서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)

김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.

Stented Graft의 임상경험

권태원,김호성,김도균,성규보,조용필,김건언 대한혈관외과학회 2000 Vascular Specialist International Vol.16 No.2

Purpose: Endovascular repair is a alternative treatment with favorable short-term result, but long term results are not available compared to standard operation. The authors have reviewed experiences of Asan Medical Center on stented graft, performed from Aug. 1998 to Feb. 2000, and the results as to age, operative indication, clinical condition, anatomic location, complication, follow-up are reported. Method: Seven patients who has received stented graft between Aug. 1998 and Feb. 2000 are reviewed retrospectively. Result: Of the seven patients, 6 were male and 1 was female. The mean age was 46.4 years (17~71). Indication for stented graft were two pseudoaneurysms, two iatrogenic arterio-venous fistulas, one thoracic aorta aneurysm, one abdominal aortic aneurysm, and one iliac artery occlusion with blue toe syndrome. Three different types of stented graft devices were utilized: Dacron-covered nitinol stented graft (made by the Asan Medical Center medical device team), Vanguard II (by Boston Scientific Corp.), and PTFE with nitinol stented graft (by Tae-woong). There was no perioperative mortality, and the technical success was achieved in five cases (71%). The patency at 14-month were 1009o (5/5). Two immediate complications are hemorrhage due to iliac & femoral artery avulsion requiring emergency bypass grafting, and deployment failure of stented graft requiring removal of retained graft device. Conclusion: Stented graft may be utilized even in complicated vascular situation but will need further development of device and more experience to prevent possible catastrophic complication. Indication should be decided by team approach and vascular surgeon should be prevent or participate during the procedure.

슬라이딩 평면을 이용한 I-PD 제어계의 구성

김성근,박건우,고태언 동의대학교 산업기술개발연구소 2001 産業技術硏究誌 Vol.15 No.-

In this paper, I-PD controller by nearal network is designed using variable structure controller. The I-PD control system is stable in the sense that the error is inside the constraint set, the variable structure controller is idle. If the error hits the boundary of constraint, the variable structure controller begins operation to force the error back to the constraint set. Applying this control technique to the position control system using a DC servo motor as a driver, the control performance of controller is verified by the results of computer simulation.

초기 소설사 이해의 시각

金槿泰 崇實語文學會 1997 崇實語文 Vol.13 No.-

사람 말초 혈액 임파구의 interleukin-2 수용체(Tac 항원)발현 및 증식능의 조절에 대한 연구

김태근,조양자,정태준,김정목 한양대학교 의과대학 1990 한양의대 학술지 Vol.10 No.1

Proliferation of T lymphocytes has been determined by a threshold of signals generated by the interaction between interleukin-2 (IL-2) and its spedific membrane receptor (IL-2R). Regulation of IL-2R expression on the surface of lymphocytes is important in the generation of cytototocix T cells and lymphokine-activated killer (LAK) cells carrying anti-tumor effector functions in the body. To obtain the ideas in designing in vivo immunotherapy using biological response modifiers, this study examined the effects of the interferon(IFN)s, steroid, or colchicine on the IL-2R expression and proliferation of human peripheral blood lymphocytes(PBL). As incubation time was lengthened up to 72 hours, the number of Tac-positive cells and prolongation potential of human PBL upon stimulation wit IL-2 or mitogens were increased. IFN-α resulted in a significant inhibition of IL-2R expression induced by IL-2 but IFN-Υ had no effect. Colchicine or dexaamethasone also inhibited IL-2R expression and cell proliferation induced by IL-2 or mitogens. These findings suggest that IL-2R expression and proliferation of human PBL are inhibited by IFN-α, colchicine, or dexamethasone.

척수손상·비손상인의 신체부위별 신체구성 및 골밀도 비교

김성수,황부근,김태수,이충일,양정수,이동희 한국특수체육학회 2003 한국특수체육학회지 Vol.11 No.1

This study was designed to compare segmental body composition and bone mineral density in spinal cord-injured(SCIS; n=9, SCIA; n=9) and non-injured control(AB; n=9) subjects. Dual-energy X-ray absorptiometry(DEXA) was used to measure %body fat, body fat mass, lean body mass, bone mineral contents, and bone mineral density in total and various body regions(arms, legs, trunk). The present results showed that body fat mass and %body fat were significantly higher and lean body mass was significantly lower in the SCIS group compared to AB group, while there was no difference between the SCIA and AB group in those of parameters. In BMC, there was no difference among groups and in BMD, SCI group was significantly lower that AB group, but there was no difference between SCIA group and AB group. Based on these results, in can be suggested that long-term regular exercise can reduce the negative changes in body composition, bone mineral density by spinal cord injury.

Streptococcus mutans의 치태형성에 대한 Leuconostoc lactis 51의 영향

김태근,양규호,오종석 대한소아치과학회 2000 大韓小兒齒科學會誌 Vol.27 No.4

치아우식증은 치아구조의 국소적, 침윤적, 분자적인 붕괴로 특징지워지는 치아 경조직에 대한 세균성질환이다. 이런 치아우식증의 주 원인균인 S. mutans의 치태형성과 증식에 대한 아동의 구강에서 분리된 L. lactis 51의 작용을 연구하여 다음과 같은 결과를 얻었다. 1.비커 와이어 검사에서 S. mutans와 L. lactis 51의 혼합배양시 S. mutans 단독배양에 비해 치태의 무게가 감소하였다. 2.S. mutans는 S. mutans와 L. lactis 51의 혼합 배양에 비교하여 S. mutans 단독배양시에 생균수가 감소하였다. 3.S. mutans와 L. lactis 51은 M17Y broth에서 단독 및 혼합배양시 배양 12시간 때까지 증가하다가 24시간 때에 감소하였으나, M17YS broth에서는 S. mutans와 L. lactis 51의 혼합배양시 S. mutans의 생균수가 시간이 지남에 따라 감소하였다. 4.L. lactis 51의 배양 상청액은 S. mutans의 치태형성과 증식에 대해 억제 작용을 하지 못하였다. 5.M17YS broth에서의 L. lactis 51 배양 상청액 성분의 thin layer chromatography에서 자당과 과당이 계속 검출되었다. 이상의 결과를 종합하면 구강에서 분리된 L. lactis 51는 S. mutans의 인공치태 형성과 증식을 억제시키는 것으로 사료된다. Dental caries is a bacterial disease of the dental hard tisssus, characterized by a localized, progressive, molecular disintegration of tooth structure. The action of Leuconostoc lactis 51 about plaque formation and replication by Streptococcus mutans was studied as follow. 1.Lower amount of plaque was produced at the mixed culture of S. mutans and L. lactis 51 than S. mutans alone on the wires in the beaker. 2.Fewer cells of S. mutans were replicated at the mixed culture of S. mutans and L. lactis 51 than S. mutans alone. 3.In M17Y broth, viable cells of S. mutans and L. lactis 51 increased for 12 hours, and decreased for 24 hours. In M17YS broth, viable cells of S. mutans showed time-dependent decrease at mixed culture of S. mutans and L. lactis 51. 4.The culture supernatant of L. lactis 51 didn't inhibit the replication of S. mutans and the formation of artificial plaque. 5. Sucrose and fructose were extracted from the culture supernatant of L. lactis 51 in M17YS broth. Thest results suggest that L. lactis 51 isolated from the oral cavity inhibits the replication of S. mutans and the formation of artificial plaque.

인산 칼슘을 사용한 수산화아파타이트 시멘트의 응결·경화 특성에 관한 연구

김한엽,박찬근,송태웅 경남대학교 신소재연구소 1996 論文集 Vol.6 No.-

습식법이나 수열법으로 합성한 hydroxyapatite(HAp)의 분말을 성형, 열처리한 소결체는 지금까지 알려진 바이오 세라믹스 중 생체친화성이 가장 우수한 것으로 입증되고 있으나 소결에 따르는 제조상의 몇가지 문제점을 안고 있다. 본 연구에서는 소결에 의하지 않고 tetracalcium phosphate(TTCP)분말과 dicalcium phosphate dihydrate(DCPD) 분말의 혼합물로 만든 paste를 용해·침전반응으로 응결·경화시켜 직접 HAp 경화체를 얻고, 이때 몇가지 변수가 HAp의 생성과 응결 및 경화특성에 미치는 영향을 검토하였다. TTCP와 DCPD로 조합한 시멘트의 수화반응생성물은 HAp 경화체였으며 이의 미소결정의 interlocking에 의해 응결·경화 하였다. 반응온도 및 HAp 종자의 첨가는 주로 초기단계의 반응속도에 영향을 주었다. 50℃에서의 HAp 생성 반응은 24시간 이내에 거의 완료되었다. Hydroxyapatite ceramics, one of the excellent biocompatible materials, are usually prepared by sintering of hydroxyapatite powders from wet chemical methods. But some problems caused by sintering process are still remained. In this study, instead of powder sintering methods. hardened bodies of hydroxyapatite were prepared by self-hardening reaction of cement paste composed of powdered tetracalcium phosphate(TTCP) and dicalcium phosphate dihydrate(DCPD). Some effects of seeding, reaction temperature on setting and hardening properties were investigated . The hydration products of the hardened paste were composed of finely-crystallized hydroxyapatite which causes setting and hardening by interlocking themselves. Self setting and hardening reaction are accelerated by elevating reaction temperature and addition of hydroxyapatite powders as a seeding materials. The hydration reaction of the paste. at 50C. was nearly finished within 24 hours after mixing with water.

Streptococcus mutans의 치태형성에 대한 Leuconostoc lactis 51의 영향

김태근,양규호,오정석 전남대학교 치과대학 2000 전남치대논문집 Vol.12 No.1

Dental caries is a bacterial disease of the dental hard tisssus, characterized by a localized, progressive, molecular disintegration of tooth structure. The action of Leuconostoc lactis 51 about plaque formation and replication by Streptococcus mutans was studied as follows. 1. Lower amount of plaque was produced at the mixed culture of S. mutans and L. lactis 51 than S. mutans alone on the wires in the beaker. 2. Fewer cells of S. mutans were replicated at the mixed culture of S. mutans and L. lactis 51 than S. mutans alone. 3. In M17Y broth, viable cells of S. mutans and L. lactis 51 increased for 12 hours, and decreased for 24 hours. In M17YS broth, viable cells of S. mutans showed time-dependent decrease at mixed culture of S. mutans and L. lactis 51. 4. The culture supernatant of L. lactis 51 didn't inhibit the replication of S. mutans and the formation of artificial plaque. 5. Sucrose and frutose were extracted from the culture supernatant of L. lactis 51 in M17YS broth. These results suggest that L. lactis 51 isolated from the oral cavity inhibits the replication of S. mutans and the formation of artificial plaque.

Monasucs anka의 적색조 생산 특성

김희구,박근태,손홍주 한국식품영양학회 1998 韓國食品營養學會誌 Vol.11 No.6

Monascus anka KFCC 4478의 적색소 생산력을 증가시키기 위하여 배지조성 및 배양조건에 대하여 검토하였다. 공시균주의 색소 생성력은 탄소원으로 glucose 4.0%, 유기질소원으로 peptone 3.0%, 무기질소원으로 NaNO_3 0.15%, 비타민 성분으로 thiamine-HCI 및 nicotinic acid 각 10㎍/l였으며, 배양온도 30℃, 초기 pH 7.0이었다. 특히 유기질소원과 무기질소원을 복합 처리함으로서 색소 생성력이 향상되었다. 결정된 색소생성 최적조건하에서 본 공시균주는 배양 5일만에 최대 균체 증식과 색소 생성력을 나타내었다. Optimal media and cultural conditions for the production of red pigment were established using Monascus anka KFCC 4478. The optimal temperature and initial pH for the production of red pigment were 30℃ and 7.0, respectively. Glucose turned out to be most suitable carbon source for red pigment production. Optimal glucose concentration was 3.0%. Addition combined of nitrogen sources of peptone and NaNO_3 induced good red pigment production. Thiamine-HCL and nicotinic acid were increased the production of red pigment. Under optimal conditions, maximum red pigment production and cell growth were observed after 5 days of incubation.