귀국 대학생들의 문화 가치, 문화 지능과 재적응의 관계: 사회적 지지의 매개 효과

임선민,연규진 한국상담심리학회 2020 한국심리학회지 상담 및 심리치료 Vol.32 No.4

This study examined whether the effects of cultural values on readjustment were mediated by social support among South Korean students who studied in North America before college(returnees). A mediation model of social support on the relationship between South-Korean cultural values and readjustment in which the relationship between South-Korean cultural values and social support was moderated by North American cultural values was tested. A sample of 563 college students (104 returnees, 366 Korean-educated-only) completed a self-report questionnaire. Welch’s T-test was conducted to examine differences in the study variables between the two groups. The moderated mediation analysis showed that the relationship between South-Korean cultural values and readjustment was mediated by social support, and this mediation effect was moderated by North American cultural values. This finding suggests that returnees using integration strategies and embracing cultural values of both societies are more likely to receive social support and readjust effectively in Korea. 본 연구는 문화변용전략의 이론적 관점을 활용하여 북미에서 3년 이상 수학하고 귀국한 대학생들의 문화가치가 사회적 지지를 매개하여 한국 재적응을 예측하는지 알아보고자 하였다. 구체적으로 귀국 학생들을 대상으로, 문화 지능을 통제한 후 한국 문화 가치와 재적응의 관계에서 북미 문화 가치에 의해 조절된 사회적 지지의 매개효과를 확인하였다. 총 563명의 대학생(귀국 학생 104명, 국내 학생 366명)이 연구에 참여하였고, 귀국 학생과 국내에서 수학한 학생들이 연구변인에서 차이가 있는지 Welch’s t-test를 통해 비교하였다. 귀국한 학생들을 대상으로 한 조절된 매개효과 검증 결과, 한국 문화 가치와 재적응의 관계에서 북미 문화 가치에 의해 조절된 사회적 지지의 매개효과가 유의하였다. 이는 귀국 학생들이 통합의 전략을 사용하여 양쪽 문화 가치를 모두 수용하고 있을 때 주변의 지지를 잘 받고 재적응을 잘 할 수 있음을 의미한다. 연구 결과를 토대로 귀국 학생들의 재적응을 조력할 수 있는 방안을 논의하고, 본 연구의 제한점과 후속 연구에 대한 제언을 논하였다.

Real World Experience of Nivolumab in Non-Small Cell Lung Cancer in Korea

임선민,김상위,조병철,강진형,안명주,김동완,김영철,이진수,이종석,이승룡,박건욱,안호정,조은경,장태원,김봉석,김주항,이성숙,나임일,유승수,이기형 대한암학회 2020 Cancer Research and Treatment Vol.52 No.4

Purpose The introduction of immune checkpoint inhibitors represents a major advance in the treatment of lung cancer, allowing sustained recovery in a significant proportion of patients. Nivolumab is a monoclonal anti–programmed death cell protein 1 antibody licensed for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy. In this study, we describe the demographic and clinical outcomes of patients with advanced NSCLC treated with nivolumab in the Korean expanded access program. Materials and Methods Previously treated patients with advanced nonsquamous and squamous NSCLC patients received nivolumab at 3 mg/kg every 2 weeks up to 36 months. Efficacy data including investigator-assessed tumor response, progression data, survival, and safety data were collected. Results Two hundred ninety-nine patients were treated across 36 Korean centers. The objective response rate and disease control rate were 18% and 49%, respectively; the median progression-free survival was 2.1 months (95% confidence interval [CI], 1.87 to 3.45), and the overall survival (OS) was 13.2 months (95% CI, 10.6 to 18.9). Patients with smoking history and patients who experienced immune-related adverse events showed a prolonged OS. Cox regression analysis identified smoking history, presence of immune-related adverse events as positive factors associated with OS, while liver metastasis was a negative factor associated with OS. The safety profile was generally comparable to previously reported data. Conclusion This real-world analysis supports the use of nivolumab for pretreated NSCLC patients, inclu-ding those with an older age.

과실의 배꼽부위 돌출제거 방법이 배 품질 향상에 미치는 영향

임선민 단국대학교 최고농업경영자과정 1997 논문집 Vol.1 No.-

IEEE 802.22 WRAN 시스템에서 확신 벡터를 이용한 데이타 퓨전

임선민,송명선,정회윤 한국통신학회 2009 韓國通信學會論文誌 Vol.34 No.8

For operation of IEEE 802.22 WRAN system, spectrum sensing is a essential function. However, due to strict sensing requirement of WRAN system, spectrum sensing process of CR nodes require long quiet period. In addition, CR nodes sometimes fail to detect licensed users due to shadowing effect of wireless communication environment. To overcome this problem, CR nodes collaborate with each other for increasing the sensing reliability or mitigating the sensitivity requirement. A general approach for decision fusion, the “k out of N” rule is often taken as the decision fusion rule for its simplicity. However, since k out of N rules can not achieve better performance than the highest SNR node when SNR is largely different among CR nodes, the local SNR of each node should be considered to achieve better performance. In this paper, we propose two novel data fusion methods by utilizing confidence vector which represents the confidence level of individual sensing result. The simulation results show that the proposed schemes improve the signal detection performance than the conventional data fusion algorithms. IEEE 802.22 WRAN의 사용을 위해서는 TV 대역의 스펙트럼 센싱이 필수적이다. 그러나 WRAN의 센싱 요구 조건을 만족하기 위해서는 긴 휴지 시간이 필요하고 쉐도윙 등의 환경적인 요인에 의해 기면허 사용자를 검출하 지 못하는 문제점을 가지고 있다. 이러한 문제를 극복하기 위해 협력 센싱을 통해 각 CPE의 센싱 요구 조건을 완화시키거나 스펙트럼 센싱의 신뢰성을 높인다. 일반적으로 협력 센싱은 k-out-of-N 규칙이 단순한 계산으로 인 해 많이 사용된다. 그러나 이 방식의 경우 각 CPE의 SNR의 차이가 많은 경우 협력 센싱을 통해 얻은 센싱 성능 이 가장 좋은 SNR을 가지는 CPE의 검출 성능보다 나쁘게 나타난다. 이러한 문제점을 해결하기 위해서 각 노드 의 SNR을 반영하여 데이터 퓨전을 수행하는 방법들이 제안되는데 본 논문에서는 새로운 확신 벡터를 이용한 데 이터 퓨젼 방식을 제안하였으며 전산 모의 실험 결과 제안된 방식이 기존 방식보다 검출 성능이 개선된 것으로 나타났다.

Investigating the Feasibility of Targeted Next-Generation Sequencing to Guide the Treatment of Head and Neck Squamous Cell Carcinoma

임선민,조상희,황인규,최재우,장현,안명주,박건욱,김지원,고윤호,안희경,조병철,남병호,전상훈,홍지형,권정혜,최종권,강은주,윤탁,이근욱,김주항,김진수,이현우,김민경,정동민,김지은,김범석,윤환중,김상우,김혜련 대한암학회 2019 Cancer Research and Treatment Vol.51 No.1

Purpose Head and neck squamous cell carcinoma (HNSCC) is a deadly disease in which precision medicine needs to be incorporated. We aimed to implement next-generation sequencing (NGS) in determining actionable targets to guide appropriate molecular targeted therapy in HNSCC patients. Materials and Methods Ninety-three tumors and matched blood samples underwent targeted sequencing of 244 genes using the Illumina HiSeq 2500 platform with an average depth of coverage of greater than 1,000. Clinicopathological data from patients were obtained from 17 centers in Korea, and were analyzed in correlation with NGS data. Results Ninety-two of the 93 tumors were amenable to data analysis. TP53 was the most common mutation, occurring in 47 (51%) patients, followed by CDKN2A (n=23, 25%), CCND1 (n=22, 24%), and PIK3CA (n=19, 21%). The total mutational burden was similar between human papillomavirus (HPV)–negative vs. positive tumors, although TP53, CDKN2A and CCND1 gene alterations occurred more frequently in HPV-negative tumors. HPV-positive tumors were significantly associated with immune signature-related genes compared to HPV-negative tumors. Mutations of NOTCH1 (p=0.027), CDKN2A (p < 0.001), and TP53 (p=0.038) were significantly associated with poorer overall survival. FAT1 mutations were highly enriched in cisplatin responders, and potentially targetable alterations such as PIK3CA E545K and CDKN2A R58X were noted in 14 patients (15%). Conclusion We found several targetable genetic alterations, and our findings suggest that implementation of precision medicine in HNSCC is feasible. The predictive value of each targetable alteration should be assessed in a future umbrella trial using matched molecular targeted agents.

$rho$차 역필터 기법을 이용한 OFDM 시스템의 메모리가 없는 비선형 고전력 증폭기의 전치 보상기 설계

임선민,은창수,Lim, Sun-Min,Eun, Chang-Soo 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.2c

본 논문에서는 OFDM 신호의 높은 PAPR과 전력 증폭기의 비선형성에 의한 신호의 왜곡과 스펙트럼의 확산을 방지하기 위하여 $rho$차 역필터 구조를 사용하는 전치 보상기를 구현하는 방안을 제시한다. 메모리가 없는 고전력 증폭기를 다항식으로 모델링 하고 전치 보상기로써 비선형 증폭기 특성의 역모델인 $rho$차 역필터 구조를 이용한다. $rho$차 역필터 구조는 비선형 시스템이 다항식으로 모델링 된다면 다항식의 계수만으로 구현될 수 있으므로 많은 메모리가 필요 없다. 비선형 전력 증폭기 모델의 계수 갱신을 위하여는 LMS, RLS 알고리듬을 모두 사용할 수 있으며 계수의 개수가 적어 수렴 속도가 빠르고 복소 계산이 필요 없으므로 계산도 간단하다. In this paper, we propose a method to implement a predistorter of the $rho$-th order inverse filter structure to prevent signal distortion and spectral re-growth due to the high PAPR (peak-to-average ratio) of the OFDM signals and the non-linearity of high-power amplifiers. We model the memory-less non-linearity of the high-power amplifier with a polynomial model and utilize the inverse of the model, the $rho$-th order inverse filter, for the predistorter. Once the non-linearity is modeled with a polynomial, since we can determine the $rho$-th order inverse filter only with the coefficients of the polynomial, large memory is not required. To update the coefficients of the non-linear high-power amplifier model, we can use LMS or RLS algorithms. The convergence speed is high since the number of coefficients is small, and the computation is simple since manipulation of complex numbers is not necessary.

중년 남성 하지에 발생한 근혈관주위세포종 1예

임선민,김한샘,남재희,이가영,김원석 대한피부과학회 2018 大韓皮膚科學會誌 Vol.56 No.2

P차 역필터 기법을 이용한 OFDM 시스템의 메모리가 없는 비선형 고전력 증폭기의 전치 보상기 설계

임선민,은창수 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.2

The Effect of the Menstrual Cycle on Inflammatory Bowel Disease: A Prospective Study

임선민,천재희,남정모,이신애,김은혜,홍성필,김태일,김원호 거트앤리버 소화기연관학회협의회 2013 Gut and Liver Vol.7 No.1

Background/Aims: The symptoms of inflammatory bowel disease (IBD) fluctuate considerably over time. However, it has not been determined whether these symptoms are affected by the menstrual cycle in female IBD patients. This study analyzed the effects of the menstrual cycle on IBD symptom variation. Methods: This was a prospective study of 91 study subjects (47 IBD patients and 44 healthy controls) who reported daily symptoms and signs throughout their menstrual cycles. Results: IBD patients had significantly more frequent gastrointestinal symptoms, such as nausea (30% vs 7%, p=0.006), flatulence (53% vs 22%, p=0.003), and abdominal pain as compared to controls (68% vs 38%, p=0.006). The IBD patients also experienced more frequent systemic premenstrual symptoms than the controls (79% vs 50%, p=0.003). More severe abdominal pain (p=0.002) and lower mean general condition scores (p=0.001) were noted during the menstrual phase as compared to the pre- or post-menstrual phase in both groups. IBD patients experienced more frequent premenstrual gastrointestinal symptoms than controls, but their IBD symptoms did not change significantly during the menstrual cycle. Conclusions: Knowledge of the cyclic alterations in gastrointestinal and systemic symptoms may be helpful in determining the true exacerbation of disease in female IBD patients.

Treatment Outcome of Patients with Anaplastic Thyroid Cancer: A Single Center Experience

임선민,조병철,신상준,정웅윤,박정수,남기현,강상욱,금기창,김주항,조재용,홍윤경 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.2

Purpose: Anaplastic thyroid cancer is known to have a poor prognosis due to its aggressive and rapid metastasis with median survival of less than 6 months. Multimodal treatment involving surgery and chemoradiotherapy has been used to improve the survival of patients. Here, we retrospectively review of treatment outcome of 13 consecutive patients who were treated at a single center. Materials and Methods: We retrospectively reviewed medical records of 13 anaplastic thyroid cancer patients who received multidisciplinary treatment between 2006 and 2010. Kaplan-Meier survival curve was used to analyze progression-free survival and overall survival of patients. Results: The median patient age at diagnosis was 69 years, and six patients had stage IVc diseases. Eight patients received primary surgery followed by radiotherapy or concurrent chemoradiotherapy (CCRT). Five patients received weekly doxorubicin-based definitive CCRT, but only one patient’s condition remained stable, while the rest experienced rapid disease progression. The median progression-free survival was 2.8 months (95% CI, 1.2-4.4 months), and the median overall survival was 3.8 months (95% CI, 3.0-4.6 months). Conclusion: Patients with anaplastic thyroid cancer showed poor prognosis despite multimodality treatment. Therefore, identification of novel therapeutic targets is warranted to take an effective mode of treatment.