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류마티 질환에서 항 Cardiolipin 항체의 출현 빈도와 임상적 의의
송영욱,계경채,박선양,최강원 대한내과학회 1990 대한내과학회지 Vol.38 No.5
We analyzed the frequency and clinical significance of serum anticardiolipin antibodies by enzyme linked immunosorbent assay in 67 patients with various rheumatic diseases. A significantly elevated frequency of anticardiolipin antibody was found in patients with systemic lupus erythematosus(44%), rheumatoid arthritis(39%) and dermatomyositis(20%). None of the patients with progressive systemic sclerosis had anticardiolipin antibody. In the case of SLE, the anticardiolipin antibody level seemed to parallel the disease activity. Along with clinical improvement, the anticardiolipin antibody and anti-ds DNA antibody level decreased, while the serum complement increased. The presence of anticardiolipin antibody correlated with elevated ESR and positive Coombs' test in patients with systemic lupus erythematosus. These results suggest that the anticardiolipin antibody levels reflect disease activity and that some anticardiolipin antibody may be capable of recognizing a phospholipid epitope on the surface of the red blood cell. No significant association was found between the anticardiolipin antibody and the rheumatoid factor or the antinuclear antibody in patients with rheumatoid arthritis. There was no significant association between the anticardiolipin antibody and skin rash, Raynaud's phenomenon, antinuclear antibody or the rheumatoid factor in patients with dermatomyositis.