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비·부비동 종양의 신생혈관 형성에서 COX-2 및 VEGF의 역할
도남용,박성용,조성일,윤혁수,박선홍,박영균,권대승,임성철 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1
Background and Objectives : COX-2, the inducible form of cyclooxygenase(COX), is upregulated in transformed cells and in malignant cells, which have important roles in promotion of colorectal carcinogenesis, invasiveness and angiogenesis. Vascular endothelial growth factor(VEGF) may act as endothelial cell mitogen in various cancer tissues. It will increase tumor growth and angiogenesis. Aims of this study were to asses COX-2/VEGF expression and it's clinical correlation in sinonasal tumors and to investigate the effects on angiogenesis also. Materials and Method : The study samples were obtained from surgical removal of 27 cases of inverted papilloma(IPs), 5 cases of IP with malignant transformation(IP-MT), 16 cases of Squamous cell carcinoma(SCC) in sinonasal cavity COX-2 and VEGF expressions were assessed by immunohistochemical staining. Synchronism of COX-2/VEGF expression in one tumor cell was demonstrated with double immunofluorescence technique. Results : The expression rates of COX-2 were 37% in IP, 80% in IP-MT and 100% in SCC. The positive rates of VEGF were 29 6% in IP, 100% in IP-MT and SCC. COX-2 and VEGF expressions were increased as tumor progressed, and there is a positive correlation between COX-2 &EGF expressions. All clinical features which were compared are not associated with COX-2 &EGF expressions except malignant change in IP(p=0 028). Synchronism of COX-2/VEGF expressions was noted in all positive immunostaining samples. Conclusion : These findings suggest the role of COX-2 pathway could be involved in sinonasal tumor angiogenesis, which is modulated by VEGF COX-2 may act as autocrine factor in VEGF expression. There is a potential role for selective COX-2 inhibitors in the treatment of these lesions.
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야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로
조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6
Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.
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趙晟龍,薛盛用,全燾基 慶北大學校 醫科大學 1981 慶北醫大誌 Vol.22 No.1
1978年과 1979年에 大邱地方에서 分離한 Shigella는 大部分이 chloramphenicol(Cm), tetracycline(Tc), streptomycin(Sm) 및 sulfisomidine(Sa) 또는 ampicillin, trimethoprin 또는 nalidixic acid(Na) 등에 多藥劑耐性이었으며 이들 耐性菌의 80% 以上이 Na를 除外한 全耐性을 接合에 의하여 E. coli에 傳達시킬 수 있어 이들 耐性은 R plasmid에 由來하는 것임을 알 수 있었다. 任意로 選擇한 各 耐性樣相을 가진 菌의 R plasmid에 對하여 表面排除를 實驗한바 A 群由來의 Cm, Tc, Sm 및 Sa 耐性 plasmid를 除外한 全供試 plasmid는 相互間에 導入排除가 强하여 이들은 같은 非適合性群에 屬하는 것으로 思料되며 各 非適合性群의 標準 plasmid와의 反應에서는 FⅣ 非適合性群 plasmid와의 表面排除가 强하여 이 群 또는 이와 關係가 깊은 群의 plasmid로 推測되었다. Cm, Tc, Sm 및 Sa 耐性 plasmid를 갖은 A群(S. dysenteriae)菌이 4株 있었는데 그 중 1株의 R plasmid만이 O非適合性群임이 導入實驗에 의하여 判明되었고 殘餘 3株의 plasmid는 O群과의 適合性이며 FⅣ 또는 이와 關係가 깊은 非適合性群임을 알 수 있었다. The majority of Shigella strains isolated in 1978 and 1979 in Taegu area were found resistant to four or more drugs of chloramphenicol (Cm), tetracycline (Tc), streptomycin (Sm), sulfisomidine (Sa), ampicillin, trimethoprim, and nalidixic acid (Na). Approximately 80% of multiply drug-resistant strains transferred by conjugation the complete resistance to drugs except Na to E. coli K12 substrains, and the resistance was determined as plasmid-mediated. Plasmids encoding various patterns of drug resistance were transferred to E. coli and the mutual surface exclusion was studied on randomly selected plasmids in Shigella of various patterns of resistance. All plasmids except one from S. dysenteriae were found to be mutually incompatible. The surface exclusion test of these plasmids with standard R plasmids of known incompatibility group showed that all these plasmids were strongly excluded when introduced in Inc FⅣ, while well accepted by other incompatibility group plasmids. One plasmid from S. dysenteriae conferring resistance to Cm, Tc, Sm, and Sa was confirmed belong to Inc group 0 by surface exclusion and colony tests. There were four strains resistant to Cm, Tc, Sm, and Sa in S. dysenteriae, and the other three plasmids were suspectcd belong to Inc FⅣ or related group.
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조성도,박태우,우종근 대한슬관절학회 2002 대한슬관절학회지 Vol.14 No.2
목적: 후방 반월상 연골-대퇴 인대가 외측 반월상 연골의 장력을 유지하여 주는 기능이 있음을 돼지의 슬관절을 이용하여 실험적으로 증명하고자 하였다. 대상 및 방법: 실험용 재료로는 돼지의 슬관절을 이용하였으며 후방 반월상 연골-대퇴 인대가 정상 및 단열된 상태에서 각각 1) 정상 외측 반월상 연골, 2) 외측 반월상 연골 후각부의 방사상 파열, 3) 외측 반월상 연골 전절제술의 상태를 만들어 실험하였다. Instron기계를 이용하여 슬관절의 신전위에서 150kg의하중이 슬관절에 전달되도록 하였으며 pressure-sensitive film(저압용 Prescale film. Fuji)을 이용하여 가압 면적, 최대 압력 및 평균 압력을 측정하였다. 판독은 후지필름 Prescale 압력 화상 해석 시스템인 FDP-901E series를 이용하였다. 결과: 후방 반월상 연골-대퇴 인대가 정상이면 정상군과 방사상 파열군에서 가압 면적, 최대압력 및 평균 압력이 큰 차이를 보이지 않았다. 하지만 후방 반월상 연골-대퇴 인대의 단열된 경우에는 외측 반월 연골의 상태에 관계없이 압력이 한 곳에 집중되는 소견을 보여 후방 반월상 연골-대퇴 인대가 정상인 상태에서 외측 반월상 연골 전절제술의 경우와 결과가 비슷하였다. 결론: 돼지의 후방 반월상 연골-대퇴 인대가 축성 부하에 대하여 외측 반월상 연골의 장력을 유지하여 주는 기능을 담당한다는 것을 알 수 있었다. Purpose: To prove experimentally if the posterior meniscofemoral ligament (PML) has hoop tensioning function for the lateral meniscus using the knee joint of the pig. Materials and Method: Amputated stumps with the knee joint of the pig (Yorkshire) were used. The experiment performed under 6 conditions; 1) intact PML with intact lateral meniscus (LM) 2) intact PML with radial tear of posterior horn of LM, 3) intact PML with intact lateral meniscus (LM), 2) intact PML with radial tear of posterior horn of LM, 3) intact PML with total lateral meniscectomy, 4) cut PML with intact LM, 5) cut PML with radial tear of posterior horn of LM, and 6) cut PML with total lateral meniscectomy. The pressure-sensitive film (Prescale, Fuji) was inserted under the lateral femoral condyle and axial loads was transmitted to the knee joint with universal testing machine (Instron, model No. 4469, USA). The pressed area, maximum pressure and average pressure were measured by the Prescale imaging analysis system FDP-901E series. Results: With the intact PML, there was little difference in pressed area and maximum and average pressures between the conditions of intact meniscus and radial tear of posterior horn of LM. With the cut PML, regardless of the states of the LM, pressure concentration (much decreased pressed area, and increased maximum and average pressures) occurred, which had similar results to the condition of total lateral meniscectomy with intact PML. Conclusion: The PML of the pig had hoop tensioning function for the LM under axial loads.
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