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Beagle dog에 있어서 rifapentine의 독성동태연구
신호철,이혜숙,차신우,한상섭,노정구,김진석,이원창,Shin, Ho-chul,Lee, Hye-suk,Cha, Shin-woo,Han, Sang-seop,Roh, Jung-ku,Kim, Jin-suk,Lee, Won-chang 대한수의학회 1995 대한수의학회지 Vol.35 No.4
The toxicokinetics of rifapentine was studied after an oral administration to beagle dogs. High-performance liquid chromatography(HPLC) using column-switching technique was performed to determine the serum concentrations of rifapentine. The pharmacokinetic profiles of rifapentine were analysed using one-compartment open model. Following a single oral administration of 10mg/kg, pharmacokinetic parameters were determined as follows: maximum serum concentration($C_{max}$), $28.90{\mu}g/ml$; maximum concentration time($T_{max}$), 3.7hr; elimination half-life($t_{1/2}$, 4.7hr; area under the curve(AUC), $339.0{\mu}g{\cdot}hr/ml$; volume of disiribution/bioavailability (Vd/F), 0.21 l/kg; lag time, 24min; absorption rate constant($k_a$), $0.445hr^{-1}$; elimination rate constant($k_{el}$), $0.148hr^{-1}$. After 6 month multiple oral doses of 10mg/kg/day, parameters were as follows: $C_{max}$, $34.40{\mu}g/ml$; $T_{max}$, 2.6hr; $t_{1/2}$, 6.7hr; AUC, $391.3{\mu}g{\cdot}hr/ml$; Vd/F, 0.291/kg; $k_a$, $0.976hr^{-1}$; $k_{el}$, $0.104hr^{-1}$. The consistant kinetic parameters after a single and multiple oral administration show that there was no accumulation of rifapentine after 6 month oral administration. We also simulated the concentration of rifapentine after oral multiple administration of 10 and 50mg/kg/ day, based on the parameters obtained form the single administration. The measured serum concentrations of rifapentine were well fitted to the simulated results. The simulated results show that rifapentine readily reaches to steady-state after about 3 doses and the steady-state serum concentrations($C_{ss}$) are fluctuated in between $2.2{\sim}25.2{\mu}g/ml$, and $10.6{\sim}125.2{\mu}g/ml$ at the doses of 10 and 50mg/kg/day, respectively.
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신호철,차신우,배주현,김현주,정태천,박종일,윤종만,김계웅,김진석,한상섭,Shin, Ho-chul,Cha, Shin-woo,Bae, Ju-hyun,Kim, Hyun-ju,Jeong, Tae-cheon,Park, Jong-il,Yoon, Jong-man,Kim, Gye-woong,Kim, Jin-suk,Han, Sang-seop The Korean Society of Veterinary Science 1996 대한수의학회지 Vol.36 No.1
The biliary excretion kinetics of the active folate derivatives were examined after an intravenous injection of methotrexate at doses of 0.3 and 10mg/kg to clarify the mechanism of the acute decrease in the plasma folate by the dihydrofolate reductase inhibitors. Even at a higher dose than used in the clinical therapy, methotrexate did not cause any acute depletion of folate denvatives in the excreted bile. Therefore, the decrease in the plasma folate appeared not to be related with the biliary excretion process of folates. A factor responsible for the plasma folate depletion by DHFR inhibitors may be due to the malabsorption of folate derivatives excreted into the small intestine.
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Chemical components of aqueous humor in Korean native cattle and Holstein-friesian cattle
신호철,Shin, Ho-chul The Korean Society of Veterinary Science 1996 대한수의학회지 Vol.36 No.3
Chemical components of bovine aqueous humor were analyzed. Significant levels of protein, urea nitrogen, creatinine, cholesterol, calcium and electrolytes including sodium, potassium and chloride were detected. The composition of bovine aqueous humor is similar to that of cerebrospinal fluids, rather than that of plasma. It was also found that there is no significant difference in most components between aqueous humor of Korean native cattle and that of Holstein-Friesian cattle.
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Active metabolites in rat bile after intravenous injection of [<sup>3</sup>H] pteroylglutamic acid
신호철,시모다 미노루,코쿠에 에이치,Shin, Ho-chul,Shimoda, Minoru,Kokue, Eiichi The Korean Society of Veterinary Science 1993 대한수의학회지 Vol.33 No.4
Active metabolites in rat bile after an intravenous injection of $[^3H]$ pteroylglutamic acid(PteGlu)were studies using high-performance liquid chromatography(HPLC). Predominant four radioactive metabolites and parent compound PteGlu were detected on the chromatogram of HPLC with liquid scintillation counting system. These metabolites were identified as tetrahydrofolate, 10-formyltetrahydrofolate, 5-methyltetrahydrofolate and para-aminobenzoyl glutamate. The identification of active folate metabolites was based on the consistency of retention time profiles and hydrodynamic voltammograms which were obtained by HPLC with the electrochemical detection system, and characteristics of UV absorbance spectra obtained by HPLC with photodiode array detection system.
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온라인 판매촉진활동 분석을 통한 고객 리뷰평점 추천 및 예측에 관한 연구 : S사 Wearable 상품중심으로
신호철 한국콘텐츠학회 2022 한국콘텐츠학회논문지 Vol.22 No.4
The purpose of this report is to study a strategic model of promotion activities through various analysis and sales forecasting by selecting wearable products for domestic online companies and collecting sales data. For data analysis, various algorithms are used for analysis and the results are selected as the optimal model. The gradation boosting model, which is selected as the best result, will allow nine independent variables to be entered, including promotion type, price, amount, gender, model, company, grade, sales date, and region, when predicting dependent variables through supervised learning. In this study, the review values set as dependent variables for each type of sales promotion were studied in more detail through the ensemble analysis technique, and the main purpose is to analyze and predict them. The purpose of this study is to study the grades. As a result of the analysis, the evaluation result is 95% of AUC, and F1 is about 93%. In the end, it was confirmed that among the types of sales promotion activities, value-added benefits affected the number of reviews and review grades, and that major variables affected the review and review grades. 본 논문에서는 국내 온라인 기업의 Wearable 제품을 선정하고 판매 데이터를 수집해 다양한 분석과 매출 예측을 통해 판촉 활동의 전략 모델을 연구하는 데 목적이 있다. 데이터 분석을 위해 여러 가지의 알고리즘을 사용하여 분석할 것이며, 최상의 모형으로 결과를 선택할 것이다. 최상의 결과로 선택된 모형인 Gradient Boosting 모델은 지도학습을 통해 종속변수 예측에 있어서 판촉 유형, 가격, 판매 수량, 성별, 모델, 판매경로, 제품 성능, 판매 날짜, 지역 등 9개의 독립변수를 투입할 수 있게 된다. 본 연구에서는 판매촉진 유형별로 종속변수로 설정된 리뷰 값을 앙상블 분석 기법을 통해 더욱더 세부적으로 학습하고 분석 및 예측이 주목적이며, 판매촉진 활동을 통한 고객에게 할인 혜택을 주어질 경우와 주어지지 않을 경우에 리뷰 평점을 연구하는 데 목적이 있다. 분석 결과로 본다면 평가 결과는 AUC 95% 수준이며, F1도 93% 정도이다. 결국 판매촉진 활동 유형 중 가치 부가 혜택이 리뷰 수와 리뷰 평점에 영향을 준다고 것을 확인할 수 있었으며, 주요 변인들이 리뷰와 리뷰 평점의 영향을 준다는 것도 확인할 수 있었다.
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