백서 척수강내 이식한 부신수질 크로마핀 세포의 진통 효과

백운이,임정옥,김유미,문철원,전영훈,한창규 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.41 No.4

Succinylcholine chloride 정주시 가토 혈청 K^(+)와 Na^(+)치의 변동

백운이 慶北大學校 醫科大學 1986 慶北醫大雜誌 Vol.27 No.4

점령전후 미국의 일본 천황제 개혁에 관한 연구

백운용(白雲龍) 일본어문학회 2006 일본어문학 Vol.33 No.-

효육적인 경피 흡수를 위한 Liposome형 혼합국소마취제 제조 및 마취 효과 연구

백운이,이원기,임정옥,김수정 한국생체재료학회 2002 생체재료학회지 Vol.6 No.4

In order to improve the transdermal delivery of local anesthetic for topical anesthesia, various concentrations of either lidocaine or tetracaine, and mixture combinations of lidocaine and tetracaine were formulated into liposomes using selected lipids. The topical anesthetic effects of those liposomal mixture of local anesthetics compared with EMLA and single local anesthetic were then evaluated by a pinprick test on healthy adult volunteers. The liposomal mixture of local anesthetics exhibited significantly improved anesthetic effect compared to EMLA and single local anesthetic liposome. The liposomal mixture of local anesthetics had a faster onset time of approximately thirty minutes and lasted for at least four hours demonstrating enhanced transdermal delivery of local anesthetic agents. The EMLA was comparatively ineffective; it took at least an hour to become effective and its duration was only two hours. The liposomal formulation of mixture of tetracaine and lidocaine appears to produce synergic effect compared to single local anesthetic liposomes. Accordingly mixture of local anesthetics exhibited improved topical anesthesia which can provide a faster effectiveness and longer analgesia.

체외순환을 위한 냉각과 재가온시 이산화탄소가스의 첨가에 따른 체온변화

백운이,김시오,손현호,도건호 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.35 No.5

Background : It is well known that the addition of CO2 gas during cardiopulmonary bypass (CPB) can increase cerebral blood flow (CBF). In this study, we tried to find whether the increase of CBF by CO2 gas could be expressed on the measurement of body temperatures. Methods : This study included 22 adult patients who underwent CPB with moderate hypothermia and were assigned randomly to two groups by adding CO2 gas (CO2 group and Air group). We measured each tympanic (TM), nasopharyngeal (NP), oral, forehead, finger, rectal and CPB arterial line temperatures of CPB circuit for 20 times during cooling in every one minute for 20 minutes and during rewarming every two minutes for 40 minutes. Results : During cooling and rewarming, the TM, NP and oral temperatures changed more rapidly than the rectal and finger temperatures. In TM temperature, as time changed, the percent changes of temperature varied more prominently in the CO2 gas group than in the Air group. The statistical differences were significant especially during 13 minutes to 20 minutes in cooling and 8 minutes to 20 minutes during rewarming. Conclusion : From this data, we can postulate the effect of CO2 gas on CBF indirectly by measuring several sites of body temperatures. (Korean J Anesthesiol 1998; 35: 958∼964)

작용시간 연장을 위해 고안된 이식형 혼합국소마취제의 효과

백운이,최병영,전영훈,임정옥 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

Prolonged Regional Nerve Blockade from Implantable pellets Containing Mixture of Local Anesthetics and Biodegradable Polymer Background: The Currently available local anesthetics have limitations in action duration. The duration ranges from 3 to 8 hours. Long acting anesthetic agents are particularly desirable to manage postoperative pain, relieve severe pain associated with terminal cancer, and for nerve blocks carried out in pain clinics. In this paper mixture of local anesthetics was formulated into cylindrical pellet using biodegradable polymer and its efficacy and safety was evaluated. Methods: Pellets were prepared by modified melting process with biodegradable polyester 30 wt%, bupivacaine 35 wt%, lidocaine 35 wt% and dexamethasone 0.05 wt% of polymer and drug. In vitro release kinetics of local anesthetics from pellet were determined in PBS at pH 7.4. 37℃, and the released local anesthetics were analyzed by HPLC. Nine male Sprague Dawley weighing 300∼350 gm were implanted with pellets along the sciatic nerve and the sensory blockade was assessed by an analgesiometer. The duration data were analyzed by paired t-test using SAS 6.11 Results: Local anesthetics were released in a controlled manner in vitro. In general, 40~50% of the drug released for the first day, and thereafter approximately 5% released daily. Sensory blockade lasted to beyond 2 days at the dose of 7 mg/100 g bupivacaine and lidocaine respectively. All of the animals exhibited no systemic toxicity and complete recovery. Conclusions: The results indicated that the mixture pellet demonstrated efficient and safe in prolongation of sensory blockade for significant period of time. The mechanisms underlying the mixture effect are under investigation. (Korean J Anesthesiol 1998; 34; 493∼478)

흡입마취제의 복합 투여시 흰쥐 노파스펙트럼의 변화

백운이 대한마취과학회 1996 Korean Journal of Anesthesiology Vol.31 No.3

Background: The electroencephalogram(EEG) has long been used to study the effects of anesthetic drugs on central nervous system function. This study was designed to evaluate the accuracy of two EEG parameters for assessing anesthetic depth during inhalation of 1.5 MAC three inhalation anesthetics (halothane, enflurane, and isoflurane) with 50%-N₂O in rats. Methods: Total 15 rats weighing between 300~350 g, with 5 rats for each anesthetic group were tested for investigation the anesthetic depth. EEG spectrum analysis was evaluated for three inhalation anesthetics which all were added with 50%-N₂O. The spectral edge frequency(SEF), median power frequency(MPF) were obtained from the EEG spectrum analysis of raw EEG via fast Fourier transform(FFT). Results: Raw EEG of halothare demonstrated sigmoidal shaped EEG, enflurane abundant spike waves, and isoflurane burst suppression. When 50%-N₂O was added to each anesthetic group, the characteristics of the raw EEG were disappeared. EEG spectrum analysis enabled to tinguish the effects of each anesthetic on the anesthetic depth. EEG spectrum analysis demonstrated after 50%-N₂O was added that the values of MPF and SEF were significantly decresed as 2.5 Hz and 6.5 Hz from 5.2 Hz and 14.2 Hz respectively. Conclusions: It is speculated that SEF and MPF was decreased due to the suppression of cerebral electrical activity. The decreases of SEF and MPF from analysis of EEG spectra confirm that the addition of 50%-N₂0 to each inhalation anesthetics enabled the deeper anesthetic depth.

심포지움 2 : Pain Clinic에서의 Interventional Pain Management

백운이 대한내과학회 2000 대한내과학회 춘계학술대회 Vol.2000 No.-

작용시간 연장을 위해 고안된 이식형 혼합국소마취제의 효과

백운이,임정옥,최병영,전영훈 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.34 No.3

Background: The currently available local anesthetics have limitations in action duration. The duration ranges from 3 to 8 hours. Long acting anesthetic agents are particularly desirable to manage postoperative pain, relieve severe pain associated with terminal cancer, and for nerve blocks carried out in pain clinics. In this paper mixture of local anesthetics was formulated into cylindrical pellet using biodegradable polymer and its efficacy and safety was evaluated. Methods : Pellets were prepared by modified melting process with biodegradable polyester 30 wt%, bupivacaine 35 wt%, lidocaine 35 wt% and dexamethasone 0.05 wt% of polymer and drug. In vitro release kinetics of local anesthetics from pellet were determined in PBS at pH 7.4, 37oC, and the released local anesthetics were analyzed by HPLC. Nine male Sprague Dawley weighing 300∼350 gm were implanted with pellets along the sciatic nerve and the sensory blockade was assessed by an analgesiometer. The duration data were analyzed by paired t-test usingSAS 6.11. Results : Local anesthetics were released in a controlled manner in vitro. In general, 40∼50% of the drug released for the first day, and thereafter approximately 5% released daily. Sensory blockade lasted to beyond 2 days at the dose of 7 mg/100 g bupivacaine and lidocaine respectively. All of the animals exhibited no systemic toxicity and complete recovery. Conclusions : The results indicated that the mixture pellet demonstrated efficient and safe in prolongation of sensory blockade for significant period of time. The mechanisms underlying the mixture effect are under investigation. (Korean J Anesthesiol 1998; 34: 493∼498)

日本 象徵天皇制의 支持基盤과 手段에 관한 硏究

白雲龍(백운용) 일본어문학회 2006 일본어문학 Vol.34 No.-