seed size and yellow cotyledon. The preliminary, advanced and regional yield trials for evaluation and selection of this cultivar were carried out from 2001 to 2006. It has determinate growth habit, purple flower, brown pubescence, black pod color, black seed coat, green cotyledon, spherical seed shape, oval leaf shape and middle seed size (24.8 grams per 100 seeds), and it was 2 days earlier in maturity than the check cultivar Cheongjakong. Heugmi was better in the seed quality of crude protein contents, sucrose and total sugar contents than the check cultivar. It also has been identified to have resistance to SMV which was the troublesome soybean diseases. The average yield of Heugmi was 2.53 ton per hectare in the regional yield trials carried out in seven locations of Korea from 2004 to 2006, which was 8 percent higher than the check cultivar Cheongjakong.