정신장애인 치료에 중요 역할 담당자의 정신질환에 대한 태도조사

김병후,정선욱,강연화,김윤,김창엽,홍진표,한오수,조맹제,김용익 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.5

Objectives : Attitudes of families of mentally ill, health personnels and community leaders to the mentally ill after the development and utilization of the community mental health program and reintegration of the chronically ill patients into society. This study was designed to compare the attitudes toward the mentally ill patient of the persons who have important role in treating the mentally ill and to find the variables influencing the attitudes. Methods : We measured attitudes toward mental illness in psychotic patients' families(N=139), community leaders(N=180) and health personnels(N=324) including mental health personnels before the implementation of community mental health services in Yonchon county and Seodaemun district area. The instrument used to measure attitudes was Opinion about Mental Illness(O. M. I.) scale. Results : 1) Health personnel showed lower Authoritarianism(Factor A) and higher Benevolence(Factor B) scores on the average than community leaders and psychotic patients families. 2) Current residence affect the attitudes in psychotic patients' families, not in community leaders and health personnels. Families in urban area showed lower Authoritarianism(Factor A) and Social Restrictiveness(Factor D) and higher Benevolence(Factor B) scores than in the rural areas. 3) Many patient variables were correlated to the attitudes of families. Duration of illness, number of recurrence, number of admission, age of patient and family burden were positively correlated mainly to Social Restrictiveness(Factor D). 4) Sex and religion of respondents showed no or weak relationship with the factor scores. Conclusions : Education for community leaders and families is required to achieve successful community mental health services. Community support program should be developed for chronic, recurrent and burdensome psychiatric patients in the first place.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

한국인에서 8 % Homomenthyl Salicylate 로숀의 광원에 따른 광방어지수의 비교

윤재일 ( Jai Il Youn ),김병국 ( Byoung Kook Kim ),서대헌 ( Dae Hun Suh ),오선진 ( Sun Jin Oh ),김진준 ( Jin Jun Kim ),강세훈 ( Seh Hoon Kang ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.1

Background: The need for using sunscreen is increasing today, but we know little about the effect of sunscreens on the skin of Korean people. Objective : We tried to estimate and compare the SPF of 8% homomenthyl salicylate lotion, which was recommended as the control in SPF experiments by the FDA, USA, in Koreans according to different light sources Methods : After application of 8% homomenthyl salicylate lotion to the back, 33 men of the third decade were irradiated by xenon arc solar simulator or by fluorescent sunlamp, We estimated the SPF of them 24 hours later. Results : The SPF of 8% homomenthyl salicylate lotion was 4.8+0.8 with the solar simulator, 2.7+0.6 with the fluorescent sunlamp. Conclusion : We confimed that the SPF of 8% homomenthyl salicylate lotion with xenon arc solar simulator can be used as a control value in Koreans, and found out that the SPF with the fluorescent sunlamp was significantly lower than that with the xenon arc lamp. So it should be taken into consideration that differences of SPF according to light sources exists in studying sunscreens. (Kor J Dermatol 1996;34(1): 46-51)

The survey of Ornithodoros spp. in western and southern island area in the Republic of Korea

Sun Woo Han,Jeong Byoung Chae,Young Sun Jo,Yoon Kyoung Cho,Jun Gu Kang,Nam Shik Shin,Hee Jeong Youn,Hwa Young Youn,Hyang Mi Nam,Hyun Joo Kim,Hae Eun Kang,Joon Seok Chae 대한수의학회 2017 대한수의학회 학술대회발표집 Vol.2017 No.-

Significant Change of Stress-related Proteins and Gene Profile in the Liver of Long-term Ground Transported Animals

Sun Bo Shim,Se Hyun Lee,Dae Youn Hwang,Chuel Kyu Kim,Bung Guk Kim,Yong Kyu Kim,Seung Wan Jee,Su Hae Lee,Ji Soon Sin,Chang Jun Bae,Byoung Chun Lee,Mi Kyong Jang,Min Sun Kim,Su Youn Yim,Jung Sik Cho,Kab 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.1

The transportation stress cause rise in the levels of many hormones and proteins to maintain homeostasis in the laboratory animals. In order to study whether the stress induced by long-term ground transport could contribute to change in the stress-related protein and profile of stress-regulated gene expression, these factors were detected in the animals between before and after the ground transportation. Herein, it is concluded that; ⅰ) the transported mice significantly exhibited the increase of corticosterone concentration in serum. ⅱ) the heat shock protein 70 (HSP70) in the liver were significantly decreased in the transported animals. ⅲ) 372 and 272 genes were up- and down-regulated, respectively, by stress in the long-term ground transported mice compare to the controls. ⅳ) genes encoding for immunity, signal transduction response and response to protein metabolism were significantly over-represented in the up-regulated group. ⅴ) among the down-regulated transcripts, those encoding for protein metabolism were dramatically over-represented, followed by those related to lipid metabolism and development process. These results suggested that the stress induced by ground transportation could significantly changed the level of stress-indicator hormone, proteins and gene profile in the mice. Therefor, the animal transported a long distance should be had the adaptation period to recover the normal physical state.

Differential Interaction between Selenoprotein M and Apoptosis-Related Proteins in HEK 293 Cell and Transgenic Rat Overexpressing the Human Selenoprotein M

Dae Youn Hwang,Ji Soon Sin,Yong Kyu Kim,Chuel Kyu Kim,Byung Guk Kim,Sun Bo Shim,Seung Wan Jee,Su Hae Lee,Chang Jun Bae,Byoung Chun Lee,Mee Kyung Jang,Min Sun Kim,Su Youn Yim,Jung Sik Cho,Kab Ryong Cha 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.3

Selenoprotein M (SeIM) is a eukaryotic selenoprotein containing one selenocysteine (Sec) and Sec insertion sequence (SECIS) in 3' untranslated regions. In order to examine whether SelM expression and selenium treatment were influenced on expression level of the apoptosis-related proteins, pCMV/hlDE fusion gene were overexpressed in the HEK 293 cell line and hSelM-Tg rat. Herein, it is concluded that; ⅰ) two transgenic mice were identified by PCR analysis using specific primers by screening 28 newborn founder mice, ⅱ) the GFP-hSeIM fusion protein were successfully detected on the protein level in the HEK 293 cell line and hSeIM-Tg rat. ⅲ) it was also observed that p53 proteins were significantly changed in the HEK 293 cell under the condition of hSeIM overexpression and selenuim treatment, while not changed in the kidney tissue of hSeIM-Tg rat. ⅳ) Bax proteins were significantly changed in the kidney of hSeIM-Tg rat under the condition of hSeIM overexpression and sel treatment, while not changed in the HEK 293 cell line. ⅴ) Bel2 proteins in the HEK 293 cell were significantly decreased in the hSeIM transfectants, but hSeIM-Tg rat were shown the different expression patterns in the sel treated condition. These results suggest that selenium treatment and SeIM overexpression were differently influenced the expressions of apoptosis-related proteins in the tumor cell line and transgenic tissue

Phthalic Anhydride Can Induce the Difference on Skin Inflammation and Interleukin-4 Expression in BALB/c, TG2576 and NOD Mice

Chang Joon Bae,Min Sun Kim,Su Youn Yim,Dae Youn Hwang,Cheul Kyu Kim,Byoung Guk Kim,Sun Bo Shim,Seung Wan Jee,Su Hae Lee,Ji Soon Sin,Byoung Chun Lee,Jong Min Woo,Mee Kyung Jang,Kab Ryong Chae 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.1

Allergic disease such as atopic dermatitis, asthma and rhinitis is an immune disease characterized by the skin inflammation and the abnormal expression of cytokines including interleukin. It has been reported that the immune response is differently changed according to a kind of a chemical allergens or an inbred mouse strain. However, in preview studies, there have been no trials to elucidate an allergic response in the chronic diseases model. Thus, the aim of this study was to investigate whether a phthalic anhydride (PA) as chemical allergen would impact on the immonological factors of several disease model such as TG2576 (Alzheimer’s disease model) or NOD (type I diabetes disease model). To accomplish this, the 15% (w/v) PA solution was repeatedly spread on the ear’s dorsum of three types of animals including BALB/c, TG2576 and NOD mice and the ear thickness of them was measured by vernier calipers for 12 days. After treatment, the immune response-related factors were detected in the lymph node of three kinds of mice, respectively. The ear thickness indicating degree of skin inflammation was significantly increased in the TG2576 and NOD mice compared with BALB/c mice. Also, interleukin-4 in auricular lymph node was significantly changed in the disease model mice. These findings suggest that the PA solution as chemical allergen can induce the difference on skin inflammation and interleukin-4 expression as the allergic-related immunological factors among the BALB/c, TG2576, NOD mice.

Kinetics of the 1,3-dipolar Cycloaddition of p-substituted 3-phenylsydnones with DMAD

Youn, Byoung-Hee,Lyu, Hak-Soo,Han, Jee-Hyun,Hahn, Soon-Jong,Kim, Sun-Hwan Korean Chemical Society 1987 Bulletin of the Korean Chemical Society Vol.8 No.4

The kinetics of the 1,3-dipolar cycloaddition of p-substituted 3-phenylsydnones 1a-d with DMAD have been investigated. The reaction rates over a temperature range $100-140^{\circ}C$ were measured by UV spectrometry. The reactions found to be second-order overall, insensitive to the dielectric constants of the solvents, and characterized by a large entropy of activation. These findings are consistent with the rate-determining step involving the formation of cyclic transition state 1 and the reaction proposed to be concerted.

모낭 선종 -1 증례 보고-

이연수,지미경,강석진,김병기,김선무 대한병리학회 1993 Journal of Pathology and Translational Medicine Vol.27 No.1

Korean Association for Clinical Oncology : Slide Session ; P-40 : Hepato-Biliary-Pancreatic Cancer ; Improvement in Locoregional Control with Radiation Dose Escalation for R1 Resected Extrahepatic Bile Duct Cancer

( Byoung Hyuck Kim ),( Eui Kyu Chie ),( Kyu Bo Kim ),( Jin Young Jang ),( Sun Whe Kim ),( Sae Won Han ),( Do Youn Oh ),( Seock Ah Im ),( Tae You Kim ),( Yung Jue Bang ),( Sung W Ha ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: To date, there is a paucity of information regarding optimal radiation dose after microscopic positive (R1) resection in patients with extrahepatic bile duct cancer. This study was conducted to evaluate the impact of radiation dose escalation for R1 resection margin (RM). Methods: A retrospective review was performed on 251 patients who underwent curative resection followed by adjuvant chemoradiotherapy between 1995 and 2009. Eighty-six patients had R1 RM which included invasive carcinoma (n=63) and carcinoma in situ/high-grade dysplasia (n=23). Among them, 54 patients received radiation dose < 54 Gy (range, 40-50.4 Gy) and 32 patients received = 54 Gy (range, 54-56 Gy). Concomitant fi uoropyrimidine-based chemotherapy was administered. Acute and late gastrointestinal (GI) toxicity were evaluated using Radiation Therapy Oncology Group criteria. The median follow-up duration was 27 months for all patients and 92 months for survivors. Results: Radiation dose = 54 Gy was associated with improved locoregional control (LRC) (5yr rate, 73.8% vs. 47.1%, p = 0.038), but not disease-free survival (5yr rate, 43.4% vs. 32.6%, p = 0.427) and overall survival (5yr rate, 40.6% vs. 29.6%, p = 0.393). In multivariate analysis for LRC, R1 with invasive carcinoma (HR 3.31, 95% CI 1.11-9.85, p = 0.032) and radiation dose < 54 Gy (HR 3.09, 95% CI 1.14-8.39, p=0.027) were independent adverse prognostic factors. Between the two dose groups, there was no signifi cant difference in acute GI toxicity =grade 2 and in late GI toxicity =grade 3. Conclusions: The current study demonstrated that radiation dose = 54 Gy was associated with improved LRC in patients with R1 RM and also well tolerated. Therefore, dose escalation could be considered for R1 RM. Prospective study is needed to verify these results.