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간세포암과 하대정맥 막성폐쇄의 치료 후 호전된 백혈구파괴혈관염 1예
이준엽 ( Jun Yeob Lee1 ),이주원 ( Ju Won Lee1 ),이진욱 ( Jin Wook Lee ),박현준 ( Hyun Joon Park ),장국환 ( Gook Hwan Jang ),김다정 ( Da Jung Kim ),김선민 ( Sun Min Kim ),한병훈 ( Byung Hoon Han ),정규식 ( Gyoo Sik Jung ),김근태 ( 대한류마티스학회 2015 대한류마티스학회지 Vol.22 No.5
저자들은 하지 자색반과 고환 통증으로 내원한 알코올성 간경화증 환자에서 LCV의 원인 감별하는 과정에서 HCC와 하대정맥 막성폐쇄를 진단하고 이에 대한 치료 후 LCV의 호전된 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Vasculitis is a heterogeneous group of diseases that destroy blood vessel walls by inflammation. Approximately half of vasculitis cases are idiopathic, but sometimes associated with genetic factors, medicines, chronic infection, autoimmune diseases, and malignancies. Although the mechanism remains unclear, vasculitis secondary to malignancy, also known as paraneoplastic vasculitis, has been reported. It is generally associated with hematologic malignancies rather than solid malignancies and commonly presents as leukocytoclastic vasculitis or polyarteritis nodosa. We experienced a case of leukocytoclastic vasculitis in a patient with hepatocellular carcinoma and membranous obstruction of the inferior vena cava. Here, we report this case with a brief review of literature. (J Rheum Dis 2015;22:322-326)
Kim, Hee Kyung,Kim, Sun Young,Lee, Su Jin,Kang, Mihyeon,Kim, Seung Tae,Jang, Jiryeon,Rath, Oliver,Schueler, Julia,Lee, Dong Woo,Park, Woong Yang,Kim, Sung Joo,Park, Se Hoon,Lee, Jeeyun Neoplasia Press 2016 Translational oncology Vol.9 No.3
<P><I>BACKGROUND:</I> Although pazopanib treatment has become the standard chemotherapy in salvage setting for metastatic sarcoma patients, most patients progress after pazopanib treatment in 4 to 6 months. After failure to pazopanib, patients have limited options for treatment. Therefore, subsequent therapy in patients who failed to pazopanib is urgently needed and the use of patient derived cells or patient derived tumors for accompanying testing with various pharmacological inhibitors could offer additional treatment options for these patients. <I>METHODS:</I> Patient derived tumor cells were collected from ascites at the time of progression to pazopanib and a 13-drug panel was tested for drug sensitivity. We confirmed the results using <I>in vitro</I> cell viability assay and immunoblot assay. We also performed the genomic profiling of PDX model. <I>RESULTS:</I> The growth of patient derived tumor cells was significantly reduced by exposure to 1.0 μM AZD2014 compared with control (control versus AZD2014, mean growth = 100.0% vs 16.04%, difference = 83.96%, 95% CI = 70.01% to 97.92%, <I>P</I> = .0435). Similarly, 1.0 μM BEZ235 profoundly inhibited tumor cell growth <I>in vitro</I> when compared to control (control versus BEZ235, mean growth = 100.0% vs 7.308%, difference = 92.69%, 95% CI = 78.87% to 106.5%, <I>P</I> < .0001). Despite the presence of CDK4 amplification in the patient-derived tumor cells, LEE011 did not considerably inhibit cell proliferation when compared with control (control vs LEE011, mean growth = 100.0% vs 80.23%, difference = 19.77%, 95% CI = 1.828% to 37.72%, <I>P</I> = .0377). The immunoblot analysis showed that BEZ235 treatment decreased pAKT, pmTOR and pERK whereas AZD2014 decreased only pmTOR. <I>CONCLUSION:</I> Taken together, upregulation of mTOR/AKT pathway in sarcoma patient derived cells was considerably inhibited by the treatment of AZD2014 and BEZ235 with downregulation of AKT pathway (greater extent for BEZ235). These molecules may be considered as treatment option in STS patient who have failed to pazopanib in the context of clinical trials.</P>
월남전 당시 살포된 고엽제에 의해 발생한 것으로 생각되는 피부 질환
이증훈,김윤동,서기범,박장규 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2
Although many dermatologists need adequate information about Agent Orange-related skin lesions, there have been few researches about them. We observed various skin manisfestations from 266 Korean Vietnam veterans who visited Department of Dermatology, Chungnam National University Hospital, inculding seborrheic dermatitis(46%), xerotic eczema(45%), chloracne(30%), generalized pruritus (10%), dermographism (5%), chronic urticaria (4%), photosensitive dermatitis (3%), etc. Among them chloracne is well known as a disease which results from exposure to Agent Orange which was used for a defoliating agent during Vietnam war. It is a refractory acneiform eruption due to halogenated polyaromatic compounds(eg. dioxin, dibenzofurane, polychlorinated biphenyls, etc.). 2,3,7,8-tetrachlorodibenzo-p-dioxin, a kind of dioxin isomer, contained in the Agent Orange which was used for a defoliating agent during Vietnam war. It is characterized by recalcitrant comedones and cysts predominantly in the malar and postauricular area. We concluded that the various skin lesions in Vietnam veterans resulted from probably the chemicals in defoliant and further researches would be required to find out subjective guidelines for the evaluation of the skin lesions.
이송우,문장천,김도한,이창한,최동훈,류동춘,송승구 부산대학교 환경문제연구소 2000 環境硏究報 Vol.18 No.-
The purpose of this study is to investigate the variation of pore size distribution of the coal-based extruded activated carbon. The extruded activated carbon was prepared by extruding the mixture of coal powder and coal tar. Pore size distribution of the extruded activated carbon was compared with that of the extruded coal and the extruded char. Also it was compared with that of the crushed activated carbon, raw coal and char. The extruded coal had coarser surface than that of raw coal. Macropores of the extruded coal were funned near 10,000Å in diameter during carbonization process and steam penetrated easily between particles and were growing between 3,000Å and 20,000Å in diameter during activation process.
이장훈,권혁구,박승호,김동진,홍철호 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.2
Air quality monitoring is a primary activity for industrial and social environment. The government identifies the pollutants that each industry must monitor. Especially, the VOCs(Volatile Organic Compounds), which are very harmful to human body and environment atmosphere, should be controlled under the government policy. However, the VOCs, which have not been confirmed in emission sources are very difficult to monitor. It is needed to develop the monitoring system that allow the continuous and in situ measurement of VOCs mixture in different environmental matrices. Gas chromatography and mass spectrometry are the most prevalent current techniques among those available for the analysis of VOCs. But, they need a large size analytical instrument, which costs a great deal for purchase and operation. In addition, it has some limitations for real time environmental monitoring such as location problems and slow processing time. Recently, several companies have commercialized a portable VOCs measurement systems, which cannot classify various kinds of VOCs but total quantities. We have developed a VOCs measurement system, which recognizes various kinds and quantities of VOCs, such as benzene, toluene, and xylene(BTX). Also, it can be used as a stand-alone type and/or fixed type in the vehicle with rack for real-time environmental monitoring.
이훈재,장익훈 경운대학교 산업기술연구소 2000 産業技術硏究論文誌 Vol.3 No.1(B)
Among zero-suppression (AS) algorithms proposed for synchronous stream cipher system, ZS-1 has the difficulty on the implementation of the stream cipher system, ZS-2 has a weakness of channel error propagation, and ZS-3 has the complexity on the hardware. Because each algorithm must be chosen carefully to the application system, in this paper, we propose a criterion of the system adapted from the simulated results on the parameter changed.
이상훈,박정희,이장우 동의대학교 경제경영전략연구소 2009 經濟經營硏究 Vol.4 No.2
This study analyzes the effect of capital investment on firm valuation. The portfolios classified by size and B/M have different extent of capital expenditure. It is found that the capital expenditure on total assets can explain returns to portfolios. Specifically, firms showing lower B/M ratios are found to invest more and are with greater market values. Firms showing greater B/M ratios show the other side but with increasing capital expenditures afterwards. Market valuation, however, does not reveal any consistent patterns. Our results also show that firms with formerly higher capital expenditures are shown to be linked to significantly lower stock returns