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4-Methoxyaniline으로 부터 7-Hydroxy-2-aminophenazine-5, 10-dioxide의 합성과 항균성
한성욱 대구보건대학 1991 대구보건대학 論文集 Vol.12 No.-
7-Hydroxy-2-aminophenazine-5,10-dioxide was synthesized from 4-aminophenol and 6-hydroxiben-zofuroxan was previously obtained through various reaction steps starting from 4-methoxyaniline. All the intermediates and final product were purified by way of recrystallization, and extraction, and were identified by using IR and NMR spectrophotometer. Amtimicrobial activity of phenazine dioxide derivative was also determined for some Gram positive and negative bacteria. It was observed that 7-hydroxy-2-aminophenazine-5 10-dioxide was stronger antimicrobial activity against both Gram positive and negative microbes than phenazine dioxides bearing methoxy, methyl, hydrogen, acetyl and nitro groups. From the result of this study, it might be concluded that electron density of the oxygen on N→O bond.
How to Achieve Complete and Permanent Pulmonary Vein Isolation without Complications
한성욱,Chun Hwang 대한심장학회 2014 Korean Circulation Journal Vol.44 No.5
The efficacy and safety of catheter ablation for the management of atrial fibrillation (AF) has been improved in recent years. Radiofrequency(RF) catheter ablation for maintaining sinus rhythm is superior to the current antiarrhythmic drug therapy in selected patients. Pulmonaryvein isolation (PVI) is the cornerstone of various catheter ablation strategies. It is well recognized that pulmonary vein (PV) antrum contributesto the AF initiation and/or perpetuation. Since PV stenosis is a complication of ablation within a PV, the ablation site for PVI has shiftedto the junction between the left atrium and the PV rather than the ostium of the PV. However, PV reconnection after ablation is themajor cause of recurrence of AF. The recovery of PV conduction could be caused by anatomical variations such as the failure to producecomplete transmural lesion or gaps at the ablation line due to the transient electrophysiologic effects from the RF ablation. In this review,we discussed several factors to be considered for the achievement of the best PVI, including clinical aspects and technical aspects.