정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

The effect of structural changes of electron donor-acceptor complex on the dynamics of contact radical ion pair separation

한철희 선문대학교 자연과학대학 2001 자연과학논총 Vol.4 No.-

The objective of this paper is to design and implement an engineering database for integrated structural design system of the pre-engineered buildings, and to represent the methodology of it. In this paper an object model was developed by OMT and IDEFO and converted to an relational database. The database in this paper is confined to the structural design process arid contains the analysis data and design data.

움직임 추정과 웨이블릿 변환을 적용한 비디오 디코더용 3D 적응 comb 필터링에 관한 연구

한희철,김진상,조원경,김남섭 경희-다반 ASIC 설계교육센터 2002 경희-다반 ASIC센터 논문집 Vol.3 No.-

NTSC 비디오 신호에서 comb 필터링은 라인과 프레임 사이의 위상차를 이용하여 Y와 C를 분리하는 기술이다. comb 필터링의 가장 중요한 부분은 기준 라인을 가지고 가장 높은 상관관계를 가지는 라인을 찾는 것이다. 본 논문에서는 프레임 안에 라인 사이의 유사성을 계산하기 위해 움직임 추정과 웨이블릿 변환을 적용한 새로운3D Y/C 분리 방법을 제안한다 제안한 알고리즘을 comb 필터링에 적용하였을 때, 화질은 기존의 시간 영역의 3D comb 필터링보다 약 1~2dB 향상되었다. 차후 연구 과제로 NTSC 비디오 신호의 유사성 검출에 효율적인 웨이블릿을 찾는 것과 잡음에 대한 내성을 강화해야 하며 최종적으로 하드웨어로 구현하는 것이다.

Wechsler 記憶檢査(改訂版)의 妥當度 硏究

韓五洙,柳希姃,金晟倫,金昌潤,李楨敎,李哲,朴仁鎬 서울醫大 1997 精神醫學 Vol.22 No.1

Solvent Effects on the ion-pair dynamics of Charge-Transfer complex where bipheny1(derivative) is a doner

한철희 선문대학교 1994 鮮文論叢 自然科學 編 Vol.- No.4

Charge-Transfer Complex has a structure similar to that of the transition state in Solvolysis reaction, thus any information on the charge-transfer Complex and charge transfer reactions is important in organic chemistry. The importance of electron transfer is not limited to organic chemistry, but extends to a wide variety of chemical and biological systems, Biphenyl is frequently used as electron donor in the quenching experiment, and it readily forms a Charge-Transfer Complex with TCNB(tetra cyano benzene) in common organic solvents such as dichloromethane, aceton, and acetonitrile. In our study, Charge-Transfer complexes between TCNB and biphenyl(derivatives) have been investigated indifferent solvents using picosecond laser spectroscopy, Optical excitation of the ground-state charge-transfer complex with picosecond laser pulse generates contact ion pair(CIP) within the time resolution of the experiment. Direct monitoring of the transient absorption of biphenyl(derivative) cation makes possible the investigation of the dynamics of electron back-transfer and ion-pair separation. The variation in ion-pair dynamics with changes in solvent is discussed in terms of the CIP structure, the exoergicity of the reactions, and the thermodynamic driving force.

치성 낭종의 임상-병리학적 소견과 TGF-α 및 TGF-β 발현

한경민,김용환,박진혁,윤형기,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : Periapical cyst is a relatively common disease but heterogenous in histogenesis, and inflammatory reaction and fibrosis of varying degree are associated in the cystic wall. The aim of thes study is to evaluate the clinico-pathologic characteristics such as patient's age, ses, location, and the degree of inflammatory reaction and fibrosis of periapical cyst and the role of TGF-α and TGF-β cytokines in the inflammed periapical cyst. Methods and Material : The materials were 43 cases of periapical cyst and clinical information with age, sex, location(maxilla vs mandible, right vs left, region involved) were recorded. Histopathological examination on the degree of inflammatory reaction and fibrosis and immunohistochemical stining for TGF-α and TGF-β were perfomed. Satistical analyses between clinical parameters, the degree of inflammation and fibrosis and expressions for TGF-α and TGF-β were followed. Results : 1. Thirt(69.8%) of 43 cases were older than 20 year-old. and no significant differences of incidence according to patient's sex was noted. In 25(58.1%) out of 43 case. 20(54.1%) out of 37 cases, and 20(48.8%) of 41cases, the cyst was located on the maxilla. in right side and in premolar region respectively. 2. The cysts of developmental and inflammatory origin were 24(55.8%) and 19(44.2%) of 43 cases, respectively and there were no siginificant differences of patient's age, sex, and location of cysts according to the origin of cysts. 3. Fibrosis was more conspicuous in cases older than 20 year-old. (p=0.0179), but no significant difference in the degree of inflammatory reaction according to patient's age and in the degree of inflammatory reaction and fibrosis according to sex and location of the cysts were seen. 4. Inflammatory reaction was slightly more in cysts of inflammatory origin, but no significant defferences in degree of inflammation and fibrosis according to origin of the cysts. 5. The degree of inflammatory reaction and TGF-α and TGF-β expressions showed a tendency of positive correlation(p=0.1563), but there were no statistically significant relationships between the degree of inflammation and fibrosis and TGF-α and TGF-β expressions. 6. In the cysts of developmental origin, TGF-α expression in the epithelial cells was significantly increased than inflammatory origin, but TGF-α and TGF-β expressions in the inflammatory cells and stromal cells showed no significant difference according to the origin Conclusion : The degree of inflammatory reaction and fibrosis of periapical cysts was different according to patient's age and location of the cyst. TGF-α and TGF-β cystokines seemed to be involved in the inflammatory reaction and fibrosis of periapical cyst, however, TGF-α and TGF-β expressions was not parallel to the degree of inflammatory reaction and fibrosis. These results suggest that other cytokines in addition to TGF-α and TGF-β may also be involved in the inflammatory reaction and fibrosis of periapical cyst. Increased TGF-expression in the epithelial cells of the cysts of developmental origin could be a helpful finding to defferentiate the origin of the periapical cyst.

비엔나 검사총집의 임상적용을 위한 한국표준화 연구(II):서울 성인군에 대한 Standard Progressive Matrices 검사

한오수,유희정,김창윤,박인호,이철 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.1

본 연구에서는 서울 거주 중산층에 속하는 20대 남녀 대학생 96명, 20대 일반성인 111명 및 30대 일반성인 88명을 대상으로 하여 SPM 검사의 표준화 연구를 실시하였다. 재검사 신뢰도는 0.72였고 내적일치도 계수인 Cronbach alpha 신뢰도계수는 .79였다. SPM검사와 Wechsler지능검사와의 상관은 .30이었다. 이에 따라 본 연구결과 SPM 검사의 신뢰도 및 타당도가 통계적으로 유의하였다. 본 연구에서 남녀간의 성별차이가 없었음은 물론 기존의 외국에서 이루어진 전산화된 검사결과와 비교할 때 두드러진 문화적 차이도 나타나지 않았다. 20대와 30대간의 유의한 차이는 연령증가에 따른 지능저하의 결과로 해석된다. 문항반응이론에 기초하여 SPM 검사를 구성하는 문항을 분석한 결과, 쉬운 문항수가 많은 편이었으나 전반적으로 문항의 난이도, 변별력 및 추측도가 비교적 적절하였다. 본 연구결과, SPM 검사가 비언어적인 지능을 측정할 수 있는 문화적, 교육적 및 성차에 별로 영향을 받지 않는 유용한 검사임이 입증되었다. 앞으로 진행될 연구에서는 지필검사를 통해 전 연령층으로 확장된 규준을 작성하여 정상인의 지능평가와 동시에 정신지체, 뇌기능장애를 비롯한 다양한 환자집단은 물론 학교, 산업장면에서도 활용토록하며 신경심리학적 평가도구로도 임상에서 유용하게 활용해야 할 것이다. This study was aimed to standardize the standard progressive matrices(SPM) test in the PC/S Vienna test system. The SPM test was administered to 295 adults in Seoul, comprised of 96 university students, 111 adults of twenties and 88 adults of thirties. The test-retest reliability of the SPM with an interval of 2 weeks was found to be .72. The internal consistency reliability of SPM as computed by Cronbach alpha was .79. product moment correlation between the full KWIS score and SPM was .30. The reliability and validity coefficients of the test were statistically significant. No significant sex differences were observed in this study. And no significant cross-cultural differences were noted when comparing the computerized SPM results studied by Luxemburg and the results of this study. But significant age differences were found between twenties and thirties. The results suggested that increasing in age might be a key factor in lowering of intellectual functions to adults. According to the item analysis based on the item response theory, the results showed that the SPM consists of many easy items, but the average 'item difficulty', average 'item discriminaion' and average 'guessing' were in the moderate level. Conclusionally, the SPM test may provide a culture-free, verbal-free promising tool for the measurement of nonverbal intelligence in a Korean context. Future study will be extending to range of sampling to include all aged normal group, mental retardation, other patient groups and industrial setting. In the future, SPM will be used to neuropsychological test in clinical settings.

이온화에너지 처리 아이스크림 및 우유의 단회투여 독성시험

이희준,최현종,한선경,구본철,신명수,함준상,조철훈,이완규 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

韓國人의 食餌障碍의 疫學 및 性格特性

韓五洙,柳希姃,金昌潤,李哲,閔秉根,朴仁鎬 서울醫大 1990 精神醫學 Vol.15 No.4

Modulation of Ion Pair Dynamics by Variation of Ionic Character

한철희 선문대학교 자연과학대학 2000 자연과학논총 Vol.3 No.-

광학적으로 생성된 1,2,4,5-테드라시아노벤젠 음이온과 바이페닐 유도체 양 이온간의 이온쌍에 대한 용액상 동력학이 이온성질의 변화에 의하여 조절되는 것이 관찰되었다. 주개 분가의 오르토 위치에 친전자성 또는 친핵성 치환에 따라서 이온쌍 의 분해속도가 증가 또는 감소됨이 분석결과 나타났다. We have observed modulation of solution dynamics of the photogenerated ion pair between 1 ,2,4,5-tetracyanobenzene anion and biphenyl derivative cation by variation of ionic character. Our analysis shows that the rate of ion pair separation can be made to increase or decrease, depending on the electrophilic or nucleophilic substitution in the ortho position of the donor molecule.