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UVB 에 의한 홍반반응 및 색소반응의 Dose - response Angle과 피부의 자외선 감수성 지표들과의 상관관계에 관한 연구
김병국,박석범,윤재일 ( Byoung Kook Kim,Seok Beom Park,Jai Il Youn ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6
Background: There are many predictors of sensitivity to UVR, but controversies exist about their objectivity, correlation bet,ween them, and applicability to various races. Objective : In 42 healthy volunteers, we assessed the validaty of dose response angle of erythe ma(DRAE) and delayed tanning(DRADT) after UVB irradiation, and also evaluated the correlation hetween dose-response angb s and other predictors of UV sensitivity. Methods : We measured erythema and melanin index using reflectance spectrophotometer aft,er irradiation of UVB on the back of 42 males. When the erythema index and melanin index were plotted against UV doses for each patient, a dose response curve was obtained. Linear regression analysis was used to calculate the slope of those curves for erythema and delayed tanning, which were called DRAE and DRADl respectively. Also we checked predictots of UV sensitivity such as skin type, MED, MMD, consiitutional and facult,ative skin color, then analyzed the relation be tween dose response angles and other predictors. Results : Statistically significa it linear regression lines were obtained from 41 subjects regar d- ing to erythema and frorn 31 subjects regarding to delayed tanning. As for the relationship he tween the pvedictors of UV senitivity, only the MED correlated well with DRAE. Conclusion : We found that dose response angles, especially DRAE, were an objective and adequate predictor of cutaneous LJV sensitivity, but could not find validity of skin type and skin color in Koreans. A more organized study with a larger number of subjects is needed to clarify the usefulness of the predictors. (Korean J Dermatol 1997;35(6): 1177-1183)
지도모양 혀와 균열 혀를 동반한 전신성 농포성 건선 2예
김병국,윤재일 ( Byoung Kook Kim,Jai Il Youn ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2
Generalized pustular psoriasis is a rare disease, even psoriasis involving oral mucosa is very rare. There are many reports of tongue lesions in patients with psoriasis that are clinically and histologically indistinguishable from geographic tongue, and there are many reports of fissured tongue in association with psoriasis. It has been debated whether oral psoriasis exists or not, or occurs as part of generalized pustular psoriasis. We experienced two cases of combined geographic tongue and fissured tongue in patient with generalized pustular psoriasis, and report these cases with review of the literature about the oral lesions in psoriasis, geographic tongue, and fissured tongue. (Kor J Dermatol 1997;35(2): 383-387)
김병국(Byoung Kook Kim),이진학(Jin Hak Lee),박선양(Seon Yang Park),이제환(Je Hwan Lee),양성현(Sung Hyun Yang),서철원(Cheol Won Suh),이재훈(Jae Hoon Lee),김승택(Seung Taik Kim),김은실(Eun Shil Kim),최강원(Kang Won Choe),오명돈(Myung D 대한내과학회 1994 대한내과학회지 Vol.47 No.2
N/A Objectives: We report the results of 11 patients with chronic myelogenous leukemia treated with allogeneic bone marrow transplantation using marrow cells from HLA-identical sibling donors, Methods: Patients with chronic myelogenous leukemia less than 40 years of age were eligible for study entry. Bone marrow donors were HLA-identical siblings. The conditioning regimens consisted of busulfan plus cyclophosphamide or cyclophosphamide plus total body irradiation, and cyclosporin-A was given to pre- vent graft-versus-host disease. Patients were managed in reverse isolation and received oral gut decontamination. Supportive cares such as transfusion and empirical antibiotics were done. Results: Seven patients were male, and four female. Median age was 27 years (range 18-36 years), and nine patients were in chronic phase at the time of transplantation, and two patients in accelerated phase. Donors had a median age of 35 years (range 15-42 years): two were male, and nine female. Median interval from diagnosis to transplantation was 13 months (range 3-26 months). Median duration of severe neutropenia (neutrophil < 0.5 x 10/L) was 20 days (range 16-42 days). Six patients developed grade I-II acute graft-versus- host-disease, mainly involving the skin. Four patients developed chronic graft-versus-host-disease, which mainly involved oral mucosa and skin. Four patients relapsed cytogenetically within 12 months posttransplant. Five patients developed infections within 30 days posttransplant, three had pneumocystis carinii pneumonia after 100 days posttransplant. Six patients were alive after median follow-up of 25 months, and the median leukemia-free survival of all patients was 6 months (range 3.5-75 months). Three patients died from relapse, and two from interstitial pneumonitis. Conclusion: This report confirms high probability of the cure of chronic myelogenous leukemia with allogeneic bone marrow transplantation, especially in chronic phase, and showed milder complications associated with transplantation than previous reports.
김병국 ( Byoung Kook Kim ),윤재일 ( Jai Il Youn ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.1
Annular pustular psoriasis is a rare variant of the generalized pustular psoriasis characterized by subacute onset of annular lesions with pustules on the advancing edge. Compared with the Zumbusch type, annular type is less severe and has a more benign course, and it is known to respond more rapidly to therapy. Histologically, spongiform pustules are seen in the epidermis and discrimination from subcorneal pustular dermatosis may be difficult. We report four cases of annular pustular psoriasis. Two cases were adult female patients who had been given long-term systemic corticosteroid therapy. In the other two patients who were a 9-year-old female and a 10-year-old male respectively, we could not find any provocating factor of pustular psoriasis. There was a past history of psoriasis vulgaris in three cases, although none had any family history of psoriasis. (Kor J Dermatol 1996;34(1): 155-159)
김병국(Byoung-Kook Kim),김용근(Yong-Gun Kim),이호재(Ho-Jae Lee),최대성(Dae-Sung Choi),단진명(Jinmyoung Dan) 대한정형외과학회 2018 대한정형외과학회지 Vol.53 No.6
최근 신체의 다양한 조직과 세포에서 면역과 증식, 분화를 조절하는 기능이 알려진 비타민 D는 정형외과 영역에서는 칼슘과 인 대사에 관여하여 뼈 발육과 성장, 건강한 골격 유지에 필수적인 역할을 하며, 특히 청소년기 비타민 D의 부족은 뼈의 무기질화에 영향을 주어 구조적인 결함을 야기하여 골절의 위험의 증가와 골절 치유에 부정적인 영향을 미친다. 저자들은 여러 부위의 성장판에 연쇄적인 골절이 발생한 13세 소아 환자에서 비타민 D 결핍이 다발 부위의 연쇄적 골절의 가능한 원인으로 확인하였다. 비타민 D 결핍이 골절 발생에 중요한 원인이므로 비타민 D의 투여가 부상에서 성공적으로 회복하고 추가적인 골절을 방지하는 데 중요함을 보고한다. Vitamin D plays a major role in bone metabolism, and its deficiency has an impact on fracture risk and healing. Low vitamin D levels are a cause of poor bone mineralization and have been associated with a significantly higher risk of physeal injury in children. This paper presents a case of a 13-year-old boy with a vitamin D deficiency, who sustained multiple sequential epiphyseal injuries at various areas. This report suggests that vitamin D deficiency is not only a significant cause of the clinical disease itself, but also an important factor affecting the successful recovery of injuries.
Retinoid - 변형 Ingram 법에 의한 건선의 치료효과 및 호전기간
김병국 ( Byoung Kook Kim ),윤재일 ( Jai Il Youn ),장승호 ( Seung Ho Chang ) 대한피부과학회 1996 大韓皮膚科學會誌 Vol.34 No.2
Background: Although treatment with etretinate or modified Ingram method is effective for psoriasis, both regimens have limitations beeause of the risk of long-term toxicity. Objective : We performed retinoid-modified Ingram combination therapy expecting greater therapeutic efficacy and less side effect. Methods : Thirty three plaque-form psoriasis patients were included. Pretreatment with etretinate for 1 to 2 weeks was followed by modified Ingram therapy in combination with etretinate. Results : l. Among 33 patients, clearing was shown in 26 patients(78.8%), 4 patients(12.1%) was improved, and 3 patients(9.1%) showed failure. The number of cleared patient was 13/15 (86.7% ) in moderate group, and 13/18 (72.2%) in severe group. 2. In cleared patients, the mean numbers, duration, and total dose of UVB therapy reaching grade 4 were 11.9, 24.5 days, 1348.5 mJ/cm in trunk, and 13.5, 29.1 days, 1733.3 mJ/cm in extremities. Their differences between trunk and extremities were not statistically significant (p>0.05). 3. In cleared patients, the mean numbers, duration, total dose of phototherapy, and total close of etretinate reaching grade 4 in severe group were not significantly higher than them in moderate group (p>0.05). 4. There were some side effects of etretinate such as cheilitis, dry mouth, and side effects of modified Ingram therapy such as erythema, pruritus. But there was no discontinuation of therapy due to side effect. 5. In 22 patients who were followed up at least,one year, the mean remission time was 14.9 months in moderate group and 6.9 months in severe group. Conclusion : Our study suggests that retinoid-modified Ingram regimen is effective and tolerable in the treatment of psoriasis, especially in severe group. (Kor J Dermatol 1996;34(2): 240-247)
장티브스 및 각종 감염성 질환에서 말초혈청 중성구의 Nitroblue Tetrazolium 색소 환원에 관한 연구
김병국 ( Byoung Kook Kim ) 대한내과학회 1973 대한내과학회지 Vol.16 No.1
This present study was performed to evaluate the linical usefulness of the NBT test and to take any preliminary information abut the mechanism of neutrophilic phagocytosis through this test, in 150 cases with healthy normal population and various infectiou