술후성협부낭종에 대한 임상적 고찰

나기상,김주영,남부현 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

The authors analyzed 24 cases of the postoperative cheek cyst who treated at the Department of Otolaryngology, Chungnam National University Hospital from 1981 to 1990. There were 17 males and 3 females with a sex ratio of 17:3. Age distribution was from 31 to 58 years, with peak incidence in the 4th decade(40%). The duration after the initial Caldwell-Luc's operation was 9 to 40 years with a average of 21.1 years. The most common chief complaints was cheek swelling(79.2%), and then, in decreasing order of frequency, were cheek pain(70.8%), toothache(45.8%), nasal obstruction(29.2%), headache(20.8%) and rhinorrhea(20.8%). During the operative procedure, the complete obstruction of the nasoantral window and natural ostium with fibrous tissue were noted in all cases. Cysts were filled with the yellowish-brown or brown colored fluid. Also, the defect of sinus bony wall were noted in all cases. In 9 cases(37.5%), multiple cysts that did not communicate each other were noted.

실험적으로 기도 알레르기를 유발시킨 마우스에 투여한 항 P-Selectin, 항 PSGL-1, 항 CD49d 항체의 염증억제효과

나기상 대한비과학회 2005 Journal of rhinology Vol.12 No.1

연령에 따른 비강내의 단면적 및 용적의 변화 : Evaluation by Acoustic Rhinometry

나기상,김인중,성열웅 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

To study the geometric changes of the nasal cavity with aging, acoustic rhinometry was carried out in 100 normal subjects before and after decongestion. From each of the chosen curves, the following variables were calculated : location and cross-sectional areas of the I-notch and C-notch, the crosssectional areas at 3.3cm, 4.0cm, and 6.4cm from the tip of nosepiece, and the total volume of the nasal cavity. Data were analyzed statistically to evaluate the differences between the various age groups and between the congested and decongested state of the mucosa. This study may serve as a basic data for the evaluation of the patients with rhinologic diseases.

Nasal Sensation of Airflow:Measurement, Reproducibility and Regional Differences

나기상,임동우,이석호,성열웅,김병국,박찬일 대한비과학회 1999 Journal of rhinology Vol.6 No.2

Background and Objectives:Although airflow sensation is believed to have a certain role in the subjective sensation of nasalpatency, there are few studies that quantify and assess the sensation of nasal airflow. We designed an apparatus that delivers apulsing jet of air to measure nasal airflow sensitivity. The aims of this study are to map out the airflow sensitivity of the nose, toevaluate the effect of decongestant on airflow sensitivity and to assess reproducibility. Materials and Methods:The test siteswere stimulated with a pulsing jet of air at gradually increasing velocities, and the minimum velocity at which the subject coulddetect the tactile sensation was recorded. The threshold velocities after phenylephrine spray were also measured and comparedwith the pre-decongestant values. The threshold velocities were obtained on two separate occasions to assess reproducibility. Results:The nasal vestibule was more sensitive than the nasal mucosa to airflow, and the most sensitive area in the proper nasalcavity was the anterior end of the inferior turbinate. Sensitivity was not affected by decongestant spray. There was strong agreementbetween the first and second measurement values. Conclusion:Our method of measuring airflow sensitivity is believed tobe useful in assesssing nasal airflow sensation.

비부비동의 국균증에 대한 임상적 연구

나기상,최원조,이범식 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

Fungal infections of the nose and paranasal sinuses are more common than previously suspected. This may be related to increased recognition of the problem with improvement of diagnostic techniques. And the factors that predispose to fungal infections have also increased. These factors include diabetes, malignant diseases, radiation, immunosuppressive therapy, long-term corticosteroid and antibiotic regimens, etc. But most of the aspergillosis of the paramnasal sinuses are found in patients in general good health. In these cases, it has been suggested that local predisposing factors such as anatomic variations and pathologic changes in ostiomeatal complex lead to a fungus infection. Twenty five cases of aspergillosis of the nose and paranasal sinuses seen during a period of 5.5 years from January 1991 through June 1996 at the Chungnam National University Hospital are reported and a review of the literature on aspergillosis is presented.

타액선종양에 대한 임상적 고찰

나기상 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

A clinical analysis was performed on 46 cases of salivary gland tumor who treated at the Department of Otolaryngology, Chungnam National University Hospital. The parotid gland was the most common site, followed by the palate and the submandibular gland. The most frequent histologic type was pleomorphic adenoma(58.7%), followed by adenoid cystic carcinoma(15.2%) and mucoepidermoid carcinoma(13.0%). Plemorphic adenoma and mucoepidermoid carcinoma were more common in female than in male, but adenoid cysitic carcinoma was more common in male. Painless, slowly growing mass was the most common chief complaint of patients with salivary gland tumor. The surgery was the main method of treatment. Although the duration of follow-up check-up in not long, recurrence is not observed.

오존노출시간 및 희생시기에 따른 백서 비점막의 형태학적 변화

나기상,김병국,김용민,박찬일 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

Ozone causes epithelial injury in the upper and lower respiratory tract of laboratory animals. Although there has been good characterization of the ozone induced lesions in the nasal mucosa, it's not clear that morphologic changes depend on the concentration of ozone and time of exposure. And also it's not clear that there is a change between time of sacrifice after last exposure, too. This study was designed to compare the morphological changes in the nasal mucosa in rats exposed to 0.6 and 1.2ppm with different time of exposure and sacrifice after last exposure. We observed infiltration of neutrophils, increased goblet cells, epithelial hyperplasia and ciliary loss in the groups that exposed for 3 and 7days. The degree of changes increased in the groups exposed for 7days than 3days. But there was no difference between the groups sacrificed in immediately and 18hours after last exposure except infiltration of neutrophils. These findings were similar to the groups exposed to 0.6 and 1.2ppm.

백서에서 실험적으로 유발된 알레르기성 비염

나기상,전우진,김용민 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2

The present study was made with the aims of establishing an acceptable nasal allergy model in rats and presenting the basic data for further studies. Eleven Wistar rats were divided into an unsensitized control group (4 rats) and sensitized allergic group (seven rats). The sensitized group were immunized intraperitoneally with ovalbumin-aluminum hydroxide gel solution, followed by intranasal nebulization of ovalbumin. One day later, nasal provocation was performed by nasal instillation of 1% ovalbumin solution. We counted the number of snorting or scratching for 5 minutes after provocation. And we observed general morphology and also examined the number of eosinophil or mast cell in the stained tissue under a light microscope at 400 times magnification. The nasal symptoms and the infiltration of eosinophil or mast cell were significantly increased in allergy group than in control group. In allergy group, loss of cilia or epithelial hyperplasia were noted in some sections. In conclusion, an animal model of nasal allergy was successfully developed in Wistar rats.

Peptidergic Innervation of the Nasal Mucosa

나기상 대한비과학회 1997 Journal of rhinology Vol.4 No.1

Local release of neurotransmitters from autonomic nerve fibers in the nasal mucosa is known to play an important role forthe protection of the lower airways. In addition to classical neurotransmitters, a diverse collection of neuropeptides are found inthe sensory, parasympathetic, and sympathetic nerve fibers and may act as co-transmitters or modulators of effects induced byclassical neurotransmitters. In the nasal mucosa, these neuropeptides are known to regulate the blood flow and content, secretoryactivity, and other epithelial functions and to be involved in the regulation of immunological reactions. There are increasingevidences that neuropeptides may play an important role in the pathophysiologic events in both specific and nonspecific hyperreactivity. Further study on the neuropeptides is needed to clarify the pathophysiologic mechanisms of nasal mucosal hyperreactivity.

만성 비부비동염 환자에서 부비동 내시경수술 후 비음도의 변화

나기상,XU JUN,박지수,박성제,강영애,김용민 대한이비인후과학회 2017 대한이비인후과학회지 두경부외과학 Vol.60 No.3

Background and Objectives The purpose of this study was to examine the effect of endoscopic sinus surgery (ESS) on nasalance in patients with chronic rhinosinusitis (CRS). Subjects and Method Eighty-one CRS patients were enrolled. The nasalance scores for oral, oro-nasal, and nasal passages were measured by nasometry and the nasal cavity volume was measured by acoustic rhinometry before and at 1 and 3 months after ESS. We divided the patients into four groups according to the following surgical interventions employed: unilateral anterior ethmoidectomy (group I), bilateral anterior ethmoidectomy (group II), bilateral total ethmoidectomy (group III), and bilateral pansinus surgery (group IV). We also divided the patients into three groups according to the CT scoring system and polyp grading system. Results In group III and IV, the nasalance scores for all passages and nasal cavity volume were significantly increased after ESS but did not return to its preoperative level at 3 months after surgery. However, there were no significant changes in nasalance scores or in the nasal cavity volume in group I. Similarly, there were no significant changes in nasalance scores in the mild group (CT scoring system) or no polyp group, whereas the nasalance scores were significantly increased postoperatively in the moderate to severe groups (CT scoring system), and in groups that have nasal polyp group. Conclusion The nasalance scores and nasal cavity volumes were increased after ESS and remained unchanged until postoperative 3 months. Postoperative changes in nasalance scores were more remarkable in patients who had more severe disease and who underwent more extensive surgery. Korean J Otorhinolaryngol-Head Neck Surg 2017;60(3):112-9