전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

일부 지역 주민에서 초기 신기능 저하의 지표로서 혈청 Cystatin C 농도의 유용성

원기범,김준섭,박준형,강혁주,이정호 동국대학교 의학연구소 2009 東國醫學 Vol.15 No.2

혈청 cystatin C농도는 혈청 creatinine농도에 비해 신기능을 정확히 반영한다고 알려져 있지만, 대규모 연구 자료가 제한적이었다. 따라서 저자는 다수의 일부 지역 주민을 대상으로 cystatin C를 creatinine과 비교하여 신기능의 지표로서 cystatin C의 유용성을 알아보고자 하였다. 2008년 7월부터 9월까지 포항지역의 건강 검진자 999명 (남자: 324명, 여자: 657명)을 대상으로 혈청 cystatin C, 혈청 creatmine, 나이, 체중을 측정하고, Cockcroft-Gault식으로 사구체 여과율을 계산하였다. 계산된 사구체 여과율을 National Kidney Foundation의 Kidney Disease Outcomes Quality Initiative (KDOQI)에서 제시한 만성 신장병 분류 기준에 따라 5단계로 분류하였지만 4단계 (중증의 사구체 여과율 저하) 및 5단계 (신부전 또는 투석) 에 포함되는 대상자들의 숫자가 적어 (4단계: 4명, 5단계: 1명) 연구 대상에서 제외하였다. 대상자들의 평균 나이는 52.1 ± 17.1 세, 평균 체중은 59.7 ± 11.3 Kg,평균 혈청 cystatin C농도는 0.9 ± 0.2 mg, 평균 creatinine 농도는 1.0 ± 0.2 mg/dL이었다. 사구체 여과율을 각 단계별로 비교해 본 결과는 다음과 같이 혈청 cystatin C농도는 1 단계 (정상 신기능)는 0.8 ± 0.1 mg, 2단계 (경도의 신기능 저하)는 0.9 U 0.1 mg, 3단계 (중등도의 신기능 저하)는 1.0 d=0.1mg로 각각 유의한 차이를 보였다 (p<0.05).혈청 creatinine농도는 1단계는 0.9 ± 0.2 mg/dL, 2단계는 0.9 ± 0.1 mg/dL, 3단계는 1.0 ± 0.1 mg/dL로 l단계와 2단계 간에 차이가 없었으나 (p>0.05), 2단계와 3단계 간에는 유의한 차이를 보였다 (p<0.05).혈청 cystatin C농도와 혈청 creatinine농도는 나이 (cystatin C: r=0.275, p<0.05; creatinine: r=0.300, p<0.05) 및 체중 (cystatin C: r=0.075, P<0.05; creatinine: r=0.162, p<0.05) 과 양의 상관 관계를 보였다. 혈청 cystatin C 농도는 성별 간의 차이가 없었고, 혈청 creatinine농도는 남성에서 유의하게 높았다. 혈청 cystatin C농도는 혈청 creatinine농도에 비해 초기 신기능 저하를 반영하는 유용한 지표라고 생각된다. Although serum cystatin C has been suggested to be a better alternative marker than serum creatinine for estimating renal function, there have been limited data about its superiority over creatinine in a large number of populations. The aim of this study was to evaluate cystatin C as a renal marker compared to creatinine in a large population of the local community. We measured serum cystatin C, creatinine, age, body weight from 999 volunteers (Male; 324, Female; 657) of a single local cohort, Phohang, from July to September, 2008, and then calculated the GFR according to Cockcroft Gault(CG) formula. The population was divided into five stages followed by the chronic renal disease classification presented by KDOQI. The numbers in stage 4 (severe renal impairment), and 5 (renal failure) were too small (4 in stage 4, 1 in stage 5) to perform statistical analysis, so we excluded them. The mean age was 52.1 ± 17.1, and body weight 59.7 ± 11.3 Kg; serum cystatin C 0.9 ± 0.2 mg/L; serum creatmine 1.0 ± 0.2 mg/dL; CG GFR 70.6 ± 19.1 ml/min/1.73 m^(2). The tests completed for the comparison among each stage suggested the following results; serum cystatin C levels in stage 1 (normal renal function), stage 2 (mild deterioration of renal function), and stage 3 (moderate deterioration of renal function) showed the significant differences (stage 1 vs 2: 0.8 ± 0.1 vs 0.9 ± 0.1, p<0.05; stage 2 vs 3: 0.9 ± 0.1 vs 1.0 ± 0.1, p<0.05). Serum creatinine levels showed no significant differences between stage 1 and stage 2 (stage 1 vs 2: 0.9 ± 0.2 vs 0.9 ± 0.1, p>0.05), but showed significant differences between stage 2 and stage 3 (stage 2 vs 3: 0.9 ± 0.1 vs 1.0 ± 0.1, p<0.05). Serum cystatin C and creatinine presented positive correlation between age (cystatin C: r=0.275, p<0.05; creatinine: r=0.300, p<0.05) and body weight (cystatin C: r=0.075, p<0.05; creatinine: r=0.162, P<0.05). Serum cystatin C levels showed no significant difference in sex, but serum creatinine levels were significantly higher in men than women. Serum cystatin C level is suggested to be more useful parameter than serum creatinine level to evaluate early renal impairment.

Monte Carlo 방법을 이용한 대기오염 배출률 예측의 불확실성 평가

정효준,김은한,서경석,황원태,한문희 한국환경과학회 2006 한국환경과학회지 Vol.15 No.4

3축 자세 제어용 센서 시스템의 구현

정종원,최우진,이준탁 동아대학교 정보기술연구소 2001 情報通信硏究所論文誌 Vol.9 No.1

In this paper, were developed the 3 axes attitude control sensor system to control and monitoring the moving object. The proposed sensor system has been studied in Japan, America for a year ago. But it is high expensive and has a difficulty in application. To overcome these problems, proposed the 3 axes attitude control sensor system is low cost and easily applied. Proposed sensor system is equipped with the 3 gyro sensors, 2 tilt sensors and 3 MR sensors using 80C51 microprocessor for signal processing. It's output value transmit at long distance using RS232 serial communication protocol. We expect this system shall have a good performances in many applications of control and monitoring the moving object.

제지폐수의 응집특성에 관한 연구

조준형,정원구,김준환 江原大學校 森林科學硏究所 1998 Journal of Forest Science Vol.14 No.-

본 연구에서는 우유팩을 이용하여 재생용 화장지를 만드는 제지공장의 제지폐수를 이용하여 폐수의 침강특성 및 SS, BOD_5, 제거 효율을 검토하고, Jar-tester를 이용하여 급속교반시간, 완속교반 시간에 따른 탁도, SS, BOD_5 및 최적 응집제 주입량을 결정하였다. 각종 응집제 첨가 및 침강 특성에 의한 탁도제거의 효율을 측정하였다. 적정 응집제 첨가량, 급속교반 및 완속교반의 시간에 따른 처리 효율의 이론식을 제시하였다. 또한 응집제 Polyalunlinium chloride(PAC) 및 Aluminium sulfate의 응집 비교 실험을 행하였다. Sedimentation characteristics SS, BOD_5 and removal efficiency of waste water in the tissue paper mill using milk carton were examined. Optimum dosage of coagulant, rapid mixing time and slow mixing time were determined by turbidity. SS and S-BOD_5 and then equation for treatment efficiency was suggested. For the coagulant, polyalumimium chloride(PAC) are compared with a little better efficiency compare to the aluminium sulfate.

한우에 있어 황토 첨가급여가 면역기능에 미치는 영향

조원모,기광석,정하연,강수원,김준식,오성종,김용국 한국국제농업개발학회 2003 韓國國際農業開發學會誌 Vol.15 No.2

본 연구는 한우 육성우에 대한 황토 첨가급여가 항병성에 미치는 효과를 구명하고자 혈액성상변화를 규명한바 아래와 같은 결과를 얻었다. 대조구 및 처리구에서 전체적인 혈액성상의 변화는 없었으나 백혈구수치가 대조구 및 처리구에서 각각 15.35K/㎕ 및 13.37K/㎕이였으며, 적혈구에 있어서도 정상수치인 5~10M/㎕보다 대조구 10.03M/㎕, 처리구 11.35M/㎕로 모두 높은 수치를 보였다. 황토첨가에 따른 혈액성상의 변화는 처리간에 유의한 차이는 보이지 않았다. The study was conducted to investigate the effect of dietary supplements of reddish clay on the immunity of growing Hanwoo steers. A total of 8 calves were divided into 2 feeding groups, control(basal diet) and treatment(basal diet plus ad libitu reddish clay) for Hanwoo steers. This study was carried out for 5 months using 8 calves. The results obtained by the present study are summarized as follows : The proportion of WBC, NE as well as LY(15.35, 6.85, 6.86K/??) was higher in the control group than in the Reddish clay-supplemented group. But no statistical differences were found in blood substances among treatment calves.

한국형 우울장애 약물치료 알고리듬 2006 (Ⅰ)

서정석,민경준,김원,석정호,박원명,송해철,이상열,전덕인,전현태,홍진표,한국형 우울장애 약물치료 알고리듬 2006 연구그룹 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

Objectives : Since the publication of Korean Medication Algorithm Project for Major depressive Disorder (KMAP-MD) in 2002, there has been a substantial need for a revision due to rapid progress in the pharmacological management for depressive disorder. We revised KMAP-MD to Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) in 2006. This paper is one of the following 4 papers consisting of Korean pharmacological algorithm for depressive disorder. Methods : The questionnaire consisted of 4 parts ; initial treatment of 1) non-psychotic depressive disorder, 2) psychotic depressive disorder, 3) treatment strategy for clinical subtypes and drug choice considering adverse effects, and 4) treatment for depressive disorder in women. It was composed of 22 questions, and each question had 54 sub-items. The questionnaire was completed by the review committee consisting of 101 experienced Korean psychiatrists. We classified the expert opinion to 3 categories (the first-line, the second-line, or the third-line). Results : For non-psychotic major depression, regardless ofthe severity of an episode, the antidepressant (AD) monotherapy was the optimal first-line treatment. SSRI, venlafaxine, and mirtazapine were the 1st-line AD. In case of a partial or no response to initial strategy, adding another AD was recommended. For psychotic major depression, combination of an AD and an atypical antipsychotic (AAP) was the treatment of choice. Among AAPs, quetiapine, rispendone, olanzapine were preferred. For non-responder to initial strategy, the next step was adding or changing AD before changing AAP. For women with premenstrual dysphoric syndrome or postpartum depression without psychotic features, AD monotherapty was a preferred strategy while for psychotic postpartum depression, combination of AD and AAP was recommended. Experts recommended various ADs according to adverse effect. Conclusion : These results suggest that the medication strategies for depressive disorder are rapidly changing and reflect the recent studies and clinical experiences.

Plyometric Training과 비타민 C 투여가 남고생의 체력, 혈중 젖산, 암모니아 및 젖산탈수소효소에 미치는 영향

장준원,김세종,이현미,서혜림,조현숙,고정림,염종우,예정복,백영호 釜山大學校 附設 體育科學硏究所 2003 體育科學硏究所 論文集 Vol.19 No.-

The purpose of this was to examine the effect of plyometric training and vitamin C ingestion on physical fitness and fatigue substance....

원발성 폐암의 CT상 병기 결정:새로 재정된 TNM 체계와의 비교

신현준,최영칠,전혜정,박정희,김요한,이원진 건국대학교 의과학연구소 1998 건국의과학학술지 Vol.8 No.-

Accurate staging of lung cancer is essential for defining operability, selecting treatment regimens, predicting survival, and reporting comparable end results. Revisions in stage grouping of the TNM subsets in the International System for Staging Lung Cancer have been adopted by the American Joint Committee on Cancer and the Union Internationale le Cancer at 1996. We compared the previous TNM systems with revised stage grouping rules, and tried to applicate the new size-criteria for metastatic lymph nodes in mediastinum. Twenty-two patients were undergone CT stagings by using three different systems of previous, revised, and modified TNM subsets. Ten patients showed different TNM stage by the revised stage grouping rules and seven patients were altered in lymph node stage by the new size-criteria. Recognition of revised stage grouping rules is very important for treatment plan and predicting the correct prognosis.

현역 군인 발생을 중심으로 본 2000년도 국내 삼일열 말라리아 발생 현황

박재원,김영아,염준섭,유정식,양병국,채종일 대한감염학회 2001 감염 Vol.33 No.4

Background : Since 1997, the annual case occurrence of vivax malaria in the Republic of Korea have exceeded 1,000 cases since 1997. The military is thought to be an important source of the current outbreak. We collected various informations about malaria cases (soldiers, veterans and civilians) which occurred in 2000, and analyzed the characteristics of the current outbreak. Methods : Informations about malaria cases of soldiers, veterans and civilians, including name, age, sex, day of onset, region, etc., were collected through the National Institute of Health. Results : Out of total 4,141 cases, 1,288 (31.1%) occurred in the military, 1,273 (30.7%) occurred among the veterans, and 1,580 (38.2%) occurred among civilians. The monthly case occurrence reached its peak in early August. Areas such as Cheolwon, Yeoncheon and Paju showed the highest prevalence. Conclusion : It is considered that the current malaria outbreak has escaped from the exponential growth phase, however, more attention should be paid to prevent further spreading of malaria infection. (Korean J Infect Dis 33:280∼284, 2001)