정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

HLD (Handicapping Labiolingual Deviation), TPI (Treatment Priority Index)와 HMAR (Handicapped Malocclusion Assessing Record)를 이용한 지역간 부정교합 양상에 관한 연구

손병화,황충주,황현식 대한치과교정학회 1993 대한치과교정학회지 Vol.23 No.1

We tried to evaluate frequencies and severities of malocclusion of various socioeconomic areas according to growth and development. To obtain objective validity, we used Handicapping Labiolingual Deviation(HLD) suggested by Draker, Treatment Priority Index(TPI) by Grainger, Handicapped Malocclusion Assessing Record(HMAR) by American Dental Association and American Association of Orthodontist. Seoul and Kwangju were selected as an urban group, Ahnyang as an middle socioeconomic group and Hwasun near the Kwangju area as an rural group. 140 (male 63, female 73) of 5th grade in 'E' elementary school students in Seoul, 202 (male 101, female 101) of 'S' elementary school students in Kwangju, 207(male 105, female 102) of 'H' elementary school students in Hwasun, and 100(male 49, female 51) of 'M' elementary school students of in Ahnyang of all the same grade were analyzed and we obtained the results as follows ; 1. TPI, HLD, and HMAR showed high coincidence and reproducibility between different observer. (p<0.01) 2. In comparison of TPI, HLD, and HMAR according to clinical decision, there was statistically difference between each other. (p<0.01) 3. As the severity of malocclusion increases there was high correlation between TPI and HLD, and between HLD and HMAR. (p<0.05) 4. With respect to differences between areas in TPI and HLD, there was statistically difference between Ahnyang and other areas. 5. In Seoul as an urban group there was a high incidence of periodic checkup and history of orthodontic treatment than other area. 6. Mode of feeding and posture during sleeping did not affect the severity of malocclusion. As a conclusion, TPI, HLD and HMAR are so reproducible and coincident that they can be used as a guide on evaluating the frequency and severity of malocclusion and determining the priority of orthodontic treatment to determine the need and supply of orthodontic treatment. Furthermore these indices can provide objectively valid data for establishing public health problem solution.

Bi를 첨가한 BaTiO_3 자기반도체

孫炳基,丁潤夏,李萬浩 慶北大學校 1976 論文集 Vol.21 No.-

The (Ba_(1-x)Bi_x) TiO_3 (0.05≤x≤5a/0) has been prepared by sintering the mixture of BaTiO_3 and Bi_2O_3. The measuremnts of the capacitance and resistance showed that the optimum doping level of Bi was 0.1≤x≤0.5a/0. Typically, for the sample of x=0.5a/0, thearea capacitance was 3.5nF/㎠ which gave the effective dielectric constant of 3.4×10^4. The change in capacitance and loss tangent were 0.4∼-26% in the temperature range of -50∼85℃ and 5∼-7% in the temperature range of -50∼150℃ relative to room temperature capacitance and loss tangent, respectively. The frequency characteristics of the capacitance and loss tangent for the sample of 0.5a/0 showed that this sample was suitable for a capacitor in the higher frequency region than 1 kHz. Although the loss tangent(0.1) and the insulation registance (0.02MΩ·μF) are lower than JIS values, the semiconductors in the optimum doping range are valuable to be used as a high dielectric capacitor. The x=0.5a/0 sample had shown a PTC thermistor characteristics by having the resistance anomaly index ψ=2.5 and the room temperature resistivity ρ=10^4Ω·㎝.

성장기 아동에 있어 gonial angle의 변화와 IMPA 변화에 관한 누년적 연구

정진수,유영규,손병화,김영준 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.4

Gonial angle은 부정교합 환자의 진단과 치료계획 수립시 중요하게 이용되고 있으며, 두 개 안면 복합체의 성장방향과 안모형의 분류 그리고 하악골의 형태학적 및 기능적인 면을 연구하는데 사용되어왔다. 또한 임상적인 치료에 있어 하악 절치의 위치는 치료의 안정성과 하안면부의 심미적인 면에서 중요하며 전후방적인 절치의 위치는 치열궁 장경에 영향을 미쳐 치료계획 중 발치 결정의 중요한 기준으로 사용되고 있다. 저자는 연세대학교 치과 대학 교정과에 소장되어있는 E 여자학교 사범대학 부속초등학교 졸업생 중에서 전신질환이 없고 발육상태가 양호한 소년 15명과 소녀 19명을 대상으로, 7세부터 15세까지 만 9년간 누년적으로 촬영한 측모두부방사선 규격사진을 이용하여, gonial angle의 연령에 따른 변화양상과 gonial angle의 변화가 하악절치의 위치에 미치는 영향에 관한 누년적 연구를 하여 다음과 같은 결론을 얻었다. 1. 성장에 따른 gonial angle의 누년적 변화양상은 25명에서는 감소를, 9명은 일정하게 유지되거나 증가하는 양상을 보였다. 2. Gonial angle이 감소한 이동에서는 IMPA가 증가하는 경향을 보였으며, gonial angle이 일정하게 유지 되거나 증가 한 아동에서는 IMPA가 점진적으로 감소하는 경향을 보였다. 3. Interincisal angel은 gonial angle의 변화 양상에 관계없이 감소하는 경향을 보였다. The study was undertaken to investigate the growth change of gonial angle and interrelationship between the growth change of gonial angle and IMPA in the longitudinal data from 7 years to 15 years. By analyzing the serial lateral cephalograms of 15 meals and 19 females of 7 years old to 15 years old who had no abnomality in growth and development and no history of orthodontic treatment, the following conclusion were obtained. 1. Gonial angle gradually decreased with aging in 25 children and in 9 children increased or maintained. 2. There was a tendency that children who decreased gonial angle with aging showed gradual increase ofIMPA and children who increased or maintained gonial angle with aging showed decrease of IMPA. 3. There was a tendency that regardless of the change of gonial angle, interincisal angle decreased with aging.

야간 혈압 변동과 좌심실 질량, 이완기 기능 및 QT 간격과의 관계

김수중,이병호,손일석,강흥선,조정휘,김권삼,송정상,배종화 대한간질학회 2003 대한간질학회지 Vol.9 No.1

치환된 프로탈로시아닌의 합성 방법 연구

河潤卿,金永寬,孫秉淸,申鉉萬,朴美敬 弘益大學校 科學技術硏究所 1996 科學技術硏究論文集 Vol.7 No.1

The octadodecanoxy derivative of the phthalocyanine which has such long hydrocarbon chains around the skeleton of the phthalocyanine was synthesized. First of all, ortho-catechol was treated with 2 moles of 1-bromododecane to yield ortho-didodecanoxybenzene(I). Second, bromination of I resulted in dibromo-didodecanoxy benzene(II) where the para positions to the dodecanoxy groups were brominated. Finally, reaction of II with an excess of CuCN under an N₂atmosphere gave the intermediate dicyano-didodecanoxy-benzene(III), in situ, and futher heating in dry DMF with more CuCN gave the final product, octadodecanoxy derivative of the phthalocyanine. The synthetic method developed herein provides a general way to synthesize the variety of the phthalocyanines which displays many different substituents such as long hydrocarbons around its skeleton and contains a various metal inside of the phthalocyanine.

비복근-지방근막 피판을 이용한 하지의 연부조직 결손의 재건

손병규,이상순,정윤재 大韓成形外科學會 2001 Archives of Plastic Surgery Vol.28 No.4

Satellite-observed moistening processes in the tropical upper troposphere and their consequences in water vapor feedback

Byung-Ju Sohn,Johannes Schmetz,Eui-Seok Chung 한국기상학회 2008 한국기상학회 학술대회 논문집 Vol.2008 No.-

From the findings that UTH increase begins with a build-up of positive divergence even before the evaporation of cloud hydrometeors takes place and that UTH increase ends with an appearance of negative divergence values even before the evaporation ends, it is strongly suggested that moistening of the UT is more closely tied with water vapor transport from the convection center to surrounding areas than with the evaporation of cloud hydrometeors. Considering that vapor concentrations are nearly an order of magnitude larger than those of cloud ice, the higher degree of correlation shown between UTH tendency and divergence supports the notion that advection of moist air from the convection center is likely to be the main factor responsible for moistening of the UT.

Analysis of Expressed Sequence Tags of the Spider, Araneus ventricosus

Chung, Eun-Hwa,Lee, Kwang-Sik,Han, Ji-Hee,Sohn, Hung-Dae,Jin, Byung-Rae Korean Society of Sericultural Science 2001 International Journal of Industrial Entomology Vol.3 No.2

We have constructed a cDNA library from the whole body of the spider, Araneus ventricosus. Sequence analysis of randomly selected cDNA clones was performed to obtain genetic information on the spider A. ventricosus, of which genetic information is currently not available. We have partially sequenced randomly selected 385 clones of the cDNA library constructed from A. ventricosus. This expressed sequence tags (EST) analysis revealed 383 genes had high homologies to known genes in GenBank. In this report, 241 independent genes were analyzed in detail.

CloudSat shedding new light on high-reaching tropical deep convection observed with Meteosat

Chung, Eui-Seok,Sohn, Byung-Ju,Schmetz, Johannes American Geophysical Union 2008 Geophysical research letters Vol.35 No.2