尹草窓의 生涯와 草窓訣에 關한 硏究

金準泰,尹暢烈 대한한의학원전학회 1992 대한한의학원전학회지 Vol.6 No.-

I have studied life of Yoon-Dong-Li(尹東里), who applied Un-Ki(運氣) theory to medicine during Suk-Jong(肅宗) to Jeong-Jo(正祖) in Yi-Dynasty and also studied his existing writings named 《Cho-Chang-kyeol》(草窓訣). The referenced original work prints were based on 1980's pring of Chung-Ku oriental medical society and National Central Library and The academy a korean studies possessed print. Studied with these books, I have concluded as follows. 1. Yoon-Dong-Li(尹東里) courtesy name is Ja-Mi(子美), pen name is Cho-Chang(草窓). He was born in 1705, Suk-Jong(肅宗) 31yrs, and died in 1784, Jeong-Jo(正祖) 3yrs in Yi-Dynasty. He had lineage of third-generationed-doctor and learned medicine from his uncle, Yoon-Woo-Kyo(尹雨敎). His father Yoon-Yi-Kyo(윤이교) gaved him second influence. 2. Confucianal physician in Ming Dynasty You-Bu(劉溥) respected Ju-Ryeom-Kyo(周濂溪), confucianist in Song-Dynasty and You-Bu(劉溥) does not removed grass in front of window (because in chinese, Cho-Chang(草窓) means grass in front of windows), and named himself Cho-Chang(草窓). Yoon-Dong-Li(尹東里) followed this suit so called himself Cho-Chang(草窓). 3. The main contents of 《Cho-Chang-Kyeol》(草窓訣), <Un-Ki-Yeon-Lon>(運氣衍論) was written in 1725, when Yoon-Dong-Li(尹東里) was 21yrs old and printed in 1736. The other part of 《Cho-Chang-Kyeol》(草窓訣), <Yong-Yak-Pyeon>(用藥篇) was written in 1746. These two parts were not written in the same time. The <Un-Ki-Yeon-Lon>(運氣衍論) was written 11years earlier than <Yong-Yak>(用藥). Two parts were combined another day and named 《Cho-Chang-Kyeol》(草窓訣). 4. Existing 《Cho-Chang-Kyeol》(草窓訣) is transcribed printing with the content of "Five elements motion and the six kind of natural factors theory"(五運六氣論). Each edition is generally similar in content, but also has different points each other so naw we hardly finds a complete set of works. 5. 《Cho-Chang-Kyeol》(草窓訣) is a first technical book which treats of Un-Ki(運氣) theory in korea. 6. The contents of <Un-Ki-Yeon-Lon>(運氣衍論) of 《Cho-Chang-Kyeol》(草窓訣) is mechanism of diease according to excess and insuffciency of five elements motion and six kinds of natural factors, and symptoms and priscriptions, includes variated priscriptions. 7. Two parts in <Un-Ki-Yeon-Lon>(運氣衍論) of 《Cho-Chang-Kyeol》(草窓訣), 'Sang-tong'(相通) and 'Kak-Tong'(各通), threats of mechanisim of the disease according to five elements, with the principle of inter-promoting and inter-acting, in the change of ten heavenly stems and five elements motion. 8. In the <Yong-Yak-Pyeon>(用藥篇) of 《Cho-Chang-Kyeol》(草窓訣) describes priscription for clinical application according to Un-Ki(運氣) and also records about misuse of medicine. 9. In the 《Cho-Chang-Kyeol》(草窓訣), most of priscription are common using one, which also found in 《Dong-Ui-Bo-Gam》(東醫寶鑑) and there are few of priscriptions by Yoon-Dong-Li(尹東里).

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

喩昌의 生涯와 醫學思想

金秀烈,尹暢烈 대한한의학원전학회 1990 대한한의학원전학회지 Vol.4 No.-

At early Cheong (淸) dynasty, in medical aspect by dependent on practical studying attitude that must found a theory only by an evidence, there had been a tendancy that hoped direct research of sages' mind-eye by escaping the theory of individual classes since Geum-Won (金-元)dynasty. Yoo Chang(喩昌), born in Man-Ryeok(萬曆) 12th year of Myung(明) dynasty (A.D.1583) and dead in Gang-Hee(康熙) 3rd year of Cheong(淸) dynasty (A.D.1664). The results were as follows after studying his practical idea of medicine. 1. Yoo Chang, by recognizing the 《Sang-Han-Ron》 has lost its true meaning after commented by Wang hee(王熙), Lim Eog(林億), Seong Moo-I(成無己), etc. according to Bang Yoo-Jip's(方有執) Chak-Gan-Jung-Jeong(錯簡重訂) theory, he diversified the protocal of 《Sang-Han-Ron》 397 method and arranged under Six Meridian part.(六經) 2. The theory of Sam-Gang-Jeong-Rip(三網鼎立) can be summerized Gye-Ji(桂枝) syndrome which is the case of WInd(風) has injured Wi(衛) stage, Ma-hwang(麻黃) syndrome which is the case of Cold(寒) ahs injured Yeong(榮) stage, Dae-Cheong-Ryong(大靑龍) syndrome which is the case both of Wind-Cold(風寒) ahs injured Yeong-Wi(榮衛) stage, and there has been Sam-Gang-Jeong-Rip theory by anterior medical practitioners already but the person who formally used its Sam-Gang-Jeong-Rip term is Yoo-Chang. 3. Yoo Chang seized the On Byeng(溫病) by dividing three category and in Byon-Jeung-Si-Chi(辨證施治) he influenced to many aspect of establishment of later Byon-Jeung system On-Byong(溫病의 辨證體系) pertaining to Triple-Warmer by O-Dang(오당) introducing Triple-Warmer Theory.(三焦理論) 4. At Chu-Jo-Ron(秋燥論) of 《Eui-Moon-Beop-Ryol》, while 《Nae-Gyeong》 describing if humidity injury Lung, then occur a disorder in it, Yoo Chang recognized that of autuam when dryness injure Lung there occure a disorder is it so he insisted that at this case, must use Cheong-Joe-Goo-Pye method (淸燥救肺法) with herbs, pertaing to Gam-Yoo-Ja-Yoon(甘柔滋潤性) property and he invented Cheong-Joe-Goo-Pye-Tang.(淸燥救肺湯) 5. You Chang', so called, Dae-Gi(大氣) indicates Yang-Gi(陽氣) of chest, he insisted that man's creation and every physiological activity depends on maintainence of Dae-Gi, and it integrate Yeong-Gi(榮氣), Wea-Gi(衛氣), Jong-Gi(宗氣), Jang-Boo-Ji-Gi(臟腑之氣), Gyeong-Rak-Ji-Gi.(經絡之氣) 6. Yoo Chang's expression about partical function and character of stomach, not only bolster its theory of historical physician's expression, that is stomach is foundatness of postnatal period, but also it has correponding aspect with modern medicine and clinic. 7. Yoo Chang emphasized "if one cure a disease, be must understood the character of disease first and use drugs later"(先議病 後用藥) phrase about of drug usage, and his theory of Geup-Rew-Man-Joo method(急流挽舟) and three therapy of Simple Ascite(單腹脹) are all unique opinion based upon this phrase mentioned above. 8. Yoo Chang's practical idea of medicine greatly influenced to Jang Ro(張??), Hwang Won-A(黃元御), Oh Eui-Rak(吳儀洛) ,Joo Yang-Joon(周??俊), etc. and theory of Sam-Gang-Jeng-Rip(三網鼎立), Thriple Warmer Theory of On Byong (溫疫의 三焦論治), Chu-Jo-Ron(秋燥論), Dae-Gi-Ron(大氣論) etc. became important object to student of Sang-Han(傷寒) and On-Byeng.(溫病) 9. Yoo Chang's Writings has more practical meaning than other physician's, especially, later the idea of Sang-Han(傷寒) and On-Byong(溫病) greatly contributed to development of Sang-Han theory and formation of On-Byong theory.

소설 『벌레 이야기』와 영화 〈밀양〉의 상관관계

김창윤(Kim Chang-Yoon) 강원대학교 인문과학연구소 2008 인문과학연구 Vol.0 No.20

본고는 들뢰즈와 가타리의 자본주의와 정신분열증을 토대로 소설『벌레 이야기』와 영화 〈밀양〉의 상관관계를 분석해 보았다. 소설『벌레 이야기』는 다분히 정치적이며, 소설의 기표인 기독교라는 거대한 영토와 광주민주화운동이라는 기표 속에 숨어 있는 탈영토화된 기의는 서로 상충되는 관념적 코드지만, 이창동은 이러한 이청준의 관념적 코드를 정확히 읽어내어 영화로 재해석해 냈다. 들뢰즈와 가타리의 자본주의와 정신분열증에서 중요한 영토화, 탈영토화, 재영토화, 초코드화와 세 가지 선분인 유연한 분자적 선분성, 경직된 몰적 선분성 그리고 탈주선에 대해 정의하고, 그것을 바탕으로 소설『벌레 이야기』에서 영화 〈밀양〉으로의 확대를 분석했는데, 그것은 인물의 확대, 공간과 서사의 확대, 주제의 변이 세 가지를 중심으로 이루어졌다. 먼저, 인물의 확대에 대해 살펴보았는데, 소설에서의 ‘아내’가 영화에서의 ‘신애’로 어떻게 변주되었는지, 영화에서 창조된 인물인 김종찬의 역할은 무엇인지, 그리고 소설과 영화에서의 역할이 비슷한 박도섭(김도섭)과 김집사에 대해서도 살펴보았다. 두 번째로 공간과 서사의 확대에 대해 살펴보았는데, 소설에서 중요한 제재가 아닌 밀양(密陽)이라는 공간이 영화에서 어떻게 중요한 공간으로 변주되는지 분석해 보았다. 세 번째로 주제의 변이에 대해 살펴보았는데, 소설과 영화의 하느님이라는 절대자와 인간이라는 관계에 대한 주제의식에서, 소설과 달리 영화에서 이창동 감독이 신애를 자살의 죽음으로부터 건져냄으로서 주제를 어떻게 확장시켰는지 분석해 보았다. This study analyzes the correlation between the novel A Story of Insects and the movie 〈Secret Sunshine〉 based on the capitalism and schizophrenia of Deleuze and Guattari. A Story of Insects is quite political, and the extensive territory of Christianity, which is the signifier of the novel, and the deterritorialized signified hidden territory in the signifier of the Gwangju Democratic Movement are mutually conflicting conceptual codes. Lee Chang-Dong read these conceptual codes of Lee Cheong-Jun accurately and reinterpreted them in his movie. We defined territorialization, deterritorialization, reterritorialization, and overcoding which is important in capitalism and schizophrenia of Deleuze and Guattari, and three types of segments flexible molecular segmentarity, rigid molaire segmentarity and line of flight. Based on the definitions, the study analyzed the expansion of the novel A Story of Insects to movie 〈Secret Sunshine〉, focusing on the expansion of characters, the expansion of space and narration, and the change of themes. First, with regard to the expansion of characters, we examined how ‘Wife’ in the novel was changed to ‘Sin-ae’ in the novel, what roles Kim Jong-chan created in the movie, and who Park Do-Seop (Kim Do-Seop) and Deacon Kim are, whose roles in the novel and the movie are similar to each other. Second, with regard to the expansion of space and narration, we analyzed how the space of Secret Sunshine, which was not an important subject in the novel, became an important space in the movie. Third, with regard to the change of themes, we analyzed how, concerning the relation between God as the Absolute and humans, Director Lee Chang-Dong expanded the theme by saving Sin-ae from her suicide in the movie, which is different from what happened in the novel.

급성 심근허혈에 따른 심실활성시간(Ventricular Activation Time)의 변화

한성욱,김윤년,김기영,남창욱,김기식,김권배 대한순환기학회 2001 Korean Circulation Journal Vol.31 No.3

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

만성 두부외상 환자에서 99mTc - HMPAO Brain SPECT의 임상적 유용성

서정호(Jung Ho Suh),김동익(Dong Ik Kim),정태섭(Tae Sub Chung),이종두(Jong Doo Lee),박창윤(Chang Yoon Park),정진일(Jin Ill Chung),김영수(Young Soo Kim) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1

N/A Minima1 deterioration of cerebral perfusion or microanatomical changes were undetectable on conventional Brain CT or MRI. So evaluation of focal functional changes of the brain parenchyme is essential in chronic head injury patients, who did not show focal anatomical changes on these radiological studies. However, the patients who had longstanding neurologic sequelae following head injury, there had been no available imaging modalities for evaluating these patients precisely. Therefore we tried to detect the focal functional changes on the brain parenchyme using Tc-99m-HMPAO Brain SPECT on the patients of chronic head injuries. Twenty three patients who had suffered from headache, memory dysfunction, personality change and insomnia lasting more than six months following head injury were included in our cases, which showed no anatomical abnormalities on Brain CT or MRI. At first they underwent psychological test whether the symptoms were organic or not. Also we were able to evaluate the cerebral perfusion changes with Tc-99m-HMPAO Brain SPECT in 22 patients among the 23, which five patients were focal and 17 patients were nonfocally diffuse perfusion changes. Thus we can predict the perfusion changes such as local vascular deterioration or functional defects using Tc-99m-HMPAO Brain SPECT in the patients who had suffered from post-traumatic sequelae, which changes were undetectable on Brain CT or MRI.

북서태평양에 서식하는 살오징어(Todarodes pacificus) 계군 분석에 대한 고찰

김정연,문창호,윤문근,강창근,김경렬,나태희,최은정,이충일,Kim, Jeong-Yun,Moon, Chang-Ho,Yoon, Moon-Geun,Kang, Chang-Keun,Kim, Kyung-Ryul,Na, Taehee,Choy, Eun Jung,Lee, Chung Il 한국해양학회 2012 바다 Vol.17 No.4

This paper reviews comparison analysis of current and latest application for stock identification methods of Todarodes pacificus, and the pros and cons of each method and consideration of how to compensate for each other. Todarodes pacificus which migrates wide areas in western North Pacific is important fishery resource ecologically and commercially. Todarodes pacificus is also considered as 'biological indicator' of ocean environmental changes. And changes in its short and long term catch and distribution area occur along with environmental changes. For example, while the catch of pollack, a cold water fish, has dramatically decreased until today after the climate regime shift in 1987/1988, the catch of Todarodes pacificus has been dramatically increased. Regarding the decrease in pollack catch, overfishing and climate changes were considered as the main causes, but there has been no definite reason until today. One of the reasons why there is no definite answer is related with no proper analysis about ecological and environmental aspects based on stock identification. Subpopulation is a group sharing the same gene pool through sexual reproduction process within limited boundaries having similar ecological characteristics. Each individual with same stock might be affected by different environment in temporal and spatial during the process of spawning, recruitment and then reproduction. Thereby, accurate stock analysis about the species can play an efficient alternative to comply with effective resource management and rapid changes. Four main stock analysis were applied to Todarodes pacificus: Morphologic Method, Ecological Method, Tagging Method, Genetic Method. Ecological method is studies for analysis of differences in spawning grounds by analysing the individual ecological change, distribution, migration status, parasitic state of parasite, kinds of parasite and parasite infection rate etc. Currently the method has been studying lively can identify the group in the similar environment. However It is difficult to know to identify the same genetic group in each other. Tagging Method is direct method. It can analyse cohort's migration, distribution and location of spawning, but it is very difficult to recapture tagged squids and hard to tag juveniles. Genetic method, which is for useful fishery resource stock analysis has provided the basic information regarding resource management study. Genetic method for stock analysis is determined according to markers' sensitivity and need to select high multiform of genetic markers. For stock identification, isozyme multiform has been used for genetic markers. Recently there is increase in use of makers with high range variability among DNA sequencing like mitochondria, microsatellite. Even the current morphologic method, tagging method and ecological method played important rolls through finding Todarodes pacificus' life cycle, migration route and changes in spawning grounds, it is still difficult to analyze the stock of Todarodes pacificus as those are distributed in difference seas. Lately, by taking advantages of each stock analysis method, more complicated method is being applied. If based on such analysis and genetic method for improvement are played, there will be much advance in management system for the resource fluctuation of Todarodes pacificus. 본 종설논문은 살오징어의 기존 및 최근에 새롭게 적용되고 있는 계군 분석방법들을 비교 분석하여 각 분석방법의 장단점과 분석방법간의 상호보완에 대하여 고찰하였다. 살오징어는 북서태평양의 넓은 지역을 회유하는 어종으로 생태계 및 상업적으로 중요한 자원이다. 살오징어는 해양환경변화의 생물학적 지표로서의 가능성을 평가 받고 있으며, 장단기적인 어획량 및 분포역의 변화가 환경 변화와 함께 나타난다. 예를 들어, 1987/1988 무렵에 발생한 기후체제전환 이후 한류성 어종으로 분류되는 명태의 어획량은 급감하여 현재까지 그 영향이 지속되고 있는 반면, 살 오징어 어획량은 크게 증가하였다. 현재까지 명태 어획량의 감소에 대하여 남획과 기후변화에 초점이 맞추어진 해석이 있으나, 뚜렷한 원인 분석은 이루어지지 않고 있다. 그 이유 중 한 가지는 계군 분석에 근거한 생태, 환경적 측면에 대한 정확한 원인 분석이 이루어지지 않고 있는 것과 관련이 된다. 계군은 유사한 생물학적 특징을 가진 개체들이 제한된 영역 내에서 유성생식과정을 통하여 동일한 유전자 풀(gene pool)을 공유하는 집단으로, 동일 계군을 형성하는 개체들은 산란에서 자원으로 가입 후 다시 재생산 과정에 이르기까지 시간 및 공간적으로 각기 다른 환경의 영향을 받을 수 있다. 따라서, 종에 대한 정확한 계군 분석은 자원의 효과적인 관리 및 급격한 변화에 대한 중요한 대응 방안의 역할을 할 수 있다. 살오징어 계군 분석에 적용된 주요 방법은 크게 4가지로 형태학적 방법, 생태학적 방법, 표지방류법, 유전학적 방법이 있다. 형태학적인 방법은 분석방법이 가장 간단하고 다수의 개체를 비교적 쉽게 분석할 수 있지만 각 형질들은 성장기간 동안 환경에 의해 영향을 많이 받게 되어 개체간의 차이가 생긴다. 생태학적 방법은 주로 개체의 생리적인 변화와 분포 및 회유상태, 기생충의 기생상태나 종류 및 기생률 등을 분석, 산란장의 차이를 알아보는 연구이며, 현재 활발히 연구되고 있는 방법으로 유사한 환경에서 생활하는 집단을 알 수 있지만 유전적으로 같은 집단인지는 알기 어렵다. 표지방류법은 직접적인 방법으로 계군의 회유 및 분포, 산란장의 위치를 파악할 수 있지만 수거가 어렵고 초기 단계에는 표식을 하기 어렵다. 수산생물의 계군 분석을 위한 유전학적 방법은 자원관리학적 연구에 관한 기본적 정보를 제공해 왔다. 계군 분석을 위한 유전학적 방법은 이에 사용하는 유전자 마커(marker)의 감도에 따라 결정되며, 유전자 마커의 다형성이 높은 것을 선택해야 한다. 계군 분석을 위한 유전자 마커로는 오랜 기간 동안 동위효소 다형이 사용되어졌으며, 최근에는 mitochondria, microsatellite와 같이 DNA 염기배열 중에서도 변이성이 높은 영역을 선택하여 마커로 이용한 연구가 증가되고 있다. 기존의 형태학적 방법, 표지방류법, 생태학적인 방법들은 살오징어의 생활사, 회유경로, 산란장의 변화 등을 밝혀내어 계군을 파악하는데 많은 기여를 하였지만 여전히 각 해역에 분포하는 살오징어의 계군을 파악하기에는 어려움이 있다. 최근에는 기존의 계군 분석이 지닌 장단점을 비교 분석하여 복합적인 방법의 계군 분석이 이루어지며, 이러한 정보들을 바탕으로 유전학적 방법을 보완한다면 살오징어 자원의 변동에 대한 관리 방안을 마련하는데 도움을 줄 것이다.

스포츠 두부 손상

윤영설,진동규,김긍년,장진우,김영수 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

Head injury is the most frequent direct cause of death in sports. Furthermore, injury to the head takes an singular importance when we realise the brain is neither capable of regeneration nor, unlike many other body parts and organs, of transplantaion. Every effort must be made to protect the athlete's head as injury can lead to dementia, epilepsy, paralysis and death. There are three distinct types of stress that can be generated by an acceleration force to the head : compressive, tensile and shearing forces. The differential diagnosis with a head injury includes cerebral concussion, intracranial hemorrhage, postconcussion syndrome, second impact syndrome, malignant brain edema. 90 to 95% of all head injuries are cerebral concussions and more than 90% all cerebral concussions fall into mild categories. With a head injury the ABCs of first aid must be followed and then a neurological examination will be followed. In the case of the intracranial hematoma. definite surgical evacuation is indicated and in cases of the closed head injuries and most severe degree of concussion. observation is appropriate, with careful neurological monitoring. Over the last 20 years there has been a dramatic decrease in the most serious head injuries due to multiple factors. There are five areas that can affect a reduction in head injuries. The first two involve rules and coaching technique changes. The other three areas involve improvements in conditioning (especially of the neck), equipment, and finally medical supervision. The reduction in incidence and severity of athletic head injury gas been the results of changes and improvements instituted following constant study and research. And also, for the reduction in incidence of athletic head injury every effort or team physician, athletic trainer, physical trainer and team coaches should be necessary.

흰쥐 이자 Insulin과 Neuropeptide Y 분비세포의 발생에 관한 면역조직화학적 연구

장인엽,박태우,정윤영,김종중,문정석,김영택,안계훈,김남훈,선희매 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

Cells immunoreactive to insulin(INS-IR) and neuropeptide Y(NPY-IR) were found in prenatal(E15, 17, 19) and postnatal(P0, 5, 10, 15, 30, adult) rat pancreas using immunohistochemistry. Pancreatic INS-IR and NPY-IR were detected by day E17. They were found initially in the interlobular pancreatic duct, intralobular pancreatic duct and pancreatic islet gradually. Especially, INS-IR was detected in the dorsal pancreatic bud by day E19. The INS-IR and NPY-IR patterns were nearly similiar to each other, and many cells revealed colocalization of INS and NPY until day P10. But there was a change between them by the day P15 ; central INS-IR cells and peripheral NPY-IR in the pancreatic islet. The number of pancreatic islets per square millimeter of pancreatic tissue were decreased, and the number of immunoreactive endocrine cells per islet was increased according to development. These results suggest NPY may play a role in the development of the pancreatic endocrine cells.