http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 천재희 (검색결과 146 건)
- 무료
- 기관 내 무료
- 유료
-
-
Characteristics and Treatment Outcomes of Transition among Patients with Inflammatory Bowel Disease
천재희,유은진,조상훈,박수정,김태일,김원호 연세대학교의과대학 2023 Yonsei medical journal Vol.64 No.9
Purpose: This study aimed to assess disease characteristics and outcomes of transition in patient care among adolescent patients with inflammatory bowel disease (IBD). Materials and Methods: Data from patients younger than 18 years who were diagnosed with IBD (Crohn’s disease, ulcerative colitis, or intestinal Behçet’s disease) were investigated. We categorized the patients into two groups: transition IBD group (Group A, diagnosed in pediatric care followed by transfer to/attendance in adult IBD care) and non-transition group (Group B, diag nosed and followed up in pediatric care or adult IBD care without transfer). Results: Data from a total of 242 patients [Group A (n=29, 12.0%), Group B (n=213, 88.0%)] were analyzed. A significantly higher number of patients was diagnosed at an earlier age in Group A than in Group B (p<0.001). Group A patients had more severe dis ease in terms of number of disease flare ups (p=0.011) and frequency of bowel-related complications (p<0.001). Multiple linear re gression analysis showed that Group B patients had more medical non-compliance than Group A patients (β=2.31, p=0.018). After transition, IBD-related admission frequency, emergency admission frequency, disease flare frequency, and medical non-compli ance were significantly improved. Conclusion: The transition IBD group had more severe disease. Medical non-compliance was lower in the transition IBD group. Clinical outcomes improved after transition.
-
-
-
-
단일 기관에서 치료한 간세포암종 1,078예의 임상 백서
천재희,박중원,박경우,김영일,김성훈,이우진,박홍석,박상재,홍은경,김창민 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.4
Background/Aims: Hepatocellular carcinoma (HCC) is the third leading cause of cancer and the 5 year survival rate is 9.6% in Korea. To develop a strategy for surveillance and treatments, we studied the recent clinical characteristics of HCC diagnosed at single institution in Korea, where is in an endemic area of chronic hepatitis B. Methods: One thousand and seventy eight patients with HCC who visited the National Cancer Center between June 2001 and December 2003 were retrospectively studied. Results: The male/female ratio was 4.5:1. The mean age of the patients was 56.3 years. 74.2% of patient had hepatitis B virus (HBV) infections, 8.6% had hepatitis C virus (HCV) infections, 6.9% of the patients abused alcohol and 10.3% of the patients had non-B non-C considered as the etiologic factors of their HCC. Only 10.0% of patients had a tumor sized 2 cm or less and 53.3% of patients had a large tumor over 5 cm in diameter. 33.2% of patients had a single tumor. At the time of diagnosis, the modified UICC staging was as follows: 6.5%, 20.1%, 30.9%, 25.2% and 17.3% in stages I, II, III, IVa and IVb, respectively. The initial treatment performed was transcatheter arterial chemoembolization (48.2%), radiofrequency ablation (1.5%), hepatic resection (11.2%), systemic chemotherapy (7.5%), radiotherapy (2.1%), and conservative medical treatments (29.5%). The mean number of treatments was 1.65. The response rates to the initial treatments were 27.9% (complete response), 23.6% (partial response), 7.5% (minimal response), 14.2% (stable disease), and 30.4% (progressive disease). Conclusions: HBV infection is a major etiologic factor for Korean HCC patients. Most cases are still in advanced stages and these cases responded poorly to any treatments. The national surveillance program and its guideline for HCC are expected to improve the survival of HCC patients. 목적: 간세포암종은 우리나라 전체 암 중 발생 건수 3위를 차지하며 예후도 매우 불량한 암으로서 연구와 진료를 위해 정확한 임상 현황이 필요한 상태이다. 이에 연구자들은 국립암센터 개원 이래 간세포암종으로 진단 후 치료를 받은 모든 환자들을 대상으로 임상적 특징을 조사하여 추후 시행할 여러 연구에 도움이 되고자 하였다. 대상과 방법: 2001년 6월부터 2003년 12월까지 국립암센터에서 간세포암종으로 진단받고 치료를 받은 1,078명의 환자를 대상으로 임상 특성과 치료 방법, 치료에 대한 반응을 후향적으로 조사하였다. 결과: 남녀 비는 4.5:1로 남자에 많았으며, 평균 연령은 56.3세였다. 위험 인자로는 만성 B형간염(74.2%), 만성 C형간염(8.6%), 알코올 만성 간질환(6.9%), 기타(10.3%) 등이었다. 내원 당시 주 증세는 상복부 불쾌감(38.3%), 정기검진 이상(24.8%), 전신 쇠약감(10.0%), 우연히 발견(9.0%), 복수(6.9%) 등의 순이었다. 간세포암종의 크기는 1 cm 이하가 1.3%, 2 cm 이하가 8.7%, 3 cm 이하가 11.8%, 5 cm 이하가 24.3%, 10 cm 이하가 30.9%, 15 cm 이하가 19.4%, 20 cm 이하가 2.8%였고, 간세포암종의 개수는 1개 33.2%, 2개 16.3%, 3개 7.7%, 4개 3.4%, 5개 이상 37.5%이었다. 내원 당시 병기는 UICC I기, II기, III기, IVa기, IVb기가 각각 6.5%, 20.1%, 30.9%, 25.2%, 17.3%이었다. 첫 치료로서 경동맥화학색전술(48.2%), 내과적 보존치료(29.5%), 수술적 절제술(11.2%), 항암치료(7.5%), 방사선치료(2.1%), 고주파열치료(1.5%) 순으로 시행되었다. 병기 I, II기 274예에 시행된 첫 치료로는 경동맥화학색전술 146예(53.3%), 수술적 절제술 85예(31.0%)이었다. 간세포암종에 대한 총 치료 횟수는 최고 11회, 평균 치료 횟수는 1.65회였다. 첫 치료에 대한 반응은 완전 반응(27.9%), 부분 반응(23.6%), 미소 반응(7.5%), 불변(6.7%), 진행(30.4%), 알 수 없었던 경우(3.9%)로 분석되었다. 결론: 이상의 결과로써 단일 기관에서 2년 6개월 동안 진단-치료된 1,078예의 간세포암종 환자들의 전반적 임상 특징을 정리할 수 있었으며, 향후 생존율, 치료 예후, 예후 인자 분석 등을 조사할 수 있는 토대를 마련하였다.
-
-
-
-
천재희 대한병리학회 2015 Journal of Pathology and Translational Medicine Vol.49 No.3
Endoscopic assessment has a crucial role in the management of inflammatory bowel disease (IBD). It is particularly useful for the assessment of IBD disease extension, severity, and neoplasia surveillance. Recent advances in endoscopic imaging techniques have been revolutionized over the past decades, progressing from conventional white light endoscopy to novel endoscopic techniques using molecular probes or electronic filter technologies. These new technologies allow for visualization of the mucosa in detail and monitor for inflammation/dysplasia at the cellular or subcellular level. These techniques may enable us to alter the IBD surveillance paradigm from four quadrant random biopsy to targeted biopsy and diagnosis. High definition endoscopy and dyebased chromoendoscopy can improve the detection rate of dysplasia and evaluate inflammatory changes with better visualization. Dye-less chromoendoscopy, including narrow band imaging, iScan, and autofluorescence imaging can also enhance surveillance in comparison to white light endoscopy with optical or electronic filter technologies. Moreover, confocal laser endomicroscopy or endocytoscopy have can achieve real-time histology evaluation in vivo and have greater accuracy in comparison with histology. These new technologies could be combined with standard endoscopy or further histologic confirmation in patients with IBD. This review offers an evidencebased overview of new endoscopic techniques in patients with IBD.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
