우리나라의 政策決定過程(정책결정과정)과 民意(민의)의 反映(반영)

김명현 조선대학교 동북아연구소(구 통일문제연구소) 1980 동북아연구 Vol.2 No.-

MRI Features of Atypical Cavernous Hemangioma Showing Central Filling Defect: A Case Report

김명현,유인규 대한영상의학회 2018 대한영상의학회지 Vol.78 No.4

Cavernous hemangioma is a benign tumor composed of vascular structures and connective tissue. Typical imaging findings of cavernous sinus cavernous hemangioma are a well-defined contour-bulging mass, with homogeneous high signal intensity on T2-weighted images (T2WI), marked homogeneous enhancement of the cavernous sinus, and some sellar extension on magnetic resonance images. However, we experienced an unusual case of cavernous hemangioma, with central filling defects on delayed contrast-enhanced T1-weighted images and central, dark signal intensities on T2WI, which made the diagnosis difficult. The central portion of the lesion was pathologically consistent with central thrombosis. We present the clinical and imaging findings of this unusual case of cavernous hemangioma.

흰목이버섯 분말을 첨가한 쿠키 품질 특성

김명현,한영실 (사)한국조리학회 2020 한국조리학회지 Vol.26 No.8

The purpose of this study is to evaluate the quality characteristics and the antioxidant activity in developing cookies using Tremella fuciformis Berk powder. Cookies were made of different concentrations (0%, 4%, 8%, 12% and 16% of the flour quantity) of Tremella fuciformis Berk powder. Density of cookie dough, pH, moisture content, spread factor, hardness, color, antioxidant activity, and sensory attributes of cookies were measured. The pH of cookie dough decreased as the amount of Tremella fuciformis Berk powder increased. The moisture content ranged from 6.06% to 9.74% and was the highest among the control groups. The polyphenol content and DPPH radical scavenging activity increased accordingly with increase of Tremella fuciformis Berk powder level. According to sensory evaluation, 8% was preferred the most in terms of color, flavor, taste, appearance, texture, and overall palatability. Therefore, it’s considered that cookies prepared by adding Tremella fuciformis Berk powder has a high value as functional food source and is likely to be used as an ingredient for health and various product developments.

경추부 인공관절 수술의 조기 방사선학적 결과

김명현,조도상 이화여자대학교 의과학연구소 2008 EMJ (Ewha medical journal) Vol.31 No.2

전방 경유 골유합술은 50여년 전부터 시술이 시작되어 최근까지 경추부 퇴행성 질환에 대한 대표적인 수술로 알려져 왔다3-5)18). 그 수술 결과는 이미 많은 저자들에 의해 비교적 좋은 결과를 보인다고 발표되어 왔는데, 한편으로는 수술 후 장기간의 보조구 착용으로 인한 사회 경제적인 손실, 골유합으로 인한 경추부 운동 장애, 인접한 추체와 추간판의 심한 퇴행성 변화와 이차적인 병적 상태 발생 등이 문제점으로 거론되어 왔다2)6)9)10)12)13). 특히 여러 분절에 걸친 다발성 경추부 퇴행성 질환인 경우에는 수술 후 매우 심각한 지경의 후유증이 발생한다. 어떤 보고에 의하면 인접한 분절에 발생한 병변으로 골유합술을 시행 받은 환자들 중에서 1년에 2.9%의 환자들이 재수술을 받으며, 10년 내에 25.6%의 환자가 재발된 증상에 대해 추가적인 수술을 받을 수 있다고 보고한 바 있다13). 최근 이러한 단점을 보완하기 위해 경추부의 운동 분절을 유지하며 병적 상태를 제거할 수 있는 수술법들이 시도되고 있는데 대표적인 것이 신경공 확장술(Anterior microforaminotomy)과 다양한 종류의 인공디스크 수술이다. 신경공 확장술은 추간판의 대부분을 보존하면서 비교적 경추 운동에 영향을 미치지 않는 구상돌기의 일부를 제거하여 이를 통해 신경공을 감압하는 방법이며14), 인공디스크 수술은 추간판을 모두 제거하고 이를 통해 병적인 상태를 제거한 후 운동성을 가진 인공디스크로 대체하는 일종의 인공관절 수술이다1)8)11). 인공디스크 수술은 관절 운동을 유지하고, 골유합술의 단점을 피하며, 빠른 회복을 통해 환자로 하여금 일상생활이나 직업생활로 빠르게 복귀하도록 하기 위해 고안되었다. 이 수술의 목표는 디스크의 높이를 유지하고, 신경을 압박하는 모든 병적 상태를 제거한 후 운동 관절을 유지하기 위한 것이며, 아울러서 인접한 관절의 정상적인 상태를 유지하도록 하는 것이다. 저자는 다양한 경추부 퇴행성 질환에 대해 널리 사용되는 인공디스크 중 주로 Bryan을 사용한 수술을 시행하여 그 결과를 알아보고자 하였다. Object:Recently, motion preservation has come to the forefront of emerging technologies in spine surgery. This is the important background information of the emergence of cervical arthroplasty as an alternative to arthrodesis that offers the promise of restoring normal spinal movement and reduces a kinematic strain on adjacent segments. The study was designed to evaluate early surgical outcome and radiological effects of Bryan cervical disc prosthesis. Method:The authors retrospectively reviewed radiographic and clinical outcomes in 49 patients who received the Bryan Cervical Disc prosthesis, for whom follow-up data were available. Static and dynamic radiographs were measured by computer to determine the angles formed by the endplates of the natural disc preoperatively, those formed by the shells of the implanted prosthesis, the angle of the FSU, and the C2-7 Cobb angle. The range of motion(ROM) was also determined radiographically, whereas clinical outcomes were assessed using Odom’s criteria. Result:A total of 66 Bryan disc were placed in 49 patients. A single-level procedure was performed in 35 patients, a two-level procedure in 14 patients, and a three-level procedure in 3. Radiographic and clinical assessments were made reoperatively. Mean follow-up duration was 29.2 months, ranging from 6 to 36 months. All of the patients were satisfied with the surgical results by Odom’s criteria. The postoperative ROM of the implanted level was preserved without significant difference from preoperative ROM of the operated level. 90% of patients with a preoperative lordotic sagittal orientation of the FSU were able to maintain lordosis. The overall sagittal alignment of the cervical spine was preserved in 89.4% of cases at the final follow up. Interestingly, preoperatively kyphotic FSU resulted in lordotic FSU in 57.7% of patients during the late follow up, and preoperatively kyphotic overall cervical alignment resulted in lordosis in 62.5% of the patients postoperatively. Conclusion:Arthroplasty using the Bryan disc seemed to be safe and provided encouraging clinical and radiologic outcome in our study. Although early and intermediate results are promising, this is also a relatively new approach, long-term follow up studies are required to prove its efficacy and its ability to prevent adjacent segment disease.

Synthesis and Evaluation of 99mTc-Labeled Folate-Tripeptide Conjugate as a Folate Receptor-Targeted Imaging Agent in a Tumor-Bearing Mouse Model

김명현,김우형,김창근,김대응 대한핵의학회 2015 핵의학 분자영상 Vol.49 No.3

Purpose The folate receptor (FR) is an attractive molecular target since it is overexpressed in a variety of human tumors. The purpose of the present study was to synthesize and evaluate the feasibility of a novel 99mTc-ECG-EDA (Glu-Cys-Gly-ethylenediamine)-folate as an FR-positive tumor imaging agent in a mouse tumor model. Materials and Methods ECG-EDA-folate was synthesized using solid phase peptide synthesis (SPPS) and radiolabeled with 99mTc using tripeptide ECG as a chelator. FR-positive KB cells were inoculated in athymic nude mice. Following injection of 99mTc-ECG-EDA-folate, serial scintigraphy and micro-SPECT/CT imaging were performed at various time points with and without pre-administration of excess free folate. Mean count densities (MCD) for regions of interest drawn on KB tumors and major normal organs at each time point were measured, and uptake ratios of tumor to normal organs were calculated. Results ECG-EDA-folate was labeled with 99mTc with high radiolabeling efficiency and stability (>96 %). FR-positive tumors were clearly visualized on both scintigraphy and micro- SPECT/CT images and the tumor uptake of 99mTc-ECGEDA- folate was markedly suppressed with faint visualization of tumors by pre-administration of excess free folate on serial planar scintigraphy, indicating FR-specific binding of the agent. Furthermore, semiquantitative analysis of MCD data showed again that both tumor MCD and tumor-to-normal organ ratios decreased considerably by pre-administration of excess free folate, supporting FR-specific tumor uptake. Tumor-to-normal organ ratios approximately increased with time after injection until 4 h. Conclusion The present study demonstrated that 99mTc-ECGEDA- folate can bind specifically to FR with clear visualization of FR-positive tumors in a mouse tumor model.

Challenge Zone_Health people - 5집 가수, 메인 MC, 연기자 이승기의 무한도전

김명현,Kim, Myeong-Hyeon 한국건강관리협회 2012 건강소식 Vol.36 No.2

이승기는 5집 가수다. 예능 프로그램에서, 드라마에서 자리를 확실히 잡은 이승기지만, 가수 활동의 기분은 남다른 것이 아닐까. 소년시절을 졸업하고, 좀 더 자신만의 주관으로 자신의 진로를 말할 수 있게 된 청년 이승기가 풀어낸 이야기다.

고속도로 합류차량의 합류위치 및 간격수락에 관한 실증분석

김명현,고승영,이청원(Lee, Cheong-Won) 대한교통학회 2015 대한교통학회 학술대회지 Vol.72 No.-

단일 3차 의료기관에서 수집한 약물 유해반응의 양상 분석

김명현,정한영,손명균,김성은,이용원,박중원,홍천수 대한알레르기학회 2008 천식 및 알레르기 Vol. No.

Background: Clinical features of adverse drug reactions (ADR) are different and the incidence is increasing. However, there have been only a few data on the clinical features of ADR in Korea. Method: We prospectively collected ADR cases at Severance Hospital between October 2003 and April 2006, analyzed the clinical features. Result: Three hundred and fifty-seven ADR cases were reported. The most common causative drugs were radiocontrast media and nonsteroidal anti-inflammatory drugs (NSAIDs), followed by anticonvulsants, such as lamotrigine, carbamazepine, theophyllines and cephalosporins. Most of the causative radiocontrast media were nonionic, low molecular and iodinated. The leading clinical features were skin eruptions and urticaria. Nine cases of serious ADR were induced by general medication, including 1 case of mortality due to allopurinol-induced toxic epidermal necrolysis. ADR cases induced by contrast media were 245. Conclusion: The most common causative drugs which induced adverse drug reactions were NSAIDs and radiocontrast media. The leading clinical features were skin eruptions and urticaria. Among radiocontrast media, nonionic low molecular iodinated contrast media mainly induced adverse drug reactions. Further epidemiologic studies will validate our study and help reveal the incidence of ADR in Korea.

Seasonal Change in C₃/C₄ Mixed Vegetation Populations over Paddy Levees in South Korea

김명현,오영주,김미란,Kim, Myung-Hyun,Oh, Young-Ju,Kim, Miran Korean Society of Agricultural and Forest Meteorol 2012 한국농림기상학회지 Vol.14 No.4

본 연구에서는 기후변화가 농업생태계 식물군락에 미치는 영향을 해석하기 위하여 기상요건이 다른 해남, 영동, 철원 3지역의 논둑에서 시기별로 식생변화를 조사하였다. 그 결과 출현종수에서 $C_3$식물은 해남과 영동에서는 이른 봄부터 5월 중순까지 증가하다가 $C_4$식물이 출현하는 이후부터 계속적으로 감소하였지만, 철원에서는 이른 봄부터 가을까지 계속적으로 증가하는 경향을 나타냈다. $C_4$식물은 해남과 영동에서는 6월 중순, 철원에서는 7월 하순에 출현하여 가을까지 계속적으로 증가하는 경향을 나타냈다. 종다양성의 계절변화에서 해남은 $C_4$식물이 출현하기 전에 가장 높은 값을 나타냈으며 이후에는 급격히 감소하였다. 영동은 $C_3$와 $C_4$식물이 혼생하는 초기에 가장 높은 값을 나타냈으며 이후에 서서히 감소하였다. 철원은 감소경향이 나타나지 않고 계속적인 증가 패턴을 나타냈다. 이들 논둑에 출현하는 식물을 $C_3$와 $C_4$ 두 그룹으로 나누어 상대피도 및 상대우점율의 계절변화를 확인한 결과 지역별 차이를 나타내기는 하지만 $C_3$식물에서 $C_4$식물로 교대가 나타나는 것을 확인할 수 있었다. 이러한 교대시기를 온도와 일조시간을 고려한 관계식을 이용하여 추정할 수 있었으며, 일평균기온 5 이상인 날에 대한 일조시간의 누적 합이 1017시간에서 논둑식생의 상대우점율이 $C_3$식물에서 $C_4$식물로 교대하는 것으로 예측했다. 이러한 연구결과는 기후변화에 따른 국내 식생분포의 예측에도 중요한 기초자료로 활용될 수 있을 것으로 판단된다. Studies of seasonal changes in $C_3/C_4$ mixed communities are rare, particularly in Asian summer monsoon climate zones. In our present study, seasonal changes in the profile and coverage of $C_3$ and $C_4$ plants were investigated in 2009 in Haenam, Yeongdong and Cheorwon regions of South Korea (all at different latitudes). The aim was to estimate the impacts of temperature and sunshine duration on species composition and transition timing of the $C_3$ and $C_4$ plants. From our results, the number of $C_3$ plants was found to increase from early spring to mid-May, and then decrease again until September in the Haenam and Yeongdong regions, but continuously increase from early spring to September in the Cheorwon region under relatively low summer temperatures. On the other hand, the number of $C_4$ plants increased from June or July to September in all three regions. These seasonal changes in species number and ratio have a direct impact upon species diversity which is highest when there are no dominant species. The relative coverage and relative summed dominance ratio (SDR') of the $C_3$ plants decreased from spring to autumn, but increased for the $C_4$ plants during this time in an exponential fashion with increasing accumulated temperature and sunshine duration. The transition timing from $C_3$ to $C_4$ plants occurred when the sum of sunshine duration for the days with daily mean temperature above $5^{\circ}C$ was 1017 hrs for the SDR'.

뇌하수체 종양에 대한 내시경 수술

김명현 이화여자대학교 의과대학 2010 EMJ (Ewha medical journal) Vol.33 No.1

Objectives:Surgical approaches to the pituitary adenoma have undergone numerous refinements. Surgery on the pituitary adenoma is increasingly being performed through an endoscopicapproach. The aim of this study is to report the results of a consecutive series of patients undergoing pituitary surgery using a pure endoscopic endonasal approach(EEA) and to evaluate the efficacy and safety of this procedure. Materials and Methods:We reviewed 24 consecutive patients with pituitary adenoma who underwent purely endoscopic transsphenoidal resection of their lesions. The patients’ clinical outcomes, including remission rates, degrees of tumor removal, and complications were evaluated. Results:Between September 2000 and August 2009, 76 patients with pituitary adenoma were operated on at Ewha University Mokdong Hospital. Of these, 24 patients were operated on using EEA. There were 18 nonfunctioning, 4 growth hormone-secreting, and 2 prolactin-secreting adenomas. Gross total removal was achieved in 62.5% of the cases after surgery. Visual disturbance was seen in 18 patients, which was improved in all patients. The main cause of failure of total removal was invasion to cavernous sinus. The remission results for patients with nonfunctioning adenomas was 83.3% and for functioning adenomas were 83.3%(75% for GH hormone-secreting, 100% for prolactin hormone-secreting), with no recurrence at the time of the last follow-up. Post-operative complications were present in 4(16.7%) cases. Three cases showed immediate postoperative CSF leakage, one case showed transient diabetes insipidus. There was no death related to the procedure in this series. Conclusion:The endoscopic endonasal approach for resection of pituitary adenomas, provides acceptable results representing a safe alternative procedure to the microscopic approach. This less invasive method, associated with a small number of complications, provides acceptable tumor removal rates and represents an important tool for the achievement of good results in the pituitary surgery.