카드뮴 및 청국장 첨가식이가 흰쥐의 생육과 체내 카드뮴 분포에 미치는 영향

주현규,강경원,사동민 선문대학교·중소기업기술지원연구소 1998 선문공대 연구/기술 논문집 Vol.3 No.1

This study was performed to investigate the effect of Chungkuk Jang added-diets on reducing cadmium toxiclt in rats (Sprague-Dalvley, ♂, 125 58±4.04g) used as experimental groups. There are six experimental groups, a normal group(Tn), a cadmium treatment group(control group Tc), four cadmium and Chungkuk Jang (0.25%, 0 50%, 1 00%, and 1 50%; T_1 T_2, T_3, and T_4) treatment groups which received different dietary feeding for 8 weeks each The results are as follows. 1 The amount of food intake at Chungkuk Jang mixed group(T_1, -T_2) was 3 5% greater than at the Tc group For the group fed Chungkuk Jang the average of weight gain was 4.42g/day, which showed higher value(2.79%) than the Tc(4 30g/day) group. The food efficency rate of intake Chungkuk Jang group (5.02) was a little higher without significance than that of the Tn(4 91) and Tc(4 99) groups. 2. The amount of water intake was the highest in the Tn(32.44?/day) group and 30.14% greater than that of the Tc(21.66?/day) group. For the water intake (T_3) among Chungkuk Jang added-diet groups showed the highest value(22.78?/day) relatively Cadmium intake of each group was in the range of 1.94 to 2.27 ppm and the T_3 group showed the highest cadmium intake. For the growth rate the Tc group was 7.62% lower than Tn group but the Chungkuk jang fed group resulted in a reduced fashion-about 3% in the growth process against the Tn group 3 There was no significant weight gain or loss of the organ and bone of rats among the experimental groups but in the case of liver and kidney the T_3 (8.59%. 12 36%) was higher than the Tc group 4 Cadmium accumulation was high to low in order of liver > kidney > spleen > heart > lung > testicle > brain > femoral muscle > femur >(T_1, T_2, T_3, and T_4). tibia > blood. The 70% accumulation rate was showed in liver (33 2%), kidney (31.25) and spleen (6 1%). The contents of cadmium in tissue and body-hair in the Chungkuk Jang intake groups(T_1, T_2, T_3, and T_4) were lower than in the Tc group. The chungkuk Jang added-diet groups (T_3, and T_4) showed low levels of cadmium accumulation

알코올리즘 환자에서 뇌교외수초용해증과 연관된 주기교대눈떨림과 주기교대주시편위

강성원,이명제,정주리,김영진,양현덕 원광대학교 의과학연구소 2009 圓光醫科學 Vol.24 No.1

주기교대눈떨림와 주기교대주시편위는 이상안구 운동에서도 흔히 관찰되지 않는다. 이런 안구운동은 뇌교와 소뇌에 병변이 있을 때 나타난다고 보고되고 있다. 50세 남자 환자가 과음을 하고 난 이후 심하게 구토를 하여 입원하였다. 다음날 아침에 의식이 없었으며 주기교대눈떨림과 주기교대주시편위가 관찰되었다. 뇌자기공명영상에서는 뇌교나 소뇌에 병변없는 교뇌외수초용해증에 합당한 소견을 보였다. 저자는 아마도 교뇌외수초용해증이 소뇌와 전정신경핵의 경로중에 GABA 시스템에 이상이 발생하여 주기교대눈떨림과 주기교대 주시편위가 나타났을 것으로 추정한다. Background; Periodic alternating gaze deviation(PAGD) and periodic alternating nystagmus(PAN) are rare forms of abnormal eye movement. Multiple lesions in the cerebellum and brainstem have been reported with PAN and PAGD. Case Report; A 50-year-old man presented with severe vomiting after binge drinking. The next morning he. became vegetative state and showed PAGD and PAN. Brain MRI showed findings compatible with extrapontine myelinolysis(EPM) without any brainstem or cerebellar lesions. Conclusions; We postulate that the disturbed GABAnernic system in the pathway from the cerebellum to vestibular nuclei caused probably by EPM developed PAGD and PAN.

방조제 건설 전후에 목표해역의 오염물질 확산 메커니즘

강주환,임병선,이점숙,김종욱,임현식,김하송 한국환경생물학회 1998 환경생물 : 환경생물학회지 Vol.16 No.4

육상으로부터 목포해역으로 영양염류가 유입되는 곳과 간조시 갯벌을 통과한 지역의 pH, DO, COD, HN_4-N, NO_3-N 및 T-P 함량을 측정하고 RMA 모형과 FIT모형을 사용하여 방조제 건설에 따른 유기물질의 확산양태를 모의하였다. 목포 인근해역의 수질은 양호하였으며 특히, 갯벌 통과 후 질소원은 증가하였고 COD와 T-P는 감소하였다. 영암/금호 방조제 건설에 따라 방조제 인근해역에서 해수이동양상이 급격히 둔화되었고 목포해역의 북쪽과 4단계 방조제 해역간의 해수교환이 크게 증가하였으며 목포해역의 남쪽에서는 외해수와의 해수교환이 크게 감소하였다. 결과적으로 방조제 건설로 인해 방조제 인접해역에 축적되는 유기물질이 크게 증가하여 목포해역 내외부의 유기물질 확산양상에 적지 않은 영향을 미치고 있다. The pH, Do, COD, NH_4-N, NO_3-N and T-P of sea water were measured in both sites effluencing sewage and passing through salt marsh, and also the RMA and FIT model were applied to the Mokpo coastal zone to analyze the changes of pollutant dispersion mechanism by constructions of the seawalls. The nitrogen source of sea water in the sites passing through salt marsh increased but COD and T-P decreased. After constructions of the Youngam/Kumho seawalls, tidal velocity was decreased and exchange of sea water was very increased between the north of the Mokpo coastal zone and the 4th seawall region and was very decreased between the south of the Mokpo coastal zone and outer sea water. The results of simulation on diffusion of organic matter indicate that most region of the Mokpo coastal zone will suffer deepened contamination after the constructions.

내러티브 중심 교과교육에 대한 교수, 교사, 학생의 인식 차이분석

주동범,강현석 이화여자대학교 교육과학연구소 2008 교육과학연구 Vol.39 No.2

Using a total of 702 people(71 professors, 299 teachers, and 332 students), the study was analyzing how do professor, teacher, and student perceive about narrative-centered subject education and the differences among groups in the perception. The main results are as follows. First, teacher group is positive about current subject education, but professor and student group are negative. Second, compared to teacher group, professor and student group are negative about current subject education and have more needs for change. And professors are positive about the applicability of narrative, but they are likely to have cautious stance about the composition and operation of curriculum. Professor and student group are more positive about specific application of narrative such as instructional syllabus, instructional materials, and the development of instructional material. Third, processor and student group are more positive than teacher group about the necessity of mutual complement of knowledge-based subject and narrative, and possibility of narrative will be selected as a new curriculum and the increment of its importance. However, teachers are more negative than students about narrative because teachers think narrative is highly possible to be limited to an instructional method simply. Discussions on main results and recommendations for further research were presented. 본 연구의 목적은 내러티브 중심 교과교육에 대해 관련 이해당사자라 할 수 있는 교수, 교사, 학생은 어떻게 인식하고 있으며 이러한 인식이 집단 간에 차이가 있는지를 실증적·경험적으로 분석하는 것이다. 내러티브 중심 교과교육에 대한 이론적 검토를 통해 제작된 질문지를 총 702명(교수 71명 , 교사 299명, 학생 332명)을 대상으로 실시하여 얻은 자료를 분석하여 나타난 주요 결과는 다음과 같다. 첫째, 현행 교과교육에 대해 교사집단은 다소 긍정적인 반면에 교수와 학생집단은 다소 부정적이다. 둘째, 교수와 학생집단이 교사집단에 비해 현행 교과교육에 대해 더 부정적이고 더 많은 변화 요구를 가지고 있다. 그리고 교수들은 내러티브 활용가능성에 대해 긍정적이나 내러티브 교육과정의 편성 및 운영에 대해서는 신중한 입장을 보이고 있다. 수업지도안, 수업 소재, 수업 자료 개발 등과 같은 구체적인 내러티브 활용에 대해 교수집단과 학생집단이 더 긍정적이다. 셋째, 교수집단이나 학생집단은 교사집단보다 주지교과와 내러티브의 상호 보완이 필요하다고 여기며, 내러티브가 새로운 교육과정으로 채택될 가능성과 그 중요성의 증가에 대해 더 긍정적이다. 반면에 교사들은 학생들에 비해 내러티브가 단지 수업 방식에 국한될 가능성이 높다고 보고 있어서 내러티브에 대해 다소 부정적이다. 주요 결과에 대한 논의 및 후속 연구를 위한 제언 등이 제시되었다.

진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472)

진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472) 연구배경 : 일차항암화학요법 후에 생존의 이득을 얻었음에도 불구하고 비소세포폐암 환자들의 대다수가 결국은 재발하거나 진행성 병변을 보인다. 이에 저자들은 기존의 여러 연구에서 보고 된 구제요법으로서 docetaxel의 항암효과와 비교적 적은 독성의 결과를 바탕으로,platinum을 근거로 한 항암화학요법을 시행 밖았으나 개발되거나 진행된 비소세포폐암 환자들을 대상으로 docetaxel 단독요법의 치료효과와 부작용에 대하여 알아보고자 하였다. 방법 : 조직학적으로 비소세포폐암으로 진단을 받고 platinum을 근거로 한 항암화학요법을 받았으나 재발 또는 진행성 병변을 보인 31명의 환자들을 대상으로 docetaxel 75 mg/m² 또는 100 mg/m²을 3주마다 정주하였다. 임상기록을 통한 후향적인 방법으로 분석하였다. 결과 : 1) 재발 또는 진행성 병변을 보인 31명중 남녀 비는 24:7이고 중앙연령은 60세였다. 2) 반응평가로 완전 관해는 없었고 부분관해는 14명(45.2%), 불변이 10명(32.3%), 진행이 7명(22.6%)으로 전체적인 반응율은 45.2%이었다. 3)중앙생존기간은 12.5개월(95% 신뢰구간: 7.3개월 17.6개월) 이었고, 1년 생존율은 52%였다. 무진행생존기간의 중앙값은 3.0개월(95%신뢰구간: 1.6개월 -4.5개월)이며, 반응군에서의 중앙반응지속피간은 3.7개월(95% 신뢰구간: 3.0개월 - 4.4개월)이었다. 4) 60세 미만인 경우(20.1 months vs 6.6 months. p=0,0105), 조직학적 아형이 선암일 경우(25.6 months vs 7.9 months, 0=0.0055) 통계적으로 유의한 생존기간의 증가가 있었다. 5) 부작용으로 3도 이상의 백혈구 감소증은 12명(38.7%),호중구 감소증에 동반된 발열은 6명(19.3%),감염이 동반된 호중구 감소증은 4명(12.9%)에서 발생했다. 치료와 관련되어 1명이 사망하였다. 6) Docetaxel 용량에 따른 생존기간의 차이나 독성의 차이는 없었다. 결론 : Platinum을 근거로 하는 항암화학요법으로 치료받은 후 재발 또는 진행성 병변을 보이는 비소세포폐암환자들에게 docetaxel을 투여하는 것은 비교적 안전하고 효과적인 항암치료법으로 사료된다.

급성 담낭염에 대한 내과적 치료의 역할

강성원,조한래,한설해,박현주,정인성,홍선미,김성걸,이헌영 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

In 58 patients who were admitted to department of internal medicine, ChungNam national university hospital from January 1989 to March, 1993. We evaluated for medical treatments and the following results were obtained. 1) The ratio of male and female was 1 : 1 and mean age of the patients was 57.4 years. 2) At arrival on hospital, the most common clinical symptom was pain in right upper quadrant and epigastrium(93.1%), the remainders were fever and chill(79.3%), nausea(51.7%) and vomiting(36.2 %) in order of frequency. 3) The most common physical findings was tenderness on the right upper quadrant and epaigastrium(98%), the remainders were jaundice(50%) and palpable gall bladder(13.8%) in order of freguency. 4) In laboratory examination, elevated levels of ESR(82.8%), leukocytosis(67.2%), elevated levels of AST(62.0%), ALT(50.0%), serum total bilirubin(51.7%) and alkaline phosphatase (43.1%) were noted. 5) The mean period of NPO was 3.9 days and the mean hospital period was 13.5 days. 6) The rates of combined complications in patients with acute cholecystitis were 17.2%; these are gall bladder empyema(5.2%), hydrops(5.2%), perforation(3.4%), sepsis(3.4%) and intestinal obstruction (1.7%). 7) In 96.6 percent of 58 cases, the symptoms of acute cholecystitis were improved by conservative management. 8) The mean follow-up period was 25.5 months and the recurrence rate was 10% during this period.

나사형 임플란트 고정체의 길이, 직경, 플랫폼 형태에 따른 임플란트와 주위조직의 응력분포

강지은,정현주,양홍서 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.1

Seven finite element models were constructed in mandible having single screw-type implant fixture connected to the second premolar-shaped superstructure, in order to evaluate how the length, diameter and platform shape of a screw-type fixture influence the stress in the supporting tissue around fixtures. The superstructure were made using UCLA abutment, and connected to the fixture with abutment screw. Each finite element model was varied in terms of length, diameter, and platform shape of the fixture according to the commercial fixture(3i Implant Innovations Inc, Palm Beach Gardens, FL33410, USA) while the superstructure and the mandible with a single fixture placed in it shared no difference in terms of appearance. In each model, 250N of vertical load was placed on the central pit of an occlusal plane and 250N of oblique load placed on the buccal cusp. The stress distribution in the supporting tissue and the other components was analysed using 2-dimensional Finite element analysis and the maximum stress in each reference area was compared. 1. Under lateral loading, the stress was larger in the larger in the abutment/fixture interface, and in the crestal bone, compared to the stress pattern under vertical loading. 2. The amount of stress at the superstructure was similar regardless of the length, diameter and platform shape of a fixture. 3. Around the longer fixture, the stress was decreased at the bone crest and subjacent cancellous bone and increased in the cancellous bone area apical to the fixture. 4. Around the wider fixture, the stress was decreased at the abutment/fixture interface, and the bone crest and increased in the cancellous bone area apical to the fixture. 5. Around the fixture having wider platform, less stress was resulted at the abutnent/fixture interface and the upper part of the cortical bone, compared to the fixture having standard platform. In short, the stress distribution of the supporting tissue was affected by length, diameter, and platform shape of a fixture, and the fixture which was larger in diameter and length could reduce the stress in the supporting tissues at the bone-fixture interface and bone crest area.

해운대 달맞이 언덕에 있어서 바다조망경관의 역사적 변천에 관한 연구

강영조,신수안,조미나,이현주,박은희 동아대학교 건설기술연구소 2000 硏究報告 Vol.24 No.1

The purpose of this study is to clarify the historic transition of the prospects on Haeundae dalmaji hill. Dalmaji hill is well known for a character of configuration on the ground with the scene of the sea. We will infer that how did it change the prospects of Dalmaji hill's sea through the analyzing of the preset situation and location of building on the hill. (1) We investigated the stories of the building, the history, the business condition. (2) We collect the twenty four view points which is able to have seascape on the hill, being easily approaching to the road, and condition of changing the building. (3) We clarified the transition of seascape prospect and considered the characteristics of the six types from which were divided the condition of seascape prospect.

사범대학 영어 강의에 대한 학생들의 인식 및 만족도 조사

강순희,서혁,신상근,이종원,이현주,최진영 이화여자대학교 교과교육연구소 2007 교과교육학연구 Vol.11 No.2

이 연구는 교사교육의 국제화를 지향하는 사범대학 특성화 프로그램 개발을 위한 기초 조사 차원에서 2007학년도 1학기에 146명의 사범대학 학생들을 대상으로 전공 영어 강의에 대한 인식과 만족도 등에 대해 설문조사의 방법으로 이루어졌다. 학생들의 영어 능력에 대한 자기 평가 결과, 대부분의 학생들이 자신의 영어 능력이 영어 강의 수강에 부족하고, 영어 강의에 대한 심리적 부담이 크다는 반응을 나타냈다. 또 영어 강의가 한국어 강의에 비해 전공 지식을 쌓는 데 도움이 되었다는 반응은 이공계를 중심으로 한 기존의 연구 결과보다 상대적으로 낮게 나타나는데, 이는 사범대학 영어 강의의 운영과 관련하여 좀 더 다양하고도 효과적인 방안이 고려되어야 함을 시사한다. 영어 강의 수강 시 어려움을 묻는 질문에서 과제 발표하기, 질문하기, 보고서 작성하기의 순으로 어려움을 호소하고 있는데, 이 역시 영어 강의를 위해서는 전반적인 영어 표현 및 이해 능력 향상 이 전제되어야 하며 무엇보다도 말하기, 듣기의 구어 능력 신장이 우선되어야 함을 재확인해 준다. 영어 강의 개선안에 대한 의견으로는 평가 방법의 다양성 및 융통성 확대, 영어 강의 수강을 돕는 전공 교재의 개발, 영어 강의 내에서의 교수-학생 상호 작용 증대, 국제교류의 기회 확대 등의 순으로 높은 반응을 보였다. 이는 향후 사범대학 영어 강의와 관련한 프로그램 개발에 시사하는 바가 크다. 즉, 영어 강의 평가를 결과 중심의 평가뿐만 아니라 과정평가와 수행평가에 초점을 두고, 영어 표현이 어려운 복잡한 사고 과정이 요구되는 경우 제한적으로 국문 반응을 허용하는 방안도 고려할 만하다. 또한 학습자들에게 좀 더 상세화된 강의 교재를 제공하고, 온·오프라인을 모두 활용하여 교수와 학생의 상호작용을 활성화할 수 있는 방안을 적극적으로 탐색할 필요가 있다. 아울러 학생들이 실질적인 국제교류가 가능하도록 다양한 교류 방안 함께 구체적인 강좌 개설도 요구된다.