만성 승모판 패쇄부전증 환자에서의 안지오텐신 전환효소 억제제의 장기 투여 효과

김대희,이명묵,이해영,조현재,박승정,서재빈,서정원,양한모,윤창환,조상호,이준희,김용진,김명아,손대원,오병희,박영배 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

광섬유를 이용한 전류센서의 개발(Ⅲ)

손병기,이정희,김창원 경북대학교 센서기술연구소 1994 연차보고서 Vol.1994 No.-

Fabry-Perot 간섭계 형성기술 및 광 신호처리기술을 기초로 하여, 독자적인 역량으로 광섬유 전류센서를 개발하였다. 또한 미소 압력변화를 감지할 수 있는 고감도 압력센서에 응용하였다. 압전체인 PZT를 이용한 Fabry-Perot 간섭형 전류센서를 제조하였으며, 제조된 전류센서는 20 A까지 선형적인 응답특성을 나타내었다. 또한 전류센서의 특성개선을 위해 주파수가 큰 클럭을 사용하여 감도를 향상시켰다. 광섬유 전류센서시스템 제작에는 Zero-crossing 기법으로 PC와 연결된 간단한 전류센서용 신호처리회로를 제작하였다. 이 시스템에서는 100여개의 데이타를 받아들여 처리할 수 있는 프로그램을 개발하여 전류센서의 신뢰도를 높였다. 신호처리가 손쉬운 optical isolator와 경제적인 면에서 매운 유리한 time division multiplexing법을 이용한 다점측정식 전류센서를 설계하였다. Micro-cavity형 간섭계의 제조 및 특성조사에는 Si_3N_4/SiO_2/Si_3N_4 유전체 다이아프레임 박막을 가지는 광섬유 Fabry-Perot 간섭계를 제조하였으며 압력센서에 응용하였다. The development of fiber optic current sensor was carried out soley at KNU on the basis of the research on the formation technology of Fabry-Perot interferometer and optical system for the third year of the project. Additionally, micro-cavity type was fabricated. The works achieved in this project are expected to contribute to development of the domestic fiber optic sensor technology. The current sensor of the Fabry-Perot interferometric type using PZT plate show good lineality in the current range of 0∼20A. Besides the characteristics of the current sensor were improved by usage of high frequency clock, and fabricated multiple current sensor using the optical isolator and time division multiplexing. In the manufacture of the fiber optic current sensor system, designed of the fiber optic current sensor system with the connection of a new and simple signal processing circuit containing a comparator and counter to PC interface card. The micro-cavity type interferometer using IC process technique have been studied. The fiber optic interferometer with stress-free NON dielectric diaphragm thin film was applied to pressure sensor.

중국 성인여성의 의류착용 태도 특성 연구 : 내의류 및 신발을 중심으로

손희순,위혜정,김은희,강연경 숙명여자대학교 건강·생활과학연구소 2004 生活科學硏究誌 Vol.- No.21

The purpose of this study is to provide fundamental data for body compatibility improvement of Chinese adult female clothing product to domestic ready-made clothing companies as to investigates clothing wearing attitude This is done from June 23 to August 07, 2004. The subjects were 848 female women, age of 19 to 50 participated in this study. They all live in Beijing and Shanghai in China. Data was analyzed by used SPSS/WIN10.0 Program for x^(2)-test, F-test, Duncan-test. The results of this study were as follows: They almost wear brassiere and majority of them put on girdle. Winter inside undergarment above 95% wearing. To going out shoes plentifully the casual shoes, their size were 230~240mm most plentifully. They prefer comfortable shoes with the hoof 2-3cm

중국여대생의 체형연구 Ⅰ

孫喜順,林珣,金孝淑,孫希定,장희경,鄭嶸 服飾文化學會 1999 服飾文化硏究 Vol.7 No.3

This research analyzes characterization and classification of body types for the Chinese women with body measurement values. The measurement has gauged in 1999 in Beijing Institute of Clothing Technology in China. 100 women of the Chinese college women aged 17 and 24 in China were mwasured for this research. In the results of frequency analysis, the tall of Chinese women were 158.37㎝ and also has less than 150㎝ high, and has thick under bust circumference, and has a group of more than 18㎝ for width of nipple to nipple. In the results of factor analysis. Factor 1 represented the degree of abesity, while factor 2 indicated the stature and the arm length. The body types are classified into five types by cluster analysis. The stature and weight varied according to types, leading to a classification focusing on the body size determined by stature and weight factors.

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

약골 골절후 발생된 골수염의 처치의 치험례

이철희,서정식,고말식,손동석,김성국 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.3

With the use of antibiotics and improved dental care, osteomyelitis of the jaw is less common these days. But sometimes the management of osteomyelitis is more difficult because of appearance of resistant organisms to antibiotics. Treatment of the steomyelitis are incision and drainage, closed catheter irrigations, sequestrectomy, saucerization, hyperbaric ocygen therapy, and resection with or without bone graft. We experienced advanced osteomyelitis due to delayed treatment of left mandibular angle fracture. He have medical history of pschysoprenia. We decided to treat the patient with open reduction and closed cather irrigation. We achived reconsolidation of mandibular fracture accompanied by osteomyelitis by complete removal of inflammatory tissues, rigid fixation with miniplate and closed catheter irrigation.

중년 여성의 평상 식이 지방산이 체지방 함량 및 혈중 지질 함량에 미치는 영향

주은정,손희숙,차연수 동아시아식생활학회 1996 동아시아식생활학회지 Vol.6 No.1

The present study undertaken to investigate the interrelationship among their regular dietary fatty acid intake, body fat content(BFC), and plasma lipid fractions(PLF) of middle-aged Korean women. Forty-nine women(age 30 to 49) participated in this study in which the aim was to determine their total nutrient intake per day, BFC and PLF, and to analyse the intercorrelations of these. Strong correlation was seen among their body mass index, mid-upper-arm-circumference, and BFC which were positively correlated with plasma total lipids(TL) and triglycerides(TG). Dietary myristic acid and lauric acid were positively correlated with both total cholesterol(TC) and LDL-cholesterol(LDL-C) in plasma. Palmitic acid, stearic acid, oleic acid, and total monounsaturated fatty acid(MUFA) were negatively correlated with HDL-cholesterol(HDL-C). Although dietary total saturated fatty acid(SFA) was not correlated with TC and LDL-C, it was positively correlated with TL and TG in plasma. However, dieary n-3 polyunsaturated fatty acid(PUFA) in regular Korean diet was not correlated with any of lipid fractions in plasma which might he due to the high ratio of n-6/n-3 in their diet. From the above results, it was concluded that plasma lipid fractions were modulated by their dietary nutrients, especially the types of the fatty acids. Dietary SFA and MUFA intake not PUFA are strongly correlated with LDL-C and HDL-C in the Korean diet. This may relate to the frequency of coronary heart disease in the age group.

20대 빈약 유방여성의 유방형태 조사 연구

조은정,손희순 복식문화학회 2001 服飾文化硏究 Vol.9 No.1

The purpose of this study is to survey women's poor breast shapes depending on their ages and breast types, and thereupon, analyze the differences and correlations among them, and thereby, provide for some basic data useful to the development of the comfortable brassiere which can serve to correct the poor breast. 1. As a result of categorizing the types of schematic breast sides, "type 1" was characterized by medium lower part, greatest protrusion of breast itself, volumed upper part and visible breast outside, while "type 2" be characterized by medium lower part, most flatness, poor upper part, smallest outside size and medium outside, and "type 3" was characterized by least poor lower part, medium protrusion of breast poor upper part, medium outside size, and "type 4" was characterized by poorest lower part, medium protrusion of breast, poor upper part, medium outside size and poorest outside, 2. The breast locations could be categorized depending on breast side types; "type 1" had a higher location of breast than the other types, "type 2" had a lower location of breast except for the nipples than the other types, "type 3" had the lowest location of breast and "type 4" had a comparatively low location of breast but had the highest nipples.

숙명여자대학교 학위예복 디자인 개발에 관한 연구

양숙희,손휘순,박진영,양희영,위혜정 숙명여자대학교 건강·생활과학연구소 2004 生活科學硏究誌 Vol.- No.21

Academic costume is a ceremonial dress represented authority and formality. This indicates a degree in a viewpoint of personality, and symbolizes academic authority and well matched social responsibility. Besides, it emblematizes separately university's identity and tradition, and could be utilized useful culturaltools visualized national culture and tradition. That is to say, academic costume is most effect visual medium, which symbolizes our subjective culture and academic authority and phase. Accordingly, creative academic costume's development is a link of active and positive efforts to be satisfied with various needs of spearhead information society in 21C. Academic costume designing development had been progressed a public opinion survey, theoretical examination, and research on the actual condition through various actual materials. Based on the above examination, this study performs designing development of a bachelor, master, and doctor's academic costumes. Designing development of academic costumes intend to be enlarged and developed academic costume's function as a symbolic cultural tool, which includes Sookmyung women's spirit as a beginningof the racial education. Moreover, this aims at active utilizing of academic costumes as a symbolic medium expressed Sookmyung Women's University's identity, which intends to realization of the racial education establishing women's education, racial identity, and subjectivity, and represents educational objectives planning to the ruling women's bringing up.