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루프 분할과 종속함수를 이용한 다중첨자 중첩루프의 종속성 제거 기법
박상일,양황규,윤성대 東西大學校 2001 동서논문집 Vol.7 No.-
In this paper, we propose a new method to parallelize multidimensional subscript loop with non-uniform distance. A loop comprise most of the computation in a program and the most important source of parallelism. Multidimensional subscript within a loop difficult to determine for distance to be required loop dependence elimination. Therefore, we propose new methods that used dependency function to eliminate dependence.
Dae Youn Hwang,Su .lin Seo,Chul Kyu Kim,Yong Kyu Kim,Sun Bo Shim,Seung Wan Jee,Su Hae Lee,Jun Yong Cho,In Surk Jang,Byeong Cheol Kang,Jung Sik Cho 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.1
To determine whether a transgene-based small interfering RNA (siRNA) for insulin and an overexpression of human insulin degrading enzyme (hIDE) decrease the insulin level in transgenic mice, pH1/siRNAinsulin-pCMV/hlDE fusion gene for insulin inhibition were overexpressed in the transgenic (Tg) mice via microinjection. By screening 34 newborn founder mice, three transgenic mice were identified by polymerase chain reaction (PCR) and southern blot analysis using specific DNA. In each tissue of these transgenic mice, high expression of hIDE transcripts was detected both in the liver and muscle. Also, these mice were showed the high level of glucose by glucose tolerance test and high activity of hIDE in liver protein. These results suggest that these transgenic mice for the suppression of insulin secretion by the specific siRNAs and the insulin degradation by an overexpression of hIDE protein may be useful on the study of diabetes-related disease.
Survey on Current Status of Laboratory Animals for Establishing New National Policy
Dae Youn Hwang,Chul Kyu Kim,Yong Kyu Kim,Sun Bo Shim,Seung Wan Jee,Su Hae Lee,Yoon Mi Hwang,Su Jin Seo,Hyun Gu Kang,Jung Sik Cho 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.1
Laboratory animals are critical and fundamental for studying medicine, pharmacy, veterinary medicine, agriculture, nutrition, and environmental and health science. This is also useful for evaluating safety on foods and drugs. The aim of this study was to survey the current situation of the laboratory animals care and use program organization in the institutions of Korea. To do this, a total of 223 institutions having laboratory animals was chosen for search their general current situations on the institution's policy for animal use, the management program, and the environment of animal facility. Herein, the laboratory animals was mainly used in the area of basic science, followed by the teaching and education, the development of biotechnology products, and the safety test of drug. We concluded that the levels of animal care and maintenance were extremely low spite of increasing of animal users, and thereby recognizing necessity of support at the national level.
Dae Youn Hwang,Su Jin Seo,Chuel Kyu Kim,Yong Kyu Kim,Sun Bo Shim,Seung Wan Jee,Su Hae Lee,Ji Soon Sin,Mee Kyung Jang,In Surk Jang,Sang-Koo Lee,Jung Sik Cho 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.2
The selenium (Se) is now recognized as an essential component of various selenoenzymes. To study whether Se treatment affects the endoplasmic reticulum ER stress signaling pathway in the non-obese diabetic (NOD) mice, the indicator protein on the ER stress pathway was examined in the liver of the NOD mice by the western blot analysis. It was observed that Se acted as the insulin-like effects on glucose level in the Se-treated diabetes-susceptible (DS)-NOD mice. Nevertheless, Se treatment activated ER stress signal through the phosphorylation of JNK and eIF2 protein. In conclusion, these results suggest that Se component play an important role in the down-regulation of glucose level and the activation of some intermediate signaling proteins associated with ER stress signal pathway in the NOD mice.