백서의 치아이동 시 피질골 천공이 치주조직의 OPG, RANK, RANKL의 발현에 미치는 영향

박우경,김성식,박수병,손우성,김용덕,전은숙,박미화 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.3

치아이동 시 피질골 천공이 치조골 재형성에 미치는 영향을 알아보기 위해서 생후 15주된 자성백서를 사용하여 피질골 천공 후 치아이동을 실시한 실험군(Tooth movement with cortical punching: TMC group, n = 16)과 교정적 치아이동만 실시한 대조군(Tooth movement only group: TM group, n = 16)의 치아주위조직을 면역조직화학염색을 통하여 관찰하였다. 실험군과 대조군의 실험동물에 20 gm의 힘으로 상악 전치부 사이를 이개시키는 치아이동을 시행하였으며 실험군에서는 상악 전치부 구개부위에 피질골 천공을 실시하였다. 치아이동 후 1, 4, 7, 14일째에 실험군과 대조군의 실험동물을 희생시켰다. 면역조직화학염색법으로 OPG, RANK, RANKL의 발현을 비교한 결과, OPG의 발현은 양 군 모두에서 미처치 대조군에 비하여 감소되었으나, 실험군에서의 발현이 대조군보다 컸으며, RANK, RANKL은 피질골 천공을 시행한 경우에 더 강한 발현을 보이는 것이 관찰되었다. 따라서 피질골 천공이 치주조직의 OPG, RANK, RANKL의 발현에 영향을 미치며 치조골의 재형성을 향상시키는 것을 알 수 있었다. Objective: The purpose of this study was to investigate whether cortical punching could stimulate the expression of OPG, RANK, and RANKL during tooth movement by immunohistochemistry. Methods: 34 sprague-dawley rats (15 weeks old) were allocated into 3 groups: TMC group (experimental group; Tooth Movement with Corticotomy, n = 16), TM group (control group; Tooth Movement only group, n = 16), and non-treatment group (n = 2). 20 gm of orthodontic force was applied to rat incisors by inserting elastic bands. The duration of force application was 1, 4, 7 and 14 days. A microscrew (diameter 1.2 mm) was used for cortical punching of the palatal side of the upper incisors in the TMC group. Results: Distributions of OPG, RANK, and RANKL were evaluated by immunohistochemistry. OPG, RANK and RANKL were observed on experimental and control groups. On the compression side, the degree of the expression of OPG decreased in both groups. The expression of RANK was most prominent in the experimental group of day 4. The expression of RANKL was most intensive and extensive in the experimental group of day 7. However, the expression of OPG was decreased in the experimental and control groups compared to the non treatment group. The expression of OPG, RANK and RANKL after force application were decreased at day 14. Conclusions: These findings suggested that cortical punching might stimulate remodeling of alveolar bone during a 2 week period of tooth movement without any pathologic change.

특수 콘크리트를 이용한 공원시설 관련 제품에 관한 연구

박봉우,김진아,신애란,전병건 강원대학교 석재복합신소재제품연구센터 1996 석재연 논문집 Vol.1 No.-

본 연구는 특수 콘크리트를 사용하여 공원시설 관련 제품을 생산하기 위한 기초 자료를 얻을 목적으로 수행하였다. 현재 국내에서 생산하여 사용되고 있는 공원 관련 시설물을 대상으로 소재에 대한 선호도와 소재의 특성을 우편을 통한 설문 조사를 하였다. 설문의 결과 가장 선호하는 소재는 목재, 인조목, 철금속, 비철금속, 석재 등의 순서로 나타났다. 재료 별 특성은 12개 공원 관련 시설과 7개 시멘트 콘크리트 제품을 대상으로 재료별로 10개 항목에 대한 특성을 조사하여 matrix로 나타내었다. 이렇게 조사된 결과를 토대로 하여 공원 관련 제품 생산을 위한 시험적인 모델로 특수 콘크리트를 사용한 블라드와 콘크리트 판넬의 모형을 제시하였다. The purpose of this study was to obtain basic information in order to produce of park facility products using by special concrete. This study made a survey of preference and character of the raw materials on park facility products throughout the country by mail questionnaire. As a result, the ranking of preference on raw materials were wood, imitation wood made from cement concrete, steel, and nonferrous metal. Also, the 10 characters of raw material on the 12 items of park facility products and 7 items of cement concrete products investigated and their results showed by matrix. Based on these results we suggest the pilot models of bollard and concrete panel for pedestrian using special concrete.

내사시에서 양안 내직근후전술 시 기능적적도부 및 팍스의 수술양을 고려한 군 간 수술성적비교

강병완,박상우,윤경철,허환,Byung Wan Kang,MD,Sang Woo Park,MD,PhD,Kyung Chul Yoon,MD,PhD,Hwan Heo,MD,PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.1

Purpose: To compare the surgical outcomes of functional equator-considering and Parks’ methods in infantile esotropia and partially accommodative esotropia. Methods: The medical records of 96 patients with infantile esotropia and partially accommodative esotropia who underwent bilateral medial rectus muscle recession by functional equator-considering and Parks’ methods were reviewed retrospectively. The surgery success rate at 1 month, 3 months, 6 months and 12 months was compared by the deviation angle measurement. Results: Overall success rates were not statistically different between the 2 groups. Additionally, there were no differences in surgical success rate of functional equator-considering and Parks’ methods in infantile esotropia and partially accommodative esotropia. When the patients were divided into 2 groups based on 40 PD, no significant difference in success rate between the 2 groups was observed. When patients were divided into 2 groups based on 22 mm of axial length, there was no statistical difference observed. Postoperative overcorrection was 2 (4%) in the functional equator group and 3 (6.5%) in Parks’ method group and postoperative undercorrection was 9 (18%, 19.6%) in each group. The incidence of undercorrection in the Parks’ method group was significantly higher in the greater than 22 mm axial length group (7, 35.0%) than in the less than 22 mm group (2, 7.7%) (p = 0.029). Conclusions: There was no statistically significant difference in surgical success rate between the functional equator and Parks’ methods in infantile esotropia and partially accommodative esotropia. J Korean Ophthalmol Soc 2012;53(1):138-144

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

공무원 다문화역량 교육프로그램 개발연구를 위한 요구 분석

이병준,박응희,한현우 한국문화교육학회 2010 문화예술교육연구 Vol.5 No.1

노동의 세계화와 국제결혼, 다양한 종교의 유입 등 변화하고 글로벌화하는 사회환경에 따른 여러 문제들은 이제 지역차원에서의 적극적인 대응을 행정서비스에 요구하고 있다. 본 연구의 목적은 다문화사회의 진입에 따른 직접적인 행정서비스를 수행하고 있는 공무원들을 대상으로 그들의 다문화역량개발에 도움을 줄 수 있는 교육프로그램을 개발하기 위한 요구를 파악하기 위함이다. 다문화역량은 다문화학습의 과정을 거쳐 생겨난다고 알려져 있다. 특히 다문화역량의 구성요소에 관해서는 국가와 연구자별로 차이를 보이고 있는데, 미국의 경우 다문화역량은 문화적 의식, 등을 거쳐 습득되는 문화적 역량의 개념으로 이해되어지며, 독일의 경우 다문화역량은 의사소통능력, 갈등관리능력 등의 기초역량에서부터 문화 간의 차이 인정 능력에 이르기까지의 문화적 역량이 포괄된 역량으로 이해되어지고 있다. 본 연구의 결과로 나타는 현재의 공무원들의 다문화역량에 대한 의식수준은 전반적으로 평균수준이며 결핍된 역량에 대한 교육요구는 상당히 높다고 볼 수 있다. 특히 적지 않는 공무원들이 자기 자신의 변화가 우선적으로 중요하다고 답변한 것은 프로그램의 기획에 있어 시사하는 바가 적지 않다고 볼 것이다. The purpose of this study is to make basic materials of education programs helping competency development for public officials who are conducting public service directly, as the multi-cultural society has come. The variety of issues came after the changeable and globalized social environment such as globalization in labor industry, international marriage and introduction of diverse religion. Those are in need of active responses to public service. We recognize the need of education programs that fit in the multi-cultural paradigm, then it can possibly be used for building curriculum and education system of multi-cultural competency development as basic materials. We have to promote a learning culture for the proper response to the multi-cultural society. It can be helpful to enter a mature civil society when we recognize and embrace identities of minority groups through an education for public officials who directly provide the multi-cultural public service.

아세트산의 탈수반응을 위한 MCM-41의 표면개질 및 적외선 분광법을 이용한 표면특성 분석

우창수,박민태,이병민,이호인 한국공업화학회 2003 응용화학 Vol.7 No.1

Catalytic dehydration of acetic acid was performed over surface-modified MCM-41.Calcination of silylated MCM-41 under air regenerated successfully silanol groups as the active sites for dehydration of acetic acid. In-situ FTIR spectroscopy using pyridine as a probe molecule revealed that as the pretreatment temperature bofore silylation increased, the concentration of Lewis-acidic sites was enhanced. The enhanced concentration of Lewis-acidic sites augmented the bridged adsorption species of acetic acid on the surface of the modified catalyst, which significantly promoted the catalytic activity.

소아기 뇌졸중 후 발생한 간질에 대한 임상적 관찰

박현주,정경중,김근모,김병주,우영종,이정길,김재휴 대한간질학회 1998 대한간질학회지 Vol.2 No.1

오존노출이 실험적으로 유발된 알레르기성 비염에 미치는 영향

전우진,변상내,김용민,김병국,나기상,박찬일 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.11

지구성 운동이 중년여성의 혈중지질농도에 미치는 영향

朴麟基,崔大雨,李明秀,徐在河,趙炳俊,金泰亨 충남대학교 체육과학연구소 2000 體育科學硏究誌 Vol.18 No.1

The purpose of this study was to identify the effect of endurance exercise program on the middle-aged women. Six subjects were recruited from among volunteers responding to advertisements placed around the university community. All subjects, with no experience in regular physical activity participated in an interventional training consisting of swimming and stretching three days a week for 10weeks. Pre-and post blood lipid levels, such as Total Cholesterol(TC), High Density Lipoprotein Cholesterol(HDL-C), Low Density Lipoprotein Cholesterol(LDL-C), and Triglyceride(TG) were measured. A paired t-test showed results that were significant the .05 level were HDL-C , LDL-C, TG, and TC/HDL-C Ratio. The main finding of the study was that the role of endurance training, as prescribed in our study has the effect of making improvements in blood lipid levels for the middle-aged women. 1. After a 10week period of endurance exercise, the Total Cholesterol(TC) level was higher than that of pre-test. But the difference no showed the statistical significance. 2. After a 10week period of endurance exercise, the High Density Lipoprotein Cholesterol(HDL-C) Low Density Lipoprotein Cholesterol(LDL-C). Triglyceride(TG) level was higher than that of pre-test. and the difference showed the Statistical significance. In conclusion, even though there was significant in blood lipid levels after endurance exercise, swimming has a beneficial on improving in the middle-aged women.