이능화의 한국 양명학 연구

이우진(Lee, Woo-Jin),최재목(Choi, Jae-Mok) 한국양명학회 2015 陽明學 Vol.0 No.42

이 논문은 ‘한국 양명학 연구의 초석을 마련한 인물’로서 이능화(李能和)에 대한 탐구이다. 먼저, 이능화가 양명학이 어떤 측면에서 “주자학에 대항할 수 있는 가장 서구적인(=서구화할 수 있는) 사상 유형”으로 자리매김할 수 있다고 생각했는지에 대해 탐색하였다. 그 연장선에서 ‘주자학을 서구근대화의 장애물’로 판단하게 된 이유를 검토하였다. 다음으로 이능화의 조선유계지양명학파 에서 나타난 한국 양명학의 연구 관점이나 자료수집의 폭이 어떤 것이며, 그것이 이후 한국 양명학 연구자들에게 어떠한 영향을 끼쳤는지를 구체적으로 검토해보았다. 이능화는 조선을 ‘사상속박시대’라고 비난할 정도로 오직 주자학만을 유일무이한 학문으로 존숭하였던 조선 유교에 대해 비판적 입장을 지녔다. 그에 따르면, 조선의 교조주의는 근본적으로 사대주의(事大主義)에 기인한 것이었다. 또한 그러한 교조주의는 당파의 분열을 발생시켜 유교의 특장점인 정치적 · 윤리적인 사회철학적 성격을 상실케 되었다고 파악한다. 반면 이능화는 양명학을 시대변혁의 방향에 새로운 가능성을 지닌 사상으로 파악한 듯 하다. ‘전근대적인 주자학’을 탈피하여 당시의 역사적 사명인 ‘서구근대화를 이룰 수 있는 사상’으로 양명학을 바라보았던 것으로 유추된다. 이는 일본의 서구 근대화가 양명학이라는 이념적 기반에 이루어졌다는 사실에 기인한다. 이능화는 『조선유계지양명학파(朝鮮儒界之陽明學派)』에서 조선 양명학파를 학문적인 측면이 아니라 정치적인 측면에서 정리하였다. 그리고 그는 한국 양명학파를 성립시킨 인물로서 정제두로 제시하였으며, 남언경(南彦經)을 조선 최초의 양명학자로서 규정하였다. 다음으로 한국의 양명학 전래시기를 1567년 전후로 추정하였다. 이와 같은 그의 견해는 이후의 한국 양명학 연구자들에게도 고스란히 이어졌다. 특히 이능화는 조선의 양명학 배척을 역사적 사실을 통해 논증하였다. 이후 그의 한국 양명학 연구는 다카하시 도오루(高橋亨)에게 이어져 식민사관으로 재생산된다. 하지만 윤남한(尹南漢)과 유명종(劉明種)에 이르면 다카하시 도오루가 보여준 식민사관을 넘어서게 되고, 이능화가 마련한 인물 · 시각 · 자료 · 사건들을 그들의 한국 양명학 연구에서 근간으로 사용되고 있었다. 그 점에서 이능화는 ‘한국 양명학 연구의 초석을 마련한 인물’이라고 지칭해도 무리가 되지 않을 것이라 사료된다. This paper is aimed to study on Lee Nung-Hwa as ‘the drafter for research on Korean Yangmyeonghak(陽明學)’. First, we examined that why Lee considered Yangmyeonghak as most modern thought. In addition to this, We investigated that why he thought JuJahak(朱子學) as the obstacle of making Josun modern westernization. Second, we investigated Lee’s Josunyukyejiyangmyeonghakpa(朝鮮儒界之陽明學派) for seeking his research perspective and scope of data collection about Korean Yangmyeonghak. And, we examined in particular that what Lee had influenced on researchers on Korean Yangmyeonghak since he published this Josunyukyejiyangmyeonghakpa . Lee described Josun(朝鮮) as ‘the spirit bondage era.’ He had a very critical stance on the Josun Confucianism, because it only acknowledged JuJahak. At that time, any other thoughts except JuJahak were regarded as unorthodox. According to him, Jujahak dogmatism was due to toadyism basically. Jujahak dogmatism had generated multitudinous partisan brawls from the earliest days of Josun. So, the confucianim lost its advantages of ethical and political philosophy. But, Lee looked at Yangmyeonghak positively. He considered Yangmyeonghak as most modern thought. Because Yangmyeonghak was the ideological foundation of the Meiji Restoration. Lee organized the Korean Yangmyeonghak school at the political side, not the academic side in 『Josunyukyejiyangmyeonghakpa』. Lee described Jeongjedu(鄭齊斗) as the feature of establish Korean Yangmyeonghak school, and identified Namunkyung(南彦經) as the first Yangmyeonghak scholar inf Josun. And, Lee estimated the Yangmyeonghak transmission time as around 1567. Many researchers followed these his views. But, Lee analyzed the Korean Yangmyeonghak school from the perspective of colonial history. His perspective of colonial history was continued to Takahasi torou(高橋亨), but that perstpective had been refused by Yunnahan(尹南漢) and Yumyeongjong(劉明宗). However, people, data, and events selected by Lee had been accepted by almost all researchers. In that point, we identify Lee as the drafter for research on Korean Yangmyeonghak.

사례연구 : 가업승계와 가족기업의 경쟁력: 에스엘 사례

이장우 ( Jang Woo Lee ),마윤주 ( Yoon Joo Ma ),정수철 ( Su Chul Jung ) 한국중소기업학회 2010 中小企業硏究 Vol.32 No.4

본 연구의 목적은 가족기업의 핵심역량 축적과정을 살펴보고 성공적인 가업승계의 중요성을 논의하는 것이다. 이를 위해 가족기업의 경쟁우위를 설명한 Miller and Le Breton-Miller (2005)의 4C(Continuity, Community, Connection, Command)모델을 기반으로 3대에 걸친 성공적인 가업승계를 기반으로 한 에스엘의 핵심역량 축적과정을 조사했다. 국내 자동차부품회사인 에스엘의 성장과정에 관한 2차 자료를 분석하고, 대표이사와의 심층인터뷰를 통해 그 연관성을 구체적으로 살펴보았다. 분석결과 창업자 가족이 공유한 가치관과 비전, 노하우, 경험 등은 장기적인 지향성을 가지고 지속적으로 핵심역량을 개발하는데 큰 역할을 하였다. 또한 신뢰의 가치관이라는 사회적 자본을 효과적으로 전달받은, 다음 세대의 후계자는 가족 가치관을 토대로 대외 네트워크를 더욱 견고히 하고 지속적으로 발전시켰다. 에스엘은 성공적인 가업승계로 소유와 지배구조를 집중화 할 수 있었고, 이에 따라 외부 이해관계자들의 압력 없이, 가족 내부 조화를 통해 독립적이고 과감한 의사결정이 가능하였다. 이는 가족기업의 경우 고유한 공동체적 문화와 신뢰에 기반 한 외부 네트워크 형성을 통해 경쟁력 구축에 힘쓸 필요가 있으며, 일반기업의 경우에도 공동체 적 조직문화와 중장기적 관점의 외부 협력관계가 기업의 영속성 유지에 중요하다는 시사점을 제공한다. 또한 가엽승계가 기업경쟁력의 유지와 세대 간 이전에 중요한 기능을 함에 따라 이에 대한 적절한 정책적 배려가 필요하다. The purpose of this study is to examine the process of accumulating com-petences and competitiveness by family companies, and discuss the importance of successful succession of a family business. The core competence accumulation process and competitiveness sources of SL, which is based on successful succession of the family business for three generations, was examined based on the 4C (Continuity, Community, Connection, Command) model of Miller and Le Breton-Miller (2005), which explains the competitive superiority of family companies. Secondary data on the growth process of SL, a domestic auto-mobile parts company, was analyzed and their strategic implications were examined in detail through an in-depth interview with the CEO. The 4C factors, which are antecedent variables of a successful family business, played an important role on the growth process of SL. The continuity factor existed through continuous research and development that focuses on and invests in improving technology quality such as mold pro-duction, lamp production, sash production, and design automation. 2 to 3 percent of the sales amount each year was spent on research and development, regardless of the condition of the economy. As a result, the intellectual property of the company reached 1,108 items (583 applications, 440 registered properties, 47 in review, 38 trademarks) by 2006. From a long-term perspective, the company is improving their technical power to an international standard through technical investments. The continuity of investments in research and development is apparent through three generations, and it can be said that this reflects the characteristics of family business management that shares a goal, and confirms and develops the core capacities of the company. The factor of community started with the "people first" business, management philosophy of the late presi-dent, Hae-joon Lee. Then, it expanded to "human respect" during the president Choong-kon Lee`s generation, and to "ethical management" for the CEO Sung-yup Lee`s generation. The sense of community was revealed to be in the form of a community corporate culture based on a good welfare system for employees and com-munity awareness. Diverse benefits including a housing support system, housing fund support system, child-ren`s education fee support system, scholarship system, and company clubs support system were used to make people feel like "the company and I are one" and work with a sense of ownership. The fact that there has not been one conflict between labor and management since 1968, when the labor union was first established, is especially a noteworthy point. The business management based on "people first" stresses the responsibility and roles of employees and reflects the belief that a workplace should not simply be a place to make a living, but a part of life where you can cultivate character and fulfill your role as a member of society. The connection factor appears as continuous partnerships and networks with domestic and international parts suppliers and technologically advanced companies. The late honorary chairman Hae-joon Lee maintained partnerships and networks with Hyundai Motor Company and Daewoo Motors. Then, chairman Choong-kon Lee expanded the network to include KIA and Ssangyong Motors and maintained long-term relationships with domestic automobile makers. In addition, the company is maintaining cooperative relations with the Japanese company Stanley and German company Hella, and has started dealing with the U.S. company GM, too. CEO Sung-yup Lee`s generation improved the company`s relationship with GM and made the achievement of re-ceiving the QSTP Award (an award GM gives to selected skilled companies out of all the parts companies in the world) from GM for 14 consecutive years (1997-2010), solidifying its position as a skilled partner of GM. SL is also advancing into China through collaborations with the local branch to extract new cooperative relations. The value of "trust" is the motivation that helped SL maintain and strengthen relationships and networks. This value started with the founder of the company and was handed down to chairman Choon-kon Lee and CEO Sung-yup Lee, and worked as a core factor to strengthen external cooperative relationships. The factor of command is apparent from the decisions of business managers who take on a challenge, structural management that includes an endless will for innovation, and leadership. When the late honorary chairman Hae-joon Lee could not cultivate a road for the automobile parts industry because of smuggled goods, he recognized the importance of the automobile parts industry and folded his bicycle parts business, which was number one in the market at the time, without hesitation thanks to his owner-focused independent and bold decision-making skills. In the mid-1990s, when most automobile production companies experienced difficulties because of the economic crisis where Korea was dependent on the IMF, and the aftershocks of restructuring affected automobile parts manufacturing companies, chairman Choong-kon Lee considered the crisis an opportunity and acquired and merged with Seogu Industry (currently known as SL Litech), Oriental Construction and Poongi Building (currently known as SL Seo Bong Co., Ltd. Shiheung factory), creating a turning point to develop further after the crisis. CEO Sung-yup Lee pursues continuous innovation including a corporate culture that places importance on learning and admitting mistakes, change of the structural system to a project based system, and a human resources system that focuses on human resources management, and is emphasizing corporate changes according to the situation of the times. An examination of the SL core competence accumulation process based on the 4C model shows that it is establishing positive relationships and continuity based on connection and trust, leading to a cooperation sys-tem based on the value of trust. It also establishes a positive relationship with command focusing on a com-munity structure culture, which leads to structure capacity based on community culture. The factors of con-nection and community were found to be especially strong at SL. The factor of connection was a core growth motivation, influenced by the key values of family. SL reveals its growth motivation to be "unification of all employees," shares the goals and visions of family with its employees, and offers a variety of different benefits. The active will of employees to participate in this community is seen to be the background behind big accomplishments such as innovations in the field, which are still being pursued. Successful succession of the family company and family business management are strengths that lie in the center of the motivation that allowed SL to continue to grow for three generations, starting with the founder, the late honorary chairman Hae-joon Lee, who provided a foundation of growth with values of trust and peo-ple first, moving on to the second generation chairman Choong-kon Lee, who accomplished a rapid development of the company based on technological developments and respect for people, and finally through to the third generation CEO Sung-yup Lee, who is making efforts for globalization and innovation based on ethical management and change. This shows that the values of trust set by the founder have continued on for a long time, through his son, chairman Choong-kon Lee, and grandson, CEO Sung-yup Lee. Chairman Lee, CEO Lee and executive director Lee Seung-hoon are learning corporate culture and management know-how through a great will to participate and actual participation in management. SL was able to gain competitiveness and continuously reach excellent management performance through cooperation based on the value of trust and structural management that focuses on community culture. As a result of analyzing the company through the 4C model and conducting in-depth interviews with man-agement, it can be said that the values, vision, know-how and experience the founder shared with his family largely contributed to continuous development of core competence with a long-term goal. This in turn had a positive effect on establishment of a corporate community based on trust. By inducing loyalty, participation, and focus on employees in the organizational structure with something more than just financial incentives, the core values of the company are relayed through generations and play an important role in maintaining the community, and also emotionally motivating members of the community. Another point is that the successor who effectively received the social capital of trust as a value, strengthened and continued to develop the ex-ternal network based on the family values. The value of "trust" started by the founder played a key role in strengthening external cooperative relations as it was succeeded through generations. This had a positive ef-fect on connection based on the value of trust, and especially decisively contributed to maintaining close rela-tions of cooperation in the external network and long-term cooperative relationships. SL was able to focus the possession and domination structure through successful succession of the family business, and make in-dependent bold decisions through internal harmony of the family, without pressure from people involved externally. The results above lead to the following points of discussion regarding corporate management. From a busi-ness management perspective, first, a family company needs to establish an external network based on a unique community culture and trust to work on establishing competitiveness. Second, there is a need to reflect the fact that a community-like structural culture and external cooperative relations from a mid- to 0long-term perspective have an important effect on maintenance of corporate continuity, even for companies that are not family businesses, on business management. Third, there is a need to focus on the fact that a structural man-agement method that uses values such as community help secure continuity of a company. From a policy per-spective, since succession of a family business can be not succession of wealth but succession of accumulated technological core competence and good management philosophy and know-how, it is important for improve-ing national competitiveness, to maintain corporate competitiveness, and transfer the competitiveness between generations. Therefore, there is a need for appropriate policies that support the successful transgenerational succession of family businesses.

A selective cyclin-dependent kinase 4, 6 dual inhibitor, Ribociclib (LEE011) inhibits cell proliferation and induces apoptosis in aggressive thyroid cancer

Lee, Hyun Joo,Lee, Woo Kyung,Kang, Chan Woo,Ku, Cheol Ryong,Cho, Yoon Hee,Lee, Eun Jig Elsevier 2018 Cancer letters Vol.417 No.-

<P><B>Abstract</B></P> <P>The RB-E2F1 pathway is an important mechanism of cell-cycle control, and deregulation of this pathway is one of the key factors contributing to tumorigenesis. Cyclin-dependent kinases (CDKs) and Cyclin D have been known to increase in aggressive thyroid cancer. However, there has been no study to investigate effects of a selective CDK 4/6 inhibitor, Ribociclib (LEE011), in thyroid cancer. Performing Western blotting, we found that RB phosphorylation and the expression of Cyclin D are significantly higher in papillary thyroid cancer (PTC) cell lines as well as anaplastic thyroid cancer (ATC) cell lines, compared with normal thyroid cell line and follicular thyroid cancer cell line. LEE011 dose-dependently inhibited RB phosphorylation and also decreased the expressions of its target genes such as <I>FOXM1, Cyclin A1,</I> and <I>Myc</I> in ATC. Furthermore, LEE011 induced cell cycle arrest in G0-G1 phase and cell apoptosis, and inhibited cell proliferation in ATC. Consistently, oral administration of LEE011 to ATC xenograft models strongly inhibited tumor growth with decreased expressions of pRB, pAKT and Ki-67, and also significantly increased tumor cell apoptosis. Taken together, our data support the rationale for clinical development of the CDK4/6 inhibitor as a therapy for patients with aggressive thyroid cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> pRB and Cyclin D were expressed high in aggressive thyroid cancer. </LI> <LI> LEE011 suppressed pRB and also decreased the expressions of its target genes in ATC. </LI> <LI> LEE011 induced cell cycle G1 arrest and apoptosis, and inhibited cell proliferation. </LI> <LI> LEE011 inhibited in vivo tumor growth with decreased expressions of pRB and Ki-67. </LI> <LI> We could explain the anticancer effects with the RB-E2F pathway. </LI> </UL> </P>

전통주 주박의 항혈전 활성 평가

김미선(Mi-Sun Kim),이예슬(Ye-Seul Lee),김종식(Jong Sik Kim),신우창(Woo-Chang Shin),손호용(Ho-Yong Sohn) 한국생명과학회 2014 생명과학회지 Vol.24 No.8

전통주 주박을 이용한 고부가가치 식품소재 개발을 위해, 상업적 시설에서 생산된 3종 약주(J-B, J-S, J-Y) 및 2종 탁주(J-H, J-W) 주박의 ethanol 추출물 및 열수 추출물을 조제하고 이들의 혈액응고 저해활성, 혈소판 응집저해 활성 및 인간 적혈구 용혈활성을 평가하였다. 5종 주박의 pH는 3.90~4.29로 유사하였으나, brix는 5.0~27.0으로 다양하게 나타났으며, 수분 및 알코올 함량에서도 시료에 따라 1.8배의 차이를 나타내었다. 주박의 색차와 성분은 첨가된 부재료 및 사용누룩에 좌우되었으며, J-W 주박의 경우 수분함량이 80.3%, brix 13, 알코올 함량 1.8%를 함유하여 다른 주박에 비해 다양한 식품제조에 용이하게 이용 가능하리라 판단되었다. Ethanol 추출효율은 J-H, J-W, J-B, J-S, J-Y의 순, 열수 추출효율은 J-S, J-B, J-W, J-H, J-Y의 순으로 높았으며, 총폴리페놀 및 총플라보노이드함량은 ethanol 추출물 중에서는 J-H, 열수 추출물 중에서는 J-Y 주박에서 가장 높았다. 5종 주박의 10종 추출물은 모두 5 mg/ml 농도까지 인간 적혈구에 대한 용혈활성이 나타나지 않았으며, J-B, J-S, J-Y의 약주 주박의 ethanol 추출물에서 유의적인 혈액응고저해 활성이 나타났으며, J-W 탁주 주박의 열수 추출물에서 thrombin 저해 활성과 J-B, J-S 및 J-H 주박 열수 추출물에서 혈액 응고인자 저해활성을 확인하였다. 혈소판 응집저해 활성평가의 경우 J-W 탁주 주박의 ethanol 및 열수 추출물에서만 아스피린에 필적하는 우수한 활성이 확인되었다. 본 연구결과는 다양한 약주 및 탁주 주박이 항혈전 활성을 가지고 있으며, 주박으로부터 항혈전제 개발이 가능함을 제시하고 있다. In this study, ethanol and hot water extracts of lees from Korean traditional wine (J-B, J-S, J-Y, J-H, and J-W) were prepared, and their effects on blood coagulation, platelet aggregation, and hemolysis of human red blood cells (hRBCs) were investigated to develop functional food ingredients from lees. The pH and brix of the lees ranged from 3.90 to 4.29 and 5.0 to 27.0o, respectively, and there was a huge difference in the water and ethanol content among the lees. The nuruk and additives used affected the color and physicochemical properties of lees. The J-W takju made from only rice and traditional nuruk, which has 13o brix and 1.8% of alcohol, has potential as functional food ingredient. With regard to the extraction yields of lees, higher yields were obtained from J-H, which contains different medicinal plants, in ethanol, followed by J-W, J-B, J-S, and J-Y. Higher extraction yields of lees were obtained from J-S in hot water, followed by J-B, J-W, J-H, and J-Y, respectively. The ethanol extract of J-H and the hot water extract of J-Y had the highest contents of total polyphenol and total flavonoids among the lees extracts. The 10 lees extracts did not show hemolysis activity against hRBCs up to 5 mg/ml. In an anticoagulation activity assay, the ethanol extracts of three yakju lees (J-B, J-S, and J-Y) and the hot water extract of J-W inhibited thrombin activity, whereas the hot water extract of J-B, J-S, and J-H inhibited blood coagulation factors. In an antiplatelet aggregation activity assay, only the J-W takju lees showed significant inhibition activity. Our results suggest that lees from traditional wine had high potential as a novel antithrombosis agent.

아시아계 미국문학의 문화 민족주의 비판: 단 리의 『예술가 연합』

이귀우 ( Gui Woo Lee ) 미국소설학회(구 한국호손학회) 2014 미국소설 Vol.21 No.1

Don Lee`s The Collective (2012) presents a portrait of young Asian American writers situated in a “postracial” America. The plot`s metafictional theme focuses on the Gatsby-like Korean-American writer, Joshua Yoon, whose story is told by the first-person narrator Eric Cho, a third-generation Korean-American writer. The main issue for these minority writers is what their responsibilities and obligations are in regard to race. Joshua insists on taking a culturally nationalist position, arguing that Asian-American writers should limit their subject matter to Asians or Asian Americans. He is extremely race-conscious due to the racial discrimination he experienced as an adoptee growing up in, what he calls, the “racist town” of Boston. When Eric meets Joshua in Macalester College located in the hometown of F. Scott Fitzgerald, he quickly becomes fascinated with Joshua.mirroring Nick Caraway`s fawning of Jay Gatsby in The Great Gatsby. Eric is an unreliable narrator like Nick, and the attraction and repulsion Eric feels towards Joshua is effectively conveyed by this narrative technique. They form a circle of “Asian American Artist Collective” (the ‘3AC’) with a Taiwanese American painter Jessica Tsai, and re-establish the group when they met again ten years later in Boston. Joshua clashes with Esther Xing, another Asian-American writer. In the multi-ethnic Asian artist group of the late 1990s, his culturally nationalist position is seriously challenged by her denationalized position. She criticizes Joshua for being outmoded, narrow-minded, and parochial, maintaining that minority writers do not have to limit themselves to stories revolving around identity or race. Her vision of the artist is one who is free to write beyond the boundary of race. Joshua fails because he, as an idealist, has trapped himself within the position of cultural nationalism. The Collective is a critique of cultural nationalism of marginalized minority ethnic writers, but Don Lee`s use of The Great Gatsby shows that Asian american literature does belong to the larger tradition of American literature.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

An Investigation on the Life of Master Won Guk Lee, the Creator of Chung-Do-Kwan

( Seon Young Jung ),( Jun Ho Lee ),( Seung Woo Shin ),( Chun Hwan Cho ),( Seung Hyun Jang ),( Won Shin ) 경남대학교 기초과학연구소 2014 기초과학지 Vol.31 No.-

The purpose of this study is to review (or, investigate) the life of Won Guk Lee. He is the creator of Chung-Do-Kwan, which is one of the five original Taekwondo kwans. Data was gathered from advanced research, newspapers, documentaries, the Internet, magazines, and journals etc. Thus, we were able to create a sequence of events based on the research data. First, we can say that in Won Guk Lee``s career, he created Chung-Do-Kwan and brought Dangsoodo to Korea. These events have had a significant development on Taekwondo. Second, Taekwondo curriculum, which was published by Won Guk Lee, established the foundation of Taekwondo poomsae, as well as giving us the pure spirit of Korean martial arts.

Changes in the Ultrastructure of the Acinar Cell of Rat Parotid Gland During Proliferation and Its Reversal

Lee, Seok Woo The Official Publication of Korean Academy of Oral 1993 International Journal of Oral Biology Vol.17 No.1

Previous studies showed that β-agonist isoproterenol(ISO) induced proliferation of rat parotid acinar cells, mediated by cell surface galactosyltransferase(Gal-Tase). The proliferation was reversed by the addition of Gal-Tase modifiers. α-lactalbumin(α-LA) and trifluoperazine(TFP). In earlier study(Lee. et al.. 1992). it was observed that expression of proto-oncogenes induced by isoproterenol treatment was down-regulated with chronic treatment of Gal-Tase modifiers. In the present study. changes in the ultrastructure of rat parotid acinar cells were investigated with transmission electron microscopy. when they were treated with isoproterenol and Gal-Tase modifiers. α-LA and TFP. Electron micrograph showed remarkable differences in acinar cell morphology among samples. Control parotid acinar cells showed numerous electron-dense secretory granules. characteristic of rat parotid acinar cell. around the lumen. In samples treated with isoproterenol for 24 hr (ISO-24). there was a tremendous decrease of the number of secretory granules. Samples treated with the combination of α-LA or TFP with isoproterenol for 24 hr (α-LA/ISO-24, TFP/ISO-24) showed similar morphology to ISO-24. In the sample treated with isoproterenol for 3 days (ISO-72), it was observed that enlarged. electron-lucid secretory granules filled the whole cytoplasm. indicating active cellular proliferation. There was a dramatic disappearance of electron-lucid granules in samples treated with α-LA or TFP in combination with ISO for 3 days (α-LA/ISO-3d, TFP/ISO-3d); only limited number of electron-dense secretory granules were observed. Ultrastructural changes observed in this study support that ISO administration stimulates exocytosis of secretory granules and development of immature granules, leading to cellular proliferation in rat parotid gland. This dramatic morphologic change was reversed with the addition of α-LA and TFP. The results of this study are well in accordance with those of earlier study (Lee et al.. 1992), which showed that ISO-induced acinar cellular proliferation was reversed with substances blocking cell surface Gal-Tase activity.

韓國産 자작나무科의 系統分類學的 硏究(序論)

李相泰,蘇雄永,田寬培,李愚喆 全北大學校 生物學硏究所 1981 生物學硏究年報 Vol.2 No.-

The present paper is an introduction to the whole project of "The systematic studies on Korean Betulaceae". Three studies under the project were performed this year and presented in this report : a review of taxonomic literatures and the construction of distribution maps by Woo-Tchul Lee, pollen morphology by Sang-Tae Lee and Moo-Yeol Kim, and wood anatomy by Woong-Young Soh and Kwan-Bae Jeon.

Adult Patients with Congenital Muscular Torticollis Treated with Bipolar Release : Report of 31 Cases

Lee, Gun Sang,Lee, Myung Ki,Kim, Woo Jae,Kim, Ho Sang,Kim, Jeong Ho,Kim, Yun-Suk The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.1

Objective : We assessed the surgical results of bipolar release in 31 adult patients with uncorrected congenital muscular torticollis (CMT) and more than 12 months of follow-up. Methods : Thirty-one patients underwent a bipolar release of the sternocleidomastoid muscle (SCM) and were retrospectively analyzed. The mean follow-up period was 14.9 months (range, 12-30). The mean age at time of surgery was 30.3 years (range, 20-54). Patients were evaluated with a modified Lee's scoring system, cervicomandibular angle (CMA) measurement, and a global satisfaction rating scale using patient self-reporting. Results : The modified Lee's scoring system indicated excellent results in 4 (12.9%) patients, good in 18 (58.1%), and fair in 9 (29.0%) at the last follow-up after surgery. The improvements in neck movement and head tilt were statistically significant (p<0.05). The preoperative mean CMA was $15.4^{\circ}$ (range, 5.4-29.0), which was reduced to a mean of CMA of $6.3^{\circ}$ (range, 0-25) after surgery (p<0.05). The global satisfaction rating scale was 93.7% (range, 90-100). A transient sensory deficit on the ipsilateral lower ear lobe was noted in three cases. No significant permanent complications occurred. Conclusion : Bipolar release of the SCM is a safe and reliable technique for the treatment of CMT in adults.