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    • 胃潰瘍과 胃腺癌의 Carcinoembryonic antigen, Alpha fetoprotein 및 Human chorionic gonadotropin에 관한 免疫組織化學的 硏究

      金俊燮,金世民 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.3

      For the early detection and prognostic decision of tumors, many tumor markers have been suggested. Among these tumor markers, CEA for colon cancer, HCG for choriocarcinoma and AFP for hepatoma have been the most well-known and useful turmor markers. Recently, with the development of the immunohistochemical technique many studies to detect these tumor markers in the tissues of various organ have been reported. For the purpose to classify the stomach carcinoma by tumor associated or tumor specific antigens, to find out the possibility to use as guidance of diagnostic aid and to select the more specifically applicable chemotherapeutic resume, the author performed peroxidase-antiperoxidase immunohistochemical study with anti-CEA, anti-HCG and anti-AFP antibodies to the selected 5 cases of gastric ulcer as control goup and 23 cases of gastric adenocarcinoma as experimental group which were the most frequent diseases in this country. The findings were analysed and the results obtained are as follows. 1. In gastirc ulcers; a. CEA positive reaction to anti-CEA antibody was noted in 2 of the 5 cases. (40%) b. HCG positive reaction to anti-HCG antibody was noted in 2 of the 5 cases. (40%) c. there was no AFP positive reaction to anti-AFP antibody. 2. In gastric carcinomas; a. CEA positive reaction to anti-CEA antibody was noted in 21 of 23 cases. (91.3%) b. HCG positive reaction to anti-HCG antibody was noted in 6 of the 23 cases. (26%) c. AFP positive reaction to anti-AFP antibody was noted in 2 of the 23 cases. (8.7%) 3. There is no difference in CEA positivity between early and advanced gastric adeno-carcinoma and there was no HCG and AFP positive reaction to their antibodies in early gastric carcinoma. 4. CEA was also useful tumor marker for gastric adeno-carcinoma and it is not the only specific antigen for colon cancer.

    • KCI등재

      방선균증과 동반된 비부비동 및 비인두 Natural Killer/T 세포 림프종 1예

      김준섭,안태훈,여남경 대한이비인후과학회 2022 대한이비인후과학회지 두경부외과학 Vol.65 No.11

      Actinomycosis is a rare anaerobic, gram-positive bacterial infection caused by Actinomyces. As an infection site for the disease, the cervicofacial area is common but the nasal cavity andthe nasopharynx are rare. Actinomycosis causes chronic purulent granulomatous infection andis characterized by extensive infiltration, necrosis, and bone destruction on CT. Extranodalnatural killer/T cell (NK/T cell) lymphoma, nasal type is more common in East Asia thanelsewhere, comprising up to 7%-10% of all non-Hodgkin’s lymphoma. Early nasal symptomsare nonspecific and similar to chronic rhinosinusitis, such as nasal obstruction and nasalbleeding. With disease progression, inflammation and necrosis of the mucosa increase. Weexperienced a case of extranodal NK/T cell lymphoma in a 60-year-old female, who was diagnosedwith opportunistic infection of actinomycosis. We report this case with a review ofliterature.

    • KCI등재

      『國朝人物考』 편찬자 및 현전본 검토

      김준섭 한국고전번역원 2023 民族文化 Vol.64 No.-

      This article examines the compiler of Gukjo Inmulgo(國朝人物考) and the existing editions. It has been speculated that 李宜顯 compiled this text based on the records of 群書標記 but by means of analyzing the content in the 承政院日記 articles and comparing the Gugjungak edition of Gukjo Inmulgo(國朝人物考) and Inmulgo(人物考), it was possible to confirm that 李宜顯 was indeed the compiler. The Gugjungak edition of Gukjo Inmulgo(國朝人物考) has the largest remaining volume of text and has been widely used in various studies. However, it contains many content errors and has presented an inaccurate arrangement of sections since the time of its compilation. As a copied version, this text can be regarded as incomplete. There are some remaining fragments in the editions available at Yonsei University and Pusan National University. Firstly, the Yonsei University edition is a contemporary copy of the Gugjungak edition, and it also contains the same incorrectly arranged sections as the Gugjungak edition. The level of copying is similar, but some errors have been corrected. Both the Gugjungak edition and the Yonsei University edition are considered to be versions with a relatively low level of production based on the state of copying. The Pusan National University edition has a very high level of accuracy compared to the Gugjungak and Yonsei University editions. Although the time and the author of the copying process for the Pusan National University edition are unknown, there are indicators related to the abstract work of Inmulgo (人物考) in the table of contents, and throughout the book, there are seals of 摛文院, which indicates that it may be a version compiled by 李宜顯, which was given by 正祖 from his private collection. It may also be a version copied as part of the abstract work of 抄啓文臣 in early 1798. 본고는 『國朝人物考』의 편찬자와 현전하는 판본들에 대해 검토해 본 것이다. 그간 「群書標記」의 기록을 통해 이의현이 편찬한 것으로 추정되어 왔는데, 『承政院日記』 기사 내용을 분석하고, 규장각본 『국조인물고』와 『人物考』 비교를 통해 편찬자가 이의현임을 확신할 수 있었다. 규장각본 『국조인물고』는 가장 많은 분량이 남아 있어 각종 연구에 활용되고 있으나 내용 오류가 많이 발견되고 성책할 때부터 잘못 장정된 부분이 있는 등 필사본으로서 불완전한 면모가 있다. 이본으로 연세대와 부산대에 일부 잔본이 남아 있다. 우선 연세대본의 경우 규장각본과 동시기 필사된 판본으로 규장각본과 동일한 위치에 장정 오류가 발견된다. 필사의 수준 역시 비슷하였을 것이나 누군가 의해 오류가 일부 교정되어 있다. 규장각본과 연세대본은 필사 장정 상태를 보았을 때 제작 수준이 높지 않은 판본으로 판단된다. 부산대본은 규장각본과 연세대본에 비해 정확도가 매우 높다. 부산대본의 형성 시기 및 필사 주체는 알 수 없으나, 부산대본 목차에 『인물고』 초록 작업과 연관되는 점이 찍혀 있고, 책 전반에 이문원 인장이 찍혀 있는 것으로 보아 정조가 비부에서 내어 준 이의현이 편찬한 판본이거나, 1798년 초계문신의 초록 작업의 일환으로 필사된 판본일 가능성이 있다.

    • KCI등재

      生命保險經營과 支給餘力 確保方案

      김준섭 한국항만경제학회 1995 韓國港灣經濟學會誌 Vol.11 No.-

      Local Life Insurance Industry has been recently confronted with the phase of management turning-point in the process of the radical changes in financial circumstances; the opening capital market, the liberalizing interest rate level, the restructuring finance industry, etc. The core of these changes in the liberalizing and the opening of all respects concerned. The inclination of counter- steps to these changes by authorities concerned can be described as the free competition in local insurance market and the gradual regulatory mitigation for the purpose of self-regulation. Therefore, the competition in insurance market can be overheated and the various kinds of risks threatening the safety and soundness of insurance industry can be accelerated in volume.<br/> Solvency Margin regulation to insurance companies is generally regarded as a kind of restriction which makes insurers reserve funds to the extent of maintaining financial soundness. It's purpose is insurers' faithful performance of the duty imposed by a contract with policyholders, that is, preventing beforehand their insolvency. The question of securing solvecy margin is whether the insurer concerned can .secure or not enough capital for paying off surrender value and all sorts of debts at a specific point of time. But, as of today, this is not simply the question of a point of time, but the one of a concept of probability. Estimating a insurer's solvency margin, we must consider not only the portfolio of insurance and investment but the intenal financial structure at the same time. In this respect, the assessment of individual insurer's solvency margin cannot be performed simply by establishing several standards. First of all, it must be considered all sorts of factors related to insurance management..<br/> This study, therefore, tries to analyze the method of securing solvency margin relating to the regulations of insurer's one as a counter-step to various risks originating from radical changes in financial circumstances. Examining the change, of insurance circumstances, the questions of regulation solvency margin, the present regulations of solvency margin and the precedents of solvency management in U.S.A an Japan, this study intends to show the method of securing solvency margin in Local Life Insurance Industry.

    • KCI등재

      임의 탐지된 LPI 신호의 분류를 위한 딥러닝 모델 분석

      김준섭,조성환,황선일,이원진,최영윤 한국전자파학회 2024 한국전자파학회논문지 Vol.35 No.3

      본 논문은 임의 탐지된 저피탐(LPI, low probability of intercept) 신호를 모의하기 위한 신호 생성 아키텍처를 소개하고, 이를 통해 생성된 신호의 변조 기법을 분류하기 위한 딥러닝 모델의 성능을 비교하여 제시한다. 기존 연구에서 신호의분류 시간을 최소화하고 정확도를 향상하기 위해 앙상블 학습이 활용되었으나, 딥러닝 모델 채택에 대한 명확한 기준이부족하다. 본 연구에서는 시뮬레이션 결과를 통해 11개의 딥러닝 모델의 성능을 분석하고, 앙상블 학습 시 MobileNet V3 Small을 메인 모델로, Densenet-169를 서브 모델로 활용하는 방안을 제안한다. This paper presents a signal generation architecture for simulating arbitrarily intercepted low-probability-of-intercept (LPI) signals in a battlefield environment. Additionally, the performances of deep learning models in classifying the generated signals are compared in terms of the classification time, GPU memory usage, and accuracy. Previous studies have utilized ensemble learning to minimize signal classification time and enhance accuracy; however, an explicit criteria for the adoption of deep learning models have been lacking. This paper presents the analysis of the performances of 11 deep learning models on the basis of simulation results and proposes an ensemble model that utilizes MobileNet V3 Small as the main model and Densenet-169 as the sub-model.

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