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당귀 추출물이 생쥐 유래 대식세포의 일산화질소 생산에 미치는 영향
조성기,하미혜,정영란,이성태,변명우 경산대학교 생명자원개발연구소 1999 생명자원과 산업 Vol.3 No.-
1. 당귀 물추출물 단독으로는 NO생성을 유도하지 못하였다. 2. 당귀 물추출물은 LPS 단독 또는 LPS와 IFN-γ에 의해 유도되는 NO생성을 증가시키지는 못하였다. 3. IFN-γ와 당귀 물추출물을 같이 처리하였을 경우 농도 의존적으로 NO생성을 유도하였다. 4. IFN-γ와 당귀 물추출물로 유도된 NO생성은 NOS 억제제인 ??에 의해 억제되었다. 5. 복강 대식 세포에서도 동일하게 IFN-γ와 당귀 물추출물의 NO생성에 대한 상승효과가 나타났다. In this study, the objective was to determene the effect of Angelica gigantis Radix-water extract on the production of nitric oxide(NO). Angelica gigantis Radix-water extract had no effect on NO synthesis by itself. However the stimulation of mouse macrophage cell line(RAW264.7) with Angelica gigantis Radix-water extract after the treatment of murine interferon-γ(mIFN-γ) resulted in increased NO synthesis. When Angelica gigantis Radix-water extract was used in combination with mIFN-γ, there was a marked co-operative induction of NO synthesis in a dose-dependent manner. The same results were obtained in the mouse peritoneal macrophages used. The optimal concentration of Angelica gigantis Radix-water extract on NO synthesis was shown 100㎍/mL with 100U/mL of mIFN-γ. NO synthesis was inhibited by ??-monomethyl-L-arginine. Angelica gigantis Radix-water extract was endotoxin free. Theses results suggest that Angelica gigantis Radix-water extract can induces NO synthesis of mouse macrophage cell line (RAW264.7) and peritoneal macrophages in combination with mIFN-γ
Plyometric Training과 비타민 C 투여가 남고생의 체력, 혈중 젖산, 암모니아 및 젖산탈수소효소에 미치는 영향
장준원,김세종,이현미,서혜림,조현숙,고정림,염종우,예정복,백영호 釜山大學校 附設 體育科學硏究所 2003 體育科學硏究所 論文集 Vol.19 No.-
The purpose of this was to examine the effect of plyometric training and vitamin C ingestion on physical fitness and fatigue substance....
열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구
배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2
Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.
박혜순,선우성,오상우,이가영,김병성,한지혜,김선미,이혜리,유병연,이근미,서영성,남윤덕,박용우,신호철,이정권 대한비만학회 2003 The Korean journal of obesity Vol.13 No.4
연구배경: 비만 환자는 신체적, 정신적, 기능적 건강 문제를 가지게 되며 삶의 질이 낮다고 알려져 있다. 삶의 질을 측정하기 위해 외국의 도구를 번역하여 사용하는 경우 문화적인 차이와 그 나라 고유 언어표현을 충분히 반영하지 못하는 등의 문제가 있다. 이에 한국인 비만 환자에서 삶의 질을 간편하게 측정할 수 있는 도구를 개발하여 신뢰도와 타당도를 검증하였다. 방법: 한국형 건강관련 삶의 질 측정 도구를 개발한 경험이 있는 전문의와 협의하여 비만 관련 삶의 질 정의 및 영역을 설정하였다. 이를 토대로 180명의 비만 환자로부터 비만 관련 증상을 채집하였다. 채집된 증상을 같은 의미를 나타내는 증상끼리 묶고 각 영역으로 범주화하였으며 문항에 적합하게 수정하였다. 이에 대해 사전 설문 조사한 후 각 영역별로 내적일치도를 검토하여 최종 문항을 선택하였다. 7개 병원의 비만 클리닉과 가정의학과 외래로 내원한 환자 240명을 대상으로 타당도를 분석하였고, 이 중 4주 이내에 검사-재검사법을 실시한 38명의 자료에 대하여 신뢰도를 검증하였다. 결과: 총 215개의 증상이 채집되었으며 범주화를 통하여 정신사회적 건강, 신체적 건강, 직장 및 가사업무, 일상 생활, 성관계, 음식 관련 등 6개의 삶의 질 영역, 15개의 문항으로 정리되었다. 측정 도구의 내적 일치도가 비교적 높게 나타났고 검사-재검사법에 의한 상관 계수도 유의하게 높게 나타났으며, 문항-영역간, 문항-총점간 상관성도 모든 문항에서 유의성을 나타내었다. 요인 분석 결과는 3개의 요인으로 묶여 비만 관련 삶의 질을 측정하기에 타당도가 있는 것으로 나타났다. 삶의 질 각 영역별 점수는 모든 영역에서 비만군 및 복부 비만군과 대조군 사이에 유의한 차이가 있는 것으로 나타났다. 결론: 6 영역, 15 문항으로 구성된 한국형 비만 관련 삶의 질 측정도구를 개발하였으며 이 도구는 신뢰도와 타당도가 높은 것으로 나타났다. 한국인 비만 환자에게 간편하게 사용할 수 있을 것으로 여겨지며 추후 지속적인 개정 작업이 필요하다. Objective: Obesity researchers have a growing interest in measuring the impact of weight and weight reduction on quality of life. The KOQOL (Korean version of Obesity-related QOL scale) was the self-report instrument specifically developed to assess the effect of obesity on quality of life reflecting Korean's own language expression and culture. This report was conducted to establish verification of the reliability and validity of a 15-item version of the KOQOL. Methods: Symptom descriptions related with obesity were collected from 180 obese people based on definition and domains of ‘obesity related quality of life'. The collected results were categorized into each domain and edited to be used as questions. The expert panels established final 6 domains, 15 items, and item option responses. Reliability was tested by internal consistency method and 2 weeks test-retest method. Validity test was performed by factor analysis and clinical validity. Results: A total of 215 symptom descriptions were collected and categorized into 15 items of 6 domains including phychosocial health, physical health, work, routine life, sexual life, and diet distress. Items were corrected for more precise meaning, concise sentence, and proper expression. A high degree of internal consistency was observed for each of domain except routine life. Two weeks test-retest reliability correlation coefficients scores were highly significant in all domains. Item-to-scale and item-to total score correlations were highly significant for all items. A principal components analysis identified 3 factors with strong support for the adequacy of the scale structure. Significant differences in KOQOL scale and total scores were found among groups differing in body mass index or abdominal circumference, supporting the utility of the KOQOL. Conclusion: The KOQOL composed of 15 items of 6 domains (phychosocial health, physical health, work, routine life, sexual life, and diet distress) was demonstrated as an excellent tool for measuring of obesity related quality of life. The KOQOL appears to be a reliable and clinically valid brief measure of quality of life in Korean obese persons.
Environmental Analysis in Asian Dust Source Region Using Satellite Remotely Sensed Data
Hye Mee Kyung,Young Seup Kim,Sang Woo Kim 大韓遠隔探査學會 2003 大韓遠隔探査學會誌 Vol.19 No.3
With the negative influences and damage from Asian dust increasing, it`s getting important to investigate the climate and soil condition of the source region of Asian dust. There is a high possibility that the desertification and the drastic decrease of plants in China and Mongolia make worse the situation (bad effects of Asian Dust). To detect the movement of Asian dust caused by air circulation, we need to watch the state of the source region to get useful information for the prevention of the dust pollution, and to predict what part of China will become the source region. Therefore, using TOMS aerosol index data, NCEP reanalysis data that is Remote Sensing data from 1981 to 2000 (except 1993~1996, 4 years), for 16 years, examined the relation between the dust occurrence and weather elements. Dust occurrence appeared much in spring season from March to May in study areas. It had a dry climate during that season as follows: relative humidity about 20~40%, temperature about -5~5℃, precipitation about 33~180 mm, wind speed about 4~10 ms-1. Dust occurrence and weather element annual change in study areas decreased gradually till 1990, but in Gobi desert the incidence of dust occurrence increased since 1997. As a result, found out that the more the precipitation, the less dust occurrence, because the precipitation and surface wind speed had a direct influence on the soil of the source region of dust.