http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The Synthesis of Carbamoylsulfenyl Chloride and its Derivatives
문석식,오동영,Surk Sik Moon,Dong Young Oh Korean Chemical Society 1983 대한화학회지 Vol.27 No.2
N-Methylidene-2,6-diethylaniline (III)은 2,6-diethylaniline (II)과 과량의 paraformaldehyde와의 반응으로 만들었으며, 이 화합물 III에서 N=$CH_2$ 프로톤은 AB 스핀계를 나타냈다. 화합물 III과 chlorocarbonylsulfenyl chloride(IV)를 반응시켜서 N-(chloromethyl)-N-(2,6-diethylphenyl)-carbamoylsulfenyl chloride(V)를 합성하였다. 화합물 V와 여러 종류의 알콜을 반응시켜서 Alkyl N-(chloromethyl)-N-(2,6-diethylphenyl)-carbamoylsulfenate esters(VI ${\sim}$XVI)를 71{\sim}$95%의 수득률로 합성하였다. VI${\sim}$XVI은 서서히 분해되지만 S-O 결합이 S=O결합으로 변하지는 않았다. 과량의 알콜은 V의 2가 황과 N-chloromethyl기의 ${\alpha}$-탄소에 대해 친핵성 공격을 할 수 있었으며, 이렇게 하여 생긴 화합물 (XVII, XVIII)은 상당한 안정성을 가지고 있었다. N-Methylidene-2,6-diethylaniline (III) was prepared by the reaction of 2,6-diethylaniline (II) with an excess paraformaldehyde. The protons of N=$CH_2$in the compound III exhibited a second order NMR spectrum. The compound III reacted with bifunctional chlorocarbonylsulfenyl chloride(IV) to give N-(chloromethyl)-N-(2,6-diethylphenyl)-carbamoylsulfenyl chloride(V). The reaction of the compound V with various alcohols resulted in the formation of Alkyl N-(chloromethyl)-N-(2,6-diethylphenyl)-carbamoylsulfenate esters(VI${\sim}$XVI) in 71${\sim}$95% yields. The compound VI${\sim}$XVI decomposed gradually, but the thermal rearrangement of S-O bonding to S=O bonding was not found. The nucleophilic attack of an excess alcohol to the compound Ⅴ was made on both divalent sulfur and ${\alpha}$-carbon of N-chloromethyl group. The corresponding substituted products(XVII, XVIII) had considerable stability.
Tsaokoarylone, a Cytotoxic Diarylheptanoid from Amomum tsao-ko Fruits
문석식,조순장,이지영 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.3
The crude methanol extract of the fruits of Amomum tsao-ko (Zingiberaceae) showed cytotoxic activity. Bioactivity-guided separation led to the isolation of a diarylheptanoid, tsaokoarylone [7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one] (2). 2 showed cytotoxicity at 4.9 and 11.4 g/mL (IC50) against human nonsmall cell lung cancer A549 and human melanoma SK-Mel-2, respectively, determined by SRB colorimetric method. During purification 6-(4-hydroxyphenyl)-4-hydroxyhexan-2-one (4) together with three known diarylheptanoids was also isolated. Their structures were determined from interpretation of spectroscopic data (IR, UV, MS, and NMR) and synthesis confirmed the structure of 2.
조순장,문석식,Md. Zakir Sultan 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.4
Quinone type compound, pulsaquinone 1, isolated from the aqueous ethanol extract of the roots of Pulsatilla koreana exhibited antimicrobial activities against an anaerobic non-sporeforming gram-positive bacillus, Propionibacterium acnes, which is related with the pathogenesis of the inflamed lesions in a common skin disease, acne vulgaris. Compound 1 was unstable on standing and thus converted to more stable compound 2, namely hydropulsaquinone by hydrogenation, whose activity was comparable to mother compound 1 (MIC for 1 and 2 against P. acnes: 2.0 and 4.0 μg/mL, respectively). Other structurally-related quinone derivatives (3-13) were also tested for structure-activity relationship against anaerobic and aerobic bacteria, and fungi. The antimicrobial activity was fairly good when the quinone moiety was fused with a nonpolar 6- or 7-membered ring on the right side whether or not conjugated (1,4-naphtoquinone derivatives 3-5), while simple quinone compounds 6-9 showed poor activity. It seems that the methoxy groups at the left side of the quinone function deliver no considerable antimicrobial effect.
Aspergillus terreus로부터 항진균성 물질의 분리 및 구조분석
김근기,박기훈,문석식,강규영 ( Keun Ki kim,Ki Hun Park,Suk sik Moon,Kyu Young Kang ) 한국응용생명화학회 1997 Applied Biological Chemistry (Appl Biol Chem) Vol.40 No.6
In the course of search antagonistic fungi from soil in green house, four kind of fungi (AF1, AF2, AF3, AF4) were isolated, which have activities aganist Phytophthora capsici, Botrytis cinera, Rhizoctomia solani, Pythium ultimum and Fusarium oxysporum. The AF2 was identified according to the morphological description of Aspergillus terreus. This antagonistic fungus inhibiting various plant pathogens was effective to reduce disease incidence of cucumber seedlings caused by mixed inoculum of Rhizoctonia solani, Pythium ultimum and Fusarium oxysporum. Antifungal compound I was isolated and purified by fresh chromatography from A. terreus. The ¹H and ^(13)C assignment of compound I was achieved from two-dimensional ¹H-¹H COSY, HMQC, HMBC with the add of homonuclear and heteronuclear double resonance experiment. The compound I was identified butyrolactone I (α-oxo-β-(p-hydroxyphenyl)-γ-(p-hydroxy-m-3,3-dimethyl-allylbenzyl)-γ-methoxy-carbonyl-γ-butyrolactone, C_(24)H_(24)O_7, M.W.=424).