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        • KCI등재

          나와 생을 같이한 구강병리학 Ⅳ

          임창윤 대한구강악안면병리학회 2013 대한구강악안면병리학회지 Vol.37 No.6

          It is well known that oral pathology is an essential bridge between basic and clinical science in dental field. Although oral pathology has been introduced to Korean dental science since 1945, there is not yet presented about oral pathologic history. The purpose of this study are to summarize and to introduce Korean oral pathologic history in serial form for Korean oral pathologists.

        • KCI등재

          抗癌白朮散의 抗癌 및 抗轉移 效果에 關한 硏究

          李錫雨,金聖勳 대한동의병리학회 1996 동의생리병리학회지 Vol.10 No.2

          現在 大田大韓方病院에서 癌治療에 이용되고 있는 消積白朮散보다 有效한 抗癌 및 抗轉移 效果를 나타내며, 抗癌劑의 副作用을 抑制할 수 있는 새로운 韓方處方 開發을 위한 努力으로 抗暗性이 認定된는 4가지 藥物을 消積白朮散에 加味하여 抗癌 및 抗轉移 實驗을 施行하였다. in vitro에서 B16-Fo, A549 및 SUN-1등의 癌細胞에 대한 細胞毒性, A549 癌細胞에 대한 附着沮止效果, protein kinase C 沮害作用을 살펴보았고, in vivo에서는 S-180을 腹部로 移植한 후 生存比, 血液學的 變化를, B16-Fo 癌株를 尾靜脈에 移植하고 pulmonary colonization assay, 臟器의 病理組織變化 및 血液學的 變化 등을 檢討하였다. A549, B16-Fo, SNU-1, S-180 細胞에 대한 in vitro, in vivo 實驗에서 抗癌效果가 認定되었고, 癌株에 대하여서는 SNU-1, A549, B16-Fo 등의 順序로 特異한 抗腫瘍 效果를 보였으며, 抗轉利實驗으로 實施한 Protein Kinase C 活性沮害作用 및 動物組織檢事에서도 有效한 抗轉移 效果를 나타냈다. For the development of more effective new anti-cancer perscription, antitumor and antimetastatic effect of hangambaekchulsan(HBS) was evaluated experi-mentally and results were obtained as follows: 1. The concentration inhibiting cell growth below 55% was 10-3g/㎖ of HBSB against B16-Fo, 10-3g/㎖ of HBS and HBSB against A549 and 10-3g/㎖ of HBS, 10-³g/㎖∼10-⁴g/㎖ of HBSB against SNU-1. 2. HBS and HBSB acted specifically on the cancer cells of SNU-1, A549 and B16-Fo in order. 3. Medicinal herbs inhibiting cell growth such as B16-Fo, A549 and SNU-1 up over 30% were Orostachys Herba, Lonicerae Flos, Taraxaci Radix, Pinelliae Rhizoma, Scutellariae Radix, Curcumae Radix, Lithospermi Radix, Oldenlandiae diffusae Herba. 4. Over 50% inhibition of protein kinase C was shown in 125㎍/㎖ HBS and HBSB, Orostachys Herba, Lonicerae Flos, Lithospermi Radix, Coicis Semen, Aurantil nobilis Pericarpium. 5. Weight of B16-Fo tumor was significantly inhibited in HBS and HBSB treated groups as compared with control data and T/C % to S-180 was 136% and 147% respectively. 6. Number of platelet was significantly in HBS and HBSB treated groups, but platelet aggregation was significantly inhibited only in HBS treated group. 7. Over 50% inhibition of cell adhesion of A549 was 10-³g/㎖ of HBS and HBSB, Lonicerae Flos, Taraxaci Radix, Oldenlandiae diffusae Herba. 8. HBS and HBSB significantly inhibited pulmonary colonization as compared with control data. 9. In pathohistological changes HBS and HBSB inhibited the metastasis of B16-Fo as compared with control but HSBS was more effective. From the above results HBS had antitumor and antimetastatic effects in dose-dependent manner, which suggests that HBS can be clinically applied to cancer patients.

        • KCI등재

          人蔘抽出液이 Mitomycin C의 細胞毒性에 미치는 影響

          田炳薰,鄭遇悅 대한동의병리학회 1996 동의생리병리학회지 Vol.10 No.2

          人蔘의 抗癌效果는 癌細胞의 動物移殖에 대한 實驗, 化學的 發癌原에 의한 六種에 대한 效果, 培養한 腫瘍細胞등에 대한 實驗에서 많이 調査되었다. 人蔘에 대한 많은 硏究가 있었으나 腹腔內주사나 in vitro 모델등에서 實施한 것이었고, 경구투여를 통한 實驗은 거의 없었다. 한편 正常細胞에는 損傷을 주지않고 오직 癌細胞만을 살상하는 抗腫瘍成藥物은 아직까지 開發되지 않았다. 따라서 抗腫瘍成藥物의 抗腫瘍效果를 上昇的으로 增進시키고 副作用을 줄이는 藥物의 開發은 切實한 것이다. 때문에 본 論文에서는 Ehrlich carcinoma의 solid tumor와 ascites tumor에 대한 人蔘抽出物의 抗腫瘍效果를 觀察하였다 人蔘抽出物이 抗癌化學療法劑인 MMC의 抗腫瘍效果를 增加시킬 수 있는가를 살피고, 腫瘍細胞로의 MMC의 uptake, 腫瘍細胞의 lysosomal enzymes에 대한 活性 및 MMC의 細胞毒性에 어떠한 效果를 나타내는 가를 觀察하였다. 結論的으로 人蔘抽出物과 MMC를 병용투여하였을 때 ascites tumor에 대한 抗腫瘍效果가 나타나는 것은 적어도 部分的으로는 人蔘抽出物의 lysosmal lalbilizing action에 기인한다고 생각된다. 人蔘抽出物과 MMC를 병용投與한 in vivo 實驗에서 人蔘抽出物이 MMC의 腫瘍細胞內로의 浸透를 增加시켜 MMC의 細胞毒性效果를 강하게 하는 것으로 생각된다. 이러한 結果로부터 人蔘抽出物이 현저한 抗腫瘍效果가 없다고 할지라도 人蔘抽出物이 MMC의 效果를 亢進시키는 것으로 생각된다. 앞으로 MMC의 副作用에 대한 人蔘抽出物의 효과와 人蔘抽出物의 활성기전에 대한 硏究가 계속되어야 할 것으로 생각된다. The influence of the ethanol extract from Korean Red Ginseng(KRG) on the lysosome of tumor cells and on the cytocidal effect of mitomycin C(MMC) was investigated. KRG treatment showed an inhibitory effect on the solid form of Ehrlich ascites carcinoma but had no effect on the ascites form. Mitomycin C combined with RME showed stronger antitumor effects at the same time, the activity of lysosomal enzymes in tumor cells was also increased in comparison with that treated with MMC alone. Furthermore, KRG promoted the uptake of MMC into the tumor cells and enhanced in vitro the cytotoxicity of MMC against the cultured tumor cells. From these results it was concluded that KRG labilized the lysosomes of tumor cells in vivo, and increased the uptake if MMC into the tumor cells, and that the cytocidal effect of MMC was enhanced by concomitant treatment with KRG.

        • KCI등재

          脈象形成에 對한 基礎的 硏究

          安圭錫,朴鍾鉉 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-

          연구배경 : 맥진은 고대로부터 장기간에 걸쳐 임상경험을 통하여 축적되고 체계화 되어 이루어진 진단법으로, 한의학의 변증시치에 있어서 필수불가결한 객관적 근거로 인정받고 있다. 맥상을 분석하여 인체에서의 상황을 판단하려면 맥현상에 대한 기본적인 이해가 선행되어야 할 것으로 보여 맥상 형성에 대한 기초적 연구를 하고자 하였다. 방법 : 맥에 대한 한의학 문헌을 근거로 하고, 이를 물리학적인 혈류역학측면에서 맥상의 형성원리, 맥형성의 구성요소 및 맥상과 내외부 환경과의 관계에 대하여 연구 하였다. 결과 : 맥은 파동이며 인체 내부의 기가 맥이라는 파동의 형태로 변이되어 표출되는 간접적 반응이다. 맥상은 심장, 혈관, 혈액의 구조적 요소에 맥기의 기능적 요소가 결합하여 표현되는 것이며, 이 사자는 외내적 환경에 대한 구체적 표현이다. 결론 : 맥은 인체내외의 환경에 대한 인체내부 기의 구체적 표현이며 파동의 형태로 변이되어 표출되므로 맥진시에는 이러한 점을 염두에 두어야 할 것으로 판단된다.

        • KCI등재
        • KCI등재

          痲醉有無에 따른 章門·期門穴의 鬱金藥針이 高脂肪性 食餌로 因한 高脂血症 白鼠에 미치는 影響

          朴元煥 대한동의병리학회 1999 동의생리병리학회지 Vol.13 No.1

          動物性 脂肪攝取量의 增加, 運動不足, 肥滿, 스트레스의 加重, 高齡化의 增加 等의 原因으로 循環器系疾患의 發病率이 증가하고 있으며, 이러한 循環器系疾患의 危險因子로서 高脂血症이 重要하게 대두되고 있다. 韓醫學에서는 高脂血症이란 痰證을, 心悸, 眩暈, 眞心痛, 頭痛, 뇌비, 中風 等의 誘發因子로 歸屬시킬 수 있으며, 高脂血症을 誘發하는 原因으로 痰濁, 瘀血, 氣滯血瘀등과 腎虛, 脾腎虧虛, 肝腎陰虛, 脾胃濕熱 等을 言及하여 臟腑의 精氣가 虛衰한 狀態에서 飮食不節이나 肥甘厚味한 飮食을 지나치게 섭취하거나, 好坐好靜이나 七情勞傷 等의 病機에 依한 正虛邪實症으로 辨證할 수 있다. 高脂血症과 關聯하여 본 著者는 痰飮과 瘀血의 相關性 下에서 痰飮의 한 病態模型으로서 이를 硏究한 바 있으며, 高脂血症에 關한 臨床的 硏究로는 活血, 祛瘀 및 化痰을 爲主로 하는 治法을 設定하였으며, 이중 藥針療法의 實驗的 硏究도 꾸준히 계속 되고 있다. 藥針 療法은 經絡을 이용한 針治療 作用과 注射 療法을 통한 藥物의 藥理 作用을 결합한 것으로 穴位, 鍼刺, 藥物을 결합한 독특한 치료 방법인데, 이러한 藥針의 作用인 穴位, 針刺, 藥物作用중 '針刺'에 대한 자극반응을 느낄 때와 느끼지 못할 때 나타날 수 있는 藥針의 反應에 대한 硏究는 매우 유익하리라 생각되었다. 실험실에서 제작한 高脂肪性固形飼料를 rat에 자유섭취시키면서, 실험 동물에 대한 痲醉與否에 다라 針刺에 대한 痛覺的 刺戟을 조절하면서, 高脂肪性食餌 高脂血症病態白鼠에 Curcuma aromatica을 藥針製劑로 하여, 期門穴과 章門穴에 鬱金藥針을 시술한 후 白鼠의 血淸 및 肝組織液內의 total cholesterol, triglyceride, HDL cholestrol 等의 含量變化 및 血漿中 fibrinogen, PT, PTT, viscosity 등의 變化를 觀察하였다. 藥針이 經穴에 적용될 때 鍼刺戟에 대한 작용과 약물에 대한 효과를 비교하고, 藥針의 작용기전에 대하여 조금이나마 이해를 하기 위하여 본 실험에 착수 하였으나, 특정 병태 동물(흰쥐)에 특정 經穴과 특정 藥針液을 사용한 까닭으로 실험적 한계를 벗어날 수 없었으며, 본래 의도하였던 목적에는 많은 부족함을 느끼게 하였다. 하지만 이번 실험을 통하여 특정 藥針의 특정 병태에 대한 그 작용기전을 연구 할 수 있었던 점과 계속적으로 이에 대한 연구에 관심을 가질수 있었다는 데에 작은 보람으로 생각되며, 앞으로 더욱 체계적이고 심도있는 연구가 진행되어야 할 것으로 사려된다. Diet is the fundamental condition for human beings to live in good health. An improper diet can affect the physiological functions of the viscera and reduce the organism's resistance to disease. Thus becoming pathogenic factors. In particular, a heavy and fatty diet can increase opportunity for adults to become infected by diseases. Blood lipids are composed of cholesterol, triglyceride, phospholipid and free fatty acids. Hyperlipidemia implies the increased levels of cholesterol and triglyceride in the plasma. It is closely related to atherosclerosis. As blood lipids are transported in the form of lipoprotein, hyperlipidemia can also manifest itself as hyperlipoproteinemia, Hyperlipidemia is included in the categoreis of "xuan you"(vertigo), "tan zhuo"(phlegm syndrome) and others in Oriental medicine. Retention of phlegm-fluid is pathological products in the body, which manifest themselves through the course of illness. When retention of phlegm-fluid developes, it can act directly or indirectly, effect certain tissues or organs in the human body. Thus, causing new pathological changes, and forming various syndromes. Therefore it become also a group of pathogenic factors. In oriental medicine differentiation and treatment of hyperlipidemia are divided into deficiency of the Liver-yin, Kidney-yin and retention of Damp-heat in the Interior. Therapeutic principle of deficiency of the Liver-yin and Kidney-yin is nourishing the liver-yin and kidney-yin. Therapeutic principle of retention of Damp-heat in the Interior is eliminating pathogenic dampness and heat. This study is in order to investigate the effect of Curcuma aromatica aqua-acupuncture in narcosis and non-narcosis. Aqua-acupuncture treatment is composed of acupuncture-treatment and herbal drugs' action. Acupuncture-treatment is known as using by the physiological function of the Channels and Collaterals, pathological changes, induction, transmission and regulation. The channels induce stimulation and transmit information. If some region of the human body is stimulated, such stimulation will be transmitted along the channel to the reated viscera or bowels in the body. As a result, the relevant physiological or pathological changes take place. These changes are reflected on the body surface through the channels. Especially, indications of the Live Channel are stuffiness and pain in the costal regions, stuffiness in the chest, pain in the lower abdomen, hernia, pain in the top of the head. And indications of Zhangmen(LR13) and Qimen(LR14) are vomiting, diarrhea, abdominal distention, costalgia, chest pain and pain in the hypochondriac region. Curcuma aromatica is used to relieve pain by regulating the circulation of vital energy for the treatment of pains in chest, abdomen or costal regions due to stagnation of vital energy and blood, such as the pain of liver area due to hepatitis, as a cholagogue for the treatment of hepatogenic jaundice. Material and methods are as a follows. Rats(sprague dawley) were divided into 4 groups. The first, normal group is physiological normal state. The second, control group is not treated aqua-acupuncture as high lipid solid feed-treated group. The third, test 1 group is treated high lipid solid feed and Curcuma aromatica aqua-acupuncture in non-narcosis. The forth, test 2 group is treated high lipid solid feed and Curcuma aromatica aqua-acupuncture in narcosis. Hyperlipidemia was induced in male rats by high lipid solid for 20 days. Curcuma aromatica aqua-acupuncture was treated to both groups in narcosis and non-narcosis every two days in the points corresponding to Zhangmen(LR13) and Qimen(LR14) in human body. So, each of this groups were compaired and assessed by measuring the levels of total cholesterol, HDL and triglyceride in serum and liver tissue-solution, and measuring the levels of fibrinogen, prothrombin time, partial thromboplastin time and viscosity in plasma. As a result, we can conclude as follows; 1. The level of serum total cholesterol was decreased with the significance in the test 1,2 groups. and the level of liver tissue-solution total cholesterol was decreased with the significance in 10,20days of the test 1 group as compared with the control groups. 2. The level of serum HDL cholesterol was increased with significance in 20 days of test 2 group. and the level of liver tissue-solution HDL cholesterol was increased but there was not significance as compared with the control groups. 3. The level of serum triglyceride was decreased with significance in 10,20 days of test 1 group and 20 days of test 2 group. and the level of liver tissue-solution triglyceride was decreased with significance in 10,20 days of test 1 group and 10 days of test 2 group as compared with Control group 4. The level of plasma fibrinogen was increased with significance in 10 days of test 1 group 5. The level of plasma prothrombin time was increased in 10 days of test 1,2 group as compared with Control group. 6. The level of plasma partial thromboplastin time was increased in 10,20 days of test 1,2 group as compared with Control group. 7. The level of plasma viscosity was decreased with significance in shear rate 4.5 of 20 days of test 2 group as compared with the control groups. It is considered that Curcuma aromatica aqua-acupuncture at Zhangmen(LR13) and Qimen(LR14) in non-narcosis had a noticeable therapeutic effect on the hyperlipidemia induced by high lipid solid diet in male rats. So its can be can be applied as effective prvention and therapy for disturbance of lipid metabolism induced hype lipid diet, hyperlipidemia and atherosclerosis induced disturbance of lipid metabolism.

        • KCI등재

          少陰人補中益氣湯과 少陰人補中益氣湯加味方의 抗癌效果 및 Cyclophosphamide 에 의한 副作用減少에 미치는 影響

          郭桂豪,金聖勳 대한동의병리학회 1996 동의생리병리학회지 Vol.10 No.2

          最近에는 韓藥劑를 利用한 抗癌治療와 化學療法 및 放射線療法의 副作用 減少에 대한 硏究가 活潑히 進行되고 있는 實情이다. 이중 生體의 免疫機能으 增進시키는 것으로 알려진 扶正爲主의 治療法은 西洋醫學에서의 短點을 補完할 수 있어, 本 論文에서는 少陰人 體質의 代表的인 處方중 하나인 少陰人補中益氣湯을 이용하여 少陰人補中益氣湯과 抗癌性이 認定되는 白花蛇舌草와 魚腥草를 加味한 少陰人補中益氣湯加味方의 抗癌效果 및 抗癌劑에 의한 副作用에 減少에 미치는 影響을 探索하여 癌 治療에 도움이 되고자 한다. in vitro에서 B16-Fo과 A549에 대한 細胞毒性效果, B16-Fo과 A549 및 SNU-1에 대한 ED50값, A549에 대한 細胞附着 沮止作用을 觀察하였고, in vitro에서 C57BL/6系와 ICR系에 sarcoma-180을 移植한 후 體重變化, 生命延長율, 腫瘍 미 脾臟의 重量 變化, PFC(plaque forming cell)數, 血液學的 變化, LI-2(interleukin-2)의 生産能 變化 및 FACS에 이한 免疫細胞 變化 등을 觀察하였으며, cyclophosphamide로 副作用을 誘發한 후 脾臟과 肝臟의 重量 및 血液 變化 등을 觀察하였다. in vitro에서 B16-Fo, A549癌株에 대하여 유효한 항종양 효과가 인정되었고, A549癌株에 대한 細胞附着沮止는 SBT-Ⅲdml 10-3g/㎖가장 顯著하였다. S-180에 의한 동물실험에서도 有意性있게 抗腫瘍 效果가 認定되었으며, PFC數, IL-2의 生産能, T cell, B cell수에서도 유의성있는 增加를 나타내었고, Cyclophosphamide의 副作用에 대한 影響에 있어 GOP活性度는 모든 實驗群에서, GPT活性度는 SBT, SBT-Ⅱ 및 SBT-Ⅲ에서, BUN含量은 SBT-Ⅲ에서, creatinine含量은 SBT-Ⅱ와 SBT-Ⅲ에서 有意性있게 減少하였다. In order to prove in effects of Souminbojungikgitang(SBT) & Souminbojungikgitangkamibang(SBT-Ⅰ, SBT-Ⅱ and SBT-Ⅲ) on the anticancer activity and the reduction of side effect by cyclophosphsphamide experimentally, the following studies were done. The results were obtained as follows: 1. The concentration which showed the cytotoxicity against B16-Fo below 55% was 10-3g/㎖ of SBT-Ⅱ and SBT-Ⅲ groups. 2. The concentration which showed the cytotoxicity against A549 below 55% was 10-3g/㎖ of SBT-Ⅰ and SBT-Ⅲ groups. 3. The values of ED50 below 100㎍/㎖ were showing in SBT-Ⅱ and SBT-Ⅲ groups against B16-Fo, in SBT-Ⅰ, and SBT-Ⅲ groups against A549, and in all groups against SNU-1. 4. The inhibitory effect of cell adhesion to A549 was showing in all groups and SBT-Ⅲ was most effective. 5. The change of bodyweight was significant in all groups, the tumor weight was was significantly in SBT-Ⅰ, SBTⅡ and SBT-Ⅲ groups. 6. Survival time was significantly extended in all groups and T/C was 123% in SBT group, 130% in SBT-Ⅰ group, 132% in SBT-Ⅱ group and 141% in SBT-Ⅲ group. 7. The number of PFC was significantly increased in SBT-Ⅰ, SBTⅡ and SBT-Ⅲ groups. 8. The number of platelet in SBT-Ⅰ, SBT-Ⅱ and SBT-Ⅲ groups, and platelet aggregation in SBT-Ⅱ and SBT-Ⅲ on C57BL/6 intraperitoneally with sarcoma-180 and in all groups on ICR subcutaneous with sarcoma 180 were significantly increased. 9. IL-2 were increased in 100% concentration of all groups, in 50% concentration of SBT, SBT-Ⅱ and SBT-Ⅲ groups and 25% concentration of all groups. 10. T cell in all concentration of all groups, B cell in all concentration of SBT-Ⅰ, macrophage in all concentration of SBT, SBT-Ⅱ and SBT-Ⅲ groups were increased. 11. Side effects induced by cyclophosphamide, GOT in all groups, and in SBT, SBT-Ⅱ and SBT-Ⅲ groups, and the amount of BUN in SBT-Ⅲ groups, and creatinine in SBT-Ⅱ and SBT-Ⅲ groups were significantly reduced. According to the above results, it can be conducted that Souminbojungikgitang and Souminbojungikgitangkamibang have anticancer effects and are effective in reducing side effects induced by cyclophosphamide, SBT-Ⅲ it were more effective, therefore it can be studied applied clinically and had better be more in future.

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