원저 : 집단치료를 통한 비만환자의 체중감량이 삶의 질에 미치는 영향

강준구 ( Joon Gu Kang ),이창범 ( Chang Beom Lee ),이혜순 ( Hye Soon Lee ),배상철 ( Sang Cheol Bae ),최웅환 ( Woong Hwan Choi ) 대한비만학회 2005 The Korean journal of obesity Vol.14 No.3

연구배경: 집단치료를 받고 있는 비만환자에서 체중 감량을 하였을 때 나타나는 삶의 질 변화를 수량화된 척도로 알아보고자 이 연구를 시행하였다. 방법: 2003년부터 2004년까지 한양대학교 구리병원 내분비내과에서 체중감량 치료 방법에 동의한 9명의 환자를 대상으로 조사하였다. 체중감량의 목표는 첫 내원시 체중의 10%로 정하였다. 건강관련 삶의 질 측정도구(Health-related quality of life instrument)를 치료 시작 전과 후에 측정하였다. 일반적 건강 프로필로서 건강 관련 삶의 질을 측정하는 KSF-36 (Korean Medical Outcomes Study 36-Item Short Form)을 사용하였다. 결과: 1. 대상환자의 임상적 특성과 비만 치료 전후의 변화 연구대상 환자 9명은 모두 목표 체중감량에 성공하였다. 개별적 특성은, 전원 여성이었고 전체 환자의 평균값은 연령 59.3±2.0세, 신장 160.0±9.1㎝, 체중 70.9±2.0㎏, BMI 28.8±0.9㎏/㎡이었다 (Table 1). 20주간의 식사요법, 운동요법, 약물요법, 행동그룹치료 후 체중 63.6±2.9㎏ (P<0.05), BMI 25.9±1.1 ㎏/㎡ (P<0.05)로 감소하였다. 2. 건강관련 삶의 질 측정 비만환자의 평균 KSF-36 전반적 건강값 (Global)은 49.43±5.25 (38.8~56.4)에서 57.62±8.10 (50.3~65.8)로 수치상의 증가만을 보이나 체부 통증 (bodily pain)이 36.25±21.34 (30~70)에서 33.75±13.03 (20~50)로 (P<0.05), 정신적 건강 (mental health)이 47.50±20.33 (16~84)에서 62.00±10.69 (48~80)으로 (P<0.05)으로 향상되었다. 결론: 집단치료를 받고 있는 비만환자에서 체중 감량을 하였을 때 삶의 질 향상을 가져올 수 있음을 알 수 있었다. 그러므로 앞으로 더 많은 숫자의 환자를 대상으로 한 대규모 연구가 필요할 것으로 생각된다. Background: This study was to exam the effect of weigh reduction after group therapy on the quality of life of patients with obesity. Methods: The participants of this study were 9 women with obesity who visitied the Hanyang University Hospital Obesity Clinic. Data were collected for 2 years from 2003 to 2004. Weight, height, abdominal circumference, and BMI were measured before and after group therapy which consisted of medical and behavior therapy. And also KSF-36 (Korean Medical Outcomes Study 36-Item Short Form) was used as a Health-related quality of Life instrument. Results: In use of KSF-36, Global score before and after treatment showed no significant change (49.43±5.25 (38.8~56.4) vs 57.62±8.10 (50.3~65.8)) but bodily pain (36.25±21.34 (30~70) vs 33.75±13.03 (20~50), P<0.05) and mental health (47.50±20.33 (16~84) vs 62.00±10.69 (48~80), P<0.05) showed significant changes. Conclusion: According to the result of this study, in group therapy of patients with obesity, weigh reduction improved the quality of Life.

Characterization of changes in global gene expression in the brain of neuron-specific enolase/human Tau23 transgenic mice in response to overexpression of Tau protein.

Woo, Jong-Min,Park, So Jung,Kang, Ho Il,Kim, Byoung Guk,Shim, Sun Bo,Jee, Seung Wan,Lee, Su Hae,Sin, Ji Soon,Bae, Chang Joon,Jang, Mee Kyung,Cho, Chunghee,Hwang, Dae Youn,Kim, Chuel Kyu D.A. Spandidos 2010 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.25 No.5

<P>Tau is a neuronal phosphoprotein responsible for the formation of the neurofibrillary tangles in Alzheimer's disease. To characterize the changes in global gene expression in the brain of transgenic mice that overexpress human Tau23 protein in response to the increase of Tau23 phosphorylation, total RNA extracted from the hippocampus of 12-month-old transgenic and wild-type mice was converted to cDNA, labeled with biotin and hybridized to oligonucleotide microarrays. The microarray results were confirmed by real-time RT-PCR and Western blotting method. It was determined that 43 genes were up-regulated and 8 genes were down-regulated by Tau23 in transgenic mice compared to controls, based on the arbitrary difference in the 2-fold change. Among the up-regulated transcripts, those encoding for transporter and oxidoreductase were dramatically over-represented, followed by those related to regulatory molecule, cytoskeletal protein, signaling molecule, and extracellular matrix protein. Genes encoding for transcription factor, regulatory molecule, miscellaneous function, and chaperone were significantly reduced in the down-regulated group. The major genes in the up-regulated categories included Ecrg4, Folr1, Defb11, Aqp1 and Soctdc1. The major genes in the down-regulated categories were Ncor1, Gpm6a, and Hspd1. These results indicate that the microarray analysis identifies several gene functional groups and individual genes that respond to a sustained increase in Tau23 phosphorylation levels in the brain of transgenic mice. In addition, the results suggest the microarray test is a useful tool for increased understanding of the role of Tau23 protein in regulating neurodegenerative disorders.</P>

상황 인지 기반 스마트폰 일정 관리

안형배,변상희,박한솔,이홍창,이명준,An, Hyeng-Bae,Byun, Sang-Hee,Park, Han-Sol,Lee, Hong-Chang,Lee, Myung-Joon 한국정보통신학회 2012 한국정보통신학회논문지 Vol.16 No.3

Smartphone schedule management applications are widely used in mobile environment with the help of their effective user interface and high user accessibility. Unfortunately, since the applications do not consider frequent context changes like user status or location, they can not support schedule management which reflects the changes. In this paper, we propose an intelligent notification service which gathers context information of users such as location and status, and actively provides appropriate services according to the context information. Based on the notification service, we also present a smartphone application for smart schedule management. Using the GPS sensor of a smartphone, the service can be aware of the status of the user through location and schedule information of the user. Also, according to the changed contexts, it provides proactive notifications to user. 스마트폰의 일정 관리 어플리케이션은 모바일 환경에서도 효과적인 사용자 인터페이스와 높은 사용자 접근성을 바탕으로 널리 사용되고 있다. 하지만 빈번히 변경되는 사용자의 상태나 위치 등의 상황 정보를 고려하지 않기 때문에 변화된 상황을 반영한 일정관리를 지원하지 못하고 있는 실정이다. 본 논문에서는 사용자의 상황 정보를 수집하여 이에 따른 적합한 서비스를 능동적으로 제공하는 지능형 알림서비스를 제안한다. 또한 지능형 알림서비스를 기반으로, 스마트 일정 관리를 지원하는 스마트폰 어플리케이션을 개발한다. 지능형 알림서비스는 스마트폰의 GPS 센서를 이용하여, 위치나 일정 정보에 따른 사용자의 상태를 인지하고 변화된 정보를 바탕으로 사용자에게 능동적인 알림을 제공한다.

Overexpression of Insulin Degrading Enzyme could Greatly Contribute to Insulin Down-regulation Induced by Short-Term Swimming Exercise

Min Sun Kim,Jun Seo Goo,Ji Eun Kim,So Hee Nam,Sun Il Choi,Hye Ryun Lee,In Sik Hwang,Sun Bo Shim,Seung Wan Jee,Su Hae Lee,Chang Joon Bae,Jung Sik Cho,Jun Yong Cho,Dae Youn Hwang 한국실험동물학회 2011 Laboratory Animal Research Vol.27 No.1

Exercise training is highly correlated with the reduced glucose-stimulated insulin secretion (GSIS), although it enhanced insulin sensitivity, glucose uptake and glucose transporter expression to reduce severity of diabetic symptoms. This study investigated the impact of short-term swimming exercise on insulin regulation in the Goto-Kakizaki (GK) rat as a non-obese model of non-insulin-dependent diabetes mellitus. Wistar (W/S) and GK rats were trained 2 hours daily with the swimming exercise for 4 weeks, and then the changes in the metabolism of insulin and glucose were assessed. Body weight was markedly decreased in the exercised GK rats compare to their non-exercised counterpart, while W/S rats did not show any exercise-related changes. Glucose concentration was not changed by exercise, although impaired glucose tolerance was improved in GK rats 120 min after glucose injection. However, insulin concentration was decreased by swimming exercise as in the decrease of GSIS after running exercise. To identify the other cause for exercise-induced insulin down-regulation, the changes in the levels of key factors involved in insulin production (C-peptide) and clearance (insulin-degrading enzyme; IDE) were measured in W/S and GK rats. The C-peptide level was maintained while IDE expression increased markedly. Therefore, these results showed that insulin down-regulation induced by short-term swimming exercise likely attributes to enhanced insulin clearance via IDE over-expression than by altered insulin production.

유포변경 간헐폭기식 침전지내장형 산화구시스템에 의한 하수의 탈질,탈인

장덕,홍기호,허준무,한상배 대한상하수도학회 2003 상하수도학회지 Vol.17 No.1

Phased isolation intrachannel clarifier ditch system devised in this study is an innovative biological nutrient removal system employing two ditches with intrachannel clarifiers and eliminating external per-anaerobic reactors and recycle of sludge and treated effluent. The performances of the system were evaluated through a long term pilot-scale experiments. The system operated at hydraulic retention times of 10-21hours and solids retention times of 16-36days showed removals of biochemical oxygen demand, total nitrogen, and total phosphorus in the range of 90-99%, 64-93%, and 63-98%, respectively, at the mixed liquor temperature above 10℃. The solids retention time played a relatively important role among the operational parameters of the system. As the solids retention time became longer, the effluent total nitrogen decreased dramatically, whereas the effluent total phosphorus increased. Optimal system operating strategies maximizing phosphorus release and its uptake as well as nitrification and denitrification satisfying both the best nitrogen and phosphorus removals included hydraulic retention times ranged 10-14hours and solids retention times ranged 20-25days. The phase separation in a cycle maximizing the performance of the system was completely accomplished by scheduling of alternating flow and intermittent aeration in a simplified process scheme. Especially, temporal phase separation for phosphorus release without additional anaerobic reactor was successfully accomplished during anaerobic period without any nitrate interference and carbon-limiting. The phased isolation ditch system with intrachannel clarifier developed in this study was, therefore, believed to be a simplified and improved option to solve the problems in the existing biological nutrient removal technologies.

FEM을 이용한 GMA 용접공정의 비드형상 모델링

박창언,김일수,장영호,정영재,손준식,배수연 木浦大學校 工業技術硏究所 1997 工業技術硏究誌 Vol.7 No.-

Over the last few year, there has been a growing interest in quantitative representation of heat transfer phenomena in weld pools in order to relate the processing conditions to the quality of the weldment produced and to use this information for the optimisation and robotization of the welding process. Normally, a theoretical model offers a powerful alternative to check out the physical concepts of the welding process and to calculate the effects of varying any of parameters. To solve this problem, a transient 2D(two-dimensional) heat conduction model were developed for determining weld bead geometry and temperature distribution for the GMA welding process. The equation was solved using a general thermofluid-mechanics computer program, PHOENICS code, which is based on the SIMPLE algorithm. The simulation results showed that the calculated bead geometry from the developed model reasonablely agrees with the experiment results.

소아 악골 골절의 치료에 대한 임상적 고찰 및 증례보고

서창호,김준배,배정수 東國大學校醫學硏究所 1997 東國醫學 Vol.4 No.-

소아에서는 골 및 주위 조직의 특성상 성인의 경우와는 다른 안면골 골절의 양상을 띄며 따라서 치료 방법도 각 증례에 적합한 방법이 선택되어져야 하므로 진단 및 치료계획 수립시 이러한 특징들이 잘 파악되고 있어야 한다. 저자들은 1996년 5월 1일 1997년 6월 30일까지 동국대학교병원에 내원한 3차례의 소아 악골 골절 환자들을 각각의 증례에 적합한 보존적인 방법으로 치료하여 만족할 만한 결과를 얻었기에 임상적 고찰과 함께 각각의 증례들을 보고하는 바이다. Compared to adult facial bones, growing chidren have their unique characters of bone and its surrounding structures in maxillofacial region. SO, in diagnosing, treatment planning and treating the maxillofacial injuries in children, these characters would be fully considered and adapted carefully in each separate cases. We experienced and successfully managed 3 cases of maxillofacial injuries in children during 1 year period (from May, 1996 to June, 1997) and present these cases with clinical considerations.

만성 특발성 혈소판 감소성 자반증에서의 Anti-D 정주 치료 4례

박경배,박준수,김영창 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

About 10-20% of patients who present with acute idiopathic thrombocytopenic purpura(ITP) and who have persistent thrombocytopenia for more than 6 months have choronic ITP. Treatment requires differentiating the truly idiopathic state from thrombocytopenias associated with order disorders. Therapeutic options of included corticosteroid, intravenous immunoglobulin(IVIG), and anti-D, as well as splenectomy. Good results were obtained in many chronic ITP patients treated with intravenous anti-D. immunoglobulin. The advantage of anti-D in chronic ITP patients is ease of administration and lower cost as compared to IVIG. We recently treated 4 cases of Rh(D+) chronic ITP patients with intravenous anti-D.

소아 결핵성 뇌막염에 대한 임상적 고찰

김영창,민용식,박준수,정경식,박경배 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

A total of 43 cases of tuberculous meningitis in children who were admitted to the pediatric department of Soonchunhyang Chunan hospital and Soonchunhyang Gumi hospital from Jan. 1983 to Dec. 1997 were reviewed clinically. The results were as follows; 1) The incidence of tuberculous meningitis admitted patients has been decreased. 2) The ratio of male to female was 1.5:1. 3) The incidence by age was highest under the age of 1 year (32.6%) and 72.1% of the patient were under 6 years. 4) There were tuberculous patients in the family in 34.9% of all cases. 5) The symptoms on admission were, in order: vomiting, fever, headache, irritability, impaired consciousness, lethargy and convulsion. 6) In the neurological examination on admission, 41.8% of all cases were in a coma or a semicomatose state; Kernig or Brudzinski sign was positive in 51.2% of the cases. 7) The tuberculin skin test was positive in only 14.2% of the cases. 8) On chest X-rays, tuberculous lesion was seen in 32.6%, and miliary patterns were seen in 9.1% of all cases. 9) Brain CT was performed in 8 cases and brain MRI in 1 case, with abnormal findings in 100% of these cases. The brain CT findings were hydrocephalus in 8 cases; basal cisteral enhancement in 2 cases; and infarction and tuberculoma in one case each. 10) In cerebrospinal fluid study, the mean leukocyte count was 174.3/μL (51 to 200/μL). The mean protein level was 154.9 mg/dL. The mean sugar level was 38.7 mg/dL. The mean chloride level was 110.8 mEq/L.. 11) The overall mortality rate was 11.9% and all patients classified as the 3rd stage on admission died.

가와사끼 병 환아에서 이상뇌파와 신경학적 합병증 발현과의 연관성에 대한 고찰

박준수,공도연,박경배,민용식,김영창,정순이,이혜경 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

목적 : 가와사끼 병의 뇌파 소견 및 다른 임상인자들과의 연관성을 알아보고자 하였다. 방법 : 1994년 1월부터 1995년 12월 사이에 순천향대학 천안병원 소아과에 입원한 23명의 신경학적으로 정상인 가와사끼 병 환아에게 뇌파검사를 실시하여 이를 검사시기, 성별, 연령, 혈소판, 간기능 검사치, 그리고 동맥류 유무등의 임상인자들과 비교하였다. 결과 : 이상뇌파가 23명중 52.2%인 12명에게서 관찰되었으며, 이상뇌파로는 예파 및 극파, 극·서파 복합 양상과 전반적인 배경파의 서파양상이 나타났다. 뇌파의 검사시기가 진단부터 1주 이내인 경우에 이상뇌파의 빈도가 그 후보다 의미있게 높았으나, 그 밖의 다른 임상인자와의 연관성은 별 의미가 없었다. 결론 : 가와사끼 병 초기에 이상뇌파가 나타나는 것은 비록 신경적 증상은 없지만 중추 신경계가 영향을 받는다는 간접적인 증거로 생각할 수 있어 향후 신경적 합병증 발생 여부에 대한 면밀한 관찰이 필요하다고 생각된다. Purpose : This study is to find out if there is any association between EEG abnormalities in Kawasaki disease with other clinical factors. Methods : We performed EEG in 23 Kawasaki disease patients without any neurologic sign who admitted in Soonchunhyang Chunan Hospital from 1994. 1. to 1995. 12. and compared it with sex, age, platelet count, liver function test and presence of coronary artery aneurysm. Results : Abnormal EEG findings were observed in 12 of 23 patients(52.2%) and as for abnormal EEG findings, sharp, spike, spike & slow wave complex, and generalized slow background activity were noted. When EEG was performed within a week after the diagnosis, the incidence of abnormalities of EEG increased significantly but there was no correlation with other clinical factors. Conclusion : EEG abnormalities in the early stage of Kawasaki disease indicate that although there is no abnormal neurologic signs clinically, central nervous system might be affected and there should be a close observation for the developement of neurologic complication.