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        • KCI등재

          멀티미디어 전자저널의 형식 체계 개발에 관한 연구

          남병호,윤찬종 한국디자인트렌드학회 2005 한국디자인포럼 Vol.11 No.-

          컴퓨터와 정보 기술의 발달은 출반 정보를 쉬고 신속하게 전달 할 수 있는 디지털 제작이 컴퓨터를 이용하여 이행될 수 있고 정보기술이 지리적 제한 없이 그것을 전달할 수 있기 때문에 오늘날의 출판환경에 커다란 변화를 요구하고 있다. 이러한 변화의 궁극적인 목적은 정보 사용의 혁신적인 변화이다. 인쇄 매체를 통한 일차적이고 일방적인 정보 전달 매체는 사용자가 자신의 의지에 따라 정보 전달의 흐름을 바꿀 수 있는 비직선적이고 양방향 정보 전달 형태로의 질적 변화를 이루었다. 이것은 멀티미디어에 의해 주도되었다. 인터넷의 발달로 저널과 분배 구조의 형태에도 변화가 있었다. 웹을 이용한 전자 저널과 딜러의 발달을 통한 데타데이터의 활성화는 저널의 가치와 이용을 증대시켰으며, 전자 저널은 도서관 용량을 유지하며 그것의 업무 한계를 극복한 최선의 메커니즘으로 간주되고 있다. 본 연구는 기존의 저널들의 정의와 특징을 통해 그들의 특성과 가치를 분석하고 웹과 멀티미디어 기술을 추가하여 인터페이스를 중심으로 한 전자 저널의 새로운 모델을 제시한다.또한 전통적인 인쇄 저널의 요소와 공식적인 시스템을 조사하고 그들의 장점과 단점을 비교 분석한다. The development of computer and information technology has required a great change to today publishing environment because digital work which can communicate publishing information easily and rapidly can be performed with computer and information technology can deliver it without geographical limitation. The ultimate destination of such changes is an innovative change of using information. Linear and one-way information communication media through print media has achieved a qualitative change, into non-linear and dual-way which user can change the flow of information communication in his or her own will. it has been led by multimedia. There has been a change in the form of journals and distribution structure with the development of internet. The activation of metadata through the development of electronic journals and dealers based on web has enhanced the value and use of journals and the electronic journals are regarded as the best mechanism which keeps the library capacity and overcomes the limitation of its service. This study analyzes the property and value of existing journals through definition and features of them and suggests a new model of electronic journal centering around interface by adding web and multimedia techniques.It also examines the components and formal systems of traditional printed journals and compares and analyzes their advantaged and disadvantages.

        • KCI등재후보

          Laparoscopy Assisted versus Open Distal Gastrectomy with D2 Lymph Node Dissection for Advanced Gastric Cancer: Design and Rationale of a Phase II Randomized Controlled Multicenter Trial (COACT 1001)

          남병호,김영우,Daniel Reim,엄방울,유완식,박영규,류근원,이영준,윤홍만,이준호,정오,정상호,이상억,이상호,윤기영,서경원,정호영,권오경,김태봉,이운기,박성흠,설지영,양대현,이종석 대한위암학회 2013 Journal of gastric cancer Vol.13 No.3

          Purpose: Laparoscopy-assisted distal gastrectomy for early gastric cancer has gained acceptance and popularity worldwide. However,laparoscopy-assisted distal gastrectomy for advanced gastric cancer is still controversial. Therefore, we propose this prospective randomized controlled multi-center trial in order to evaluate the safety and feasibility of laparoscopy assisted D2-gastrectomy for advanced stage gastric cancer. Materials and Methods: Patients undergoing distal gastrectomy for advanced gastric cancer staged cT2/3/4 cN0/1/2/3a cM0 by endoscopy and computed tomography are eligible for enrollment after giving their informed consent. Patients will be randomized either to laparoscopyassisted distal gastrectomy or open distal gastrectomy. Sample size calculation revealed that 102 patients are to be included per treatment arm. The primary endpoint is the non-compliance rate of D2 dissection; relevant secondary endpoints are three-year disease free survival, surgical and postoperative complications, hospital stay and unanimity rate of D2 dissection evaluated by reviewing the intraoperative video documentation. Discussion: Oncologic safety is the major concern regarding laparoscopy-assisted distal gastrectomy for advanced gastric cancer. Therefore,the non-compliance rate of clearing the N2 area was chosen as the most important parameter for the technical feasibility of the laparoscopic procedure. Furthermore, surgical quality will be carefully reviewed, that is, three independent experts will review the video records and score with a check list. For a long-term result, disease free survival is considered a secondary endpoint for this trial. This study will offer promising evidence of the feasibility and safety of Laparoscopy-assisted distal gastrectomy for advanced gastric cancer. Trial Registration: NCT01088204 (international), NCCCTS-09-448 (Korea)

        • KCI등재

          가시광 다이오드 레이저의 스펙트럼 및 주입-잠금 특성분석

          남병호,박기수,권진혁 한국광학회 1994 한국광학회지 Vol.5 No.2

          가시광 디이오드 레이저의 온도와 주입 전류에 따른 발진 스펙트럼의 특성을 분석하고 주입-잠금 실험을 수행하여 잠금 특성을 분석하였다. 다이오드 레이저의 온도와 주입전류에 따른 스펙트럼 분석 결과 모드 도약이 일어나는 것을 관찰할 수 있었으며 모드 도약이 일어나지 않는 영역에서의 온도와 주입 전류의 변화에 대한 주파수 변화율이 각각 약 $33 GHz/^{\circ}C$, 6.6 GHz/mA로 나타남을 알 수 있었다. 일반적인 근적외선 AlGaAs 다이오드 레이저에서 순간적인 모드 도약이 일어나는 것과는 달리 가시광 다이오드 레이저는 모드 도약의 영역이 넓고 다중 모드로 동작하여 불량한 스펙트럼을 나타냈다. 이러한 특성을 갖는 다이오드 레이저를 이용한 주입-잠금 실험 결과 주입 강도가 $0~25\muW$에 대하여 잠금 대역폭은 0~5 GHz로 나타남을 알 수 있었다. 또한 주입 강도를 약 $25\muW$로 고정시키고, 편광 방향을 회전시키며 주입-잠금 대역폭을 측정한 결과 편광 방향에 의존함을 알 수 있었다. 주입-잠금된 광파의 위상 변화를 측정하기 위하여 주 레이저와 종 레이저를 간섭시켜 종 레이저의 주입 전류의 변화에 대한 간섭 무늬의 이동으로 위상의 변화를 조사하였다. We investigated the spectral characteristics for temperature and driving current change in visible laser diode. As a result of spectrum analysis, the ratio of frequency change for temperature and driving current change were about $33 GHz/^{\circ}C$, 6.6 GHz/mA in the region which was not mode hopping range. Compared to the sharp mode hopping in the near IR single mode AlGaAs lasers, the visible laser diode showed relatively broad multimode operation in the mode hopping region. We performed the experiment of injection-locking characteristics analysis for visible laser diode. Locking half bandwidth(LHBW) was measured 0~5.0 GHz for $0~25\muW$ input power and it was dependent on the input power. Also, LHBW for polarization angle was dependent on the difference of polarization angle between master laser and slave laser. The phase change of injection-locked output beam of the slave laser diode as a function of the drive current was measured in the interferometer which was composed of master laser and slave laser. The ratio of phase change with the slope of 5.0~1.3 rad/mA was obtained within injection-locking range for the change of $2~25\muW$ input power. power.

        • KCI등재후보

          Is human papillomavirus genotype an influencing factor on radiotherapy outcome? Ambiguity caused by an association of HPV 18 genotype and adenocarcinoma histology

          김주영,남병호,이진아 대한부인종양학회 2011 Journal of Gynecologic Oncology Vol.22 No.1

          Objective: To evaluate whether human papillomavirus (HPV) genotype is associated with poor prognosis of uterine cervical cancer treated primarily with radiotherapy. Methods: HPV genotyping was performed in 181 radiotherapy patients using SPF10 polymerase chain reaction and HPV reverse hybridization line probe assay. Univariate and multivariate Cox regression analysis was performed to explore the prognostic factors. Bivariate analysis was performed to investigate any association between HPV genotype and the rest of the prognostic factors. Results: HPV type 18 was associated with poor disease-free survival on univariate analysis but the statistical significance was abolished when multivariate analysis was applied. Bivariate analysis was performed to examine the possible confounding factors influencing the effect of HPV 18 on prognosis. As a result, adeno/adenosquamous carcinoma histology reduced the prognostic importance of HPV 18 by 66% (2.4 to 1.6), and was the only factor which reduced the hazard ratio of HPV 18. When compared to non-18 squamous cell carcinoma, type 18 increased the risk of recurrence up to 4-fold in adeno/adenosquamous/HPV 18 and 3.7 in adeno/adenosquamous/non-18, and to 2-fold in squamous carcinoma/HPV 18, respectively. Conclusion: Our data suggest that the prognostic significance of HPV 18 genotype is substantial on radiotherapy outcome, but can be underestimated because of the close association of the HPV 18 and adenocarcinoma/adenosquamous carcinoma histology. Both HPV 18 and histologic type should be regarded as strong prognostic factors in considering the treatment outcome of the uterine cervical cancer. Objective: To evaluate whether human papillomavirus (HPV) genotype is associated with poor prognosis of uterine cervical cancer treated primarily with radiotherapy. Methods: HPV genotyping was performed in 181 radiotherapy patients using SPF10 polymerase chain reaction and HPV reverse hybridization line probe assay. Univariate and multivariate Cox regression analysis was performed to explore the prognostic factors. Bivariate analysis was performed to investigate any association between HPV genotype and the rest of the prognostic factors. Results: HPV type 18 was associated with poor disease-free survival on univariate analysis but the statistical significance was abolished when multivariate analysis was applied. Bivariate analysis was performed to examine the possible confounding factors influencing the effect of HPV 18 on prognosis. As a result, adeno/adenosquamous carcinoma histology reduced the prognostic importance of HPV 18 by 66% (2.4 to 1.6), and was the only factor which reduced the hazard ratio of HPV 18. When compared to non-18 squamous cell carcinoma, type 18 increased the risk of recurrence up to 4-fold in adeno/adenosquamous/HPV 18 and 3.7 in adeno/adenosquamous/non-18, and to 2-fold in squamous carcinoma/HPV 18, respectively. Conclusion: Our data suggest that the prognostic significance of HPV 18 genotype is substantial on radiotherapy outcome, but can be underestimated because of the close association of the HPV 18 and adenocarcinoma/adenosquamous carcinoma histology. Both HPV 18 and histologic type should be regarded as strong prognostic factors in considering the treatment outcome of the uterine cervical cancer.

        • SCOPUSKCI등재
        • KCI등재

          The Korean Gastric Cancer Cohort Study: Study Protocol and Brief Results of a Large-Scale Prospective Cohort Study

          엄방울,남병호,김영우,류근원,정현용,박영규,이영준,양한광,유완식,육정환,송근암,윤세진,김흥업,노성훈,박승배,양두현,김성 대한위암학회 2016 Journal of gastric cancer Vol.16 No.3

          Purpose: This study aimed to establish a large-scale database of patients with gastric cancer to facilitate the development of a nationalcancer management system and a comprehensive cancer control policy. Materials and Methods: An observational prospective cohort study on gastric cancer was initiated in 2010. A total of 14 cancer centers throughout the country and 152 researchers were involved in this study. Patient enrollment began in January 2011, and data regarding clinicopathological characteristics, life style-related factors, quality of life, as well as diet diaries were collected. Results: In total, 4,963 patients were enrolled until December 2014, and approximately 5% of all Korean patients with gastric cancer annually were included. The mean age was 58.2±11.5 years, and 68.2% were men. The number of patients in each stage was as follows: 3,394 patients (68.4%) were in stage IA/B; 514 patients (10.4%), in stage IIA/B; 469 patients (9.5%), in stage IIIA/B/C; and 127 patients (2.6%), in stage IV. Surgical treatment was performed in 3,958 patients (79.8%), endoscopic resection was performed in 700 patients (14.1%), and 167 patients (3.4%) received palliative chemotherapy. The response rate for the questionnaire on the quality of life was 95%; however, diet diaries were only collected for 27% of patients. Conclusions: To provide comprehensive information on gastric cancer for patients, physicians, and government officials, a large-scale database of Korean patients with gastric cancer was established. Based on the findings of this cohort study, an effective cancer management system and national cancer control policy could be developed.

        • KCI등재후보

          말기암환자 정보시스템을 이용한 우리나라 암환자 완화의료기관의 이용현황

          신동욱,최진영,남병호,서원석,김효영,황은주,강진아,김소희,김양혁,박은철,Shin, Dong-Wook,Choi, Jin-Young,Nam, Byung-Ho,Seo, Won-Seok,Kim, Hyo-Young,Hwang, Eun-Joo,Kang, Jina,Kim, So-Hee,Kim, Yang-Hyuck,Park, Eun-Cheol 한국호스피스완화의료학회 2010 한국호스피스.완화의료학회지 Vol.13 No.3

          목적: 최근 보건의료 정책 결정은 근거에 기반하여 이루어지는 추세에 있으며, 말기암환자 정보시스템은 이러한 필요에 부응하기 위하여 개발되었다. 본 고에서는 말기암환자 정보시스템의 개발과정 및 6개월 데이터로부터의 통계 결과를 보고하고자 한다. 방법: 말기암환자 정보시스템의 입력항목은 실무 전문가들의 자문을 받아 개발되었으며, 이벨로스 임상연구관리시스템을 기반으로 구축하였다. 2009년 보건복지가족부에서 지정된 34개 암환자완화의료 기관에 2009년 1월 1일부터 6월 30일까지 등록된 환자들에 대한 정보가 수집되었다. 분석은 기술적 통계를 이용하였다. 결과: 총 2,940명의 전국적으로 대표성 있는 데이터로부터 아래와 같은 결과를 얻었다. 평균연령은 $64.8{\pm}12.9$ 세였고, 56.6%가 남자였다. 폐암(18.0%)이 가장 많았다. 2인 이상의 의사에 의하여 말기진단을 받은 경우는 50.3% 였으며, 입원 당시 말기라는 사실을 알고 있는 환자는 69.7%였고, 거의 절반에 가까운 환자가 특별한 의뢰 없이 입원하였다. 평균 통증 및 최고 통증은 입원 1주 후에 통계적으로 유의하게 감소하였다. 사망 퇴원한 환자가 73.4%였으며, 집으로 퇴원하는 경우는 13.3%에 불과했다. 1회당 평균 입원일수는 $20.2{\pm}21.2$일이었으며, 중위값은 13일이었다. 결론: 말기암환자 정보시스템의 운영을 통하여 완화의료 기관 이용 환자 및 가족의 특성, 서비스 제공에 관한 현황 등에 관한 전국적으로 대표성 있는 자료를 얻을 수 있었다. Purpose: Recently, health policy making is increasingly based on evidence. Therefore, Korean Terminal Cancer Patient Information System (KTCPIS) was developed to meet such need. We aimed to report its developmental process and statistics from 6 months data. Methods: Items for KTCPIS were developed through the consultation with practitioners. E-Velos web-based clinical trial management system was used as a technical platform. Data were collected for patients who were registered to 34 inpatient palliative care services, designated by Ministry of Health, Welfare, and Family Affairs, from $1^{st}$ of January to $30^{th}$ of June in 2009. Descriptive statistics were used for the analysis. Results: From the nationally representative set of 2,940 patients, we obtained the following results. Mean age was $64.8{\pm}12.9$ years, and 56.6% were male. Lung cancer (18.0%) was most common diagnosis. Only 50.3% of patients received the confirmation of terminal diagnosis by two or more physicians, and 69.7% had an insight of terminal diagnosis at the time of admission. About half of patients were admitted to the units on their own without any formal referral. Average and worst pain scores were significantly reduced after 1 week when compared to those at the time of admission. 73.4% faced death in the units, and home-discharge comprised only 13.3%. Mean length of stay per admission was $20.2{\pm}21.2$ days, with median value of 13. Conclusion: Nationally representative data on the characteristics of patients and their caregiver, and current practice of service delivery in palliative care units were obtained through the operation of KTCPIS.

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