열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

유한요소법을 이용한 기둥형 로드셀의 비선형성 평가

배준우,황재근,박경흠,양희준,이춘열 嶺南大學校 工業技術硏究所 2004 工業技術硏究所論文集 Vol.32 No.1

Recently, force measurement systems are commonly used in many industrial fields and the precision of the measurement system is getting more important as the industry needs more precise tools and instruments to make high quality products. However, a high precision force measurement system is hard to make unless we know precisely the causes, quality and quantity of measurement errors in advance. In this work, many possible mechanical causes of measurement errors are reviewed including ratio of length to diameter of sensing part, radius of contact area, radius of bearing part, ratio of material properties and change of boundary conditions. Also, the measurement errors are analyzed by nonlinear finite element method and the nonlinear behavior of the errors are investigated. The results can be used to design force measurement systems and expected to be very useful especially for compact type load cells.

담도에 국한되어 증상을 유발한 석회쓸개즙 2 예

윤성우,이지영,하경호,이수경,한나,배효근,박선자 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Limy bile is a rare condition characterized by excessive precipitation of calcium carbonate in the gallbladder or bile duct. Recently we experienced two cases with obstructive jaundice in which limy bile in the common bile duct but not in the gallbladder for one case, and in the common bile duct and intra hepatic duct but not in the gallbladder for another case. The patients were treated by endoscopic sphincterotomy. Here, we report the cases and review the literature.

상악골 급속확장술식 전후 두경부 자세와 설골위치의 변화에 관한 연구

배현철,차경석,이진우 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.4

본 연구는 상악골 급속확장술식 후 호홉변화와 연관된 두경부 자세의 변화와 이에 따른 설골 위치 변화의 양상을 알아보기 위하여 시행하였다. 평균연령이 12세 9개월이고 Hellman stage Ⅲc에서 adult stage까지의 인두강이 정상적이며 상악골 급속활장술식을 시행한 Angle씨 Ⅲ급 골격양상의 남녀환자 32명을 대상으로 하여 이들 중 상악골 급속확장술식 시행 후 두경부각도가 증가된 군을 A군으로, 감소된 군을 B군으로 분류하였고 대조군은 연구대상과 동일한 Hellman stage이며 평균연령 12세 7개월의 Angle I급 골격양상을 띠는 남녀환자 23명으로 이들을 C군으로 하여 골격양상과 인두강크기, 두경부자세, 설골 위치에 대한 항목을 연구하여 다음과 같은 결론을 얻었다. 1. 골격양상과 인두강 비교 1) A, B군의 치료 전후 비교에서, 두 군 공히 하악이 하방경사되었고 인두강 크기는 변화가 없었다. 2) 세 군간의 치료 전후를 각가 비교한 결과, A, B군의 PMV에 대한 골격 양상과 인구강의 크기는 정상이었다. 2. 두경부 자세비교 1) A, B군의 치료 전후비교에서, A군은 두경부 각도가 상방으로 B군은 두경부 각도와 하악하연이 하방으로 경사됨을 보였다. 2) 세 군간의 치료 전후를 각각 비교한 결과, 치료전에 두경부 각도가 A군은 정상적이었으며, B군은 정상보다 상방 경사짐을 보였다. 치료후에는 A, B군 모두 정상적인 두경부각도를 보였다. 3. 설골 위치 비교 1) A, B군의 치료 전후 비교에서, 두군 공히 설골장축 각도의 변화가 없었고 전후방적으로 A군은 설골이 후방위치되었으며 B군은 변화가 없었다. 수직적으로는 A군의 APHFH가 증가되었을 뿐 나머지 항목에서는 두 군 모두 변화가 없었다. 2) 세 군의 치료 전후를 각각 비교한 결과, 설골장축 각도는 A, B군 모두 정상적이었으며, 전후방적으로 치료전에 A군이 B, C군보다 설골이 전방에 위치되었으나 치료후에는 A, B군 공히 정상적 위치였었다. 설골의 수직적 위치는 치료 전후에 A, B군 모두가 정상적이었다. The present study assessed the effects of Rapid Maxillary Expansion on head posture and hyoid bone position. For this study, 32 Angle's class Ⅲ patients - hellman 3c ~ adult, mean age 12y9m - were selected and divided into two groups, A,B according to craniocervical angulation. Crantiocervical angulation Increased in Group A and decreased in Group B after the therapy. And 23 Angle's class I persons ~ same hellman state, mean age 12y7m ~ were selected for the control group. Cephalometric analysis of skeletal pattern, pharyngeal space, head posture, hyoid bone position was performed. The results were as follows, 1. Comparison of skeletal pattern and pharyngeal space 1) All two group(A,B) had Mandibular plane inclined inferiorly and no pharyngeal space change was observed after RME therapy. 2) Skeletal pattern and pharyngeal space of Group A,B were normal before and after treatment. 2. Comparison of head posture 1) Cranicoervical angulation of Group A was increased after treatment. That of Group B was decreased and mandibular plane was inclined inferiorly after treatment. 2) Before treatment, craniocervical inclination was normal in Group A but larger than normal in Group B. After treatment, all two group(A,B) had normal craniocervical angulation. 3. Comparison of hyoid bone position. 1) After treatment, long axis of hyoid in Group A,B was not changed. Antero-posteriorly, hyoid position was changed posteriorly in Group A but no change was founded in Group B after treatment. Vertically, hyoid bone position were not changed in two groups except in crease in APHFH in Group B after treatment. 2) Long axis of hyoid bone was normal in Group A, B before and after treatment. Anteroposteriorly, hyoid bone positon was more anterior than Group B, C before treatment but all the position of two groups had normal position after treatment. Vertical position of hyoid bone was normal in all two groups before and after treatment.

Human Rotavirus 위장관염에 대한 임상적 고찰

배현,이홍준,서우철,양은석,문경래,박영봉 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

We observed clinical features of 161 patients of acute gastroenteritis who were adimitted to the Department of Pediatrics in the Chosun University Hospital from January 1. 1989 to December 31. 1993. The stool specimen on admission was tested for rotavirus Ag by ELISA(Rotazyme Ⅱ^R)method. The results are as follows : 1) HRV antigen was detected in 97 patients (58.4%) among 161 patients with gastroenteritis. 2) In monthly distribution. 77.7% of cases developed between October and December 3) The majority if patients were under 24month of age with the peak incidnce being between 6-12 month of age. 4) Mean frequency of diarrhea per day were 5.3±2.6 days in HRV antigen rhinorrhea(48.5%), cough(44.7%). Dehydration was noted 87.2% of cases and 93.9% Was isotonic dehydration. 6) The mean duration of hospitalization was 5.3±2.6 days. 7) AST and AIT elevation in HRV group were 91.5%, 42.6% respectively. AST and ALT elevation in Non-HRV group were 73.1%, 26.9% respectively. AST elevation between two group was not correlated statistically. but ALT concentration was significantly increased in HRV group above normal than Non-HRV group (p<0.05%).

정보이용을 위한 지적지원에 관한 연구

박경우,배상현 조선대학교 통계연구소 2000 統計硏究所論文誌 Vol.2 No.1

과학기술정보를 데이터베이스화한 여러 형태의 학술정보 데이터베이스중 이용자의 욕구를 충족시켜줄 수 있는 서비스는 그리 많지 않다. 따라서 본 논문에서는 이용자의 학술정보 데이터베이스의 기능을 보충하는 새로운 지식표현 패러다임을 제안한다. 이것은 기술정보로부터 자동적으로 구축되어 그 중에서 이용자가 자유롭게 탐방 할 수 있는 정보공간이다. 구축방법과 탐방기능을 명확히 하여 실 시스템을 구축, 평가하는 것이 연구의 목적이다. 이를 위해 Keyword로 기술된 논문군을 입력하여 논문내용의 항목별 요약, 유사논문의 시각적 표시와 비교, 인과관계의 추출을 시작으로 논문의 요약정보, Survey정보를 사용자에게 제공한다. 자료검색의 중심적 역할을 수행하는 것은 KP(Knowledge Piece)로 기술정보의 추출법과 구조법을 일체화한 Domain지식의 패키지이다. There have been various kinds of science information databsae which databased the science technology information, but they do not satisfy the aspiration of the users. Therefore, in the position of the users, it suggests the technology information space as a now paradigm, which supplement the function of science information DB. ICPIS which inputs described papers with keywords, offers the itemized summary of these contents, the visual indication and comparison of similar thesis, and it also supplises the abundant summary information survey information more than ten volumes of info communication thesis with starting the casual relation extraction for the users, playing a significant role in ICPIS is called KP, and it is package of domain knowledge that unifies the extraction and structure narration of the technology information.

初期發熱患者에 대한 防風解毒湯의 經時的 解熱效果

정우상,문상관,조기호,김영석,배형섭,이경섭 경희대학교 1997 慶熙醫學 Vol.13 No.4

Efavirenz, indinavir, lopinavir, ritonavir의 LC-MS/MS를 이용한 동시 정량법

채정우,배경진,백인환,서정원,이병요,이은주,남진경,강원구,권광일 충남대학교 약학대학 의약품개발연구소 2009 藥學論文集 Vol.24 No.-

Efavirenz indinavir and kaleta (co-formulation of lopinavir and ritonavir) are important antiretroviral drugs which have been proved to be human immunodeficiency virus (HIV) protease inhibitors and reduced the morbidity and mortality associated with HIV-1 infection. A brief and fast high performance liquid chromatography coupled with electrospray mass spectrometry (LC-MS/MS, API 4000) method for the determination of 4 anti-retroviral agents (efavirenz, lopinavir, indinavir, ritonavir) in human plasma was developed and validated. A simple protein precipitation method was used on 100μl of human plasma. And internal standard solution (10 ng/ml methaqualone) 1ml and reconstitution solution (MeOH) 1ml were added. After vortexing for 30 s and centrifuging at 13,200rpm for 10min, 2μl of supernatant was injected into the column (XTerra MS C_(18) column, 2.1mm × 50mm 3.5㎛ particle size). The mobile phase consisted of MeOH and 0.1% formic acid in water (80:20 , v/v). The chromatogram was run for 1.5 min at a flow rate of 300μl/min. A triple quadrupole mass spectrometer was operated in a positive ion mode (lopinavir, indinavir, ritonavir) and negative mode (efavirenz), simultaneously and multiple reaction monitoring (MRM) was used for drug quantification. The precursor-to-product ion transitions of m/z 316→69 (efavirenz) and 629→447 (lopinavir) and 614→421 (indinavir) and 721→296 (ritonavir)were used to measure and quantify the analyte. The limit of quantitation (LOQ) was 50 ng/ml (efavirenz, indinavir, ritonavir) and 100 ng/ml (lopinavir). The weighted (l/y²) calibration curve was linear over human plasma range 50∼5000ng/ml (efavirenz), 100∼20000ng/ml (lopinavir), 50∼10000ng/ml (indinavir), 50∼2000ng/ml (ritonavir), correlation coefficient(r²) of 4 antiretroviral agents were higher than 0.998. Accuracies and intra-run precisions ranged within 86.60 and 113.29%, 1.06 and 11.16% for all 4 drugs analysed. This analytical method used to determine these drugs was fast and easy to perform, with minimal sample preparation, and without compromising precision and accuracy. The developed method was successful to determine antiretroviral agents in human plasma, and proved suitable for clinical pharmacokinetic study.

석이로부터 분리한 페놀성 화합물의 phospholipase A_2 저해활성

김진우,송경식,유익동,장현욱,유승현,배강규,민태진 충남대학교 생물공학연구소 1997 생물공학연구지 Vol.5 No.-

호알카리성 진균 Cephalosporium sp. RYM-202가 생산하는 alkaline xylanase (CX-III)의 작용에 의해 xylan 기질로부터 생성되는 주요 가수분해 산물은 xylobiose와 중합도가 4 이상인 xylooligosaccharides이었다. 이 효소는 xylobiose에 대한 분해능을 가지고 있지 않지만 xylotriose로부터는 xylobiose를, xylotetraose로부터는 xylobiose와 xylotriose를 주산물로 형성하였다. 이러한 결과들은 CX-III가 transglycosidase 활성을 소유하는 전형적인 endo-type xylanase임을 보여준다. N-bromosuccinimide에 의한 CX-III의 화학적 변화 실험 결과 효소 1분자 당 2개의 tryptophan 잔기가 활성에 관여하는 것으로 나타났다. 그러나 iodoacetamide 및 diethylpyrocarbonate에 의한 효소활성의 저해효과는 나타나지 않음으로써 이 효소의 활성부위에 cysteine과 histidine 잔기가 필수적이지 않음이 확인되었다. The hydrolysis products formed from birchwood xylan by the action of an alkaline xylanase (CX-III) from alkalophilic Cephalosporium sp. RYM-202 were xylobiose and xylooligosaccharides polymerized with more than 4 sugar molecules. This enzyme was not active on xylobiose but readily attacked xylotriose accumulating xylobiose as a major product. The predominant end-products from xylotetraose by CX-III were xylobiose and xylotriose. These results indicate that the enzyme is typically endo-type xylanase possessing transglycosidase activity. Chemaical modification of CX-III with N-bromosuccinimide revealed that two tryptophan residues per molecule of CX-III were essential for its catalytic activity on xylan. On the other hand, iodoacetamide and diethylpyrocarbonate did not influence the activity of the enzyme, suggesting that cysteine and histidine residues are not involved in the active site of this alkaline xylanase.

Ontology를 이용한 지식표현에 대한연구

박경우,김희수,배상현 조선대학교 통계연구소 1999 統計硏究所論文誌 Vol.1 No.1

In an Expert-system, it is method to express an efficient and fast extraction implement for man-expert's systematic and factual knowledge and it efficiently. In this study, I want to consider expression method about reuse of the knowledge which is related to the repetition, unification, editing of knowledge to carry out meta-reasoning, that is the highest reasoning. I want to present expression method to join the part which is repeated and to improved management efficiency of reasoning reusing knowledge and using ontology.