Regulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBH

Lee, Min-Woo,Chanda, Dipanjan,Yang, Jianqi,Oh, Hyunhee,Kim, Su Sung,Yoon, Young-Sil,Hong, Sungpyo,Park, Keun-Gyu,Lee, In-Kyu,Choi, Cheol Soo,Hanson, Richard W.,Choi, Hueng-Sik,Koo, Seung-Hoi Elsevier 2010 Cell metabolism Vol.11 No.4

<P><B>Summary</B></P><P>Endoplasmic reticulum (ER)-bound transcription factor families are shown to be involved in the control of various metabolic pathways. Here, we report a critical function of ER-bound transcription factor, CREBH, in the regulation of hepatic gluconeogenesis. Expression of CREBH is markedly induced by fasting or in the insulin-resistant state in rodents in a dexamethasone- and PGC-1α-dependent manner, which results in the accumulation of active nuclear form of CREBH (CREBH-N). Overexpression of constitutively active CREBH activates transcription of <I>PEPCK-C</I> or <I>G6Pase</I> by binding to its enhancer site that is distinct from the well-characterized CREB/CRTC2 regulatory sequences in vivo. Of interest, knockdown of CREBH in liver significantly reduces blood glucose levels without altering expression of genes involved in the ER stress signaling cascades in mice. These data suggest a crucial role for CREBH in the regulation of hepatic glucose metabolism in mammals.</P> <P><B>Highlights</B></P><P>► PGC-1α/GR activates CREBH expression under fasting or insulin-resistant conditions ► CREBH enhances hepatic gluconeogenesis via a CRTC2-dependent manner ► Depletion of CREBH in the liver ameliorates fasting hyperglycemia in diabetic mice</P>

1~2기 본태성 고혈압 환자들에서 Imidapril 대 Enalapril의 항고혈압 효과를 평가하기 위한 무작위, 이중맹검 임상시험

최영진,손대원,김용진,이홍자,채인호,김효수,김철호,오병희,이명묵,박영배,채윤식,이영우 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.11

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

Temporal trends and in-hospital outcomes of primary percutaneous coronary intervention in nonagenarians with ST-segment elevation myocardial infarction

( Joon Young Kim ),( Myung Ho Jeong ),( Yong Woo Choi ),( Yong Keun Ahn ),( Shung Chull Chae ),( Seung Ho Hur ),( Taek Jong Hong ),( Young Jo Kim ),( In Whan Seong ),( In Ho Chae ),( Myeong Chan Cho ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.6

Background/Aims: Data regarding the outcomes of primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) in nonagenarians are very limited. The aim of the present study was to evaluate the temporal trends and in-hospital outcomes of primary PCI in nonagenarian STEMI patients. Methods: We retrospectively reviewed data from the Korea Acute Myocardial Infarction Registry (KAMIR) from November 2005 to January 2008, and from the Korea Working Group on Myocardial Infarction (KorMI) from February 2008 to May 2010. Results: During this period, the proportion of nonagenarians among STEMI patients more than doubled (0.59% in KAMIR vs. 1.35% in KorMI), and the rate of use of primary PCI also increased (from 62.5% in KAMIR to 81.0% in KorMI). We identified 84 eligible study patients for which the overall in-hospital mortality rate was 21.4% (25.0% in KAMIR vs. 20.3% in KorMI, p = 0.919). Multivariate analysis identified two independent predictors of in-hospital mortality, namely a final Thrombolysis in Myocardial Infarction (TIMI) flow < 3 (odds ratio [OR], 13.7; 95% confidence interval [CI], 3.2 to 59.0; p < 0.001) and cardiogenic shock during hospitalization (OR, 6.7; 95% CI, 1.5 to 30.3; p = 0.013). Conclusions: The number of nonagenarian STEMI patients who have undergone primary PCI has increased. Although a final TIMI flow < 3 and cardiogenic shock are independent predictors of in-hospital mortality, primary PCI can be performed with a high success rate and an acceptable in-hospital mortality rate.

In-hospital mortality in patients with STEMI admitted during off hours

( Sung-Soo Kim ),( Myung Ho Jeong ),( Jeong Gwan Cho ),( Young Keun Ahn ),( Jong Hyun Kim ),( Shung Chull Chae ),( Young Jo Kim ),( Seung Ho Hur ),( In Whan Seong ),( Taek Jong Hong ),( Dong-hoon Choi 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Conflicting results exist on the outcome of off hours PCI in ST elevation myocardial infarction (STEMI). However, there were only a few studies that have focused on the clinical characteristics and outcomes of off hours PCI in STEMI. So, we studied the clinical characteristics and hospital mortality in STEMI patients treated with primary PCI during regular hours (weekdays 9:00 AM to 6:00 PM) versus off hours Weekdays 6:01 PM to 8:59 AM, weekends, and holidays) in Korea Acute Myocardial Infarction Registry. We analyzed in hospital and one year mortality among 5,665 consecutive ST segment elevation myocardial infarction patients treated with primary PCI between November 2005 to January 2008. Total 2,848 (50.2%) patients were treated during off hours. Baseline finding were similar, although regular hours patients were older. Median symptom to balloon time (304 min, IQR 175 to 750 vs. 270 min, IQR 145 to 551, p=0.001) were longer for regular hours primary PCI. Median door to balloon time (71min, IQR: 48 to 132 vs. 59 min, IQR 39 to 110 min, p=0.001) were longer for off hours pPCI. Also, Cardiac enzyme such as Max CK-MB (212.1±299.3 vs 194.7±303.4, p=0.031) and max TnI (72.6±239.5 vs. 58.9±94.4, p=0.013) were increased in off hours pPCI. However, unadjusted in hospital (6.0% off hours vs. 6.0% regular hours, p=0.946) and one year cardiac mortality (11.3% off hours vs. 11.7% regular hours, p=0.661) were comparable. In multivariate analysis, off hours primary PCI did not predict an adverse outcome. In conclusion, when primary PCI was performed within an appropriate reperfusion strategy, the clinical effectiveness of either off hours or regular hours pPCI is comparable.

혈액 내 구리, 아연 및 ceruloplasmin 농도에 흡연, 음주 및 신체적 활동이 미치는 영향

홍연표,강은용,신인철,최병선,박정덕,장임원,박진완 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

Objectives : To investigate the influence of smoking, alcohol ingestion, and physical activity on copper and zinc in RBC and serum and serum ceruloplasmin, this study was performed in a cross-sectional study in 113 healthy men aged 20 to 40 years who had no symptomatic liver, heart, gastrointestinal, and other chronic diseases. Methods : At the men's entry into the study, blood samples were drawn from each subject and immediately centrifuged for analysis of copper, zinc, iron, ceruloplasmin, total cholesterol, and hematocrit. Each man completed a questionnaire that provided information on smoking, amount of alcohol intake, and physical activity. Partial regression analysis was performed on confounding variables such as age, body mass index, hematocrit, serum cholesterol, and serum iron. Results : In general linear models, adjustment for confounding variables did not show statistical differences, and there was only an increasing tendency in serum copper in heavy smoker(P=0.0678). There was no difference between high physical activity with mild smokers and lower physical with heavy smokers. Conclusions : This study suggested that copper, zinc and ceruloplasmin were not good biomarker for early effect by smoking, alcohol intake and physical activity in young adult. However, selection bias should be considered in evaluation of this result, and a large prospective study will be needed in advance on usefulness of copper, zinc and ceruloplasmin as a marker for risk factors and early change of atherosclerosis.

췌담관 합류이상이 있는 환자에서 담도계 손상 기전에 대한 연구

정인호,정용식,김지훈,최수윤,김정운,김욱환,홍정,왕희정,유병무,김진홍,한재호,김영배,김재근,김명욱 한국간담췌외과학회 2003 한국간담췌외과학회지 Vol.7 No.2

공유숙박의 법·제도에 관한 한국/일본 비교 사례연구 : 에어비앤비(Airbnb)를 중심으로

최우인 ( Choi¸ Woo-in ),김홍범 ( Kim¸ Hong-bumm ) 한국관광산업학회 2021 Tourism Research Vol.46 No.3

공유숙박 플랫폼 에어비앤비는 여행객에게는 폭넓은 숙소 선택과 함께 현지인과 다양한 라이프 스타일을 경험할 기회를 만들었다. 일반인에게는 에어비앤비의 호스트가 되어 유휴공간을 대여함으로써 부가수익을 올릴 수 있도록 했다. 이처럼 에어비앤비의 출현은 새로운 여행관이 형성되고 숙박업계의 신흥 강자가 되어 기존의 패러다임을 바꾸었다. 반면, 에어비앤비의 활용도가 높아짐에 따라 사회적으로 여러 문제가 발생하고 있다. 이에 본 연구에서는 공유숙박에 의한 제반 문제에 대해 선행연구를 바탕으로 불법 영업 문제, 주거환경 문제, 신변 안전 문제로 분류하여 우리나라보다 먼저 공유숙박 제도를 시행한 일본의 법·제도와 비교하여 살펴본바, 다음과 같은 시사점이 도출되었다. 첫째, 우리나라는 내·외국인 이용객을 구분하지만, 일본은 구분하지 않으며, 우리나라는 내국인 이용객만 연간 180일 이내로 영업일 수를 제한하려는 움직임이 있지만, 일본은 주택에 대해 영업일 수를 제한하고 있다. 우리 나라는 오로지 수익과 효율성을 중심으로 움직이기 때문에 불법 영업이 발생하고 있지만, 일본은 숙박 시설의 구조 설비나 건축물의 용도 등 영업허가 기준 충족에 따른 어려움으로 불법 영업이 발생하고 있다. 한편, 우리나라의 공유숙박 법·제도는 획일적이지만, 일본의 법·제도는 조례에 따라 지자체마다 규정이 조금씩 다른 것으로 나타났다. 둘째, 우리나라는 숙박시설 이용객에 대한 안전과 위생의 규정을 두지만, 일본은 숙박시설 이용객 및 지역 주민을 보호하는 대책을 마련하고 있고, 우리나라는 거주민의 주거 문제에 대한 규정이 없지만, 일본은 주택숙박사업법에 ‘입주자 모집이 이루어지고 있는 가옥’ 규정을 두어 입주자의 임대차 계약을 우선시하고 있다. 셋째, 우리나라는 농어촌민박사업에서 성폭력 범죄 행위에 이용되는 카메라나 이와 유사한 기능을 갖춘 기계장치의 설치를 금지하고 있지만, 일본은 신변 안전 문제와 관련한 규정이 없는 등 여러 측면에서 서로 간에 차이를 보이는 것으로 나타났다. Airbnb, a shared accommodation platform, has created many opportunities for travelers to choose a wide range of accommodations and experience various lifestyles with locals. For the general public, they became hosts of Airbnb and rented idle spaces to earn additional profits. As such, the emergence of Airbnb has changed the existing paradigm by forming a new travel channel and becoming an emerging powerhouse in the lodging industry. As the utilization of Airbnb increases, on the other hand, various social problems have been occurring as well. In this study, various problems caused by shared accommodation were classified into illegal business problems, residential environment problems, and personal safety problems, based on previous studies, and the related implications were derived together. The findings are, first, Korea distinguishes between domestic and foreign users, but Japan does not, and Korea only intends to limit the number of business days to 180 days per year, whereas Japan restricts the number of business days for housing. Although illegal operations have been occurring in Korea mainly according to much focus on profits and efficiency, in Japan, illegal operations are occurring due to difficulties in meeting business license standards such as the use of structural facilities and buildings. While Korea's shared accommodation laws and systems are somewhat uniform, Japanese laws and systems vary slightly from local government to local government according to ordinances. And, Korea has safety and hygiene regulations for accommodation users, whereas Japan has measures to protect accommodation users and local residents. Korea has no regulations on housing issues for residents, but Japan prioritizes tenant lease contracts. Finally, Korea appears to prohibit the installation of cameras or similar functions used for sexual violence crimes in rural lodging projects, whereas Japan shows differences in many aspects, including no regulations on personal safety issues.

금강의 수질, 어패류, 이끼 및 토양중의 중금속의 함량 조사

한인전,홍춘표,최용규 공주대학교 사범대학 과학교육연구소 1993 과학교육연구 Vol.24 No.1

This survey is to study the corresponding degree of water pollution of the Kum river areas, covering the eight places of main stream of the river from the Daechung dam to Kangkyung county, and two trivutary streams of Kap stream, and Miho stream. Besides, the heavy metal content of the fishes, shellfish, moss, and soil in the main stream of Kum river is investigated, whose results are as follows: 1. The water quality The water quality of the area from the Daechung dam to the Sintanjin county is first grade for the standard of drinking water in terms of BOD, COD values, that of both Kap stream and Miho stream is third or fourth grade respectively, and the other areas are turned out to be second grade. The water of the Daechung dam to the Sintanjin has little NO₂-N and ??, which can be said to be possible for the drinking water. The quantity of ?? and ?? in the water of all the areas is below the standard for the available drinking water, but, that of Kap stream and Miho stream is about two or three times higher than other areas. 2. Heavy metal The content of Cd, Cu, Mn, and Zn are shown to be comparatively less than that of Co, Fe, Ni, and Pb. And the content of Cu, Mn, Zn are less than the possible standard value for the drinking water. The relationship of the heavy metal content of the fish and shellfish were in order of Co>Zn>Cu>Cd, for the moss, Zn>Pb>Co>Cu>Cd, and for the soil, Zn>Pb>Cu>Co>Cd. The most of collecting samples in the Kumnam area have lots of heavy metals, and Pb is well contained in shells than fishes. When summarize the above result, the water in the Daechung dam and Sintanjin area is comparatively favorable for the drinking water, and the water quality below the Kumnam areas appears to be wores because of influx of Kap stream and Miho stream. In short, the necessary counter measure is to be required for the good preservation of water of fine quality in Kum River.

錦江上流地域에 있어 다슬기科의 分布에 關한 硏究

金鍾煥,崔信錫,宋仁植,洪榮杓 충남대학교 자연과학연구소 1982 忠南科學硏究誌 Vol.9 No.1

The distribution and identification of Semisulcospira species were studied at the 8 stations in the upper streams of Geum River and it's tributatries, and some physicochemical analysis were obtained from all stations. The results are summerized as follows: 1. Four species of Semisulcospira were collected from the 7 stations in the 8 stations, except a station, the Buchang stream. S. coreana was found at all the 7 stations, S. ovulum at the 6 stations, S. globus at the 4 stations, and S. tegulata was found only two stations, but the density of all the snails was generally low in a m^2. 2. Identification of the snail species were based on the external morphology, radula ribbon and central teeth patterns. 3. The chromosome numbers were observed : n = 18 in S. coreana and S. ovulum ; n = 16 in S. globus, however, in S. tegulata the chromosome was not observed. 4. Physicochemical analysis in the aquatic environment were determined from all the 8 stations. The pH, Ca, Mg, SO_4, Na and Cl values in the water varied not widely, but the values of chemical oxidation demand at the 5th station and electric conductivity at the 7th station were higher than those of the another stations.